Foreword

Buongiorno! Guten Tag! Good Morning!
My name is Aldo, I am a physician and I live in Italy. I have always read a lot of medical news, and I have realised how difficult it is to forget to read those news if you’re not disciplined enough or if you don’t make that a habit. So I have decided to help myself and the community, here and on the Telegram app, and share just two articles daily, those that get my attention.

Buona Lettura! Continue reading Foreword

Nutriome–metabolome relationships provide insights into dietary intake and metabolism

Dietary assessment traditionally relies on self-reported data, which are often inaccurate and may result in erroneous diet–disease risk associations. We illustrate how urinary metabolic phenotyping can be used as an alternative approach to obtain information on dietary patterns. We used two multipass 24 h dietary recalls, obtained on two occasions on average 3 weeks apart, paired with two 24 h urine collections from 1,848 US individuals; 67 … Continue reading Nutriome–metabolome relationships provide insights into dietary intake and metabolism

Associations between consumption of dietary #fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort

..Our objectives were to assess the associations between the intake of DFs of different types [total (TDF), soluble (SF), insoluble (IF)] and from different sources (fruits, vegetables, whole grains, legumes, potatoes and tubers) and the risk of cardiovascular diseases (CVDs), cancer, type 2 diabetes (T2D), and mortality in the large-scale NutriNet-Santé prospective cohort (2009–2019).. ..T2D risk was inversely associated with TDFs [HR for quintile 5 … Continue reading Associations between consumption of dietary #fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort

Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study

To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC).. ..The grey-level co-occurrence matrix -based texture features were most frequently extracted and the nonlinear discriminant analysis was excellent with the misclassification rate ranging from 3.33 to 14.93%. The area under the curve (AUC) of the combined texture … Continue reading Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with aging. In healthy humans, plasma trimethylamine-N-oxide was higher in middle-aged/older (64±7 years) versus young (22±2 years) adults (6.5±0.7 versus 1.6±0.2 µmol/L) and inversely related to brachial artery flow-mediated dilation (r2=0.29, P<0.00001). In young mice, 6 months of dietary … Continue reading Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Discrimination and #Hypertension Risk Among African Americans in the Jackson Heart Study

African Americans have a higher risk of hypertension compared with other racial or ethnic groups in the United States. One possible explanation for this disparity is discrimination. Few studies have examined the association between discrimination and incidence of hypertension. We examined whether everyday discrimination, lifetime discrimination, and stress from discrimination were associated with incident hypertension and whether these associations differed by gender, age, discrimination attribution, … Continue reading Discrimination and #Hypertension Risk Among African Americans in the Jackson Heart Study

Post-Discharge Prophylaxis With #Rivaroxaban Reduces Fatal and Major #Thromboembolic Events in Medically Ill Patients

Hospitalized acutely ill medical patients are at risk for fatal and major thromboembolic events. Whether use of extended-duration primary thromboprophylaxis can prevent such events is unknown.. ..Medically ill patients with a baseline creatinine clearance ≥50 ml/min were randomized in a double-blind fashion to rivaroxaban 10 mg or placebo daily at hospital discharge for 45 days. Exploratory efficacy analyses were performed with the intent-to-treat population including … Continue reading Post-Discharge Prophylaxis With #Rivaroxaban Reduces Fatal and Major #Thromboembolic Events in Medically Ill Patients

The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility

..Thyroid function and thyroid peroxidase antibody (TPOAb) data were available for 19213 and 19237 women, respectively. The prevalence of abnormal thyroid function was 4.8% (95% CI, 4.5-5.1); euthyroidism was defined as levels of thyroid-stimulating hormone (TSH) of 0.44 to 4.50 mIU/L and free thyroxine (fT4) of 10 to 21 pmol/L. Overt hypothyroidism (TSH > 4.50 mIU/L, fT4 < 10 pmol/L) was present in 0.2% of … Continue reading The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility

Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use

.. A total of 254 participants (184 men [72%]; mean [SD] age, 34 [6] years) were enrolled in the trial; 126 were randomized to receive zinc, and 128 were randomized to receive placebo. Participants had high CD4 cell counts (mean [SD], 521 [292] cells/mm3), and 188 (74%) reported heavy drinking in the past week. In the main analyses, zinc supplementation did not affect changes in … Continue reading Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use

Association of Low to Moderate #Alcohol Drinking With #Cognitive Functions From Middle to Older Age Among US Adults

..The mean (SD) age of 19 887 participants was 61.8 (10.2) years, and the majority of the HRS participants were women (11 943 [60.1%]) and of white race/ethnicity (16 950 [85.2%]). Low to moderate drinking (<8 drinks per week for women and <15 drinks per week for men) was significantly associated with a consistently high cognitive function trajectory and a lower rate of cognitive decline. Compared with never … Continue reading Association of Low to Moderate #Alcohol Drinking With #Cognitive Functions From Middle to Older Age Among US Adults

Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults

Metabolic syndrome (MetS) is a systemic inflammatory state. Low physical activity (PA) could modify this patho-physiology or act as an independent contributor to inflammation. Previous studies of both conditions have identified altered levels of inflammation- and immune-related proteins based on limited sets of candidate markers.. ..MetS was significantly associated with levels of six markers: IL18R1 [odds ratio 2.37; 95% confidence interval (CI), 1.45–3.87], CRP (2.07; … Continue reading Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults

Environmental Factors and Host Microbiomes Shape Host–Pathogen Dynamics

In many cases, interactions among host, pathogen, and environment are insufficient to describe disease dynamics in the wild. The host microbiome plays an important role in host immunity, at the interface between the host and the pathogen, and affects disease outcome. The environment, as well as environmental microbiomes, influence the host microbiome, and also influence simultaneously the host and the pathogen. The three-edged disease triangle … Continue reading Environmental Factors and Host Microbiomes Shape Host–Pathogen Dynamics

Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis

Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis. ..Sera from 302 patients with alcoholic hepatitis, 46 with alcohol‐related cirrhosis and 15 healthy controls … Continue reading Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis