Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition

The purpose of this study was to clarify the association between self‐reported night sleep duration and cognitive functions such as word memory, story memory, attention, executive function, and processing speed of older adults with normal global cognitive function. Methods A total of 241 functionally independent older adults (mean age, 75.5 ± 6.4 years) participated in this study. No participants had a history of dementia diagnosis, … Continue reading Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition

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Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial

Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older medical patients. Methods This study was a randomized double-blind controlled … Continue reading Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial

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A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association

A healthy brain is critical for living a longer and fuller life. The projected aging of the population, however, raises new challenges in maintaining quality of life. As we age, there is increasing compromise of neuronal activity that affects functions such as cognition, also making the brain vulnerable to disease. Once pathology-induced decline begins, few therapeutic options are available. Prevention is therefore paramount, and primary … Continue reading A Primary Care Agenda for #Brain Health: A Scientific Statement From the American Heart Association

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Assessment of protection against #reinfection with #SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study

The degree to which infection with SARS-CoV-2 confers protection towards subsequent reinfection is not well described. In 2020, as part of Denmark’s extensive, free-of-charge PCR-testing strategy, approximately 4 million individuals (69% of the population) underwent 10·6 million tests. Using these national PCR-test data from 2020, we estimated protection towards repeat infection with SARS-CoV-2. Methods In this population-level observational study, we collected individual-level data on patients … Continue reading Assessment of protection against #reinfection with #SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study

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An integrative study of five biological #clocks in somatic and mental #health

Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health … Continue reading An integrative study of five biological #clocks in somatic and mental #health

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Risk of Progression to #Diabetes Among Older Adults With Prediabetes

..Prediabetes defined by a glycated hemoglobin (HbA1c) level of 5.7% to 6.4%, impaired fasting glucose (IFG) level (FG level of 100-125 mg/dL), either, or both. Main Outcomes and Measures Incident total diabetes (physician diagnosis, glucose-lowering medication use, HbA1c level ≥6.5%, or FG level ≥126 mg/dL). Results A total of 3412 participants without diabetes (mean [SD] age, 75.6 [5.2] years; 2040 [60%] female; and 572 [17%] … Continue reading Risk of Progression to #Diabetes Among Older Adults With Prediabetes

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Older Adults and the Mental Health Effects of #COVID-19

As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate existing mental health conditions. Older adults tend to have lower … Continue reading Older Adults and the Mental Health Effects of #COVID-19

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#Older age does not influence the success of #weight loss through the implementation of lifestyle modification

Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following implemented lifestyle interventions. Data were stratified according to patient age … Continue reading #Older age does not influence the success of #weight loss through the implementation of lifestyle modification

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#Mediterranean diet, #stress resilience, and aging in nonhuman primates

Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term studies of diet effects on stress reactive systems are not … Continue reading #Mediterranean diet, #stress resilience, and aging in nonhuman primates

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Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort

Findings of historical studies suggest that elevated LDL cholesterol is not associated with increased risk of myocardial infarction and atherosclerotic cardiovascular disease in patients older than 70 years. We aimed to test this hypothesis in a contemporary population of individuals aged 70–100 years.. ..Between Nov 25, 2003, and Feb 17, 2015, 91 131 individuals were enrolled in CGPS. During mean 7·7 (SD 3·2) years of follow-up … Continue reading Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort

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Factors associated with social #isolation and being homebound among #older patients with #diabetes: a cross-sectional study

We aimed at investigating factors associated with social isolation and being homebound in older patients with diabetes.. ..Social isolation was defined as indulging in less than one interaction per week with individuals other than cohabiting family members. We defined homebound as going outside home less than once a day. To identify factors associated with social isolation and being homebound, we performed logistic regression analysis. The … Continue reading Factors associated with social #isolation and being homebound among #older patients with #diabetes: a cross-sectional study

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Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data

Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.. ..Of 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in Stockholm in December, 2019, 274 712 met the eligibility criteria and … Continue reading Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data

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