Background and AimsCRC is a devastating disease highly modulated by dietary nutrients. mTORC1 contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTORC1 activity following therapies that target oncogenic growth factor signaling. Amino acids potently activate mTORC1 via amino acid …
Tag: colorectal
Western-style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses from Two Large Prospective Cohort Studies
BACKGROUND AND AIMSEvidence supports a carcinogenic role of Escherichia coli carrying the polyketide synthase (pks) island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks+ E. coli.METHODSWestern diet score was …
Aspirin’s effect on kinetic parameters ofcells contributes to its role in reducingincidence of advanced colorectaladenomas, shown by a multiscalecomputational study
Aspirin intake has been shown to lead to significant protection against colorectalcancer, for example with an up to twofold reduction in colorectal adenoma incidence rates at higherdoses. The mechanisms contributing to protection are not yet fully understood. While aspirin isan anti-inflammatory drug and can thus influence the tumor microenvironment, in vitro and in vivoexperiments have …
Increasing Incidence of Early-Onset Colorectal Cancer
Early-onset disease (at <50 years of age) accounts for 10% of colorectal cancer cases, and the incidence is increasing, particularly in high-income countries. Patients often present with advanced disease in the left colon. One in six patients has deficient DNA mismatch repair. Screening is now recommended to begin at 45 years of age. https://www.nejm.org/doi/full/10.1056/NEJMra2200869
Age at Initiation of Lower Gastrointestinal Endoscopy and Colorectal Cancer Risk Among US Women
Importance In the past 4 years, the American Cancer Society and the US Preventive Services Task Force updated recommendations to initiate colorectal cancer (CRC) screening at 45 years of age to address the increasing incidence of CRC among adults younger than 50 years. However, empirical evidence evaluating the potential benefits of screening in younger populations …
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