Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials

AbstractTo evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients, a systematic review and meta-analysis of randomised, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted. Overall, 14 RCTs with a total of 104,727 participants (2015 cancer deaths) were identified and 7 RCTs, including …

Continue reading Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials

African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses in European American (EA) and AA prostate cell lines and four clinical cohorts. Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) analyses revealed that nonmalignant AA …

Continue reading African American Prostate Cancer Displays Quantitatively Distinct Vitamin D Receptor Cistrome-transcriptome Relationships Regulated by BAZ1A

Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status

IntroductionDespite the association of vitamin D deficiency with incident dementia, the role of supplementation is unclear. We prospectively explored associations between vitamin D supplementation and incident dementia in 12,388 dementia-free persons from the National Alzheimer's Coordinating Center.MethodsBaseline exposure to vitamin D was considered D+; no exposure prior to dementia onset was considered D−. Kaplan–Meier curves …

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Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes

The role of vitamin D in people who are at risk for type 2 diabetes remains unclear.Purpose:To evaluate whether administration of vitamin D decreases risk for diabetes among people with prediabetes.Data Sources:PubMed, Embase, and ClinicalTrials.gov from database inception through 9 December 2022.Study Selection:Eligible trials that were specifically designed and conducted to test the effects of …

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Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study

Aim To estimate the prevalence of micronutrient deficiencies and anaemia, and their association with body mass index (BMI) categories among Australian adults. Method We analysed data from the 2011–2013 Australian Health Survey from 3539 participants aged 18 years and over (without known pregnancy) with measured weight and height, and nutrient biomarkers. To address complex sampling, …

Continue reading Micronutrient deficiencies and anaemia associated with body mass index in Australian adults: a cross-sectional study