#Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study

Obesity shortens life expectancy. Bariatric surgery is known to reduce the long-term relative risk of death, but its effect on life expectancy is unclear.. ..In total, 2007 and 2040 patients were included in the surgery group and the control group, respectively, and 1135 participants were included in the reference cohort. At the time of the analysis (December 31, 2018), the median duration of follow-up for … Continue reading #Life Expectancy after #Bariatric Surgery in the Swedish Obese Subjects Study

Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

..Of the 7342 total sample, 4348 participants (60.3%) were women. At baseline, 4533 individuals (64.0%) were between ages 70 and 79 years, 2393 individuals (31.0%) were between 80 and 89 years, and 416 individuals (5.0%) were between 90 and 99 years; percentages were weighted. The percentage of deaths attributable to dementia was 13.6% (95% CI, 12.2%-15.0%) between 2000 and 2009. The mortality burden of dementia … Continue reading Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

Vital statistics are the primary source of data used to understand the mortality burden of dementia in the US, despite evidence that dementia is underreported on death certificates. Alternative estimates, drawing on population-based samples, are needed ..Of the 7342 total sample, 4348 participants (60.3%) were women. At baseline, 4533 individuals (64.0%) were between ages 70 and 79 years, 2393 individuals (31.0%) were between 80 and … Continue reading Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis

Results have been mixed and uncertainty still remains regarding the impact of statin adherence on premature deaths. Thus, we investigated the association between statin adherence and risks of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients in South Korea.. We used data from the National Health Insurance Service (NHIS) National Sample Cohort for the years 2003-2013, which included data on 107,954 middle-aged and elderly dyslipidemia … Continue reading Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis

#Dexamethasone in Hospitalized Patients with #Covid-19 — Preliminary Report

Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death In this controlled, open-label trial comparing a range of possible treatments in patients who were hospitalized with Covid-19, we randomly assigned patients to receive oral or intravenous dexamethasone (at a dose of 6 mg once daily) for up to 10 … Continue reading #Dexamethasone in Hospitalized Patients with #Covid-19 — Preliminary Report

Association between #prediabetes and risk of all cause mortality and #cardiovascular disease: updated meta-analysis

To evaluate the associations between prediabetes and the risk of all cause mortality and incident cardiovascular disease in the general population and in patients with a history of atherosclerotic cardiovascular disease.. ..A total of 129 studies were included, involving 10 069 955 individuals for analysis. In the general population, prediabetes was associated with an increased risk of all cause mortality (relative risk 1.13, 95% confidence interval 1.10 … Continue reading Association between #prediabetes and risk of all cause mortality and #cardiovascular disease: updated meta-analysis

Association of Rapid Eye Movement #Sleep With Mortality in Middle-aged and Older Adults

Rapid eye movement (#REM) sleep has been linked with health outcomes, but little is known about the relationship between REM sleep and mortality.. ..The MrOS cohort included 2675 individuals (2675 men [100%]; mean [SD] age, 76.3 [5.5] years) and was followed up for a median (interquartile range) of 12.1 (7.8-13.2) years. The WSC cohort included 1386 individuals (753 men [54.3%]; mean [SD] age, 51.5 [8.5] years) and … Continue reading Association of Rapid Eye Movement #Sleep With Mortality in Middle-aged and Older Adults

Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults 75 years and older.. ..Of 326 981 eligible veterans (mean [SD] age, 81.1 [4.1] years; 97% men; 91% white), 57 178 (17.5%) newly initiated statins during the study period. During a mean follow-up of 6.8 (SD, 3.9) years, a total 206 902 deaths occurred including 53 296 cardiovascular deaths, with 78.7 and 98.2 … Continue reading Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

Association of Azithromycin Use With Cardiovascular Mortality

Azithromycin is one of the most commonly prescribed antibiotics in the US. It has been associated with an increased risk of cardiovascular death in some observational studies.. ..The study included 7 824 681 antibiotic exposures, including 1 736 976 azithromycin exposures (22.2%) and 6 087 705 amoxicillin exposures (77.8%), among 2 929 008 unique individuals (mean [SD] age, 50.7 [12.3] years; 1 810 127 [61.8%] women). Azithromycin was associated with a significantly increased hazard of … Continue reading Association of Azithromycin Use With Cardiovascular Mortality

Antihypertensive Treatment in Elderly Frail Patients Evidence From a Large Italian Database

Aim of our study was to assess the relationship between adherence with antihypertensive drugs and the risk of death in frail versus nonfrail old individuals. Using the database of the Lombardy Region (Italy), we identified 1 283 602 residents aged ≥65 years (mean age 76) who had ≥3 prescriptions of antihypertensive drugs between 2011 and 2012. A nested case-control design was applied, with cases being … Continue reading Antihypertensive Treatment in Elderly Frail Patients Evidence From a Large Italian Database

Dose-Response Association of Low-Intensity and Nondaily Smoking With Mortality in the United States

An increasing proportion of US smokers smoke at low intensity and not every day. Some nondaily smokers have always had this pattern, whereas others previously smoked daily. The effect of reducing the level of smoking from daily to nondaily smoking and the dose response at low smoking levels are poorly understood.. ..Among 505 500 participants (aged 18-103 years), approximately 47 000 deaths occurred. The median number of … Continue reading Dose-Response Association of Low-Intensity and Nondaily Smoking With Mortality in the United States

Blood #Pressure at 6 Months after Acute Myocardial #Infarction and Outcomes at 2 Years: The Perils Associated With Excessively Low Blood Pressures

This study aimed to determine the association between achieved blood pressure at 6-month follow-up and cardiovascular outcomes at 2 years in patients treated with β-blockers and renin-angiotensin-aldosterone blockers after acute myocardial infarction (AMI).. ..Achieved blood pressures were categorized into 10-mm Hg increments. The primary outcome was all-cause death. The secondary outcome was a composite of all-cause death, MrI, and rHHF. Hazard ratios (HRs) were estimated … Continue reading Blood #Pressure at 6 Months after Acute Myocardial #Infarction and Outcomes at 2 Years: The Perils Associated With Excessively Low Blood Pressures