Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?

AbstractCoronavirus disease-19 (COVID-19) mRNA vaccines are the mainstays of mass vaccination campaigns in most Western countries. However, the emergency conditions in which their development took place made it impossible to fully characterize their effects and mechanism of action. Here, we summarize and discuss available evidence indicating that COVID-19 mRNA vaccines better reflect pharmaceutical drugs than …

Continue reading Understanding the Pharmacology of COVID-19 mRNA Vaccines: Playing Dice with the Spike?

Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex

AbstractBackground:Myocarditis is more common after severe acute respiratory syndrome coronavirus 2 infection than after COVID-19 vaccination, but the risks in younger people and after sequential vaccine doses are less certain.Methods:A self-controlled case series study of people ages 13 years or older vaccinated for COVID-19 in England between December 1, 2020, and December 15, 2021, evaluated …

Continue reading Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex

Role of scientific advice in covid-19 policy

Key messageGovernments claimed to be following scientific advice during the pandemic to legitimise decisionsAdvice should be autonomous to ensure that governments do not simply seek advice that aligns with what they want to hearTransparency is also essential to know who gave the advice and what the government did with itThe UK’s advice system was not …

Continue reading Role of scientific advice in covid-19 policy

Predicting the efficacy of variant-modified COVID-19 vaccine boosters

As a result of the emergence and circulation of antigenically distinct SARS-CoV-2 variants, a number of variant-modified COVID-19 vaccines have been developed. Here we perform a meta-analysis of the available data on neutralisation titres from clinical studies comparing booster vaccination with either the current ancestral-based vaccines or variant-modified vaccines. We then use this to predict …

Continue reading Predicting the efficacy of variant-modified COVID-19 vaccine boosters

Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents

COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of symptom severity that requires varying amounts of care according to the different stages of the disease. Intervening at the onset of mild to moderate COVID-19 symptoms in the outpatient setting would provide the opportunity to prevent progression to a more severe illness and long-term …

Continue reading Home as the new frontier for the treatment of COVID-19: the case for anti-inflammatory agents