644 – Development of noninvasive #diabetes monitoring method using #tear samples

To prevent diabetic complications, strict glucose control and frequent monitoring of blood glucose levels are necessary. However, all currently available methods for blood glucose monitoring, including the finger prick method, are invasive. Therefore, noninvasive blood glucose monitoring approaches have been investigated, but until date, none has been found to be a suitable substitute for direct glucose measurement in blood samples. We considered monitoring of diabetes-related … Continue reading 644 – Development of noninvasive #diabetes monitoring method using #tear samples

#Dapagliflozin in Patients with Chronic #Kidney Disease

Patients with chronic kidney disease have a high risk of adverse kidney and cardiovascular outcomes. The effect of dapagliflozin in patients with chronic kidney disease, with or without type 2 diabetes, is not known.. ..The independent data monitoring committee recommended stopping the trial because of efficacy. Over a median of 2.4 years, a primary outcome event occurred in 197 of 2152 participants (9.2%) in the … Continue reading #Dapagliflozin in Patients with Chronic #Kidney Disease

Once-Weekly #Insulin for Type 2 #Diabetes without Previous Insulin Treatment

It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes We conducted a 26-week, randomized, double-blind, double-dummy, phase 2 trial to investigate the efficacy and safety of once-weekly insulin icodec … Continue reading Once-Weekly #Insulin for Type 2 #Diabetes without Previous Insulin Treatment

#Loneliness and type 2 #diabetes incidence: findings from the English Longitudinal Study of Ageing

Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear.. ..A total of 264 (6.42%) participants developed type 2 diabetes over the follow-up period. Loneliness was a significant predictor of incident type 2 diabetes (HR 1.46; 95% CI 1.15, 1.84; p = 0.002) independent of age, sex, ethnicity, wealth, smoking status, physical activity, alcohol … Continue reading #Loneliness and type 2 #diabetes incidence: findings from the English Longitudinal Study of Ageing

An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study

..We found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and type 2 diabetes. Insomnia was identified as a novel risk factor (OR 1.17 [95% CI 1.11, 1.23]). The other 18 risk factors were depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine and leucine, liver alanine aminotransferase, childhood and adulthood BMI, body fat percentage, … Continue reading An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study

Associations of #Sleep Disordered #Breathing and Insomnia with Incident #Hypertension and #Diabetes: The Hispanic Community Health Study/Study of Latinos

Rationale: Sleep disorders are associated with hypertension and diabetes, primary risk factors for cardiovascular diseases and mortality. It is important to understand these associations in Hispanics/Latinos, in whom cardiovascular death is the leading cause of mortality. Objectives: To investigate the prospective associations of sleep disordered breathing (SDB) and insomnia with incident hypertension and diabetes among US Hispanics/Latinos over 6 years of follow-up and to assess … Continue reading Associations of #Sleep Disordered #Breathing and Insomnia with Incident #Hypertension and #Diabetes: The Hispanic Community Health Study/Study of Latinos

Risk of #amputation with #canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study

..Results Across the three databases, 310 840 propensity score matched adults who started canagliflozin or a GLP-1 agonist were identified. The hazard ratio and rate difference per 1000 person years for amputation in adults receiving canagliflozin compared with a GLP-1 agonist for each group was: group 1, hazard ratio 1.09 (95% confidence interval 0.83 to 1.43), rate difference 0.12 (−0.31 to 0.55); group 2, hazard ratio … Continue reading Risk of #amputation with #canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study

Effects of #Diet versus Gastric #Bypass on Metabolic Function in Diabetes

Some studies have suggested that in people with type 2 diabetes, Roux-en-Y gastric bypass has therapeutic effects on metabolic function that are independent of weight loss.. ..Weight loss was associated with increases in mean suppression of glucose production from baseline, by 7.04 μmol per kilogram of fat-free mass per minute (95% confidence interval [CI], 4.74 to 9.33) in the diet group and by 7.02 μmol … Continue reading Effects of #Diet versus Gastric #Bypass on Metabolic Function in Diabetes

Associations between abdominal #obesity indices and #diabetic complications: Chinese visceral #adiposity index and neck circumference

Obesity, especially abdominal obesity, has been considered a risk factor for diabetic complications. Many abdominal obesity indices have been established, including neck circumference (NC), waist-to-hip ratio (WHR), lipid accumulation product (LAP), visceral adiposity index (VAI) and the Chinese visceral adiposity index (CVAI). However, studies investigating the associations between these indices and diabetic complications are limited. The objective of this study was to investigate the associations … Continue reading Associations between abdominal #obesity indices and #diabetic complications: Chinese visceral #adiposity index and neck circumference

Association between #prediabetes and risk of all cause mortality and #cardiovascular disease: updated meta-analysis

To evaluate the associations between prediabetes and the risk of all cause mortality and incident cardiovascular disease in the general population and in patients with a history of atherosclerotic cardiovascular disease.. ..A total of 129 studies were included, involving 10 069 955 individuals for analysis. In the general population, prediabetes was associated with an increased risk of all cause mortality (relative risk 1.13, 95% confidence interval 1.10 … Continue reading Association between #prediabetes and risk of all cause mortality and #cardiovascular disease: updated meta-analysis

Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus

The effect of vitamin D supplementation on the risk of type 2 diabetes mellitus (T2DM) remains controversial because most randomized controlled trials (RCTs) have been small or have reported low doses of vitamin D.. ..Nine RCTs were included (43 559 participants). The mean age (standard deviation) was 63.5 (6.7) years. The RR for vitamin D compared with placebo was 0.96 (95% CI, 0.90-1.03); P = … Continue reading Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus

Intake of whole grain foods and risk of type 2 diabetes: results from three prospective cohort studies

..During 4 618 796 person years of follow-up, 18 629 participants with type 2 diabetes were identified. Total whole grain consumption was categorized into five equal groups of servings a day for the three cohorts. After adjusting for lifestyle and dietary risk factors for diabetes, participants in the highest category for total whole grain consumption had a 29% (95% confidence interval 26% to 33%) lower rate of type … Continue reading Intake of whole grain foods and risk of type 2 diabetes: results from three prospective cohort studies