Elevated blood pressure (BP) is a major health risk factor and the leading global cause of premature death. Hypertension is also a risk factor for cognitive decline and dementia. However, when elevated blood pressure starts impacting cerebral health is less clear. We addressed this gap by estimating how a validated measure of brain health relates … Continue reading Optimal Blood #Pressure Keeps Our #Brains Younger
Tag: Brain
A new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowledge, has not previously been described in detail. We aimed to document the features of post-vaccination cerebral venous thrombosis with and without … Continue reading #Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study
Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses•Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s•Feedback was used to train mice to volitionally control their spontaneous impulses•Mice learned to reliably modulate dopamine impulses in order to receive a reward SummaryIn their pioneering study on dopamine release, Romo and … Continue reading Reinforcement learning links spontaneous cortical #dopamine impulses to reward
Psilocybin ameliorates stress-related behavioral deficit in mice•Psilocybin increases spine density and spine size in frontal cortical pyramidal cells•Psilocybin-evoked structural remodeling is persistent for at least 1 month•The dendritic rewiring is accompanied by elevated excitatory neurotransmission SummaryPsilocybin is a serotonergic psychedelic with untapped therapeutic potential. There are hints that the use of psychedelics can produce neural … Continue reading #Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo
Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical … Continue reading Adaptive circuit dynamics across human #cortex during evidence accumulation in changing #environments
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