Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Mechanical load inhibits cancer growth in mouse and human hearts
INTRODUCTIONThe #heart is rarely affected by #cancer ; both primary cardiac tumors and metastases are uncommon despite the high vascularization of the myocardium. The mechanisms underlying this resistance remain unclear.RATIONALEMechanical load has been proposed as a major mechanism halting cardiomyocyte proliferation early after birth, thus limiting the regenerative potential of the adult mammalian heart. We… Continue reading Mechanical load inhibits cancer growth in mouse and human hearts
Efficacy of multiple acupoint stimulation therapies for primary insomnia patients: a systematic review and network meta-analysis
Background: Primary #insomnia (PI) is a chronic #sleep disorder with a complex pathogenesis, and various treatment options are available. In recent years, multiple acupoint stimulation therapies have gained increasing attention as non-pharmacological interventions. This systematic review and network meta-analysis aimed to assess the comparative efficacy of different acupoint stimulation therapies for PI.Methods: We searched eight… Continue reading Efficacy of multiple acupoint stimulation therapies for primary insomnia patients: a systematic review and network meta-analysis
Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
The association of perturbed skeletal muscle metabolism with #ICU acquired weakness (ICUAW) is not clear. The objective of the present study was to characterise temporal changes in skeletal #muscle mitochondrial function, #ATP concentration, and substrate utilisation during and up to 6 months post ICU admission in critically ill patients, and to delineate mechanisms underpinning ICUAW… Continue reading Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
The National Psoriasis Foundation Primer on GLP-1 Receptor Agonists in Psoriasis: A Review
Importance: #Psoriasis is a chronic immune-mediated disease associated with cardiovascular, metabolic, musculoskeletal, psychiatric, hepatic, kidney, and pulmonary comorbidities. Glucagon-like peptide-1 receptor agonists (#GLP-1 RAs) are approved by the US Food and Drug Administration for type 2 diabetes, obesity, cardiovascular risk reduction, chronic kidney disease, obstructive sleep apnea, and metabolic dysfunction-associated steatohepatitis-conditions common in psoriasis. Emerging… Continue reading The National Psoriasis Foundation Primer on GLP-1 Receptor Agonists in Psoriasis: A Review
Optimizing temporal windows for wearable-augmented post-discharge risk prediction: a methods study
Objective: Traditional #readmission risk models relying on static discharge data have limited predictive performance and fail to capture patients' recovery trajectories after hospitalization. We sought to identify optimal modeling parameters for dynamically predicting readmission risk using post-discharge step-count data from remote monitoring devices.Methods: We combined data for adults aged 55+ from 2 studies that collected… Continue reading Optimizing temporal windows for wearable-augmented post-discharge risk prediction: a methods study
Socioeconomic disparities in biologic persistence among patients with inflammatory bowel disease are associated with increased health care utilization
Introduction: Biologic persistence, defined as the total uninterrupted time on a biologic agent, is associated with improved outcomes in inflammatory bowel disease (#IBD ). However, social determinants of health (SDOH), such as socioeconomic status, may influence a patient's ability to access these medications. We aimed to better understand the relationship between socioeconomic status and biologic… Continue reading Socioeconomic disparities in biologic persistence among patients with inflammatory bowel disease are associated with increased health care utilization
Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study
Background: Electrolyte abnormalities following #chemotherapy are common and clinically significant complications in cancer patients and are often associated with treatment delays and adverse outcomes. This study aims to develop and validate machine learning models to predict eight electrolyte abnormalities in cancer patients receiving chemotherapy.Methods: We retrospectively analyze medical records of cancer patients from two tertiary… Continue reading Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study
Impact of body mass index on the efficacy of acupuncture treatment of postprandial distress syndrome: secondary analysis of a randomized clinical trial
Objective: To assess the impact of body mass index (#BMI ) on the effectiveness of acupuncture in treating postprandial distress syndrome (#PDS ).Methods: Data from 278 patients enrolled in a prior multicenter, randomized, sham-controlled trial were analyzed in this secondary study. Patients were classified into three groups according to baseline BMI: low, normal, and high.… Continue reading Impact of body mass index on the efficacy of acupuncture treatment of postprandial distress syndrome: secondary analysis of a randomized clinical trial
Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
Polycystic ovary syndrome (#PCOS ) and its underlying features remain poorly understood. In this genetic study (n = 544,513), we expand the number of genetic loci from 16 to 29, and additionally identify 31 associated plasma proteins. Many risk-increasing loci were associated with later age at menopause, underscoring the reproductive longevity related to an increased… Continue reading Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome
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