Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Selection of an Appropriate Tool for Assessing Geriatric Frailty in Clinical Practice: A Narrative Review
Background: Frailty is a clinically significant geriatric syndrome characterized by reduced physiological reserve and increased vulnerability to stressors, resulting in a higher risk of adverse health outcomes such as functional decline, hospitalization, institutionalization, and mortality. Its early identification is essential for risk stratification, care planning, and individualized intervention. As no universal biomarker of frailty exists,… Continue reading Selection of an Appropriate Tool for Assessing Geriatric Frailty in Clinical Practice: A Narrative Review
Non-invasive prediction of occult peritoneal metastasis (OPM) in gastric cancer using logistic regression and random forest integrative models with CT radiomics and clinical parameters: machine learning prediction of gastric OPM
Background: Occult peritoneal metastasis (OPM) in gastric cancer is frequently missed on preoperative contrast-enhanced computed tomography (CT), leading to understaging in about 30-40% of patients and necessitating invasive laparoscopy for confirmation. A non-invasive tool to preoperatively identify OPM would help avoid unnecessary surgery and guide individualized treatment, but existing models lack interpretability and do not… Continue reading Non-invasive prediction of occult peritoneal metastasis (OPM) in gastric cancer using logistic regression and random forest integrative models with CT radiomics and clinical parameters: machine learning prediction of gastric OPM
Comparative Diagnostic Performance of Oral Microbial Habitats for Periodontitis
Periodontitis affects more than 1 billion people worldwide but remains largely underdiagnosed. The oral microbiota offers a noninvasive diagnostic window, but studies based on 16S rRNA data have reported heterogeneous and often suboptimal performance. It remains unclear which oral habitat and modeling strategy best support clinical decision making. We analyzed 2,303 adult samples from 33… Continue reading Comparative Diagnostic Performance of Oral Microbial Habitats for Periodontitis
Comparative assessment of hydration status in intestinal failure patients receiving home parenteral nutrition using different bioimpedance analysis devices
Background: Intestinal failure patients receiving home parenteral nutrition (HPN) are at high risk of dehydration and malnutrition. To optimize clinical care, accurate monitoring tools are required. This study aimed to compare the accuracy of two bioelectrical impedance analysis (BIA) devices, one that offers only BIA results and the other that offers BIA results of bioelectrical… Continue reading Comparative assessment of hydration status in intestinal failure patients receiving home parenteral nutrition using different bioimpedance analysis devices
Trauma-Induced Coagulopathy: From Endotheliopathy and Fibrinolysis Phenotypes to Viscoelastic-Guided Resuscitation
Trauma-induced coagulopathy is a maladaptive, multifactorial response to severe injury that affects approximately one quarter of severely injured patients and substantially increases mortality. It arises from combined tissue injury and shock and is characterized by endothelial dysfunction, platelet abnormalities, fibrinogen depletion, and dysregulated fibrinolysis, with thrombin generation typically preserved early and reduced only later, evolving… Continue reading Trauma-Induced Coagulopathy: From Endotheliopathy and Fibrinolysis Phenotypes to Viscoelastic-Guided Resuscitation
Risk of pneumonia in adults with chronic cough: a nationwide cohort study
Background: Chronic cough affects approximately 10% of adults and is increasingly recognised as a distinct clinical condition. This symptom has increasingly been associated with significant outcomes such as pneumonia. Nevertheless, few large long-term population-based studies have been conducted.Methods: This retrospective cohort study was performed using nationwide claims data from the Health Insurance Review and Assessment… Continue reading Risk of pneumonia in adults with chronic cough: a nationwide cohort study
CT attenuation as a biomarker of mild-to-moderate anemia: development of a non-contrast chest CT prediction model
Purpose: Non-contrast thoracic computed tomography (CT) may incidentally demonstrate imaging features associated with anemia and could complement laboratory testing, particularly in mild-to-moderate cases that are often clinically unrecognized. This study aimed to evaluate the relationship between visual signs and attenuation-based measurements on non-contrast chest CT and mild-to-moderate anemia, and to develop a combined prediction model… Continue reading CT attenuation as a biomarker of mild-to-moderate anemia: development of a non-contrast chest CT prediction model
Association Between Proton-Pump Inhibitors and Muscle Strength in Older Adults: A Population-Based Analysis
Objective: We aimed to assess the association of proton-pump inhibitor (PPI) use with muscle strength in older adults.Methods: All 1940-born residents of Turku, Finland were surveyed during 2016 and 2017 as part of the New Turku Older Adults Study. Associations between PPI use, regardless of dosing pattern, and physical function were analyzed using Welch's t-test,… Continue reading Association Between Proton-Pump Inhibitors and Muscle Strength in Older Adults: A Population-Based Analysis
Artificial intelligence-assisted histopathological diagnosis of endocervical gastric-type adenocarcinoma: a multicenter model development and validation study
Endocervical gastric-type adenocarcinoma (GAS) is one of the most aggressive subtypes of cervical cancer and is frequently underdiagnosed due to morphological ambiguity, leading to delayed diagnosis. Despite the availability of molecular and genomic assays, their high cost, complexity, and limited reproducibility restrict clinical use. This study therefore proposes a highly sensitive artificial intelligence (AI)-assisted diagnostic… Continue reading Artificial intelligence-assisted histopathological diagnosis of endocervical gastric-type adenocarcinoma: a multicenter model development and validation study
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