Unresolved issues of immune tolerance in chronic hepatitis #B

During the natural course of chronic hepatitis B virus infection, immune-tolerant phase is characterized by high viral replication, the presence of HBV e antigen (HBeAg), and normal or minimally elevated serum alanine aminotransferase. Immune-tolerant phase is usually regarded as a benign course of the disease. International guidelines recommend observation rather than treatment during immune-tolerant phase. In this article, we review unresolved issues related to the … Continue reading Unresolved issues of immune tolerance in chronic hepatitis #B

Persistent #Asthma is Associated with Increased Risk for Incident Atrial #Fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)

Asthma and atrial fibrillation (AF) share an underlying inflammatory pathophysiology. We hypothesized that persistent asthmatics are at higher risk for developing AF and that this association would be attenuated by adjustment for baseline markers of systemic inflammation. ..Persistent asthma was defined as asthma requiring use of controller medications. Intermittent asthma was defined as asthma without use of controller medications.. ..In risk-factor adjusted models, persistent asthmatics … Continue reading Persistent #Asthma is Associated with Increased Risk for Incident Atrial #Fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)

Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension

Previous studies on the effect of long working hours on blood pressure have shown inconsistent results. Mixed findings could be attributable to limitations related to blood pressure measurement and the lack of consideration of masked hypertension.. Ambulatory blood pressure was defined as the mean of the next readings recorded every 15 minutes during daytime working hours. Masked hypertension was defined as clinic blood pressure < … Continue reading Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension

#Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of death, this measurement is not routinely obtained in clinical practice.. We argue that BMI alone is not sufficient to properly assess or manage the cardiometabolic risk associated with increased adiposity.. ..We recommend that decreases in waist circumference are a critically important treatment target … Continue reading #Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

Longer #commutes are associated with increased human exposure to tris(1,3-dichloro-2-propyl) phosphate

Organophosphate esters (OPEs) are a class of semi-volatile organic compounds (SVOCs) used as flame retardants, plasticizers, and anti-foaming agents. Due to stringent flammability standards in vehicles and the ability of OPEs to migrate out of end-use products, elevated concentrations of OPEs have been found in car dust samples around the world.. ..Moreover, the concentration of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) was significantly correlated with the concentration of … Continue reading Longer #commutes are associated with increased human exposure to tris(1,3-dichloro-2-propyl) phosphate

FDA Authorizes Marketing of First Cardiac #Ultrasound Software That Uses Artificial #Intelligence to Guide User

..the U.S. Food and Drug Administration authorized marketing of software to assist medical professionals in the acquisition of cardiac ultrasound, or echocardiography, images. The software, called Caption Guidance, is an accessory to compatible diagnostic ultrasound systems and uses artificial intelligence to help the user capture images of a patient’s heart that are of acceptable diagnostic quality. The Caption Guidance software is indicated for use in … Continue reading FDA Authorizes Marketing of First Cardiac #Ultrasound Software That Uses Artificial #Intelligence to Guide User

Direct Oral #Anticoagulants in Atrial Fibrillation Patients with Concomitant #Hyperthyroidism

Patients with hyperthyroidism were excluded from randomized clinical trials of direct oral anticoagulants(DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).. After PSSW, DOAC had a comparable risk of ischemic stroke/systemic embolism (IS/SE) and a lower risk of major bleeding (hazard ratio (HR):0.65; [95% confidential interval (CI):0.44-0.96]; P=0.0295) than warfarin among patients with hyperthyroidism. There were comparable risks of IS/SE and major bleeding … Continue reading Direct Oral #Anticoagulants in Atrial Fibrillation Patients with Concomitant #Hyperthyroidism

#Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort

Ultraprocessed foods (UPF) are widespread in Western diets. Their consumption has been associated in recent prospective studies with increased risks of all-cause mortality and chronic diseases such as cancer, cardiovascular diseases, hypertension, and dyslipidemia; however, data regarding diabetes are lacking. ..Consumption of UPF was associated with a higher risk of T2D (multi-adjusted hazard ratio [HR] for an absolute increment of 10 in the percentage of … Continue reading #Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort

Associations of Processed #Meat, Unprocessed Red Meat, Poultry, or #Fish Intake With Incident #Cardiovascular Disease and All-Cause Mortality

Although the associations between processed meat intake and cardiovascular disease (CVD) and all-cause mortality have been established, the associations of unprocessed red meat, poultry, or fish consumption with CVD and all-cause mortality are still uncertain.. .. Intake of processed meat (adjusted HR, 1.03 [95% CI, 1.02-1.05]; adjusted ARD, 0.90% [95% CI, 0.43%-1.38%]) or unprocessed red meat (adjusted HR, 1.03 [95% CI, 1.01-1.05]; adjusted ARD, 0.76% … Continue reading Associations of Processed #Meat, Unprocessed Red Meat, Poultry, or #Fish Intake With Incident #Cardiovascular Disease and All-Cause Mortality