Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis

To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.. ..2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion–synovitis volume on magnetic resonance imaging … Continue reading Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis

The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer … Continue reading The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies

..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis according to the symptomatic or radiological OA also found no … Continue reading Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies

Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee

..We enrolled 156 patients with a mean age of 56 years; 78 patients were assigned to each group. Baseline characteristics, including severity of pain and level of disability, were similar in the two groups. The mean (±SD) baseline WOMAC scores were 108.8±47.1 in the glucocorticoid injection group and 107.1±42.4 in the physical therapy group. At 1 year, the mean scores were 55.8±53.8 and 37.0±30.7, respectively … Continue reading Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee

Subcutaneous #tanezumab for #osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period

..Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8 weeks (three doses). ..From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically significant improvement from baseline for tanezumab 5 mg compared with placebo for WOMAC Pain (least squares mean difference±SE –0.62±0.18, p=0.0006), WOMAC … Continue reading Subcutaneous #tanezumab for #osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period

Association of intermittent and constant #knee pain patterns with knee pain severity, radiographic knee #osteoarthritis duration and severity

..Intermittent and Constant OA Pain (ICOAP) scores were characterized as 1) no intermittent or constant pain; 2) intermittent pain only; 3) constant pain only; and 4) a combination of constant and intermittent pain. Knee pain severity was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale and the Visual Analog Scale (VAS). Radiographic knee OA (ROA) severity was defined as Kellgren … Continue reading Association of intermittent and constant #knee pain patterns with knee pain severity, radiographic knee #osteoarthritis duration and severity

Reasons why #osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model

To identify potentially modifiable factors that mediate the association between symptomatic osteoarthritis (OA) and premature mortality.. ..OA was significantly associated with mortality (TE-adjusted HR 1.14; 95% CI 1.00 to 1.29). The indirect effects for walking frequency were 1.05 (95% CI 1.04 to 1.06), depression 1.02 (95% CI 1.02 to 1.03), anxiety 1.01 (95% CI 1.00 to 1.02) and unrefreshed sleep 1.01 (95% CI 1.00 to 1.01). … Continue reading Reasons why #osteoarthritis predicts mortality: path analysis within a Cox proportional hazards model

Association Between #Weight Loss and Spontaneous Changes in #Physical Inactivity in Overweight/Obese Individuals With Knee Osteoarthritis: An Eight‐Week Prospective Cohort Study

To describe spontaneous changes in time spent being physically inactive that is measured continuously by accelerometry during an 8‐week weight‐loss intervention in overweight/obese individuals with knee osteoarthritis (OA).. A total of 124 participants completed the dietary intervention and had valid accelerometer recordings. The mean weight loss was 12.7 kg (95% confidence interval [95% CI] –13.2, –12.1; P < 0.0001) after 8 weeks, which corresponded to … Continue reading Association Between #Weight Loss and Spontaneous Changes in #Physical Inactivity in Overweight/Obese Individuals With Knee Osteoarthritis: An Eight‐Week Prospective Cohort Study

State-Specific Prevalence and Characteristics of Frequent Mental Distress and History of #Depression Diagnosis Among Adults with #Arthritis— United States, 2017

..Persons with arthritis have unique challenges because the interplay between anxiety, depression, and chronic pain is cyclical, with each having the potential to exacerbate the others. What is added by this report? In 2017, frequent mental distress and history of depression were commonly reported by adults with arthritis in all states, with clustering of high prevalence of frequent mental distress in Appalachian and southern states. … Continue reading State-Specific Prevalence and Characteristics of Frequent Mental Distress and History of #Depression Diagnosis Among Adults with #Arthritis— United States, 2017

Efficacy and tolerability of #duloxetine in patients with knee #osteoarthritis: a meta‐analysis of randomised controlled trials

..Duloxetine achieved significant reductions in primary outcomes including Brief Pain Inventory 24‐h average pain score (weighted mean difference (WMD) = −0.74, 95% confidence interval (CI) = −0.92 to −0.57), weekly mean of the 24‐h average pain score (WMD = −0.76, 95% CI = −0.96 to −0.56), WOMAC stiffness score (WMD = −0.47, 95% CI = −0.60 to −0.34) and WOMAC physical function score (WMD = … Continue reading Efficacy and tolerability of #duloxetine in patients with knee #osteoarthritis: a meta‐analysis of randomised controlled trials

Results of a 6-week treatment with 10 mg prednisolone in patients with hand #osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial

..The mean change between baseline and week 6 on VAS-reported finger pain was −21·5 (SD 21·7) in the prednisolone group and −5·2 (24·3) in the placebo group, with a mean between-group difference (of prednisolone vs placebo) of −16·5 (95% CI −26·1 to −6·9; p=0·0007). The number of non-serious adverse events was similar between the groups. Five serious adverse events were reported during our study: one … Continue reading Results of a 6-week treatment with 10 mg prednisolone in patients with hand #osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial

Effect of Intra-Articular #Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With #Osteoarthritis

..Among participants with symptomatic radiographic knee osteoarthritis, the intra-articular administration of 100 μg of sprifermin every 6 or 12 months vs placebo resulted in an improvement in total femorotibial joint cartilage thickness after 2 years that was statistically significant, but of uncertain clinical importance; there was no significant difference for 30 μg of sprifermin every 6 or 12 months vs placebo. Durability of response also … Continue reading Effect of Intra-Articular #Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With #Osteoarthritis