Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Artificial intelligence in myeloproliferative neoplasms: From digital bone marrow pathology to clinical decision support
Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell disorders whose diagnosis, prognostication, and management depend on integrating heterogeneous clinical, morphological, and molecular data. This narrative review (PubMed/MEDLINE searched through August 2026, supplemented by hand-searching and conference abstracts) appraises the evidence for AI applications across the MPN continuum. Artificial intelligence (AI), and its principal subfields, machine… Continue reading Artificial intelligence in myeloproliferative neoplasms: From digital bone marrow pathology to clinical decision support
In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians
Introduction: Older patients often present with complex coronary artery disease alongside multiple comorbidities. There is limited data on the outcomes of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in octogenarians. We aim to investigate the in-hospital and 1-year outcomes following successful CTO-PCI in octogenarians.Methods: Consecutive patients who had successful CTO-PCI at a single… Continue reading In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians
Multi-method Machine-Learning Identification of IL11 as a Key Gene in Kidney Stone Disease: Mechanistic Clues and Diagnostic Potential
Background: Randall's plaque (RP) is a key initiating lesion of idiopathic calcium stones at the renal papilla, and transcriptomic profiling of human RP has revealed inflammation- and matrix-remodeling-related changes, including upregulation of interleukin 11 (IL11). However, under a pure kidney-stone phenotype, a rigorous framework combining multi-algorithm consensus screening with fuller diagnostic appraisal (calibration, internal validation,… Continue reading Multi-method Machine-Learning Identification of IL11 as a Key Gene in Kidney Stone Disease: Mechanistic Clues and Diagnostic Potential
Infliximab Monotherapy as First-Line Treatment for Hepatic, Splenic, and Pulmonary Sarcoidosis in a Patient With High Cardiometabolic Risk
Glucocorticoids remain the first-line treatment for pulmonary and extrapulmonary sarcoidosis, with anti-tumor necrosis factor-alpha (TNF-α) agents such as infliximab typically reserved as steroid-sparing alternatives or for refractory disease. Data on anti-TNF-α monotherapy as first-line treatment, avoiding glucocorticoid exposure altogether, remain limited to isolated case reports. We report the case of a 46-year-old obese man with… Continue reading Infliximab Monotherapy as First-Line Treatment for Hepatic, Splenic, and Pulmonary Sarcoidosis in a Patient With High Cardiometabolic Risk
Retinal and coronary imaging in type 1 diabetes: links between retinopathy and subclinical cardiovascular disease
Cardiovascular disease (CVD) remains the leading cause of premature morbidity and mortality in individuals with type 1 diabetes mellitus (T1DM), despite advances in glycemic management and cardiovascular prevention. Conventional cardiovascular risk assessment may underestimate risk in T1DM, particularly among younger asymptomatic individuals, highlighting the need for markers of early vascular injury. Diabetic retinopathy (DR), a… Continue reading Retinal and coronary imaging in type 1 diabetes: links between retinopathy and subclinical cardiovascular disease
A critical appraisal of guidelines and recommendations for the management of ANCA-associated vasculitis
Objectives: We aimed to appraise 11 currently available guidelines for ANCA-associated vasculitis (AAV), identify potential gaps, and provide recommendations for improvement.Methods: The guidelines were appraised using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument consisting of 23 appraisal criteria/items across six domains (D). Four reviewers independently appraised guidelines and scaled domain… Continue reading A critical appraisal of guidelines and recommendations for the management of ANCA-associated vasculitis
Pitfalls in the Diagnosis and Classification of Crohn’s Disease: Misdiagnosis, Overdiagnosis, and Misclassification
Crohn's disease (CD) remains challenging to diagnose and classify accurately despite advances in endoscopy, cross-sectional imaging, intestinal ultrasound, and inflammatory biomarkers. Earlier diagnosis and treat-to-target strategies have improved outcomes but have also increased the risk of misdiagnosis, overdiagnosis, and misclassification of disease activity or severity. Misdiagnosis may expose patients without CD to unnecessary immunosuppressive therapy… Continue reading Pitfalls in the Diagnosis and Classification of Crohn’s Disease: Misdiagnosis, Overdiagnosis, and Misclassification
Oral vs parenteral drug administration: Quantifying the future health costs of routine prescribing choices through their environmental scope
Background: Climate change is a major threat to global health, and healthcare is itself a substantial contributor. Choosing the route of drug administration may represent a simple opportunity to reduce environmental impact without compromising care.Objective: To quantify and compare the incremental environmental impacts and projected future health losses associated with oral, intravenous (IV), and intramuscular… Continue reading Oral vs parenteral drug administration: Quantifying the future health costs of routine prescribing choices through their environmental scope
The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Risk of Retinal Vascular Occlusions
Purpose: To investigate whether glucagon-like peptide-1 receptor agonists are protective against retinal vascular occlusions. Methods: Using a large aggregated, de-identified electronic health records data platform in the United States, patients with type 2 diabetes ages ≥18 years prescribed glucagon-like peptide-1 receptor agonists or non-glucagon-like peptide-1 receptor agonists (controls) and having ophthalmology follow-up of at least… Continue reading The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Risk of Retinal Vascular Occlusions
