Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease

Alcohol-associated liver disease represents a spectrum of histopathological changes from steatosis to advanced fibrosis and cirrhosis. The major goals of this retrospective study were to characterize the histologic features in patients with excessive alcohol use who presented with an abnormal hepatic panel and/or abnormal radiographic imaging and did not meet the clinical diagnosis of alcoholic hepatitis or cirrhosis. Methods We performed a retrospective study to … Continue reading Hepatic #Histopathology Among Excessive #Drinkers Without Advanced Liver Disease

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Increased #alcohol use during the #COVID-19 pandemic: The effect of mental health and age in a cross-sectional sample of social media users in the U.S.

The COVID-19 pandemic has triggered a public health crisis of unprecedented scale. Increased alcohol use has been extensively documented during other crises, particularly among persons with anxiety and depression. Despite COVID-19’s differential impact by age, the association of age, mental health and alcohol use during the pandemic has not been explored. This study aimed to examine whether age modified the association of anxiety and depressive … Continue reading Increased #alcohol use during the #COVID-19 pandemic: The effect of mental health and age in a cross-sectional sample of social media users in the U.S.

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The Tailgate Study: Differing #metabolic effects of a bout of excessive #eating and #drinking

Excess energy intake by spectators at a sporting event (i.e., a tailgate) might cause acute negative health effects. However, limited data exist regarding the effects of overeating and alcohol consumption on lipid metabolism and the potential to gain intrahepatic triacylglycerols (IHTG). We tested the hypothesis that overconsumption of food and alcohol would significantly increase both hepatic de novo lipogenesis (DNL) and IHTG. Methods Eighteen males … Continue reading The Tailgate Study: Differing #metabolic effects of a bout of excessive #eating and #drinking

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The effects of #alcohol and #cannabis use on the cortical thickness of #cognitive control and salience brain networks in emerging adulthood: a cotwin control study

Background Impairments in inhibitory control and its underlying brain networks (control/salience areas) are associated with substance misuse. Research often assumes a causal substance exposure effect on brain structure. This assumption remains largely untested and other factors (e.g., familial risk) may confound exposure effects. We leveraged a genetically-informative sample of 24-year-old twins and a quasi-experimental cotwin control design to separate alcohol or cannabis exposure effects during … Continue reading The effects of #alcohol and #cannabis use on the cortical thickness of #cognitive control and salience brain networks in emerging adulthood: a cotwin control study

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U.S. #Diet Guidelines Sidestep Scientific Advice to Cut #Sugar and #Alcohol

..Evidence suggests that added sugars, particularly those in sweetened beverages, may contribute to obesity and weight gain, which are linked to higher rates of chronic health conditions like heart disease and Type 2 diabetes, the scientific panel noted. More than two-thirds of American adults are overweight or obese; obesity, diabetes and other related conditions also increase the risk of developing severe Covid-19 illness. The scientific … Continue reading U.S. #Diet Guidelines Sidestep Scientific Advice to Cut #Sugar and #Alcohol

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Lifetime perspective on #alcohol and #brain health

Harm prevention policies must take the long view The maintenance of brain health is central to health and wellbeing across the lifespan.1 Evidence suggests three periods of dynamic brain changes that may be particularly sensitive to the neurotoxic effects of alcohol: gestation (from conception to birth), later adolescence (15-19 years), and older adulthood (over 65 years). Highly prevalent patterns of alcohol use may cause harm … Continue reading Lifetime perspective on #alcohol and #brain health

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Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults

The potential of physical activity (PA) to attenuate the effects of alcohol consumption on the risks of alcohol‐related cancer mortality is unknown. We used data from participants aged 30 years and over in 10 British population‐based surveys (Health Surveys for England 1994, 1997, 1998, 1999, 2003, 2004, 2006 and 2008 and the Scottish Health Surveys 1998 and 2003). Alcohol‐related cancer mortality included oral cavity, throat, larynx, … Continue reading Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults

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Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use

.. A total of 254 participants (184 men [72%]; mean [SD] age, 34 [6] years) were enrolled in the trial; 126 were randomized to receive zinc, and 128 were randomized to receive placebo. Participants had high CD4 cell counts (mean [SD], 521 [292] cells/mm3), and 188 (74%) reported heavy drinking in the past week. In the main analyses, zinc supplementation did not affect changes in … Continue reading Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use

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Association of Low to Moderate #Alcohol Drinking With #Cognitive Functions From Middle to Older Age Among US Adults

..The mean (SD) age of 19 887 participants was 61.8 (10.2) years, and the majority of the HRS participants were women (11 943 [60.1%]) and of white race/ethnicity (16 950 [85.2%]). Low to moderate drinking (<8 drinks per week for women and <15 drinks per week for men) was significantly associated with a consistently high cognitive function trajectory and a lower rate of cognitive decline. Compared with never … Continue reading Association of Low to Moderate #Alcohol Drinking With #Cognitive Functions From Middle to Older Age Among US Adults

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Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis

Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis. ..Sera from 302 patients with alcoholic hepatitis, 46 with alcohol‐related cirrhosis and 15 healthy controls … Continue reading Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis

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#Alcohol, Alcoholic Beverages and Risk of #Esophageal Cancer by Histological Type: A Dose–Response Meta-Analysis of Observational Studies

We conducted a dose–response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender.. A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus … Continue reading #Alcohol, Alcoholic Beverages and Risk of #Esophageal Cancer by Histological Type: A Dose–Response Meta-Analysis of Observational Studies

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Associations Between Medical Conditions and #Alcohol Consumption Levels in an Adult Primary Care Population

..Among the 2 720 231 included patients, 1 439 361 (52.9%) were female, 1 308 659 (48.1%) were white, and 883 276 (32.5%) were aged 18 to 34 years. Patients with any of the conditions (except injury or poisoning) had lower odds of drinking at low-risk and unhealthy levels relative to no reported use compared with those without the condition. Among 861 427 patients reporting alcohol use, patients with diabetes (odds ratio [OR], … Continue reading Associations Between Medical Conditions and #Alcohol Consumption Levels in an Adult Primary Care Population

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