Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Development and Validation of a Machine Learning Model for Predicting Three-Month Unplanned Readmission in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study
Purpose: Patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) face a high risk of three-month unplanned readmission after discharge, yet early identification of high-risk patients remains challenging in clinical practice. This study aimed to develop and validate machine learning (ML) models for predicting the risk and providing a reference for the subsequent development and updating… Continue reading Development and Validation of a Machine Learning Model for Predicting Three-Month Unplanned Readmission in Patients with Moderate-to-Severe Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study
Correlation between serum uric acid-to-creatinine ratio and diabetic retinopathy in type 2 diabetes mellitus patients
Background: Diabetic retinopathy (DR) is a predominant microvascular complication in patients with type 2 diabetes mellitus (T2DM) and constitutes one of the leading causes of vision loss and blindness among this population. Serum uric acid (SUA) acts as a critical biomarker for microangiopathy; however, its relationship with DR remains incompletely elucidated. To adjust for inter-individual… Continue reading Correlation between serum uric acid-to-creatinine ratio and diabetic retinopathy in type 2 diabetes mellitus patients
Lower serum C3 levels are associated with glomerulosclerosis in membranous nephropathy and ANCA-glomerulonephritis
Background: Despite the key pathogenetic role of the complement cascade in various immune-mediated kidney diseases, the clinical significance of serum C3/C4 levels in conditions where most patients exhibit complement levels within normal limits, such as membranous nephropathy (MN) and ANCA (antineutrophil cytoplasmic antibody)-glomerulonephritis (ANCA-GN), remains underexplored. This study focused on the clinico-pathological correlates of serum… Continue reading Lower serum C3 levels are associated with glomerulosclerosis in membranous nephropathy and ANCA-glomerulonephritis
Stage 1 Registered Report: sex differences in anticoagulation and stroke outcomes among patients with atrial fibrillation: a registry-based cohort study
Women with atrial fibrillation have a higher risk of ischaemic stroke and worse functional outcomes than men but may be less likely to receive adequate anticoagulation. Preliminary single-centre findings in patients treated with endovascular thrombectomy for large vessel occlusion suggest that women may be under-anticoagulated prior to stroke onset. This Stage 1 Registered Report outlines… Continue reading Stage 1 Registered Report: sex differences in anticoagulation and stroke outcomes among patients with atrial fibrillation: a registry-based cohort study
Severe Rhabdomyolysis With Minimal Muscular Symptoms After Long-Term Rosuvastatin Use: A Case Report and Brief Literature Review
Severe rhabdomyolysis may present with limited muscular symptoms despite substantial biochemical injury. We describe a case of suspected statin-associated rhabdomyolysis during prolonged rosuvastatin exposure. A 65-year-old man with advanced chronic kidney disease, poorly controlled type 2 diabetes mellitus, peripheral arterial disease requiring bilateral below-knee amputations, and previous rhabdomyolysis presented with generalized weakness, abdominal discomfort, and… Continue reading Severe Rhabdomyolysis With Minimal Muscular Symptoms After Long-Term Rosuvastatin Use: A Case Report and Brief Literature Review
Artificial intelligence in myeloproliferative neoplasms: From digital bone marrow pathology to clinical decision support
Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell disorders whose diagnosis, prognostication, and management depend on integrating heterogeneous clinical, morphological, and molecular data. This narrative review (PubMed/MEDLINE searched through August 2026, supplemented by hand-searching and conference abstracts) appraises the evidence for AI applications across the MPN continuum. Artificial intelligence (AI), and its principal subfields, machine… Continue reading Artificial intelligence in myeloproliferative neoplasms: From digital bone marrow pathology to clinical decision support
In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians
Introduction: Older patients often present with complex coronary artery disease alongside multiple comorbidities. There is limited data on the outcomes of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in octogenarians. We aim to investigate the in-hospital and 1-year outcomes following successful CTO-PCI in octogenarians.Methods: Consecutive patients who had successful CTO-PCI at a single… Continue reading In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians
Multi-method Machine-Learning Identification of IL11 as a Key Gene in Kidney Stone Disease: Mechanistic Clues and Diagnostic Potential
Background: Randall's plaque (RP) is a key initiating lesion of idiopathic calcium stones at the renal papilla, and transcriptomic profiling of human RP has revealed inflammation- and matrix-remodeling-related changes, including upregulation of interleukin 11 (IL11). However, under a pure kidney-stone phenotype, a rigorous framework combining multi-algorithm consensus screening with fuller diagnostic appraisal (calibration, internal validation,… Continue reading Multi-method Machine-Learning Identification of IL11 as a Key Gene in Kidney Stone Disease: Mechanistic Clues and Diagnostic Potential
Infliximab Monotherapy as First-Line Treatment for Hepatic, Splenic, and Pulmonary Sarcoidosis in a Patient With High Cardiometabolic Risk
Glucocorticoids remain the first-line treatment for pulmonary and extrapulmonary sarcoidosis, with anti-tumor necrosis factor-alpha (TNF-α) agents such as infliximab typically reserved as steroid-sparing alternatives or for refractory disease. Data on anti-TNF-α monotherapy as first-line treatment, avoiding glucocorticoid exposure altogether, remain limited to isolated case reports. We report the case of a 46-year-old obese man with… Continue reading Infliximab Monotherapy as First-Line Treatment for Hepatic, Splenic, and Pulmonary Sarcoidosis in a Patient With High Cardiometabolic Risk
