Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank

Tea is frequently consumed worldwide, but the association of tea drinking with mortality risk remains inconclusive in populations where black tea is the main type consumed.Objective:To evaluate the associations of tea consumption with all-cause and cause-specific mortality and potential effect modification by genetic variation in caffeine metabolism.Design:Prospective cohort study.Setting:The UK Biobank.Participants:498 043 men and women aged …

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Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study

Background and aimsAlcohol-related cirrhosis is linked to increased risk of fractures, but this has seldom been quantified nationally or compared against non-cirrhotic controls. Here, we determined the rate and risk of fractures and post-fracture mortality in patients with alcohol-related cirrhosis compared to individuals from the general population.MethodsIn this nationwide population-based cohort study, data were retrieved …

Continue reading Risk of fractures and subsequent mortality in alcohol-related cirrhosis: A nationwide population-based cohort study

The decline of COVID-19 severity and lethality over two years of pandemic

Undernotification of SARS-CoV-2 infections has been a major obstacle to the tracking of critical quantities such as infection attack rates and the probability of severe and lethal outcomes. We use a model of SARS-CoV-2 transmission and vaccination informed by epidemiological and genomic surveillance data to estimate the number of daily infections occurred in Italy in …

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Association of Statins for Primary Prevention of Cardiovascular Diseases With Hospitalization for COVID‐19: A Nationwide Matched Population‐Based Cohort Study

BackgroundThere is little evidence on the relationship between statin use and the risk of hospitalization attributable to COVID‐19. Methods and ResultsThe French National Healthcare Data System database was used to conduct a matched‐cohort study. For each adult aged ≥40 years receiving statins for the primary prevention of cardiovascular diseases, one nonuser was randomly selected and …

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Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts

BackgroundAlthough 10 000 steps per day is widely promoted to have health benefits, there is little evidence to support this recommendation. We aimed to determine the association between number of steps per day and stepping rate with all-cause mortality.MethodsIn this meta-analysis, we identified studies investigating the effect of daily step count on all-cause mortality in adults …

Continue reading Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts