Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
“Missing the forest for the trees” Is there any crisis of vocation for Emergency Medicine in Italy?
In recent years, several stakeholders in Italy have suggested a crisis of vocation for Emergency Medicine (EM). This study aimed to verify the accuracy of such claims. We conducted an observational cross-sectional study on data from the Italian national test for residency positions assignments from 2019 to 2025. We analyzed trends in the number of… Continue reading “Missing the forest for the trees” Is there any crisis of vocation for Emergency Medicine in Italy?
Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
Background: Rheumatoid arthritis (RA)-related physical limitations often hinder sustained physical activity and weight management, thereby amplifying cardiovascular risk through adverse metabolic profiles and chronic inflammation. We aimed to assess the effectiveness of semaglutide on the risk of incident major adverse cardiovascular and cerebrovascular events (MACCE) in obese adults with type 2 diabetes mellitus (T2DM) and… Continue reading Semaglutide for Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Patients with Type 2 Diabetes and Comorbid Rheumatoid Arthritis: A Target-Trial Emulation
Degree of urbanization and the prevalence of hypertension and diabetes mellitus in South Korea (Insight from Gyeonggi Province): A cross-sectional analysis with temporal trends, 2008-2023
Background: Despite South Korea's achievement of Universal Health Coverage (UHC), regional health inequities persist as a significant public health challenge. Traditional urban-rural classifications often fail to capture the nuanced spatial dynamics of modern settlement patterns. This study aimed to evaluate the prevalence of hypertension (HTN) and diabetes mellitus (DM) across the urbanization gradient-Cities, Urbanized, and… Continue reading Degree of urbanization and the prevalence of hypertension and diabetes mellitus in South Korea (Insight from Gyeonggi Province): A cross-sectional analysis with temporal trends, 2008-2023
Voluntary use of LLM-powered virtual standardized patients and medical students’ interview performance: An observational study
Background: Large language model (#LLM )-powered Virtual Standardized Patients (VSPs) offer scalable practice opportunities for clinical interviewing, but their added value within established human Standardized Patient (SP) curricula remains unclear. This study examined how self-directed VSP engagement relates to interview performance on traditional SP assessments through the lens of self-regulated learning theory.Methods: We analyzed VSP… Continue reading Voluntary use of LLM-powered virtual standardized patients and medical students’ interview performance: An observational study
Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Introduction: The #amyloid cascade hypothesis provided a compelling rationale for #Alzheimer's disease (AD) drug development, but many amyloid-β (Aβ)-targeted agents failed to show benefit. The present review article evaluated emerging Aβ-directed therapies, focusing on mechanisms, clinical efficacy, safety, and regulatory progress.Areas covered: The recent approvals of lecanemab and donanemab offered the first convincing evidence that… Continue reading Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
Background & aims: Aminotransferases are widely used for metabolic dysfunction-associated steatotic liver disease (MASLD) evaluation, especially in type 2 diabetes mellitus (T2DM). Whether within-person seasonal variation affects classification near commonly used thresholds or relates to long-term metabolic outcomes remains unclear.Methods: This registry-based cohort analysed monthly aspartate aminotransferase (AST) and alanine aminotransferase (ALT) measurements from 6039… Continue reading Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85)
AI-based burn image assessment: Reliability and clinical error patterns of multimodal large language models in a repeated-inference study
Accurate assessment of #burn depth and total body surface area (TBSA) is critical for clinical decision-making; however, it remains subjective and prone to interobserver variability. Multimodal large language models (MLLMs) are increasingly encountered in clinical contexts, but whether these systems can reliably assess burn images remains unclear. We evaluated four MLLMs (GPT-5.4 Pro, Grok 4.1,… Continue reading AI-based burn image assessment: Reliability and clinical error patterns of multimodal large language models in a repeated-inference study
Management of Infected Wounds: A Wound Healing Foundation Consensus Statement
The Wound Healing Foundation (WHF) previously organized consensus panels on the management of chronic #wounds (2022), acute wounds (2024), and diabetic wounds (2025). This WHF consensus statement, authored by a global interdisciplinary panel of clinicians and researchers, focuses on the management of infected wounds. The panel members reviewed the literature and reached consensus on elements… Continue reading Management of Infected Wounds: A Wound Healing Foundation Consensus Statement
Efficacy and safety of MIPO versus ORIF in distal tibial fractures: a systematic review and meta-analysis
Background: Distal tibial fractures are challenging to manage owing to limited soft-tissue coverage and compromised blood supply. Minimally invasive plate osteosynthesis (MIPO) and open reduction and internal fixation (ORIF) are among the widely used surgical options, but the optimal approach remains unclear. MIPO preserves periosteal blood flow with smaller incisions, while ORIF offers direct visualisation… Continue reading Efficacy and safety of MIPO versus ORIF in distal tibial fractures: a systematic review and meta-analysis
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