Buongiorno! My name is Aldo and I am an Internal Medicine Doctor. This is my Medical News Blog and I'm sure you'll find it useful and informative. All the articles can be searched by Category, Tag or Text. Just click on a post or on the Search link above.
The comparative effects of S-amlodipine versus racemic amlodipine on long-term cardiovascular outcomes in subjects with hypertension: a nationwide population-based cohort study
Although S- #amlodipine is known to have similar effects in lowering blood #pressure and fewer side effects compared to amlodipine (= mixture of S- and R-amlodipine), there are no available data on its impact on long-term cardiovascular prognosis. This retrospective cohort study analyzed claims data from Korean subjects with hypertension treated with either S-amlodipine or… Continue reading The comparative effects of S-amlodipine versus racemic amlodipine on long-term cardiovascular outcomes in subjects with hypertension: a nationwide population-based cohort study
Episode Charges and Subsequent Visits After Telemedicine vs In-Person Care
Importance: Telemedicine use increased during the COVID-19 pandemic and has remained a regular component of health care delivery. However, the financial implications of this change for health systems' reimbursement and utilization remain unclear.Objective: To compare 30-day episode charges and subsequent visits after telemedicine and in-person index visits.Design, setting, and participants: The target trial emulation conducted… Continue reading Episode Charges and Subsequent Visits After Telemedicine vs In-Person Care
Gut microbiota and metabolic dysregulation in polycystic ovary syndrome: effects of acupuncture as an adjunct to in vitro fertilization on gut dysbiosis, metabolism, and oocyte quality
Introduction: Polycystic ovary syndrome ( #PCOS ) is marked by disruptions in metabolic and reproductive endocrine functions. This study synthesizes systemic metabolic profiles, alterations in gut microbiota, and follicular fluid metabolism to elucidate the reproductive and endocrine metabolic changes associated with PCOS. Furthermore, it aims to elucidate the potential mechanisms through which acupuncture may exert… Continue reading Gut microbiota and metabolic dysregulation in polycystic ovary syndrome: effects of acupuncture as an adjunct to in vitro fertilization on gut dysbiosis, metabolism, and oocyte quality
How to predict abnormal acid reflux: recent developments
IntroductionRecent advances in physiology and technology have led to the identification of additional parameters that have the potential to enhance diagnostic accuracy and inform the management of Gastroesophageal reflux disease ( #GERD ). Whilst traditional pH monitoring and acid exposure time (AET) remain central to diagnosis, recent advances have introduced novel physiological markers that improve… Continue reading How to predict abnormal acid reflux: recent developments
Atherosclerotic Cardiovascular Risk in Patients with Chronic Hepatitis B: Tenofovir Disoproxil Fumarate Vs. Tenofovir Alafenamide: A Korean Nationwide Study
#Tenofovir alafenamide (TAF) exhibits antiviral efficacy comparable to tenofovir disoproxil fumarate (TDF). Nonetheless, concerns persist regarding TAF's impact on the lipid profile and potential atherosclerotic cardiovascular disease (ASCVD) risk. This study evaluated long-term #ASCVD risk in patients with chronic hepatitis B ( #CHB ) treated with TAF or TDF using Korean National Health Insurance Service… Continue reading Atherosclerotic Cardiovascular Risk in Patients with Chronic Hepatitis B: Tenofovir Disoproxil Fumarate Vs. Tenofovir Alafenamide: A Korean Nationwide Study
Comparison of nutrients and ultra-processed food consumption between different phenotypes defined by abdominal obesity and sarcopenia
Background: #Obesity, #sarcopenia, and sarcopenic obesity require effective nutritional strategies in public health.Methods: This cross-sectional study analyzed 535 adults aged 40–60 years in rural Korea. Participants were grouped by abdominal obesity (waist circumference ≥90 cm for men, ≥85 cm for women) and probable sarcopenia (handgrip strength ≤28 kg for men, ≤18 kg for women). Dietary intake was assessed using a… Continue reading Comparison of nutrients and ultra-processed food consumption between different phenotypes defined by abdominal obesity and sarcopenia
Beyond human gold standards: A multimodel framework for automated abstract classification and information extraction
Meta-research and evidence synthesis require considerable resources. Large language models (#LLMs ) have emerged as promising tools to assist in these processes, yet their performance varies across models, limiting their reliability. Taking advantage of the large availability of small size (<10 billion parameters) open-source LLMs, we implemented an agreement-based framework in which a decision is… Continue reading Beyond human gold standards: A multimodel framework for automated abstract classification and information extraction
Trends of myocardial infarction in young patients
Aim: While the overall incidence and mortality of ST-elevation myocardial infarction ( #STEMI ) have declined, younger adults 18-40 years of age have experienced a different trend. We examined STEMI incidence, mortality, and mechanical circulatory support (MCS) utilization in #young patients from 2004 to 2023 using the TriNetX Research Network database.Methods: We conducted an analysis… Continue reading Trends of myocardial infarction in young patients
Efficacy and safety of GLP-1 receptor agonists and SGLT2 inhibitors as adjuncts to insulin in type 1 diabetes: Systematic review and meta-analysis
AimsAdjunctive therapies to insulin for type 1 #diabetes mellitus (T1DM), including glucagon-like peptide-1 receptor agonists ( #GLP-1RAs ) and sodium–glucose cotransporter-2 inhibitors ( #SGLT2is ), may improve glycaemic control and reduce insulin requirements; however, safety concerns remain, particularly for diabetic ketoacidosis (DKA).Materials and MethodsPubMed, Ovid MEDLINE, Embase, Web of Science, Scopus and the Cochrane Library… Continue reading Efficacy and safety of GLP-1 receptor agonists and SGLT2 inhibitors as adjuncts to insulin in type 1 diabetes: Systematic review and meta-analysis
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