Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Assessing noise perceptions in Italian adolescents: validation of the Italian youth attitude to noise scale (YANS-it)
Objective: To translate, culturally adapt, and validate the Italian version of the Youth Attitude to Noise Scale (YANS-It) and to assess Italian adolescents' attitudes towards noise exposure.Design: Cross-cultural adaptation and validation study using forward-backward translation and pilot testing, followed by a nationwide online cross-sectional survey. Psychometric analysis included Confirmatory Factor Analysis with the WLSMV estimator,… Continue reading Assessing noise perceptions in Italian adolescents: validation of the Italian youth attitude to noise scale (YANS-it)
Long-term impact of acute pancreatitis on patients’ quality of life: a multi-center prospective study in Japan
Background: Although acute pancreatitis often resolves, its long-term impact on health-related quality of life (HRQoL) and social participation remains unclear. This study investigated the longitudinal changes in HRQoL and factors affecting incomplete recovery of social participation following acute pancreatitis.Methods: This multi-center, prospective cohort study included patients aged ≥ 18 years who were hospitalized with acute… Continue reading Long-term impact of acute pancreatitis on patients’ quality of life: a multi-center prospective study in Japan
The gut microbiome in chemotherapy-induced fatigue: Exploring clinical associations and modulation via fecal microbiota transplantation in female mice
Background: Fatigue is a common and debilitating side effect of chemotherapy, negatively affecting treatment adherence and survival. Chemotherapy alters gut microbiome composition, and accumulating evidence suggests that gut microbes contribute to chemotherapy-induced fatigue. Because the gut microbiome is modifiable through targeted interventions, such as fecal microbiota transplantation (FMT), microbiome modulation has emerged as a potential… Continue reading The gut microbiome in chemotherapy-induced fatigue: Exploring clinical associations and modulation via fecal microbiota transplantation in female mice
Extending the Fear-Avoidance Model of pain to youth: Psychometric evaluation of the 11-item Tampa Scale of Kinesiophobia in children and adolescents
Kinesiophobia plays a central role in understanding adult pain mechanisms, yet its assessment and theoretical relevance in pediatric pain remain poorly understood. Research to clarify the role of kinesiophobia in pediatric populations requires a valid and reliable measure of the construct. The most commonly used measure is the Tampa Scale of Kinesiophobia (TSK). Unfortunately, prior… Continue reading Extending the Fear-Avoidance Model of pain to youth: Psychometric evaluation of the 11-item Tampa Scale of Kinesiophobia in children and adolescents
Trained immunity in autoinflammatory diseases: Cellular reprogramming across the monogenic-polygenic spectrum
Trained immunity, an innate immunological memory induced by epigenetic and metabolic reprogramming, has changed the paradigm of host defense and pathogenesis of chronic inflammatory disease. Unlike adaptive immunological memory, trained immunity is characterized by the ability of innate immune cells and their progenitors to respond more robustly or differently to subsequent stimulations and contributes to… Continue reading Trained immunity in autoinflammatory diseases: Cellular reprogramming across the monogenic-polygenic spectrum
The trajectory of inflammatory bowel disease in east and southeast Asia: transitioning from acceleration in incidence to compounding prevalence
The epidemiology of inflammatory bowel disease (IBD) progresses through four stages: emergence (stage 1), acceleration in incidence (stage 2), compounding prevalence (stage 3), and prevalence equilibrium (stage 4). Most early industrialised regions (Europe, North America, and Oceania) have reached stage 3, whereas many newly industrialised regions-those that predominantly industrialised after World War 2-are in stage… Continue reading The trajectory of inflammatory bowel disease in east and southeast Asia: transitioning from acceleration in incidence to compounding prevalence
A new role of class A HBV capsid assembly modulators in core protein dynamics and cccDNA replenishment
Background & aims: Current treatments of chronic hepatitis B are rarely curative. Capsid assembly modulators (CAMs) target capsid formation by the hepatitis B virus (HBV) core protein. Class A CAMs (CAM-A) induce abnormal core protein assembly but how they affect core protein dynamics and inhibit HBV replication is only partially understood.Methods: Human liver chimeric mice… Continue reading A new role of class A HBV capsid assembly modulators in core protein dynamics and cccDNA replenishment
Left Atrial Reservoir Strain Improves Sudden Cardiac Death Risk Stratification in Hypertrophic Cardiomyopathy
Background: Current risk scores for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) have limited ability to identify high-risk subgroups. We aimed to investigate the prognostic value of left atrial reservoir strain (LARS) for SCD-related events and its utility for risk stratification.Methods: This retrospective cohort study included 1,761 patients with HCM from two referral centers.… Continue reading Left Atrial Reservoir Strain Improves Sudden Cardiac Death Risk Stratification in Hypertrophic Cardiomyopathy
Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Background: Metabolic and bariatric surgery (MBS) is an effective treatment for severe obesity, yet postoperative weight loss outcomes vary considerably between patients. With the relevance of the gut microbiome for obesity, it is of interest to understand the potential role of the oral and gut microbiota for the outcome of MBS. This pilot, hypothesis-generating study… Continue reading Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
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