While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal … Continue reading A microRNA signature that correlates with cognition and is a target against #cognitive decline
Tag: Alzheimer
Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein, raising the possibility of a lipoprotein-mediated axis for AD risk. In this study, we report that genetic modification of C57BL/6J mice engineered to … Continue reading Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Quantifying physical differences of protein aggregates implicated in Alzheimer’s disease (AD), in blood, could provide crucial information on disease stages. Here, red blood cells (RBCs) from 50 patients with neurocognitive complaints and 16 healthy individuals were profiled using an atomic force microscope (AFM). AFM measurements revealed patient age– and stage of neurocognitive disorder–dependent differences in … Continue reading Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology
One of the first signs of Alzheimer’s disease (AD) is mild cognitive impairment (MCI), in which there are small variants of brain changes among the intermediate stages. Although there has been an increase in research into the diagnosis of AD in its early levels of developments lately, brain changes, and their complexity for functional magnetic … Continue reading Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
