Analysis of Active and Passive #Tobacco Exposures and Blood #Pressure in US Children and Adolescents

..Elevated blood pressure, classified as greater than 90% for a child’s age, sex, and height according to the 2017 American Academy of Pediatrics Clinical Practice Guidelines. The a priori hypothesis that there is a positive association between tobacco exposure and elevated blood pressure in the study population was tested. Analysis included logistic regression with adjustment for possible confounders. Subgroup and sensitivity analyses were conducted. Results … Continue reading Analysis of Active and Passive #Tobacco Exposures and Blood #Pressure in US Children and Adolescents

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An integrative study of five biological #clocks in somatic and mental #health

Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health … Continue reading An integrative study of five biological #clocks in somatic and mental #health

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#Cancer Statistics, 2021

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by … Continue reading #Cancer Statistics, 2021

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#Smoking Cessation, #Weight Change, #Diabetes, and #Hypertension in Korean Adult

This study investigates the association of smoking cessation and postcessation weight gain with the development of type 2 diabetes mellitus and hypertension. Methods A total of 96,524 individuals without diabetes mellitus and hypertension aged ≥20 years between 2006 and 2008 were included, with follow-up until December 31, 2015. Smoking status and weight changes were monitored for 2 years. Hazard ratios and 95% CIs were calculated … Continue reading #Smoking Cessation, #Weight Change, #Diabetes, and #Hypertension in Korean Adult

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#Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?

The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several SARS-CoV-2 positive case studies have been reported where there are … Continue reading #Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?

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Initiating Pharmacologic Treatment in #Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline

Current tobacco treatment guidelines have established the efficacy of available interventions, but they do not provide detailed guidance for common implementation questions frequently faced in the clinic. An evidence-based guideline was created that addresses several pharmacotherapy-initiation questions that routinely confront treatment teams.. ..The guideline panel formulated five strong recommendations and two conditional recommendations regarding pharmacotherapy choices. Strong recommendations include using #varenicline rather than a nicotine … Continue reading Initiating Pharmacologic Treatment in #Tobacco-Dependent Adults. An Official American Thoracic Society Clinical Practice Guideline

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Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study

Blacks are disproportionately affected by stroke compared with whites; however, less is known about the relationship between stroke and cigarette smoking in blacks. Therefore, we evaluated the relationship between cigarette smoking and all incident stroke in the JHS (Jackson Heart Study).. JHS participants without a history of stroke (n=4410) were classified by self‐reported baseline smoking status into current, past (smoked at least 400 cigarettes/life), or … Continue reading Cigarette Smoking and Incident Stroke in Blacks of the Jackson Heart Study

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Dose-Response Association of Low-Intensity and Nondaily Smoking With Mortality in the United States

An increasing proportion of US smokers smoke at low intensity and not every day. Some nondaily smokers have always had this pattern, whereas others previously smoked daily. The effect of reducing the level of smoking from daily to nondaily smoking and the dose response at low smoking levels are poorly understood.. ..Among 505 500 participants (aged 18-103 years), approximately 47 000 deaths occurred. The median number of … Continue reading Dose-Response Association of Low-Intensity and Nondaily Smoking With Mortality in the United States

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Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract

Abstract The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic smoke exposure triggers the expansion of this cell population and … Continue reading Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract

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Effects of changes in #smoking status on blood pressure among adult males and females in Indonesia: a 15-year population-based cohort study

The continuing rise of smoking behaviours will inevitably lead to a further increase in hypertension prevalence. However, limited research has examined the impacts of changes in smoking status on blood pressure (BP). We sought to assess correlations between increases or decreases of males’ and females’ cigarette consumption on systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP), and to investigate the relationship … Continue reading Effects of changes in #smoking status on blood pressure among adult males and females in Indonesia: a 15-year population-based cohort study

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Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA–positive AAV and PR3-ANCA–positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette smoking, are poorly understood.. ..Overall, 473 cases were matched with … Continue reading Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis

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Association of Healthy #Lifestyle With Years Lived Without Major Chronic Diseases

..Four baseline lifestyle factors (smoking, body mass index, physical activity, and alcohol consumption) were each allocated a score based on risk status: optimal (2 points), intermediate (1 point), or poor (0 points) resulting in an aggregated lifestyle score ranging from 0 (worst) to 8 (best). Sixteen lifestyle profiles were constructed from combinations of these risk factors. Main Outcomes and Measures The number of years between … Continue reading Association of Healthy #Lifestyle With Years Lived Without Major Chronic Diseases

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