Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Trends of myocardial infarction in young patients
Aim: While the overall incidence and mortality of ST-elevation myocardial infarction ( #STEMI ) have declined, younger adults 18-40 years of age have experienced a different trend. We examined STEMI incidence, mortality, and mechanical circulatory support (MCS) utilization in #young patients from 2004 to 2023 using the TriNetX Research Network database.Methods: We conducted an analysis… Continue reading Trends of myocardial infarction in young patients
Efficacy and safety of GLP-1 receptor agonists and SGLT2 inhibitors as adjuncts to insulin in type 1 diabetes: Systematic review and meta-analysis
AimsAdjunctive therapies to insulin for type 1 #diabetes mellitus (T1DM), including glucagon-like peptide-1 receptor agonists ( #GLP-1RAs ) and sodium–glucose cotransporter-2 inhibitors ( #SGLT2is ), may improve glycaemic control and reduce insulin requirements; however, safety concerns remain, particularly for diabetic ketoacidosis (DKA).Materials and MethodsPubMed, Ovid MEDLINE, Embase, Web of Science, Scopus and the Cochrane Library… Continue reading Efficacy and safety of GLP-1 receptor agonists and SGLT2 inhibitors as adjuncts to insulin in type 1 diabetes: Systematic review and meta-analysis
Human-large language model collaboration in clinical medicine: a systematic review and meta-analysis
Human- #AI collaboration (H + AI) using large language models ( #LLMs ) offers a promising approach to enhance clinical reasoning, documentation, and interpretation tasks. Following PRISMA 2020 (PROSPERO registration: CRD420251068272), we systematically compared H + AI with human-only (H) workflows, searching four databases through June 28, 2025. Ten peer-reviewed studies met eligibility criteria, with… Continue reading Human-large language model collaboration in clinical medicine: a systematic review and meta-analysis
Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Background: #Cefazolin , a first-generation #cephalosporin , is the standard antibiotic for perioperative prophylaxis in patients undergoing hip or knee arthroplasty. Research has demonstrated significantly higher periprosthetic joint infection ( #PJI ) rates when non-cefazolin antibiotics are used for prophylaxis. Notably, cefazolin contains an R1 side chain that has not shown cross-reactivity with other cephalosporins.… Continue reading Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Purpose: Data on the reliability of point-of-care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) #D-dimer (DD), interleukin 6 (IL-6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL-6 and PCT in comparison… Continue reading Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
Background: #D-dimer has gained considerable attention since its inclusion as a minor criterion in the 2018 International Consensus Meeting. However, evidence regarding its diagnostic accuracy for periprosthetic joint infection ( #PJI ) remains inconclusive. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of D-dimer in diagnosing PJI and comprehensively explore the sources… Continue reading Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Asthma is a heterogeneous disease characterized by chronic airway inflammation and reversible airflow obstruction. Particularly in severe #asthma , airway #mucus plugs can contribute to substantial and persistent airflow obstruction, despite inhaled corticosteroid and bronchodilator treatment. Consequently, it is important that clinicians assess and treat mucus plugs. Increased mucus production and airway eosinophilia caused by… Continue reading Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Microvascular dysfunction in Takotsubo syndrome: a systematic review
Background: Microvascular dysfunction (MD) is advocated as one of the main pathogenic mechanisms of #Takotsubo syndrome (TTS). Several studies investigated MD in TTS using different techniques; however, no systematic review of these data is currently available.Methods: We searched the main scientific database (Embase, Medline, Scopus, PubMed) for articles written in English language using the following… Continue reading Microvascular dysfunction in Takotsubo syndrome: a systematic review
Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease ( #IBD ) is a multisystem illness with intestinal and extraintestinal manifestations. We aimed to analyze the association of developing #pulmonary diseases (PDs) in patients with IBD.Methods: In this retrospective cohort study, TriNetX was used to identify patients with IBD who were prescribed at least one IBD-specific medication or advanced therapy. Patients… Continue reading Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
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