In contrast to healthy controls, the heterotrimeric G protein, Gsalpha (GsΞ±) is ensconced predominantly in lipid rafts in subjects with major depressive disorder (MDD) resulting in impaired stimulation of adenylyl cyclase. In this small proof-of-concept study, we examined the hypothesis that translocation of GsΞ± from lipid rafts toward a more facile activation of adenylyl cyclase … Continue reading A novel peripheral biomarker for depression and antidepressant response
Tag: depression
Major life events, such as the COVID-19 pandemic, affect psychological and physiological health. Social support, or the lack thereof, can modulate these effects. The context of the COVID-19 pandemic offered a unique opportunity to better understand how dogs may provide social support for their owners and buffer heightened symptoms of stress, anxiety and depression and … Continue reading Depression, anxiety, and happiness in dog owners and potential dog owners during the COVID-19 pandemic in the United States
The high global prevalence of depression, together with the recent acceleration of remote care owingto the COVID-19 pandemic, has prompted increased interest in the efficacy of digital interventions forthe treatment of depression. We provide a summary of the latest evidence base for digital interventionsin the treatment of depression based on the largest study sample to … Continue reading Digital Interventions for the Treatment of Depression:A Meta-Analytic Review
Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and … Continue reading #Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this process is identifying risk factors for the incidence of major depression. There is accumulating biological evidence linking insulin resistance, another … Continue reading Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
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