Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants

To quantify the association of combined sleep behaviours and genetic susceptibility with the incidence of cardiovascular disease (CVD).Methods and resultsThis study included 385 292 participants initially free of CVD from UK Biobank. We newly created a healthy sleep score according to five sleep factors and defined the low-risk groups as follows: early chronotype, sleep 7–8 h per …

Continue reading Sleep patterns, genetic susceptibility, and incident cardiovascular disease: a prospective study of 385 292 UK biobank participants

Light at night in older age is associated with obesity, diabetes, and hypertension

Light at night (LAN) has been associated with negative health consequences and metabolic risk factors. Little is known about the prevalence of LAN in older adults in the U.S. and its association with cardiovascular disease (CVD) risk factors. We tested the hypothesis that LAN in older age is associated with higher prevalence of individual CVD …

Continue reading Light at night in older age is associated with obesity, diabetes, and hypertension

Rising temperatures erode human sleep globally

Insufficient sleep is a risk factor for several adverse physical and mental outcomes. A lack of sleep has been associated with reduced cognitive performance, diminished productivity, compromised immune function, adverse cardiovascular outcomes, depression, anger, and suicidal behavior. High ambient temperatures have been associated with reduced subjective sleep quality, but little is known regarding the influence …

Continue reading Rising temperatures erode human sleep globally

Poor sleep may undermine people’s attempts to keep weight off

New research being presented at this year’s European Congress on Obesity (ECO) in Maastricht, Netherlands (4-7 May), finds that not getting enough good quality sleep undermines people’s attempts to keep weight off after dieting, and suggests that around two hours of vigorous physical activity per week can help maintain better sleep. The study is by …

Continue reading Poor sleep may undermine people’s attempts to keep weight off

Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film

Sleep deficiency, a common public health problem, causes ocular discomfort and affects ocular surface health. However, the underlying mechanism remains unclear. Herein, we identified that short-term sleep deprivation (SD) resulted in hyperproliferation of corneal epithelial progenitor cells (CEPCs) in mice. The expression levels of p63 and Keratin 14, the biomarkers of CEPCs, were upregulated in …

Continue reading Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film