Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Behavioral Incentives for Exercise and Intra-Articular Corticosteroids for Knee Osteoarthritis: Results from a Factorially Designed Pragmatic Randomized Clinical Trial
Purpose: To determine the benefit of a behaviorally-designed incentive program and corticosteroid injections in reducing symptoms and promoting physical activity in patients with knee #osteoarthritis (KOA).Methods: This was a pragmatic, multi-site, factorially-designed, blinded, randomized clinical trial. Participants with a clinical diagnosis of KOA and an indication for joint injection (age 40-85 years; Kellgren-Lawrence X-ray grade… Continue reading Behavioral Incentives for Exercise and Intra-Articular Corticosteroids for Knee Osteoarthritis: Results from a Factorially Designed Pragmatic Randomized Clinical Trial
Perforating Veins Detected by Endoscopic Ultrasonography Are Useful in Predicting the Recurrence of Esophageal Varices After Endoscopic Variceal Ligation Combined With Argon Plasma Coagulation
Objectives: Few attempts have been made to determine the risk factors for the recurrence of esophageal #varices (EV) and the optimal surveillance interval. This study analyzed whether endoscopic ultrasonography can be used to predict EV recurrence and determine the optimal timing for surveillance #endoscopy post-treatment.Methods: We retrospectively evaluated patients with EVs who underwent endoscopic variceal… Continue reading Perforating Veins Detected by Endoscopic Ultrasonography Are Useful in Predicting the Recurrence of Esophageal Varices After Endoscopic Variceal Ligation Combined With Argon Plasma Coagulation
Electroacupuncture alleviates acute gouty arthritis by inhibiting NLRP3 inflammasome activation via modulation of the circadian-inflammation axis
Electroacupuncture (#EA ) has shown anti-inflammatory potential in #gouty #arthritis (GA). This study aimed to investigate its therapeutic effects and underlying mechanisms. Core acupoints (ST36 and SP6) were identified through data-mining. In MSU-induced GA rats, EA significantly alleviated joint swelling, improved gait, reduced serum TNF-α, IL-6 and IL-1β, and suppressed synovial inflammatory infiltration. Mechanistically, EA… Continue reading Electroacupuncture alleviates acute gouty arthritis by inhibiting NLRP3 inflammasome activation via modulation of the circadian-inflammation axis
Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Aims: We evaluated the impact of scenario-based multifactorial control on the 3-year incidence of fatal/non-fatal cardiovascular disease (#CVD ) and associated healthcare costs in Asian patients with type 2 diabetes (#T2D ).Materials and methods: We applied the validated 'ABC' model to simulate the 3-year impact of attaining multiple treatment targets (HbA1c < 7%, blood pressure… Continue reading Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Underlying MASLD-induced gut microbiome dysbiosis and intestinal inflammation are key to poor outcomes in vibriosis infections in a preclinical model
Metabolic dysfunction-associated steatotic liver disease (#MASLD ) is the leading cause of chronic #liver disease globally, especially in developed countries, including the United States. The etiology of MASLD is closely associated with several other cardiometabolic conditions and can further aggravate to more severe stages of liver disease, including steatohepatitis and cirrhosis. Moreover, patients with underlying… Continue reading Underlying MASLD-induced gut microbiome dysbiosis and intestinal inflammation are key to poor outcomes in vibriosis infections in a preclinical model
Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Aims: Although pregabalin is a first-line therapy for painful #diabetic #polyneuropathy (PDPN), its optimal dose-response relationship remains unclear. We conducted a network meta-analysis to evaluate the efficacy and safety of fixed pregabalin dosages in PDPN patients.Materials and methods: We systematically searched major databases through October 2025 comparing various doses of pregabalin (75, 150, 300, and… Continue reading Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Blood Pressure Control and Mortality Among US Veterans
Background: Intensive blood #pressure (#BP) control reduces mortality and cardiovascular disease in clinical trials. However, real-world BP measurements often differ from standardized protocols. We evaluated the impact of real-world systolic BP on mortality among US Veterans.Methods: We conducted a retrospective cohort study of Veterans with hypertension, defined by diagnostic codes, antihypertensive prescriptions, or ≥2 office… Continue reading Blood Pressure Control and Mortality Among US Veterans
Cough as a clinical manifestation of giant cell arteritis
Objectives: #Cough is an underrecognized and atypical manifestation of giant cell #arteritis (GCA), which may lead to diagnostic delay. Literature on cough in GCA is limited and lacks comprehensive data on clinical relevance. The aim of this study was to assess the frequency of cough at diagnosis in GCA patients and to compare clinical characteristics… Continue reading Cough as a clinical manifestation of giant cell arteritis
β-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK-orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats
Irritable bowel syndrome (#IBS ) is characterized by chronic abdominal pain and altered bowel habits, with visceral hypersensitivity and impaired intestinal barrier function as key pathophysiological features. Although peripheral determinants of barrier dysfunction have been studied, the contribution of central regulatory mechanisms remains unclear. β-Hydroxybutyrate (#BHB ), a major ketone body elevated during fasting, exhibits… Continue reading β-Hydroxybutyrate modulates intestinal barrier function and visceral sensitivity via a brain AMPK-orexin pathway recruiting histamine H1 receptors, basal forebrain cholinergic neurons, adenosine A2B receptors, and vagal output in rats
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