Older Adults and the Mental Health Effects of #COVID-19

As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate existing mental health conditions. Older adults tend to have lower … Continue reading Older Adults and the Mental Health Effects of #COVID-19

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#Older age does not influence the success of #weight loss through the implementation of lifestyle modification

Age is sometimes a barrier for acceptance of patients into a hospital‐based obesity service. Our aim was to explore the effect of age on the ability to lose weight through lifestyle interventions, implemented within a hospital‐based obesity service.. Primary outcome measures were percentage weight loss (%WL) and percentage reduction in body mass index (%rBMI) following implemented lifestyle interventions. Data were stratified according to patient age … Continue reading #Older age does not influence the success of #weight loss through the implementation of lifestyle modification

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#Mediterranean diet, #stress resilience, and aging in nonhuman primates

Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term studies of diet effects on stress reactive systems are not … Continue reading #Mediterranean diet, #stress resilience, and aging in nonhuman primates

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Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort

Findings of historical studies suggest that elevated LDL cholesterol is not associated with increased risk of myocardial infarction and atherosclerotic cardiovascular disease in patients older than 70 years. We aimed to test this hypothesis in a contemporary population of individuals aged 70–100 years.. ..Between Nov 25, 2003, and Feb 17, 2015, 91 131 individuals were enrolled in CGPS. During mean 7·7 (SD 3·2) years of follow-up … Continue reading Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort

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Factors associated with social #isolation and being homebound among #older patients with #diabetes: a cross-sectional study

We aimed at investigating factors associated with social isolation and being homebound in older patients with diabetes.. ..Social isolation was defined as indulging in less than one interaction per week with individuals other than cohabiting family members. We defined homebound as going outside home less than once a day. To identify factors associated with social isolation and being homebound, we performed logistic regression analysis. The … Continue reading Factors associated with social #isolation and being homebound among #older patients with #diabetes: a cross-sectional study

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Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data

Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.. ..Of 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in Stockholm in December, 2019, 274 712 met the eligibility criteria and … Continue reading Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data

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#Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress

Key points In humans, hypohydration attenuates sweat secretion and attenuates whole‐body heat loss, probably to mitigate further fluid losses and thereby support blood pressure regulation. Recently, however, we demonstrated that the hypohydration‐mediated reduction in net whole‐body heat exchange (evaporative heat loss – dry heat gain) was blunted in middle‐aged compared to younger men during moderate exercise in dry heat; albeit, the underpinning mechanisms could not … Continue reading #Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress

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The temporal association between incident late‐life #depression and incident #dementia

There is an established association between depression and subsequent dementia. The present study examined temporal associations between incident late‐life depression and subsequent dementia, also considering age and sex.. ..Incident depression was associated with a higher risk of subsequent dementia (incidence rate ratios (IRR) adjusted for age and sex: IRR = 1.58, 95% CI = 1.51‐1.64). The strongest association was found for the shortest interval of … Continue reading The temporal association between incident late‐life #depression and incident #dementia

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Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults 75 years and older.. ..Of 326 981 eligible veterans (mean [SD] age, 81.1 [4.1] years; 97% men; 91% white), 57 178 (17.5%) newly initiated statins during the study period. During a mean follow-up of 6.8 (SD, 3.9) years, a total 206 902 deaths occurred including 53 296 cardiovascular deaths, with 78.7 and 98.2 … Continue reading Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

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Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with aging. In healthy humans, plasma trimethylamine-N-oxide was higher in middle-aged/older (64±7 years) versus young (22±2 years) adults (6.5±0.7 versus 1.6±0.2 µmol/L) and inversely related to brachial artery flow-mediated dilation (r2=0.29, P<0.00001). In young mice, 6 months of dietary … Continue reading Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

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Predictors of a long length of stay in the emergency department for older people

..For older people, a long stay in the emergency department (ED) may reflect the complexity of their presentation, or deficiencies in systems that manage these complexities. ..Of 16 791 ED presentations made by older people, 4192 experienced a LLoS; 55% were admitted. Increasing age was associated with an increasing ED LoS. Factors most predictive of LLoS for both admitted and discharged patients included: investigations (both pathology … Continue reading Predictors of a long length of stay in the emergency department for older people

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Estimates of the severity of #coronavirus disease 2019: a model-based analysis

Using data on 24 deaths that occurred in mainland China and 165 recoveries outside of China, we estimated the mean duration from onset of symptoms to death to be 17·8 days (95% credible interval [CrI] 16·9–19·2) and to hospital discharge to be 24·7 days (22·9–28·1). In all laboratory confirmed and clinically diagnosed cases from mainland China (n=70 117), we estimated a crude case fatality ratio (adjusted … Continue reading Estimates of the severity of #coronavirus disease 2019: a model-based analysis

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