MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies

The risk of being exposed to Covid-19 indoors can be as great at 60 feet as it is at 6 feet in a room where the air is mixed.Existing safety guidelines have omitted too many factors to accurately quantify the risk of airborne transmission, such as time, mask use and ventilation rates.Bazant and Bush question long-held Covid-19 guidelines that recommend 6 feet of distance between … Continue reading MIT researchers say time spent indoors increases risk of #Covid at 6 feet or 60 feet in new study challenging social distancing policies

Rate This

#Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort

Cognitive leisure activity, such as reading, playing mahjong or cards and computer use, is common among older adults in China. Previous studies suggest a negative correlation between cognitive leisure activity and cognitive impairment. However, the relationship between cognitive leisure activity and all-cause mortality has rarely been reported. ObjectivesThis study aims to explore the relationships between cognitive leisure activity and all-cause mortality in a community-based older … Continue reading #Cognitive #leisure activity and all-cause mortality in older adults: a 4-year community-based cohort

Rate This

Trends in Patient Characteristics and #COVID-19 In-Hospital #Mortality in the United States During the COVID-19 Pandemic

In-hospital mortality rates from COVID-19 are high but appear to be decreasing for selected locations in the United States. It is not known whether this is because of changes in the characteristics of patients being admitted. Objective To describe changing in-hospital mortality rates over time after accounting for individual patient characteristics. Design, Setting, and Participants This was a retrospective cohort study of 20 736 adults with … Continue reading Trends in Patient Characteristics and #COVID-19 In-Hospital #Mortality in the United States During the COVID-19 Pandemic

Rate This

Systems level profiling of #chemotherapy-induced stress resolution in #cancer cells reveals druggable trade-offs

Cancer therapies often fail to cure patients because a proportion of tumor cells withstand the toxic effects of chemotherapy. How surviving cancer cells recover from sublethal drug-induced stress is not known, but given that cellular resources are finite, stress resolution may come at the expense of less essential systems. Here, we studied the global cellular events of stress buildup and resolution in the bone marrow … Continue reading Systems level profiling of #chemotherapy-induced stress resolution in #cancer cells reveals druggable trade-offs

Rate This

#Disruption of the blood−brain barrier in 22q11.2 deletion syndrome

Neuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia. As the blood−brain barrier is the immunological interface between the brain and the periphery, we investigated whether this vascular phenotype is intrinsically compromised in the most common genetic risk factor for schizophrenia, the 22q11.2 deletion syndrome (22qDS). Blood−brain barrier like endothelium differentiated from human 22qDS+schizophrenia-induced pluripotent stem cells exhibited impaired barrier integrity, a phenotype substantiated in … Continue reading #Disruption of the blood−brain barrier in 22q11.2 deletion syndrome

Rate This

Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women

The objective of this study was to analyze changes in serum markers of bone turnover across multiple decades in osteoporotic women compared with nonosteoporotic controls, to determine their utility as potential predictors for osteoporosis. Early prediction of those at risk for osteoporosis can enable early intervention before the irreversible loss of critical bone mass. MethodsSerum samples were obtained from 20 women given the diagnosis of … Continue reading Longitudinal Analysis of Circulating Markers of #Bone Turnover Across Multiple Decades in #Osteoporotic Women

Rate This

#Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients

Reports of severe COVID-19 being associated with thrombosis, antiphospholipid antibodies (APLA), and antiphospholipid syndrome have yielded disparate conclusions. Studies comparing patients with COVID-19 with contemporaneous controls of similar severity are lacking. Methods 22 COVID-19+ and 20 COVID-19– patients with respiratory failure admitted to intensive care were studied longitudinally. Demographic and clinical data were obtained from the day of admission. APLA testing included anticardiolipin (aCL), anti-β2glycoprotien … Continue reading #Anticardiolipin and other #antiphospholipid antibodies in critically ill #COVID-19 positive and negative patients

Rate This

Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study

Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. We aimed to examine this association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and other health conditions. MethodsIn this prospective, community-based, cohort study, we used de-identified patient-level data from the QResearch database of general practices in England, UK. We extracted data for patients aged 20 years and older who … Continue reading Associations between #body-mass index and #COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study

Rate This

Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

The effects of pharmacological blood pressure lowering at normal or high-normal blood pressure ranges in people with or without pre-existing cardiovascular disease remains uncertain. We analysed individual participant data from randomised trials to investigate the effects of blood pressure lowering treatment on the risk of major cardiovascular events by baseline levels of systolic blood pressure. MethodsWe did a meta-analysis of individual participant-level data from 48 … Continue reading Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

Rate This

Automated quantitative thin slice volumetric low dose #CT analysis predicts disease severity in #COVID-19 patients

This study aimed to identify predictive (bio-)markers for COVID-19 severity derived from automated quantitative thin slice low dose volumetric CT analysis, clinical chemistry and lung function testing. MethodsSeventy-four COVID-19 patients admitted between March 16th and June 3rd 2020 to the Asklepios Lung Clinic Munich-Gauting, Germany, were included in the study. Patients were categorized in a non-severe group including patients hospitalized on general wards only and … Continue reading Automated quantitative thin slice volumetric low dose #CT analysis predicts disease severity in #COVID-19 patients

Rate This

Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis

To assess the overall effect of delayed antibiotic prescribing on average symptom severity for patients with respiratory tract infections in the community, and to identify any factors modifying this effect. Design Systematic review and individual patient data meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Ovid Medline, Ovid Embase, EBSCO CINAHL Plus, and Web of Science. Eligibility criteria for study selection Randomised controlled trials … Continue reading Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis

Rate This

Effectiveness of #polymyxin B-immobilized hemoperfusion against #sepsis and septic #shock: A systematic review and meta-analysis

PurposeTo evaluate the efficacy and safety of Polymyxin B-immobilized hemoperfusion (PMX-HP) against sepsis or septic shock. MethodsWe searched databases (PubMed, EMBASE and Cochrane Library) to identify eligible randomized controlled trials (RCTs). The primary outcomes we included in this review were mortality at the longest follow-up available and serious adverse events associated with treatments. We used the Cochrane risk of bias assessment tool to evaluate risk … Continue reading Effectiveness of #polymyxin B-immobilized hemoperfusion against #sepsis and septic #shock: A systematic review and meta-analysis

Rate This