Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

Background. Associations between vitamin D (VD) deficiency and the risk of SARS-CoV-2 infection have been documented in cross-sectional population studies. Intervention studies in patients with moderate to severe COVID-19 have failed to consistently document a beneficial effect. Objective. To determine the efficacy and safety of VD-supplementation in the prevention of SARS-CoV-2 infection in highly exposed …

Continue reading Efficacy and Safety of Vitamin D Supplementation to Prevent COVID-19 in Frontline Healthcare Workers. A Randomized Clinical Trial

Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome

Vitamin D is best known for its role in maintaining bone health and calcium homeostasis. However, it also exerts a broad range of extra-skeletal effects on cellular physiology and on the immune system. Vitamins D2 and D3 share a high degree of structural similarity. Functional equivalence in their vitamin D-dependent effects on human physiology is …

Continue reading Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome

Inverse association between serum 25-hydroxyvitamin D and nonalcoholic fatty liver disease

AbstractBackground & AimsSerum 25-hydroxyvitamin D (S-25(OH)D) and nonalcoholic fatty liver disease (NAFLD) are correlated in many observational studies, whereas the causality of this association is uncertain, especially in European populations. We conducted a bidirectional Mendelian randomization study to determine the association between S-25(OH)D and NAFLD. MethodsSeven and six independent genetic variants associated with S-25(OH)D and …

Continue reading Inverse association between serum 25-hydroxyvitamin D and nonalcoholic fatty liver disease

Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness

Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2. ParticipantsThe records of individuals …

Continue reading Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness

Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trialβ€”a randomized controlled trial

Vitamin D insufficiency is associated with risk of cardiovascular diseases (CVD) and cancer in observational studies, but evidence for benefits with vitamin D supplementation is limited. ObjectivesTo investigate the effects of vitamin D3 supplementation on CVD and cancer incidence. DesignThe study was a 5-year randomized placebo-controlled trial among 2495 male participants β‰₯ 60 years and …

Continue reading Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trialβ€”a randomized controlled trial