Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
Effectiveness and safety of three years of bulevirtide monotherapy in patients with HDV-related compensated cirrhosis: the Italian compassionate use program
Background: Bulevirtide (BLV) monotherapy for up to 144 weeks was safe and effective in patients with chronic hepatitis D (CHD) in a phase III trial, but long-term real-world data are limited. We evaluated its effectiveness and safety in patients with HDV-related cirrhosis in clinical practice.Methods: Consecutive patients with HDV-related cirrhosis treated with BLV 2 mg/day… Continue reading Effectiveness and safety of three years of bulevirtide monotherapy in patients with HDV-related compensated cirrhosis: the Italian compassionate use program
Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
Lipoprotein(a) [Lp(a)] is a genetically determined, apolipoprotein B-containing lipoprotein that contributes to cardiovascular risk through atherogenic, proinflammatory, and potentially antifibrinolytic mechanisms. Genetic, epidemiological, and mechanistic evidence supports a causal role for elevated Lp(a) in atherosclerotic cardiovascular disease and calcific aortic valve disease. In contrast, associations with other cardiovascular phenotypes are less consistent. Since circulating concentrations… Continue reading Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
When Speech Signals Wilson Disease: A Case Report
Wilson disease (WD) is a rare autosomal recessive disorder of copper metabolism that usually presents with a wide spectrum of seemingly unrelated symptoms, such as dysarthria, tremors, dystonia, features of advanced liver disease, and psychiatric manifestations. Atypical presentation may lead to delayed diagnosis. We present the case of a 25-year-old man who presented with slurred… Continue reading When Speech Signals Wilson Disease: A Case Report
Sicker at all ages? Two decades of changing disease histories and mortality in the United States
Background: Stagnating cardiovascular disease mortality and rising drug- and suicide-related deaths are key drivers of stalled US mortality improvements. However, prior research has largely overlooked disease histories preceding death, despite increasing multimorbidity. We examined changes in disease-history profiles in the US population and assessed how shifts in profile composition and within-profile mortality shaped mortality trends.Methods:… Continue reading Sicker at all ages? Two decades of changing disease histories and mortality in the United States
Increasing daily step count in mild cognitive impairment: a 12-month randomised controlled trial
Introduction: Despite numerous studies confirming the beneficial effects of physical activity on cognitive function, there is a lack of randomised controlled trials involving long-term, continuous monitoring of physical activity that assess the effect of step-based intervention on cognition-related outcomes. Therefore, this study evaluated whether increasing daily step count improves cognitive performance and brain health markers… Continue reading Increasing daily step count in mild cognitive impairment: a 12-month randomised controlled trial
Effects of warm water footbath on sleep quality and fatigue in patients with heart failure: a randomized controlled study Introduction: Poor sleep quality and fatigue are common and clinically important problems in patients with heart failure (HF). Warm water footbaths are a form of local heat therapy that can induce comfort, relieve fatigue, and improve… Continue reading
Preventing Weight Regain After Glucagon-Like Peptide‑1 Therapy Discontinuation: A Pilot Randomized Controlled Trial
Objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective treatments for obesity, but discontinuation is common due to cost, insurance coverage limitations, side effects, patient preference, and other factors. Weight regain often occurs rapidly after cessation, yet few evidence-based strategies exist to support weight maintenance during this transition. This pilot randomized trial examined whether a… Continue reading Preventing Weight Regain After Glucagon-Like Peptide‑1 Therapy Discontinuation: A Pilot Randomized Controlled Trial
Antithrombotic Therapy in Patients with Chronic Coronary Disease on Anticoagulation: Evidence from Contemporary Trials
Introduction: Chronic coronary disease (CCD) commonly coexists with long-term oral anticoagulation (OAC), particularly for atrial fibrillation (AF). Combination antiplatelet therapy increases bleeding, whereas ischemic protection with OAC alone remains a concern. We critically appraised contemporary evidence and guidelines to define optimal long-term maintenance therapy.Methods: We synthesized WOEST, PIONEER AF-PCI, RE-DUAL PCI, AUGUSTUS, AFIRE, OAC-ALONE, PRAEDO-AF,… Continue reading Antithrombotic Therapy in Patients with Chronic Coronary Disease on Anticoagulation: Evidence from Contemporary Trials
User Beware: Inaccuracy and Inconsistency of Large Language Models in Providing Precision Dosing Recommendations for Patients With Kidney Impairment-A Case Series
Introduction: Evidence-based dosing guidance for medications in critically ill patients with acute kidney injury (AKI) and receiving continuous kidney replacement therapy (CKRT) is limited. Freely available large language models (LLMs) can generate confident, human-like outputs. The accuracy and reproducibility of LLMs in providing precision drug dosing recommendations in the setting of AKI and CKRT have… Continue reading User Beware: Inaccuracy and Inconsistency of Large Language Models in Providing Precision Dosing Recommendations for Patients With Kidney Impairment-A Case Series
