Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Genotype-Guided Antidepressant Prescribing for Patients With Depression: A Randomized Clinical Trial
Importance: The effectiveness of pharmacogenetics to guide prescribing of selective serotonin reuptake inhibitors (#SSRIs ) for depression remains unclear, despite the well-established association between SSRI pharmacokinetics and genetic variation.Objective: To determine whether pharmacogenetic-guided prescribing of SSRIs improves treatment response in patients with #depression .Design, setting, and participants: The ADOPT PGx (A Depression and Opioid Pragmatic… Continue reading Genotype-Guided Antidepressant Prescribing for Patients With Depression: A Randomized Clinical Trial
Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
Introduction: When a patient's presentation raises suspicions for conditions other than diabetic kidney disease (DKD), such as sudden onset proteinuria <5 years after the onset of type 2 diabetes, proteinuria without retinopathy or neuropathy, acute kidney injury, active urinary sediment, or hematuria, clinically indicated kidney biopsies are typically carried out. Consequently, a high incidence of… Continue reading Clinical Predictors and Histopathological Spectrum of Nondiabetic Kidney Disease in Type 2 Diabetes
Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
,BackgroundLower childhood #socioeconomic status (cSES) has been linked to a higher risk of #Alzheimer's disease and related #dementia (ADRD). Yet, the mechanisms underlying this association remain unclear.ObjectiveThis study examined whether poorer health behaviors in adulthood mediate the association between lower cSES and ADRD risk. We further explored whether the mediating effects of health behaviors vary… Continue reading Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
A Novel, Interpretable Machine Learning Model Predicts Furosemide Dosing After Congenital Cardiac Surgery
Fluid overload is common after neonatal congenital #cardiac surgery (CCS) and is frequently managed with continuous furosemide infusions requiring iterative dose titration. An interpretable prediction model could support more consistent early postoperative dosing decisions. We hypothesized that a novel, interpretable machine learning approach could accurately predict furosemide dosing decisions in neonates following CCS. We identified… Continue reading A Novel, Interpretable Machine Learning Model Predicts Furosemide Dosing After Congenital Cardiac Surgery
Reevaluation of surgical strategies for chronic periprosthetic joint infection: a comparison of short-term outcomes between one-stage and two-stage revision
Objective: This study aims to compare the short-term clinical outcomes of one-stage and two-stage revision surgeries for treating chronic periprosthetic joint infection (#PJI ), addressing the limitations of the prolonged treatment cycle and heavy medical burden associated with two-stage revision, and evaluating the feasibility and effectiveness of one-stage revision as an alternative therapeutic strategy.Methods: This… Continue reading Reevaluation of surgical strategies for chronic periprosthetic joint infection: a comparison of short-term outcomes between one-stage and two-stage revision
Mechanical load inhibits cancer growth in mouse and human hearts
INTRODUCTIONThe #heart is rarely affected by #cancer ; both primary cardiac tumors and metastases are uncommon despite the high vascularization of the myocardium. The mechanisms underlying this resistance remain unclear.RATIONALEMechanical load has been proposed as a major mechanism halting cardiomyocyte proliferation early after birth, thus limiting the regenerative potential of the adult mammalian heart. We… Continue reading Mechanical load inhibits cancer growth in mouse and human hearts
Efficacy of multiple acupoint stimulation therapies for primary insomnia patients: a systematic review and network meta-analysis
Background: Primary #insomnia (PI) is a chronic #sleep disorder with a complex pathogenesis, and various treatment options are available. In recent years, multiple acupoint stimulation therapies have gained increasing attention as non-pharmacological interventions. This systematic review and network meta-analysis aimed to assess the comparative efficacy of different acupoint stimulation therapies for PI.Methods: We searched eight… Continue reading Efficacy of multiple acupoint stimulation therapies for primary insomnia patients: a systematic review and network meta-analysis
Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
The association of perturbed skeletal muscle metabolism with #ICU acquired weakness (ICUAW) is not clear. The objective of the present study was to characterise temporal changes in skeletal #muscle mitochondrial function, #ATP concentration, and substrate utilisation during and up to 6 months post ICU admission in critically ill patients, and to delineate mechanisms underpinning ICUAW… Continue reading Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness
The National Psoriasis Foundation Primer on GLP-1 Receptor Agonists in Psoriasis: A Review
Importance: #Psoriasis is a chronic immune-mediated disease associated with cardiovascular, metabolic, musculoskeletal, psychiatric, hepatic, kidney, and pulmonary comorbidities. Glucagon-like peptide-1 receptor agonists (#GLP-1 RAs) are approved by the US Food and Drug Administration for type 2 diabetes, obesity, cardiovascular risk reduction, chronic kidney disease, obstructive sleep apnea, and metabolic dysfunction-associated steatohepatitis-conditions common in psoriasis. Emerging… Continue reading The National Psoriasis Foundation Primer on GLP-1 Receptor Agonists in Psoriasis: A Review
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