Background: Fatigue is a common and debilitating side effect of chemotherapy, negatively affecting treatment adherence and survival. Chemotherapy alters gut microbiome composition, and accumulating evidence suggests that gut microbes contribute to chemotherapy-induced fatigue. Because the gut microbiome is modifiable through targeted interventions, such as fecal microbiota transplantation (FMT), microbiome modulation has emerged as a potential… Continue reading The gut microbiome in chemotherapy-induced fatigue: Exploring clinical associations and modulation via fecal microbiota transplantation in female mice
Category: Gastroenterology
The trajectory of inflammatory bowel disease in east and southeast Asia: transitioning from acceleration in incidence to compounding prevalence
The epidemiology of inflammatory bowel disease (IBD) progresses through four stages: emergence (stage 1), acceleration in incidence (stage 2), compounding prevalence (stage 3), and prevalence equilibrium (stage 4). Most early industrialised regions (Europe, North America, and Oceania) have reached stage 3, whereas many newly industrialised regions-those that predominantly industrialised after World War 2-are in stage… Continue reading The trajectory of inflammatory bowel disease in east and southeast Asia: transitioning from acceleration in incidence to compounding prevalence
Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Background: Metabolic and bariatric surgery (MBS) is an effective treatment for severe obesity, yet postoperative weight loss outcomes vary considerably between patients. With the relevance of the gut microbiome for obesity, it is of interest to understand the potential role of the oral and gut microbiota for the outcome of MBS. This pilot, hypothesis-generating study… Continue reading Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Translating artificial intelligence into clinical practice for gastrointestinal endoscopy: current applications and future perspectives
Artificial intelligence (AI) has emerged as a transformative tool in gastrointestinal (GI) endoscopy, addressing challenges in detection, diagnosis, and decision-making. In upper GI endoscopy, AI supports blind spot monitoring, Helicobacter pylori diagnosis, and the identification of premalignant and malignant lesions, with high accuracy and reduced miss rates. In lower GI endoscopy, computer-aided detection improves adenoma… Continue reading Translating artificial intelligence into clinical practice for gastrointestinal endoscopy: current applications and future perspectives
Association Between Helicobacter pylori Infection and Iron Deficiency Anemia in Adult Patients Attending a Tertiary Care Hospital
Background: Iron deficiency anemia (IDA) has been increasingly associated with Helicobacter pylori (H. pylori) infection, especially in developing countries.Objective: This study aimed to evaluate the association between H. pylori infection and IDA severity and to compare hematological parameters between H. pylori-positive and -negative adult patients attending a tertiary care hospital.Methodology: This was a cross-sectional analytical… Continue reading Association Between Helicobacter pylori Infection and Iron Deficiency Anemia in Adult Patients Attending a Tertiary Care Hospital
Colorectal cancer incidence and mortality by age group, colon location, and histology in Canada
Background: Colorectal cancer (CRC) incidence is increasing among younger individuals in many countries. We examined CRC incidence and mortality by age group, site, and histology in Canada.Methods: Data from the Canadian Cancer Registry and the Canadian Vital Statistics Death Database were used to determine CRC incidence from 1992 to 2019 and mortality from 1974 to… Continue reading Colorectal cancer incidence and mortality by age group, colon location, and histology in Canada
Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Background: REBYOTA and VOWST are the first FDA-approved live biotherapeutic products (LBPs) for recurrent Clostridioides difficile infection (rCDI). Prior FDA safety alerts (2019-2020) regarding invasive infections from investigational fecal microbiota transplantation underscore the need for post-marketing surveillance of these novel products.Aims: To characterize the real-world safety profiles of REBYOTA and VOWST using the FDA Adverse… Continue reading Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease
This document outlines an updated guideline from the British Society of Gastroenterology, detailing the standards for diagnosing and managing adult coeliac disease (CD). A multidisciplinary panel from across the UK, Sweden, Italy and Australia contributed to the development of these guidelines. This update is prompted by recent advancements in the diagnosis and treatment of adult… Continue reading The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease
Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Background and aims: Esophageal varices (EV) are a major complication of portal hypertension in decompensated chronic liver disease (DCLD), but endoscopy is invasive and resource-limited. This study assessed serum-ascites albumin gradient (SAAG) as a noninvasive predictor of EV occurrence and severity.Patients and methods: Prospective cross-sectional study (January 2023-May 2024) of 76 adults (≥18 years) with… Continue reading Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
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