Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death

The intestinal microbiome releases a plethora of small molecules. Here, we show that the Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly people, whereas Ruminococcaceae phages, belonging to the Myoviridae family, are reduced. Young mice orally administered IAA show cognitive decline, whereas Myoviridae phage administration reduces IAA levels. Mechanistically, IAA promotes apoptosis …

Continue reading Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death

To what extent does confounding explain the association between breastfeeding duration and cognitive development up to age 14? Findings from the UK Millennium Cohort Study

BackgroundBreastfeeding duration is associated with improved cognitive development in children, but it is unclear whether this is a causal relationship or due to confounding. This study evaluates whether the observed association is explained by socioeconomic position (SEP) and maternal cognitive ability. MethodsData from 7,855 singletons born in 2000โ€“2002 and followed up to age 14 years …

Continue reading To what extent does confounding explain the association between breastfeeding duration and cognitive development up to age 14? Findings from the UK Millennium Cohort Study

Association of midlife antibiotic use with subsequent cognitive function in women

The gut microbiome is increasingly recognized to play a role in cognition and dementia. Antibiotic use impacts the gut microbiome and has been linked with chronic disease. Despite these data, there is no evidence supporting an association between long-term antibiotic use in adults and cognitive function. We conducted a prospective population-based cohort study among 14,542 …

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Association of the Gut Microbiota With Cognitive Function in Midlife

Question Is the gut microbiota associated with cognitive function? Findings In this cross-sectional study, ฮฒ-diversity, a measure of gut microbial community composition, was statistically significantly associated with all measures of cognitive function. Several specific genera were also significantly associated with 1 or more measures of cognitive function after adjustment for multiple comparisons. Meaning These results …

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Evaluation of Adiposity and Cognitive Function in Adults

Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not well characterized. Objective To investigate the association …

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