Although a target of 80% medication adherence is commonly cited, it is unclear whether greater adherence improves survival after stroke or transient ischemic attack (TIA). We investigated associations between medication adherence during the first year postdischarge, and mortality up to 3 years, to provide evidence-based targets for medication adherence. Methods:Retrospective cohort study of 1-year survivors … Continue reading Greater Adherence to Secondary Prevention Medications Improves Survival After #Stroke or Transient #Ischemic Attack: A Linked Registry Study
Tag: stroke
Atrial fibrillation and heart failure with reduced ejection fraction (HFrEF) are common sources of cardioembolism. While oral anticoagulation is strongly recommended for atrial fibrillation, there are marked variations in guideline recommendations for HFrEF due to uncertainty about net clinical benefit. This systematic review and meta-analysis evaluates the comparative association of oral anticoagulation with stroke and … Continue reading Association of Oral #Anticoagulation With #Stroke in Atrial #Fibrillation or Heart #Failure: A Comparative Meta-Analysis
A recent study suggested that the CHA2DS2-VASc score can risk stratify heart failure (HF) patients without atrial fibrillation (AF) for stroke. We performed a retrospective analysis using the national Veteran Affairs database to externally validate the findings. Crude incidence rates of end points were calculated. A Cox proportional model was used to study the association … Continue reading The #CHA2DS2-VASc Score for Risk Stratification of #Stroke in Heart Failure With-vs-Without Atrial #Fibrillation
Clinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietary choline and TMAO generation, directly impact cerebral infarct size and adverse outcomes following stroke. Fecal … Continue reading #Gut microbes impact #stroke severity via the trimethylamine N-oxide pathway
