Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis

Results have been mixed and uncertainty still remains regarding the impact of statin adherence on premature deaths. Thus, we investigated the association between statin adherence and risks of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients in South Korea.. We used data from the National Health Insurance Service (NHIS) National Sample Cohort for the years 2003-2013, which included data on 107,954 middle-aged and elderly dyslipidemia … Continue reading Statin adherence and risk of all-cause, cancer, and cardiovascular mortality among dyslipidemia patients: A time-dependent analysis

Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

Data are limited regarding statin therapy for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults 75 years and older.. ..Of 326 981 eligible veterans (mean [SD] age, 81.1 [4.1] years; 97% men; 91% white), 57 178 (17.5%) newly initiated statins during the study period. During a mean follow-up of 6.8 (SD, 3.9) years, a total 206 902 deaths occurred including 53 296 cardiovascular deaths, with 78.7 and 98.2 … Continue reading Association of Statin Use With All-Cause and Cardiovascular Mortality in US Veterans 75 Years and Older

Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies

..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis according to the symptomatic or radiological OA also found no … Continue reading Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies

#Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Our studies establish a connection between two isolated observations that 1) statins, taken by millions to lower cholesterol, have antitumor activity and 2) Ras-induced macropinocytosis is important in tumorigenesis. We discover that by depleting GGPP required for pseudopod extension and macropinocytosis, statins selectively kill cells with oncogenic defects by limiting nutrient uptake. https://bit.ly/2wT1ypw Continue reading #Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

Diagnosis of #osteoporosis in #statin-treated patients is dose-dependent

..There was a highly non-trivial dependence of statin dosage with the ORs of osteoporosis. Osteoporosis was underrepresented in low-dose statin treatment (0–10 mg per day), including lovastatin (OR: 0.39, CI 0.18 to 0.84, p<0.05), pravastatin (OR: 0.68, 95% CI 0.52 to 0.89, p<0.01), simvastatin (OR: 0.70, 95% CI 0.56 to 0.86, p<0.01) and rosuvastatin (OR: 0.69, 95% CI 0.55 to 0.87, p<0.01). However, the exceeding of the 40 mg threshold … Continue reading Diagnosis of #osteoporosis in #statin-treated patients is dose-dependent

#Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database

Among the 3900 patients aged 80 years and older, 2 years of statin prescriptions resulted in a lower risk of the composite outcome (adjusted HR = 0.81; 95% confidence interval [CI] = 0.66‐0.99) and of all‐cause mortality (adjusted HR = 0.84; 95% CI = 0.73‐0.97). During 4.5 years of median follow‐up, the NNT for prevention of the primary outcome was 59; and for mortality, the NNT was 36. Correcting … Continue reading #Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database