Heterogeneity in statin responses explained by variation in the human gut microbiome

Despite the undeniable cholesterol lowering benefits of statin therapy, considerable heterogeneity exists in individual responses to the same treatment. Human gut bacteria are known to metabolize statins in vitro, but there is limited information on how microbiome composition may contribute to statin on-target and/or adverse effects. Here, the authors identify a novel blood-based biomarker for …

Continue reading Heterogeneity in statin responses explained by variation in the human gut microbiome

Cost-Effectiveness of Lipid-Lowering Treatments in Young Adults

BackgroundRaised low-density lipoprotein cholesterol (LDL-C) in young adulthood (aged 18-39 years) is associated with atherosclerotic cardiovascular disease (ASCVD) later in life. Most young adults with elevated LDL-C do not currently receive lipid-lowering treatment. ObjectivesThis study aimed to estimate the prevalence of elevated LDL-C in ASCVD-free U.S. young adults and the cost-effectiveness of lipid-lowering strategies for …

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Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection

Statins may be protective in SARS-CoV-2 infection. The aim of this study was to evaluate the effect of in-hospital statin use on 28-day mortality and ICU admission among patients with SARS-CoV-2 stratified into 4 groups: those who used statins prior to hospitalization (continued, discontinued) and those who did not (newly initiated, never). MethodsIn a cohort …

Continue reading Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection

Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study

Statin therapy has been associated with increased insulin resistance; however, its clinical implications for diabetes control among patients with diabetes is unknown. Objective To assess diabetes progression after initiation of statin use in patients with diabetes. Design, Setting, and Participants This was a retrospective matched-cohort study using new-user and active-comparator designs to assess associations between …

Continue reading Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study

#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis

Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT), aspartate transaminase (AST), and gamma-glutamyl transpeptidase (GGT) in NAFLD patients treated or not with statins. MethodsWe performed a systematic review of MEDLINE via PubMed and EMBASE databases and metanalysis …

Continue reading #Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis