BackgroundThe colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage. The diet of high-income countries contains increasing amounts of sugar, such as sucrose. ISCs and TA cells are sensitive to dietary metabolites, but whether excess sugar affects their function …
Tag: colorectal
Analysis of Body Mass Index in Early and Middle Adulthood and Estimated Risk of Gastrointestinal Cancer
Importance In a population with significantly increasing rates of individuals with overweight or obesity, understanding the association of obesity with long-term disease risk, such as cancer, is necessary to improve public health.Objective To investigate the association between body mass index (BMI) and gastrointestinal (GI) cancer risk (colorectal cancer [CRC] and noncolorectal GI cancer) in the Prostate, Lung, …
Dysregulated amino acid sensing drives colorectal cancer growth and metabolic reprogramming leading to chemoresistance
Background and AimsCRC is a devastating disease highly modulated by dietary nutrients. mTORC1 contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism of mTORC1 activation. However, compensatory pathways exist to sustain mTORC1 activity following therapies that target oncogenic growth factor signaling. Amino acids potently activate mTORC1 via amino acid …
Western-style Diet, pks Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses from Two Large Prospective Cohort Studies
BACKGROUND AND AIMSEvidence supports a carcinogenic role of Escherichia coli carrying the polyketide synthase (pks) island that encodes enzymes for colibactin biosynthesis. We hypothesized that the association of western-style diet (rich in red and processed meat) with colorectal cancer incidence might be stronger for tumors containing higher amounts of pks+ E. coli.METHODSWestern diet score was …
Aspirin’s effect on kinetic parameters ofcells contributes to its role in reducingincidence of advanced colorectaladenomas, shown by a multiscalecomputational study
Aspirin intake has been shown to lead to significant protection against colorectalcancer, for example with an up to twofold reduction in colorectal adenoma incidence rates at higherdoses. The mechanisms contributing to protection are not yet fully understood. While aspirin isan anti-inflammatory drug and can thus influence the tumor microenvironment, in vitro and in vivoexperiments have …
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