MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies

The risk of being exposed to Covid-19 indoors can be as great at 60 feet as it is at 6 feet in a room where the air is mixed.Existing safety guidelines have omitted too many factors to accurately quantify the risk of airborne transmission, such as time, mask use and ventilation rates.Bazant and Bush question long-held Covid-19 guidelines that recommend 6 feet of distance between … Continue reading MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies

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Trends in Patient Characteristics and #COVID-19 In-Hospital #Mortality in the United States During the COVID-19 Pandemic

In-hospital mortality rates from COVID-19 are high but appear to be decreasing for selected locations in the United States. It is not known whether this is because of changes in the characteristics of patients being admitted. Objective To describe changing in-hospital mortality rates over time after accounting for individual patient characteristics. Design, Setting, and Participants This was a retrospective cohort study of 20 736 adults with … Continue reading Trends in Patient Characteristics and #COVID-19 In-Hospital #Mortality in the United States During the COVID-19 Pandemic

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#Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients

Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of similar severity are lacking. Methods 22 COVID-19+ and 20 COVID-19– patients with respiratory failure admitted to intensive care were studied longitudinally. Demographic and clinical data were obtained from the day of admission. APLA testing included anticardiolipin (aCL), anti-β2glycoprotien … Continue reading #Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients

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Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study

Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. We aimed to examine this association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions. MethodsIn this prospective, community-based, cohort study, we used de-identified patient-level data from the QResearch database of general practices in England, UK. We extracted data for patients aged 20 years and older who … Continue reading Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study

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Automated quantitative thin slice volumetric low dose #CT analysis predicts disease severity in #COVID-19 patients

This study aimed to identify predictive (bio-)markers for COVID-19 severity derived from automated quantitative thin slice low dose volumetric CT analysis, clinical chemistry and lung function testing. MethodsSeventy-four COVID-19 patients admitted between March 16th and June 3rd 2020 to the Asklepios Lung Clinic Munich-Gauting, Germany, were included in the study. Patients were categorized in a non-severe group including patients hospitalized on general wards only and … Continue reading Automated quantitative thin slice volumetric low dose #CT analysis predicts disease severity in #COVID-19 patients

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Association between #periodontitis and severity of #COVID‐19 infection: A case–control study

COVID‐19 is associated with an exacerbated inflammatory response that can result in fatal outcomes. Systemic inflammation is also a main characteristic of periodontitis. Therefore, we investigated the association of periodontitis with COVID‐19 complications. Materials and MethodsA case–control study was performed using the national electronic health records of the State of Qatar between February and July 2020. Cases were defined as patients who suffered COVID‐19 complications … Continue reading Association between #periodontitis and severity of #COVID‐19 infection: A case–control study

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Initial Findings From the North American #COVID-19 Myocardial #Infarction Registry

The coronavirus disease 2019 (COVID-19) pandemic has impacted many aspects of ST-segment elevation myocardial infarction (STEMI) care, including timely access to primary percutaneous coronary intervention (PPCI). ObjectivesThe goal of the NACMI (North American COVID-19 and STEMI) registry is to describe demographic characteristics, management strategies, and outcomes of COVID-19 patients with STEMI. MethodsA prospective, ongoing observational registry was created under the guidance of 3 cardiology societies. … Continue reading Initial Findings From the North American #COVID-19 Myocardial #Infarction Registry

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Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered. Reporting of adverse events is a critical postmarketing activity. METHODS We report findings in 23 patients who presented with thrombosis and thrombocytopenia 6 to 24 days after receiving the first dose … Continue reading Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

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Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

To the editors, The population with severe mental disorders (SMD) is a medically and socially vulnerable group for a worse outcome in COVID-19. This population has been identified as high-risk group for COVID-19 due to lower awareness of risk, higher prevalence of cognitive impairment and who have limitations to maintain adequate barriers against virus propagation such as living in long-term care facilities, and people with … Continue reading Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

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Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis

Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients on maintenance hemodialysis and the factors associated with it. Design, … Continue reading Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis

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#COVID-19 Pandemic: A Wake-Up Call for Clean #Air

..Since its identification in Wuhan, China, coronavirus disease 2019 (COVID-19) has infected more than 104 million and killed over 2.2 million people worldwide (1). Recent studies of air pollution and COVID-19 cases and mortality in diverse international settings add convincingly to a large body of evidence showing that exposure to air pollution exacerbates viral respiratory infections and consequently widens health disparities. Meanwhile, the global lockdown … Continue reading #COVID-19 Pandemic: A Wake-Up Call for Clean #Air

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The #COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal #Antibodies for the Treatment of COVID-19

The COVID-19 Treatment Guidelines Panel (the Panel) recommends using one of the following combination anti-SARS-CoV-2 monoclonal antibodies to treat outpatients with mild to moderate COVID-19 who are at high risk of clinical progression, as defined by the Emergency Use Authorization (EUA) criteria (listed in alphabetical order): Bamlanivimab 700 mg plus etesevimab 1,400 mg (AIIa); or Casirivimab 1,200 mg plus imdevimab 1,200 mg (AIIa). Treatment should … Continue reading The #COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal #Antibodies for the Treatment of COVID-19

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