Aging clocks are tools that quantify biological #aging through the integration of multi-omics data, encompassing epigenetic, transcriptomic, proteomic, metabolic, and microbial information, together with functional biomarkers. These tools show significant potential for use in preventive medicine, early detection of chronic conditions, and monitoring the effectiveness of interventions designed to enhance population health. The advancement of… Continue reading The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration
Tag: Ageing
Exploring the link between water-soluble vitamins and aging-associated immune system status
Background: #Aging is associated with numerous physiological changes that contribute to immunosenescence and inflammaging, resulting in a decline in immune defense and an increased susceptibility to infections. Older adults are at risk of inadequate dietary intake and suboptimal supply of micronutrients, including water-soluble #vitamins, even those generally considered sufficient in the overall population. These deficiencies… Continue reading Exploring the link between water-soluble vitamins and aging-associated immune system status
Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults
Sedentary #ageing is linked to low cardiorespiratory fitness and the development of a small, stiff #heart - risk factors for heart failure. Endurance exercise training reverses the effects of sedentary ageing on the heart when started in middle age; however, blunted training responses of females have been reported. Differences in baseline cardiac size or exercise-induced… Continue reading Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults
Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
Background: #Sarcopenia, the age-related loss of skeletal muscle mass and function, has been linked to adverse health outcomes. Cross-sectional associations have been observed between skeletal and cardiac muscle mass and function in healthy, community-dwelling older adults during normative aging. Further longitudinal studies on the skeletal muscle-cardiac axis during aging are needed to inform the temporal… Continue reading Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
The effectiveness of Zhi-Shi plaster acupoint therapy combined with lactulose in the treatment of geriatrics functional constipation: a randomized controlled trial
Objective: This study aimed to evaluate the effectiveness and adverse effects of Zhi-Shi plaster acupoint therapy combined with Lactulose in the Treatment of geriatrics Functional Constipation.Methods: A total of 62 geriatrics Functional Constipation patients were randomly assigned to the intervention group (n = 31) and control group (n = 31). The intervention group received oral lactulose (20 mL daily for… Continue reading The effectiveness of Zhi-Shi plaster acupoint therapy combined with lactulose in the treatment of geriatrics functional constipation: a randomized controlled trial
Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
This study investigated real-world edoxaban concentrations across different dosing regimens, with a specific focus on patients who met the inclusion criteria of low-dose edoxaban for the Elder Care Atrial Fibrillation (ELDERCARE-AF) trial. Patients with atrial fibrillation receiving edoxaban were enrolled to measure trough concentrations. The levels were compared with the expected therapeutic range (12–43 ng/mL) to… Continue reading Real-World #Edoxaban Concentrations in #Older Patients Receiving Reduced-Dose Regimens
Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
Objective To examine the associations between the number of days per week achieving various daily step thresholds and all-cause mortality and cardiovascular disease (CVD) incidence in older women.Methods We conducted a prospective cohort study of 13 547 women free of CVD and cancer (mean age 71.8 years). We included participants who wore an ActiGraph GT3X+ accelerometer for… Continue reading Association between frequency of meeting daily step thresholds and all-cause #mortality and #cardiovascular disease in older women
Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Previous studies have highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the “relative association” to ascertain the optimal consumption strategy (including… Continue reading Relative associations of #coffee, #tea, and plain #water with all-cause and cause-specific #mortality: a prospective cohort study
Effects of 2-year #cocoa extract# supplementation on #inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial Get access Arrow
ObjectiveTo examine the long-term effect of cocoa flavanols on inflammaging biomarkers in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).MethodsCOSMOS is a large, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial testing the effects of a cocoa extract supplement (containing 500 mg cocoa flavanols/day, including 80 mg (−)-epicatechin) among women aged ≥65 years and men aged ≥60… Continue reading Effects of 2-year #cocoa extract# supplementation on #inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial Get access Arrow
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