Tag: colorectal

Gastroenterology, Oncology

Racial Disparities in Epigenetic Aging of the Right vs Left #Colon

There are well-documented racial differences in age-of-onset and laterality of colorectal cancer. Epigenetic age acceleration is postulated to be an underlying factor. However, comparative studies of side-specific colonic tissue epigenetic aging are lacking. Here, we performed DNA methylation analysis of matched right and left biopsies of normal colon from 128 individuals. Among African Americans (n = 88), the right colon showed accelerated epigenetic aging as compared to … Continue reading Racial Disparities in Epigenetic Aging of the Right vs Left #Colon

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Diet, Gastroenterology, Oncology

Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to #cancer: French NutriNet-Santé study

High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human-like” mice. Human anti-Neu5Gc IgG and red meat are both independently proposed to increase cancer risk, yet how diet affects these antibodies is largely unknown.. ..We found that high-Neu5Gc diet, gender, and age affect the specificity, … Continue reading Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to #cancer: French NutriNet-Santé study

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Gastroenterology, Oncology

Association Between Time to Colonoscopy after Positive Fecal Testing and Colorectal Cancer Outcomes: a Systematic Review

Colonoscopy is required following a positive fecal screening test for colorectal cancer (CRC). It remains unclear to what extent time to colonoscopy is associated with CRC-related outcomes. We performed a systematic review to elucidate this relationship.. ..From 1,612 initial studies, 8 were included in the systematic review, with 5 reporting outcomes for FIT. Although meta-analysis was not possible, consistent trends between longer time delays and … Continue reading Association Between Time to Colonoscopy after Positive Fecal Testing and Colorectal Cancer Outcomes: a Systematic Review

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Diet, Gastroenterology, Oncology

Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer

Several compounds found in coffee possess antioxidant, anti-inflammatory, and insulin-sensitizing effects, which may contribute to anticancer activity. Epidemiological studies have identified associations between increased coffee consumption and decreased recurrence and mortality of colorectal cancer. The association between coffee consumption and survival in patients with advanced or metastatic colorectal cancer is unknown.. ..Among the 1171 patients included in the analysis (694 men [59%]; median age, 59 … Continue reading Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer

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Endocrinology, Gastroenterology, Gynaecology, Oncology

#Obesity Has a Stronger Relationship with Colorectal #Cancer in Postmenopausal Women Than Premenopausal Women

Background: To examine the relationship between obesity measured by waist circumference (WC) and body mass index (BMI) and the incidence of colorectal cancer (CRC) in premenopausal and postmenopausal women. Methods: A total of 1,418,180 premenopausal and 4,854,187 postmenopausal women without cancer at baseline and aged over 40 were identified using the Korean National Health Insurance System Cohort during 2009-2014. The hazard ratio (HR) for CRC … Continue reading #Obesity Has a Stronger Relationship with Colorectal #Cancer in Postmenopausal Women Than Premenopausal Women

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Hypertension, Oncology

#ACE (Angiotensin-Converting Enzyme) Inhibitors/Angiotensin Receptor Blockers Are Associated With Lower #Colorectal Cancer Risk

Whether ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers modify colorectal cancer risk remains controversial. We aimed to determine association between their use and colorectal cancer risk after a negative baseline colonoscopy. This is a territory-wide retrospective cohort study recruiting patients aged ≥40 who had undergone colonoscopy between 2005 and 2013. Exclusion criteria included colorectal cancer detected <6 months of index colonoscopy, prior colorectal cancer, … Continue reading #ACE (Angiotensin-Converting Enzyme) Inhibitors/Angiotensin Receptor Blockers Are Associated With Lower #Colorectal Cancer Risk

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Gastroenterology, Oncology

Impact of the faecal immunochemical test on colorectal cancer survival

There is already evidence that the faecal immunochemical test (FIT) is a useful tool for the diagnosis of colorectal cancer (CRC) that helps to identify symptomatic patients requiring early colonoscopy. Although the recommendation to use FIT is widely accepted, there are no data concerning whether this strategy improves patient survival.The objective was to assess whether the survival is higher if CRC patients have been first … Continue reading Impact of the faecal immunochemical test on colorectal cancer survival

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Oncology

CDC Colorectal Cancer Screening Test Use

Colorectal cancer (CRC) is the second leading cause of cancer death in the United States of cancers that affect both men and women. Despite strong evidence that screening for CRC reduces incidence and mortality, CRC screening prevalence is below the national target. This report describes current CRC screening prevalence by age, various demographic factors, and state.. In 2018, 68.8% of adults were up to date … Continue reading CDC Colorectal Cancer Screening Test Use

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Diet, Oncology

#Colorectal Cancer Risk Following #Bariatric Surgery in a Nationwide Study of French Individuals With Obesity

..The mean (SD) follow-up was 6.2 (2.1) years for patients who underwent adjustable gastric banding, 5.5 (2.1) years for patients who underwent sleeve gastrectomy, and 5.7 (2.2) years for patients who underwent gastric bypass. In total, 13 052 incident colorectal cancers (1.2%) and 63 649 colorectal benign polyps were diagnosed. The rate of colorectal cancer was 0.6% in the bariatric surgery cohort and 1.3% in the cohort … Continue reading #Colorectal Cancer Risk Following #Bariatric Surgery in a Nationwide Study of French Individuals With Obesity

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