ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021

1. We recommend CRC screening in average-risk individuals
between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC.
Strong recommendation; moderate-quality evidence

2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC.
Conditional recommendation; very low-quality evidence

3. We suggest that a decision to continue screening beyond age 75 years be individualized.
Conditional recommendation; very low-quality evidence

4. We recommend colonoscopy and FIT as the primary screening modalities for CRC screening.
Strong recommendation; low-quality evidence

5. We suggest consideration of the following screening tests for individuals unable or unwilling to undergo colonoscopy or FIT: flexible sigmoidoscopy, multitarget stool DNA test, CT colonography or colon capsule.Conditional recommendation; very low-quality evidence

6. We suggest against Septin 9 for CRC screening.
Conditional recommendation, very low-quality of evidence

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