Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study

Highlights•We assessed the association between sugary drinks and mortality in Japan. •Sugary drink consumption was positively associated with all-cause mortality. •Sugary drinks increased risk of death from circulatory system diseases. AbstractBackgroundFew epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations. MethodsThis study included 70,486 participants in the Japan Public Health Center-based Prospective Study at the age of 45–74 … Continue reading Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study

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#Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis

Neuroticism is linked to mood disorders and Alzheimer’s disease, but fewer studies have tested the prospective association with Parkinson’s disease (PD). ObjectivesTo examine the association between neuroticism and risk of PD in a large cohort and a meta‐analysis of prospective cohort studies. MethodsParticipants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006–2010. Incident PD was ascertained using electronic health records or … Continue reading #Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis

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Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women

Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio … Continue reading Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women

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Therapeutic Repurposing of #Biguanides in #Cancer

Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides. Biguanides modulate antitumor immunity by targeting immune cells in the … Continue reading Therapeutic Repurposing of #Biguanides in #Cancer

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Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered. Reporting of adverse events is a critical postmarketing activity. METHODS We report findings in 23 patients who presented with thrombosis and thrombocytopenia 6 to 24 days after receiving the first dose … Continue reading Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

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Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

To the editors, The population with severe mental disorders (SMD) is a medically and socially vulnerable group for a worse outcome in COVID-19. This population has been identified as high-risk group for COVID-19 due to lower awareness of risk, higher prevalence of cognitive impairment and who have limitations to maintain adequate barriers against virus propagation such as living in long-term care facilities, and people with … Continue reading Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

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Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study

To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the occurrence of PSE. Methods :A total of 1152 patients with newly diagnosed ischemic stroke admitted to our hospital from March to August 2017 were selected, 1033 of whom were followed-up. Patients … Continue reading Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study

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The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial

It is currently unknown whether exergaming is efficacious in people with major neurocognitive disorder (MNCD) residing in long-term care facilities. This pilot randomized controlled trial (RCT) explored the efficacy of a stepping exergame program on gait speed, balance, mobility, reaction time, cognitive and neuropsychiatric outcomes, quality of life, and daily life functioning in people with MNCD residing in long-term care facilities. Methods Participants were randomly … Continue reading The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial

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Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled … Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

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Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study

The association between psychosocial stress and coronary heart disease (CHD) may be stronger in women than men and may differ across types of stressors. In this study, we assessed associations of psychosocial stressors, including job strain, stressful life events, and social strain with the incidence of CHD in women. Methods and Results We used longitudinal data from 80 825 WHI‐OS (Women’s Health Initiative Observational Study) … Continue reading Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study

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Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis

Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients on maintenance hemodialysis and the factors associated with it. Design, … Continue reading Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis

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Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites

Probiotic milk-fermented microorganism mixtures (e.g., yogurt, kefir) are perceived as contributing to human health, and possibly capable of protecting against bacterial infections. Co-existence of probiotic microorganisms are likely maintained via complex biomolecular mechanisms, secreted metabolites mediating cell-cell communication, and other yet-unknown biochemical pathways. In particular, deciphering molecular mechanisms by which probiotic microorganisms inhibit proliferation of pathogenic bacteria would be highly important for understanding both the … Continue reading Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites

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