Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases

Importance Sleep disturbance is common among patients with neurodegenerative diseases. Examining the subcortical neuronal correlates of sleep disturbances is important to understanding the early-stage sleep neurodegenerative phenomena. Objectives To examine the correlation between the number of important subcortical wake-promoting neurons and clinical sleep phenotypes in patients with Alzheimer disease (AD) or progressive supranuclear palsy (PSP). …

Continue reading Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases

Midlife lipid and glucose levels are associated with Alzheimer’s disease

IntroductionIt is unknown whether vascular and metabolic diseases assessed in early adulthood are associated with Alzheimer's disease (AD) later in life. MethodsAssociation of AD with lipid fractions, glucose, blood pressure, body mass index (BMI), and smoking obtained prospectively from 4932 Framingham Heart Study (FHS) participants across nine quadrennial examinations was evaluated using Cox proportional hazard …

Continue reading Midlife lipid and glucose levels are associated with Alzheimer’s disease

Longitudinal Associations of Mental Disorders With Dementia30-Year Analysis of 1.7 Million New Zealand Citizens

Mental disorders are an underappreciated category of modifiable risk factors for dementia. Developing an evidence base about the link between mental disorders and dementia risk requires studies that use large, representative samples, consider the full range of psychiatric conditions, ascertain mental disorders from early life, use long follow-ups, and distinguish between Alzheimer disease and related …

Continue reading Longitudinal Associations of Mental Disorders With Dementia30-Year Analysis of 1.7 Million New Zealand Citizens

Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques

AbstractBackground and Objectives To determine the diagnostic accuracy of a plasma Aβ42/Aβ40 assay in classifying amyloid PET status across global research studies using samples collected by multiple centers that utilize different blood collection and processing protocols. Methods Plasma samples (n = 465) were obtained from 3 large Alzheimer disease (AD) research cohorts in the United …

Continue reading Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques

Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer’s Disease

With increasing life span and prevalence of dementia, it is important to understand the mechanisms of cognitive aging. Here, we focus on a subgroup of the population we term “cognitively frail,” defined by reduced cognitive function in the absence of subjective memory complaints, or a clinical diagnosis of dementia. Cognitive frailty is distinct from cognitive …

Continue reading Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer’s Disease