Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Risk of Retinal Vascular Occlusions
Purpose: To investigate whether glucagon-like peptide-1 receptor agonists are protective against retinal vascular occlusions. Methods: Using a large aggregated, de-identified electronic health records data platform in the United States, patients with type 2 diabetes ages ≥18 years prescribed glucagon-like peptide-1 receptor agonists or non-glucagon-like peptide-1 receptor agonists (controls) and having ophthalmology follow-up of at least… Continue reading The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Risk of Retinal Vascular Occlusions
Psychosocial Factors Associated with Diabetes Distress Among Adults with Type 2 Diabetes Mellitus: The Roles of Perceived Social Support and Diabetes Management Self-Efficacy in an Indonesian Outpatient Sample
AbstractPurpose: Diabetes distress represents a diabetes-specific emotional burden associated with the challenges of long-term diabetes management. Psychosocial factors, including perceived social support and diabetes management self-efficacy, may influence how individuals experience and adapt to type 2 diabetes mellitus (T2DM). However, the relationships among these factors remain insufficiently characterized when diabetes distress is considered the primary… Continue reading Psychosocial Factors Associated with Diabetes Distress Among Adults with Type 2 Diabetes Mellitus: The Roles of Perceived Social Support and Diabetes Management Self-Efficacy in an Indonesian Outpatient Sample
Relationship between vitamin D serum concentration and inflammatory bowel disease demographics: A cross-sectional study
Vitamin D deficiency is increasingly recognized as a common comorbidity in patients with inflammatory bowel disease (IBD), potentially influencing immune regulation and disease outcomes. Despite high rates of vitamin D deficiency reported globally, data from the Middle East remain scarce. This study aimed to evaluate the relationship between vitamin D concentration and the demographics of… Continue reading Relationship between vitamin D serum concentration and inflammatory bowel disease demographics: A cross-sectional study
Metabolic Dysfunction-Associated Fatty Liver Disease-Cardiovascular-Kidney-Metabolic (MAFLD-CKM): A Modified Framework to Predict Long-Term Mortality
BACKGROUND Cardiovascular-kidney-metabolic (CKM) syndrome reframes cardio-renal-metabolic risk but omits hepatic dysfunction, particularly metabolic dysfunction-associated fatty liver disease (MAFLD). This study assesses whether integrating MAFLD into the CKM framework improves mortality risk discrimination compared with the original CKM framework. MATERIAL AND METHODS We used data of 10 335 adults aged 20 to 74 years from the… Continue reading Metabolic Dysfunction-Associated Fatty Liver Disease-Cardiovascular-Kidney-Metabolic (MAFLD-CKM): A Modified Framework to Predict Long-Term Mortality
The 2026 British Society for Rheumatology guideline for the treatment of polymyalgia rheumatica
Polymyalgia rheumatica (PMR) is a common inflammatory rheumatic condition in older adults. Glucocorticoids (GCs) remain the cornerstone of treatment, but many people with PMR relapse during tapering and are exposed to prolonged GC therapy with associated toxicity. There is therefore a need for evidence-based strategies that optimize disease control while minimizing GC-related harm. This guideline… Continue reading The 2026 British Society for Rheumatology guideline for the treatment of polymyalgia rheumatica
Impact of preoperative osteoporosis on short- and long-term complications following ankle ORIF: A multi-institutional propensity-matched analysis
Background: Osteoporosis may impair fracture healing and fixation durability after ankle ORIF. This study evaluated postoperative complications of preoperative osteoporosis.Methods: Patients undergoing ankle ORIF from 2004 to 2022 with ≥ 2 years of follow-up were identified from a multi-institutional database. Those with and without preoperative osteoporosis, defined with ICD-10 code M80 & M81, were compared… Continue reading Impact of preoperative osteoporosis on short- and long-term complications following ankle ORIF: A multi-institutional propensity-matched analysis
Effectiveness and safety of three years of bulevirtide monotherapy in patients with HDV-related compensated cirrhosis: the Italian compassionate use program
Background: Bulevirtide (BLV) monotherapy for up to 144 weeks was safe and effective in patients with chronic hepatitis D (CHD) in a phase III trial, but long-term real-world data are limited. We evaluated its effectiveness and safety in patients with HDV-related cirrhosis in clinical practice.Methods: Consecutive patients with HDV-related cirrhosis treated with BLV 2 mg/day… Continue reading Effectiveness and safety of three years of bulevirtide monotherapy in patients with HDV-related compensated cirrhosis: the Italian compassionate use program
Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
Lipoprotein(a) [Lp(a)] is a genetically determined, apolipoprotein B-containing lipoprotein that contributes to cardiovascular risk through atherogenic, proinflammatory, and potentially antifibrinolytic mechanisms. Genetic, epidemiological, and mechanistic evidence supports a causal role for elevated Lp(a) in atherosclerotic cardiovascular disease and calcific aortic valve disease. In contrast, associations with other cardiovascular phenotypes are less consistent. Since circulating concentrations… Continue reading Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
When Speech Signals Wilson Disease: A Case Report
Wilson disease (WD) is a rare autosomal recessive disorder of copper metabolism that usually presents with a wide spectrum of seemingly unrelated symptoms, such as dysarthria, tremors, dystonia, features of advanced liver disease, and psychiatric manifestations. Atypical presentation may lead to delayed diagnosis. We present the case of a 25-year-old man who presented with slurred… Continue reading When Speech Signals Wilson Disease: A Case Report
