#Handgrip strength variability during serial testing as an entropic biomarker of #aging: a Poincaré plot analysis

..An observational cross-sectional study was performed on 80 young adults (18–22 years old, mean age 20.01 years) and 80 older people (65–69 years old, mean age 67.13 years), with a sex ratio of 1:1 for both groups.. The analysis of the differences between groups revealed statistically significant results for most HGS-derived indices (p ≤ 0.05), and the magnitude of the differences indicated, in most situations, a large effect size (r > 0.5). Our … Continue reading #Handgrip strength variability during serial testing as an entropic biomarker of #aging: a Poincaré plot analysis

Skeletal #muscle mass in relation to 10 year #cardiovascular disease incidence among middle aged and older adults: the ATTICA study

Skeletal muscle mass (SMM) is inversely associated with cardiometabolic health and the ageing process. The aim of the present work was to evaluate the relation between SMM and 10 year cardiovascular disease (CVD) incidence, among CVD-free adults 45+ years old. The 10 year CVD incidence increased significantly across the baseline SMI tertiles (p<0.001). Baseline SMM showed a significant inverse association with the 10 year CVD incidence (HR 0.06, 95% CI … Continue reading Skeletal #muscle mass in relation to 10 year #cardiovascular disease incidence among middle aged and older adults: the ATTICA study

Regulation of #lifespan by #neural excitation and REST

..Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex that is characterized by downregulation of genes related to neural excitation and synaptic function. In Caenorhabditis elegans, neural excitation increases with age and inhibition of excitation globally, or in glutamatergic or cholinergic neurons, increases longevity. Furthermore, longevity is dynamically regulated by the excitatory–inhibitory balance of neural … Continue reading Regulation of #lifespan by #neural excitation and REST