Vitamin #D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with #COVID-19 infection

..Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels of C-reactive protein (CRP) and an increase in lymphocyte percentage. Only 9.7% of patients older than 40 years who were vitamin D sufficient … Continue reading Vitamin #D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with #COVID-19 infection

Vitamin #D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with #COVID-19 infection

To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection.. ..Based on CDC criteria, among our study patients, 74% had severe COVID-19 infection and 32.8% were vitamin D sufficient. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical … Continue reading Vitamin #D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with #COVID-19 infection

Vitamin #D receptor is overexpressed in the duodenum of patients with #irritable bowel syndrome

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders and bile acids are thought to be associated with the pathogenesis of IBS. Bile acid receptors are expressed on intestinal epithelial cells. However, no study has assessed bile acid receptor proteins in IBS. Therefore, we examined the intestinal mucosal expression of bile acid receptors in patients with IBS.. Intestinal biopsies were performed … Continue reading Vitamin #D receptor is overexpressed in the duodenum of patients with #irritable bowel syndrome

Vitamin #D for treatment of non‐alcoholic #fatty liver disease detected by transient elastography: A randomized, double‐blind, placebo‐controlled trial

To evaluate the effects of vitamin D on transient elastography (TE, FibroScan) indices of liver steatosis (controlled attenuation parameter [CAP]) and fibrosis (liver stiffness measurement [LSM]) in adults with non‐alcoholic fatty liver disease (NAFLD).. ..Both CAP and LSM gradually decreased in vitamin D‐treated patients and slightly increased in the placebo arm. Vitamin D was superior to placebo for both primary outcomes (mean differences in CAP … Continue reading Vitamin #D for treatment of non‐alcoholic #fatty liver disease detected by transient elastography: A randomized, double‐blind, placebo‐controlled trial

Effect of Long-term Vitamin #D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant #Depressive Symptoms and on Change in Mood Scores A Randomized Clinical Trial

Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there have been few long-term, high-dose large-scale trials.. Randomized assignment in a 2 × 2 factorial design to vitamin D3 (2000 IU/d of cholecalciferol) and fish oil or placebo; 9181 were randomized to vitamin D3 and 9172 were randomized to matching placebo.. Among the 18 353 randomized participants (mean age, 67.5 … Continue reading Effect of Long-term Vitamin #D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant #Depressive Symptoms and on Change in Mood Scores A Randomized Clinical Trial

Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus

The effect of vitamin D supplementation on the risk of type 2 diabetes mellitus (T2DM) remains controversial because most randomized controlled trials (RCTs) have been small or have reported low doses of vitamin D.. ..Nine RCTs were included (43 559 participants). The mean age (standard deviation) was 63.5 (6.7) years. The RR for vitamin D compared with placebo was 0.96 (95% CI, 0.90-1.03); P = … Continue reading Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus

JOINT GUIDANCE ON VITAMIN D IN THE ERA OF COVID-19 FROM THE ASBMR, AACE, ENDOCRINE SOCIETY, ECTS, NOF, AND IOF

In response to the current COVID-19 global pandemic, and the attendant impact on outdoor physical activity and leisure time, the American Society for Bone and Mineral Research (ASBMR), American Association of Clinical Endocrinologists (AACE), Endocrine Society, European Calcified Tissue Society (ECTS), National Osteoporosis Foundation (NOF), and International Osteoporosis Foundation (IOF) remind individuals of the importance of obtaining the daily recommended dosage of vitamin D. The … Continue reading JOINT GUIDANCE ON VITAMIN D IN THE ERA OF COVID-19 FROM THE ASBMR, AACE, ENDOCRINE SOCIETY, ECTS, NOF, AND IOF

The Possible Role of Vitamin #D in Suppressing Cytokine Storm and Associated Mortality in #COVID-19 Patients

Large-scale data show that the mortality of COVID-19 varies dramatically across populations, although the cause of these disparities is not well understood. In this study we investigated whether severe COVID-19 is linked to Vitamin D (Vit D) deficiency. Method Daily admission, recovery and deceased rate data for patients with COVID-19 from countries with a large number of confirmed patients (Germany, South Korea (S. Korea), China … Continue reading The Possible Role of Vitamin #D in Suppressing Cytokine Storm and Associated Mortality in #COVID-19 Patients

Association of #bisphosphonate therapy with incident lower extremity #fractures in persons with spinal cord injuries/disorders

To investigate the association between prescriptions for bisphosphonates, calcium/Vitamin D supplements, and receipt of DXA screening, and incident fracture risk in men and women with a spinal cord injury/disorder (SCI/D).. There was no significant association between prescriptions for bisphosphonates and incident lower extremity fractures in men (OR 1.04, 95% CI: 0.62-1.77) or women (OR 1.02, 95% CI 0.28-3.75). In men, similar null associations were seen … Continue reading Association of #bisphosphonate therapy with incident lower extremity #fractures in persons with spinal cord injuries/disorders

Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients

Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients.. ..A total of 1360 patients were found to be vitamin D–deficient during point-of-care screening and underwent randomization. Of these patients, 1078 had baseline vitamin D deficiency (25-hydroxyvitamin D level, <20 ng per milliliter [50 nmol per liter]) confirmed by subsequent testing and were included in the primary analysis … Continue reading Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients

Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults

..(VITAL) tested vitamin D (2000 IU/day) and/or n-3 FA (1 g/day) supplementation in a 2 × 2 factorial design among women ≥55 and men ≥50 years of age. Baseline characteristics were well balanced. In the active arms, 25-OH vitamin D rose 39% and n-3 FA rose 55% vs minimal change in placebo arms. Neither supplement reduced biomarkers at 1 year. Vitamin D resulted in 8.2% … Continue reading Effects of One Year of Vitamin #D and Marine #Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults

Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity

..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role of vitamin D-VDR signalling and replicated the findings in TCGA … Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity