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Foreword

Buongiorno! Guten Tag! Good Morning! My name is Aldo, I am a physician and I live in Milano, Italy. I have always read a lot of medical news, and I have realised how difficult it is to forget to read those news if you’re not disciplined enough or if you don’t make that a habit. So I have decided to help myself and the community, here and on the Telegram app, and share just two articles daily, those that get my attention. All the articles can be searched by Category or Tag. Buona Lettura!

Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians

...Recommendation 1a:ACP recommends monotherapy with either cognitive behavioral therapy or a second-generation antidepressant as initial treatment in patients in the acute phase of moderate to severe major depressive disorder (strong recommendation; moderate-certainty evidence).Recommendation 1b:ACP suggests combination therapy with cognitive behavioral therapy and a second-generation antidepressant as initial treatment in patients in the acute phase of …

Continue reading Nonpharmacologic and Pharmacologic Treatments of Adults in the Acute Phase of Major Depressive Disorder: A Living Clinical Guideline From the American College of Physicians

Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

Antibody delivery to the CNS remains a huge hurdle for the clinical application of antibodies targeting a CNS antigen. The blood–brain barrier and blood–CSF barrier restrict access of therapeutic antibodies to their CNS targets in a major way. The very high amounts of therapeutic antibodies that are administered systemically in recent clinical trials to reach …

Continue reading Intranasal delivery of full-length anti-Nogo-A antibody: A potential alternative route for therapeutic antibodies to central nervous system targets

Association of Eating and Sleeping Intervals With Weight Change Over Time: The Daily24 Cohort

BackgroundWe aim to evaluate the association between meal intervals and weight trajectory among adults from a clinical cohort.Methods and ResultsThis is a multisite prospective cohort study of adults recruited from 3 health systems. Over the 6‐month study period, 547 participants downloaded and used a mobile application to record the timing of meals and sleep for …

Continue reading Association of Eating and Sleeping Intervals With Weight Change Over Time: The Daily24 Cohort

Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes

Coffee may protect against non-alcoholic fatty liver disease (NAFLD), but the roles of the caffeine and non-caffeine components are unclear. Coffee intake by 156 overweight subjects (87% with Type-2-Diabetes, T2D) was assessed via a questionnaire, with 98 subjects (all T2D) also providing a 24 h urine sample for quantification of coffee metabolites by LC–MS/MS. NAFLD …

Continue reading Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes

Social isolation and 9-year dementia risk in community-dwelling Medicare beneficiaries in the United States

BackgroundSocial isolation can influence whether older adults develop dementia. We examine the association between social isolation and incident dementia among older adults in a nationally representative sample of community dwelling older adults in the United States (U.S.). We also investigate whether this association varies by race and ethnicity.MethodsData (N = 5022) come from the National Health and …

Continue reading Social isolation and 9-year dementia risk in community-dwelling Medicare beneficiaries in the United States