RORβ modulates a gene program that is protective against articular cartilage damage

Osteoarthritis (OA) is the most prevalent chronic joint disease which increases in frequency with age eventually impacting most people over the age of 65. OA is the leading cause of disability and impaired mobility, yet the pathogenesis of OA remains unclear. Treatments have focused mainly on pain relief and reducing joint swelling. Currently there are …

Continue reading RORβ modulates a gene program that is protective against articular cartilage damage

Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

Osteoarthritis is a common condition, but curative therapies are limited. Here, Liu and colleagues developed a biodegradable scaffold using PLLA [poly(L-lactic acid)] nanofibers that when placed under applied force generated a piezoelectric charge, leading to improved chondrogenesis in vitro. Rabbits with osteochondral defects in the medial femoral condyle that were treated with the PLLA scaffold …

Continue reading Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis

To evaluate if gait biomechanics are associated with increased risk of structurally diagnosed disease onset or progression of lower limb osteoarthritis (OA). MethodA systematic review of Medline and Embase was conducted from inception to July 2021. Two reviewers independently screened records, extracted data and assessed risk of bias. Included studies reported gait biomechanics at baseline, …

Continue reading Are biomechanics during gait associated with the structural disease onset and progression of lower limb osteoarthritis? A systematic review and meta-analysis

Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis

Scalable knee osteoarthritis programs are needed to deliver recommended education, exercise, and weight loss interventions. Objective:To evaluate two 6-month, telehealth-delivered exercise programs, 1 with and 1 without dietary intervention. Design:3-group, parallel randomized (5:5:2) trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000930280) Setting:Australian private health insurance members. Participants:415 persons with symptomatic knee osteoarthritis and a body …

Continue reading Comparing Video-Based, Telehealth-Delivered Exercise and Weight Loss Programs With Online Education on Outcomes of Knee Osteoarthritis

Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function

To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale [VAS], Hanover Functionality Status Questionnaire [FFbH]) measured before and 12 months after arthroplasty are associated with the risk of long-term mortality in a cohort of patients with advanced OA of the …

Continue reading Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function