Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Left Atrial Reservoir Strain Improves Sudden Cardiac Death Risk Stratification in Hypertrophic Cardiomyopathy
Background: Current risk scores for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) have limited ability to identify high-risk subgroups. We aimed to investigate the prognostic value of left atrial reservoir strain (LARS) for SCD-related events and its utility for risk stratification.Methods: This retrospective cohort study included 1,761 patients with HCM from two referral centers.… Continue reading Left Atrial Reservoir Strain Improves Sudden Cardiac Death Risk Stratification in Hypertrophic Cardiomyopathy
Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Background: Metabolic and bariatric surgery (MBS) is an effective treatment for severe obesity, yet postoperative weight loss outcomes vary considerably between patients. With the relevance of the gut microbiome for obesity, it is of interest to understand the potential role of the oral and gut microbiota for the outcome of MBS. This pilot, hypothesis-generating study… Continue reading Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Factors Associated with Outgrowing Food Allergies: Insights from a Large Food Allergy Cohort
Background: Food allergy (FA) is increasing in prevalence among children worldwide, and this diagnosis creates substantial health, psychosocial, and financial burdens. Although some children may eventually achieve resolution of certain food allergies, the factors associated with resolution are poorly understood.Objective: The objective of this study was to identify factors associated with FA resolution at baseline… Continue reading Factors Associated with Outgrowing Food Allergies: Insights from a Large Food Allergy Cohort
Encapsulated faecal microbiota transfer to target immune activation in patients with cirrhosis and ascites (TransImmune): protocol for a randomised, double-blind, Phase IIa, placebo-controlled trial
Introduction: Bacterial translocation and gut dysbiosis are key drivers of systemic immune activation in decompensated cirrhosis, precipitating inflammatory complications such as acute-on-chronic liver failure (ACLF). Currently, no licensed therapies effectively restore intestinal barrier function or reverse dysbiosis in this vulnerable population. While previous studies have suggested benefits of faecal microbiota transfer (FMT) in hepatic encephalopathy… Continue reading Encapsulated faecal microbiota transfer to target immune activation in patients with cirrhosis and ascites (TransImmune): protocol for a randomised, double-blind, Phase IIa, placebo-controlled trial
Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk
Background and objectives: Limited data on the comparative efficacy and safety of potent P2Y₁₂ inhibitors versus clopidogrel in patients with acute myocardial infarction (AMI) stratified by bleeding risk. This study evaluated the differential prognostic impact of potent P2Y₁₂ inhibitors in patients with AMI by bleeding risk.Methods: From the nationwide pooled registry of the Korea Acute… Continue reading Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk
“Hospital-at-home and 30-day readmission among clinically eligible patients: a prospective cohort study with a capacity-constrained comparator group
Background and aims: To evaluate the association between hospital-at-home (HaH) care and unplanned 30-day hospital readmission using a capacity-based comparator group of clinically eligible patients admitted to conventional hospitalization (CH) because of lack of HaH capacity.Methods: This prospective observational study was conducted between 2023 and 2026 at a tertiary hospital in Spain. A total of… Continue reading “Hospital-at-home and 30-day readmission among clinically eligible patients: a prospective cohort study with a capacity-constrained comparator group
Hyponatremia as a Prognostic Marker in Cirrhosis: A Systematic Review of Its Role Beyond the Model for End-Stage Liver Disease in Predicting Mortality
This systematic review evaluates the prognostic significance of hyponatremia in patients with cirrhosis across diverse clinical settings. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science for studies published between January 2000 and December 2025, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and a… Continue reading Hyponatremia as a Prognostic Marker in Cirrhosis: A Systematic Review of Its Role Beyond the Model for End-Stage Liver Disease in Predicting Mortality
Digital Therapeutics for Postoperative Rehabilitation after Arthroscopic Rotator Cuff Repair: A Single-Center, Assessor-Blinded, Randomized Pilot Study
Background: Home-based rehabilitation after arthroscopic rotator cuff repair (ARCR) often lacks objective monitoring. To address this limitation, we developed the ANAPA digital rehabilitation (DR) system, which includes a patient-facing mobile application for clinical efficacy evaluation (ANAPA ME) and a physician-facing measurement application for technical assessment (ANAPA PS). This study compared the safety and preliminary efficacy… Continue reading Digital Therapeutics for Postoperative Rehabilitation after Arthroscopic Rotator Cuff Repair: A Single-Center, Assessor-Blinded, Randomized Pilot Study
Acute Phosphate Nephropathy Following Oral Sodium Phosphate Bowel Preparation
Acute phosphate nephropathy (APN) is a rare but important cause of acute kidney injury (AKI), most commonly associated with the use of oral sodium phosphate bowel preparations administered prior to colonoscopy. In this report, we describe the case of a 60-year-old female patient who developed severe AKI necessitating temporary hemodialysis after bowel preparation with a… Continue reading Acute Phosphate Nephropathy Following Oral Sodium Phosphate Bowel Preparation
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