To test the hypothesis that higher level of cognitive activity predicts older age of dementia onset in Alzheimer's disease (AD) dementia. Methods: As part of a longitudinal cohort study, 1,903 older persons without dementia at enrollment reported their frequency of participation in cognitively stimulating activities. They had annual clinical evaluations to diagnose dementia and AD, … Continue reading #Cognitive Activity and Onset Age of Incident #Alzheimer Disease #Dementia
Tag: Alzheimer
Due to difficulty in early diagnosis of Alzheimer’s disease (AD) related to cost and differentiated capability, it is necessary to identify low-cost, accessible, and reliable tools for identifying AD risk in the preclinical stage. We hypothesized that cognitive ability, as expressed in the vocal features in daily conversation, is associated with AD progression. Thus, we … Continue reading #Dementia risks identified by vocal features via #telephone conversations: A novel machine learning prediction model
The glymphatic system plays an important role in clearing the amyloid-β (Aβ) and tau proteins that are closely linked to Alzheimer disease (AD) pathology. Glymphatic clearance, as well as Aβ accumulation, is highly dependent on sleep, but the sleep-dependent driving forces behind cerebrospinal fluid (CSF) movements essential to the glymphatic flux remain largely unclear. Recent … Continue reading Reduced coupling between cerebrospinal fluid flow and global #brain activity is linked to #Alzheimer disease–related pathology
Epidemiological data link traffic-related air pollution (TRAP) to increased risk of Alzheimer’s disease (AD). Preclinical data corroborating this association are largely from studies of male animals exposed acutely or subchronically to high levels of isolated fractions of TRAP. What remains unclear is whether chronic exposure to ambient TRAP modifies AD risk and the influence of … Continue reading The Effects of Chronic Exposure to Ambient #Traffic-Related Air #Pollution on #Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats
