Background #Clostridioides difficile infection (CDI) remains a major cause of healthcare-associated morbidity and mortality, with antibiotic exposure recognized as the principal modifiable risk factor. Variability in antibiotic class, duration, and overlap may influence CDI risk and clinical severity. Local audits of prescribing patterns are essential to inform antimicrobial stewardship strategies. Objective The objective of the… Continue reading Antibiotic Exposure Patterns and Clinical Outcomes Preceding Clostridioides difficile Infection: A Retrospective Observational Study
Category: Gastroenterology
Perforating Veins Detected by Endoscopic Ultrasonography Are Useful in Predicting the Recurrence of Esophageal Varices After Endoscopic Variceal Ligation Combined With Argon Plasma Coagulation
Objectives: Few attempts have been made to determine the risk factors for the recurrence of esophageal #varices (EV) and the optimal surveillance interval. This study analyzed whether endoscopic ultrasonography can be used to predict EV recurrence and determine the optimal timing for surveillance #endoscopy post-treatment.Methods: We retrospectively evaluated patients with EVs who underwent endoscopic variceal… Continue reading Perforating Veins Detected by Endoscopic Ultrasonography Are Useful in Predicting the Recurrence of Esophageal Varices After Endoscopic Variceal Ligation Combined With Argon Plasma Coagulation
β-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK-orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats
Irritable bowel syndrome (#IBS ) is characterized by chronic abdominal pain and altered bowel habits, with visceral hypersensitivity and impaired intestinal barrier function as key pathophysiological features. Although peripheral determinants of barrier dysfunction have been studied, the contribution of central regulatory mechanisms remains unclear. β-Hydroxybutyrate (#BHB ), a major ketone body elevated during fasting, exhibits… Continue reading β-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK-orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats
Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity by Suppressing Eosinophil-Induced TRPV1 Expression on Duodenum
Background and aims: #Electroacupuncture (EA) has been reported to have a therapeutic potential for visceral #hypersensitivity. Recent studies have highlighted the crucial role of the duodenum in visceral hypersensitivity, suggesting it as a potential therapeutic target. This study investigates how EA regulates visceral hypersensitivity in the duodenum.Method: We established a visceral hypersensitivity model in rats… Continue reading Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity by Suppressing Eosinophil-Induced TRPV1 Expression on Duodenum
Artificial intelligence assisted colorectal lesion detection in private practices a randomized controlled study
Computer-aided #colonoscopy (CAC) may improve polyp detection and characterization compared to traditional colonoscopy (TC). However, recent studies also reported no relevant effect on #adenoma detection rate (ADR). This study evaluates the real-time #polyp detection system EndoMind during screening and surveillance colonoscopy in a multicenter randomized controlled trial. From November 2021 to November 2022, 933 individuals… Continue reading Artificial intelligence assisted colorectal lesion detection in private practices a randomized controlled study
Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
Purpose: Patients with acute coronary syndrome (#ACS ) on ticagrelor-based dual antiplatelet therapy (#DAPT ) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors against DAPT-induced gastric mucosal injury remains limited.Materials and methods: This was a single-center, prospective, open-label, observational trial enrolling patients with ACS who… Continue reading Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
Clinical Observation of Music Therapy Combined with Acupoint Application for the Treatment of Functional Constipation
This study assessed the clinical efficacy of combining five-tone therapy with acupoint application, guided by the #TCM midnight-noon ebb-flow theory, for treating functional #constipation (FC). A total of 103 FC patients were divided into a study group (n=52) and a control group (n=51). The control group received oral polyethylene glycol with routine diet and exercise.… Continue reading Clinical Observation of Music Therapy Combined with Acupoint Application for the Treatment of Functional Constipation
Impact of tobacco use on inpatient outcomes in inflammatory bowel disease: a retrospective matched cohort study
#Tobacco plays a complex role in patients with inflammatory bowel disease (#IBD ). Its impact on inpatient outcomes of IBD needs additional study. We aimed to assess the impact of smoking on clinical outcomes in hospitalized patients with IBD. Methods We conducted a retrospective cohort study using data from the National Inpatient Sample (NIS) spanning… Continue reading Impact of tobacco use on inpatient outcomes in inflammatory bowel disease: a retrospective matched cohort study
Association of pre-endoscopic fresh frozen plasma transfusion with clinical outcomes in patients with acute upper gastrointestinal bleeding and mild coagulopathy: a two-center retrospective cohort study
The clinical benefit of fresh frozen plasma ( #FFP ) transfusion prior to endoscopy in patients with acute upper gastrointestinal bleeding (AUGIB) and mild coagulopathy remains uncertain. We evaluated the association between pre-endoscopic FFP transfusion and clinical outcomes in patients with AUGIB and an international normalized ratio (INR) of 1.5-2.5. We conducted a retrospective two-center… Continue reading Association of pre-endoscopic fresh frozen plasma transfusion with clinical outcomes in patients with acute upper gastrointestinal bleeding and mild coagulopathy: a two-center retrospective cohort study
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