AI-based CT Body Composition Identifies Myosteatosis as Key Mortality Predictor in Asymptomatic Adults

BackgroundBody composition data have been limited to adults with disease or older age. The prognostic impact in otherwise asymptomatic adults is unclear.PurposeTo use artificial intelligence–based body composition metrics from routine abdominal CT scans in asymptomatic adults to clarify the association between obesity, liver steatosis, myopenia, and myosteatosis and the risk of mortality. Materials and MethodsIn …

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Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study

Osteoporosis is becoming a global epidemic in aging societies. Anti-osteoporotic medications can prevent fractures, and their pleiotropic effect on mortality is interesting but not well compared among each other.ObjectiveTo provide real-world evidence on the pleiotropic effect of different anti-osteoporotic medications on all-cause mortality, stratified by fracture site, sex, and age.MethodsThis longitudinal population-based postfracture cohort study, …

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Age-stratified infection fatality rate of COVID-19 in the non-elderly population

The largest burden of COVID-19 is carried by the elderly, and persons living in nursing homes are particularly vulnerable. However, 94% of the global population is younger than 70 years and 86% is younger than 60 years. The objective of this study was to accurately estimate the infection fatality rate (IFR) of COVID-19 among non-elderly …

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Community-level age bias and older adult mortality

As the older adult population increases, understanding the health effects of bias against older adults is increasingly important. Whether structural forms of age bias predict worse health has received limited attention.ObjectiveWe hypothesized that communities with greater age bias would have higher mortality among residents aged 65 and older. We expected the association to be unique …

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Association Between Smoking, Smoking Cessation, and Mortality by Race, Ethnicity, and Sex Among US Adults

Key PointsQuestion  What are the contemporary hazards of cigarette smoking and benefits of quitting smoking by race, ethnicity, and sex among US adults?Findings  In this prospective cohort study of 551 388 US adults, smoking was associated with appreciably greater all-cause mortality compared with never smoking irrespective of race, ethnicity, or sex. Quitting smoking was associated with a reduction …

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