Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults
Sedentary #ageing is linked to low cardiorespiratory fitness and the development of a small, stiff #heart - risk factors for heart failure. Endurance exercise training reverses the effects of sedentary ageing on the heart when started in middle age; however, blunted training responses of females have been reported. Differences in baseline cardiac size or exercise-induced… Continue reading Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults
Machine learning prediction of sudden cardiac death incorporating multiple lipid markers: evidence from the Taiwan Chin Shan community cohort
Background: Sudden cardiac death (SCD) is a major contributor to cardiovascular mortality, but reliable long-term risk prediction in community-based populations remains limited. Machine learning (#ML ) offers potential advantages, yet its application to #SCD prediction remains comparatively limited, particularly in community-based populations.Methods: We used data from the Chin-Shan Community Cardiovascular Cohort (CCCC), a prospective community-based… Continue reading Machine learning prediction of sudden cardiac death incorporating multiple lipid markers: evidence from the Taiwan Chin Shan community cohort
A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
#Diabetes mellitus and #prediabetes represent major global health challenges associated with metabolic and cardiovascular complications. This review was conducted to evaluate herbal medicines as complementary strategies for glycaemic control and metabolic risk reduction. This systematic review assessed the efficacy, metabolic and cardiovascular effects, and clinical safety of herbal medicines used in diabetes and prediabetes management.… Continue reading A Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
Effect of methotrexate on endothelial function in psoriasis patients
Introduction: #Psoriasis is a chronic immune-mediated inflammatory dermatosis associated with systemic comorbidities, including metabolic disorders, atherosclerosis, and increased cardiovascular mortality.Objectives: To evaluate the impact of #methotrexate (MTX) on clinical manifestations of psoriasis, lipid profile, endothelial function, nitric oxide bioavailability, and pro-inflammatory biomarkers.Methods: This prospective, open-label pilot study assessed patients before and after 12 weeks of… Continue reading Effect of methotrexate on endothelial function in psoriasis patients
High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
Background/aims: #Pancreatic exocrine insufficiency (PEI) is a condition characterized by impaired digestion and absorption resulting from insufficient exocrine secretion of the pancreas. The current study aimed to determine the prevalence, clinical characteristics, and associated risk factors of PEI in patients presenting to the gastroenterology outpatient clinic with common gastrointestinal complaints such as abdominal pain, dyspepsia,… Continue reading High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
The impact of immediate surgical intervention versus conservative treatment on functional recovery and quality of life in older adults with distal radius fractures
Distal radius #fractures are among the most prevalent fractures, accounting for approximately 17% of all fractures treated. Given the high prevalence of these fractures, particularly in the older adults population, determining the optimal treatment approach is of utmost clinical importance. While previous research has highlighted both the advantages and drawbacks of surgical and conservative treatment… Continue reading The impact of immediate surgical intervention versus conservative treatment on functional recovery and quality of life in older adults with distal radius fractures
Outcomes of Patients With Hepatocellular Carcinoma Treated With Durvalumab Plus Tremelimumab in Real-World Clinical Practice Who Met or Did Not Meet the Inclusion Criteria for the Phase 3 HIMALAYA Trial
Background and aim: This study evaluated clinical outcomes in patients with hepatocellular carcinoma (#HCC ) treated with #durvalumab plus #tremelimumab (Dur/Tre) in routine practice, stratified by whether they fulfilled the eligibility criteria of the phase 3 HIMALAYA trial.Methods: A total of 412 patients with unresectable HCC receiving Dur/Tre at 30 Japanese institutions were enrolled. Of… Continue reading Outcomes of Patients With Hepatocellular Carcinoma Treated With Durvalumab Plus Tremelimumab in Real-World Clinical Practice Who Met or Did Not Meet the Inclusion Criteria for the Phase 3 HIMALAYA Trial
Direct Oral Anticoagulant Consumption and the Risk of Acute Interstitial Lung Diseases: A Case-Crossover Study Using Japanese Administrative Data
Background: Direct oral anticoagulants (#DOACs ) offer advantages over warfarin; however, concerns exist regarding their association with acute interstitial lung diseases (ILDs). This study investigated the risk of acute-onset ILDs associated with DOAC use.Methods: We conducted a case-crossover study to assess the risk of hospitalization for acute-onset #ILDs following DOAC initiation using the JMDC database,… Continue reading Direct Oral Anticoagulant Consumption and the Risk of Acute Interstitial Lung Diseases: A Case-Crossover Study Using Japanese Administrative Data
Data-driven decision support in hospital resource planning: an artificial intelligence-based model proposal for emergency department demand
Background: The sustainability of service quality in healthcare systems is directly related to accurate resource planning, especially in #emergency departments with high unpredictability. This study aims to analyze the impact of meteorological factors on emergency department visits and propose a highly accurate and explainable artificial intelligence-based decision support model for hospital management. Within the scope… Continue reading Data-driven decision support in hospital resource planning: an artificial intelligence-based model proposal for emergency department demand
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