Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Reversible alterations of brain acetate metabolism associated with alcohol consumption
#Alcohol consumption elevates circulating acetate. Prior studies showed that acute alcohol reduces brain glucose uptake and increases #brain acetate oxidation. Previously we showed that heavy drinkers have elevated capacity to oxidize brain acetate. Here we repeat the study, adding individuals with alcohol use disorder (AUD). Four groups were enrolled. The analysis data set included Light… Continue reading Reversible alterations of brain acetate metabolism associated with alcohol consumption
Exploratory Comparison of Meld, Meld-Na, and Meld 3.0 Scores for Prognostic Assessment at Diagnosis in Hepatocellular Carcinoma Using Machine Learning Approaches
Background: Hepatocellular carcinoma (#HCC ) is the most common primary liver tumor. Despite efforts to mitigate risk factors and implement surveillance programs in high-risk populations, such as screening, these strategies alone appear insufficient to significantly improve prognosis at diagnosis. The identification of novel prognostic factors remains an underdeveloped field that may play a key role… Continue reading Exploratory Comparison of Meld, Meld-Na, and Meld 3.0 Scores for Prognostic Assessment at Diagnosis in Hepatocellular Carcinoma Using Machine Learning Approaches
Association of HbA1c levels with neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with diabetes mellitus: a case-control study
Background: The prevalence of diabetes mellitus in the general population has been increasing in recent years, and diabetes-related complications contribute substantially to morbidity, mortality, and healthcare system burden. This study aimed to evaluate the relationship between glycated hemoglobin (HbA1c) levels and inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR),… Continue reading Association of HbA1c levels with neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in patients with diabetes mellitus: a case-control study
Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults
Sedentary #ageing is linked to low cardiorespiratory fitness and the development of a small, stiff #heart - risk factors for heart failure. Endurance exercise training reverses the effects of sedentary ageing on the heart when started in middle age; however, blunted training responses of females have been reported. Differences in baseline cardiac size or exercise-induced… Continue reading Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults
Machine learning prediction of sudden cardiac death incorporating multiple lipid markers: evidence from the Taiwan Chin Shan community cohort
Background: Sudden cardiac death (SCD) is a major contributor to cardiovascular mortality, but reliable long-term risk prediction in community-based populations remains limited. Machine learning (#ML ) offers potential advantages, yet its application to #SCD prediction remains comparatively limited, particularly in community-based populations.Methods: We used data from the Chin-Shan Community Cardiovascular Cohort (CCCC), a prospective community-based… Continue reading Machine learning prediction of sudden cardiac death incorporating multiple lipid markers: evidence from the Taiwan Chin Shan community cohort
A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
#Diabetes mellitus and #prediabetes represent major global health challenges associated with metabolic and cardiovascular complications. This review was conducted to evaluate herbal medicines as complementary strategies for glycaemic control and metabolic risk reduction. This systematic review assessed the efficacy, metabolic and cardiovascular effects, and clinical safety of herbal medicines used in diabetes and prediabetes management.… Continue reading A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
Effect of methotrexate on endothelial function in psoriasis patients
Introduction: #Psoriasis is a chronic immune-mediated inflammatory dermatosis associated with systemic comorbidities, including metabolic disorders, atherosclerosis, and increased cardiovascular mortality.Objectives: To evaluate the impact of #methotrexate (MTX) on clinical manifestations of psoriasis, lipid profile, endothelial function, nitric oxide bioavailability, and pro-inflammatory biomarkers.Methods: This prospective, open-label pilot study assessed patients before and after 12 weeks of… Continue reading Effect of methotrexate on endothelial function in psoriasis patients
High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
Background/aims: #Pancreatic exocrine insufficiency (PEI) is a condition characterized by impaired digestion and absorption resulting from insufficient exocrine secretion of the pancreas. The current study aimed to determine the prevalence, clinical characteristics, and associated risk factors of PEI in patients presenting to the gastroenterology outpatient clinic with common gastrointestinal complaints such as abdominal pain, dyspepsia,… Continue reading High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
The impact of immediate surgical intervention versus conservative treatment on functional recovery and quality of life in older adults with distal radius fractures
Distal radius #fractures are among the most prevalent fractures, accounting for approximately 17% of all fractures treated. Given the high prevalence of these fractures, particularly in the older adults population, determining the optimal treatment approach is of utmost clinical importance. While previous research has highlighted both the advantages and drawbacks of surgical and conservative treatment… Continue reading The impact of immediate surgical intervention versus conservative treatment on functional recovery and quality of life in older adults with distal radius fractures
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