Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Risk Assessment in MASLD and MetALD: Current Approaches and Future Directions
Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) exist on a continuous spectrum in which fibrosis stage remains the dominant predictor of liver‑related complications. Contemporary non‑invasive risk stratification uses simple serum scores (e.g., Fibrosis‑4 index [FIB‑4]) as a first step, followed by vibration‑controlled transient elastography (VCTE) or liver‑specific blood… Continue reading Risk Assessment in MASLD and MetALD: Current Approaches and Future Directions
Curcumin Suppresses Growth of Recurrent Colorectal Adenoma After Endoscopic Resection: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Introduction: Experimental and limited clinical studies suggest that curcumin has chemopreventive activity in the colorectum. This large-scale clinical trial evaluated the efficacy and safety of curcumin in patients with previously endoscopically resected colorectal neoplasia.Methods: This randomized, double-blind, placebo-controlled multicenter trial enrolled patients with previously resected colorectal neoplasia. Eligible patients were randomly assigned (1:1), using a… Continue reading Curcumin Suppresses Growth of Recurrent Colorectal Adenoma After Endoscopic Resection: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease
Background: Evidence on the effects of 12-week telehealth-supported home-based exercise in advanced non-dialysis chronic kidney disease (CKD) remains limited. This study evaluated its effects on functional capacity, sarcopenia risk, and patient-reported outcomes in patients with stage 4-5 CKD.Methods: In this prospective, parallel-group randomized controlled trial (October 2024-July 2025), 54 non-dialysis patients aged ≥45 years with… Continue reading Effects of a telehealth-supported home-based exercise program on functional capacity, sarcopenia risk, and patient-reported outcomes in non-dialysis stage 4-5 chronic kidney disease
Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Background: Patients with atrial fibrillation (AF) who are at increased risk of both thrombotic and haemorrhagic events represent a heterogeneous and broad clinical entity, characterized by the presence of several Janus-faced risk factors. We aimed to identify clinical phenotypes and assess the association of ABC pathway adherence with one-year outcomes in patients with AF at… Continue reading Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
Background: Older adults account for an increasing proportion of emergency department visits for mild traumatic brain injury (mTBI). Although age is incorporated as a high-risk criterion in major clinical decision rules, the operational impact of risk stratification on computed tomography (CT) utilization in very elderly patients remains uncertain.Methods: We conducted a retrospective cohort study including… Continue reading Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Purpose: This study aimed to compare the associations and predictive performance of atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index for incident cardiometabolic multimorbidity (CMM).Methods: Data was analyzed from 2261 adults (mean age 63 years; 45.0% men) in the English Longitudinal Study of Ageing without a history of cardiometabolic disease at baseline (2008-2009).… Continue reading Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Korean Clinical Practice Guidelines for Interstitial Lung Disease: Part 2. Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia characterized by declining lung function, severe dyspnea, and a poor prognosis. Although antifibrotic agents have improved outcomes in patients with IPF, important challenges remain in the diagnosis, monitoring, and long-term management of the disease. Since the publication of the first Korean clinical practice guideline… Continue reading Korean Clinical Practice Guidelines for Interstitial Lung Disease: Part 2. Idiopathic Pulmonary Fibrosis
Explainable Machine Learning for Predicting Deep Vein Thrombosis in Critically Ill Patients with COPD: Development and Multicenter External Validation
Background: Deep vein thrombosis (DVT) is a frequent yet underrecognized complication in critically ill patients with chronic obstructive pulmonary disease (COPD). Existing risk assessment tools are not specifically tailored to this high-risk population. We aimed to develop and externally validate an interpretable machine-learning model for early prediction of DVT in ICU-admitted COPD patients.Methods: Adult COPD… Continue reading Explainable Machine Learning for Predicting Deep Vein Thrombosis in Critically Ill Patients with COPD: Development and Multicenter External Validation
Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study
Background Intracerebral hemorrhage (ICH) is associated with high mortality and limited therapeutic options. The impact of statin therapy on outcomes following ICH remains controversial. Methods A retrospective cohort study was conducted using the TriNetX Global Collaborative Network. Adult patients (≥18 years) with nontraumatic ICH were identified and stratified based on statin use within three months… Continue reading Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study
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