Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study

AbstractBackgroundLow vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.MethodsMR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from …

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Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19

Vitamin D deficiency is a global public health problem, a pandemic that commonly affects the elderly and those with comorbidities such as obesity, diabetes, hypertension, respiratory disorders, recurrent infections, immune deficiency, and malignancies, as well as ethnic minorities living in temperate countries. The same groups were worst affected by COVID-19. Since vitamin D deficiency weakens …

Continue reading Rapidly Increasing Serum 25(OH)D Boosts the Immune System, against Infections—Sepsis and COVID-19

Vitamin D and brain health: an observational and Mendelian randomization study

BackgroundHigher vitamin D status has been suggested to have beneficial effects on the brain. ObjectivesTo investigate the association between 25-hydroxyvitamin D [25(OH)D], neuroimaging features, and the risk of dementia and stroke. MethodsWe used prospective data from the UK Biobank (37–73 y at baseline) to examine the association between 25(OH)D concentrations with neuroimaging outcomes (N = …

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Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population

To assess whether eldecalcitol, an active vitamin D analogue2, can reduce the development of type 2 diabetes among adults with impaired glucose tolerance. Design Double blinded, multicentre, randomised, placebo controlled trial. Setting Three hospitals in Japan, between June 2013 and August 2019. Participants People aged 30 years and older who had impaired glucose tolerance defined …

Continue reading Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population

Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

Background. Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect. Objective. To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed …

Continue reading Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial