Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study

Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were underweight had an increased risk of dementia (hazard ratio [HR] … Continue reading Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study

Post-traumatic stress disorder as a risk factor for #dementia: systematic review and meta-analysis

Post-traumatic stress disorder (PTSD) has been identified as a potential risk factor for developing dementia. There are currently, however, no meta-analyses quantifying this risk.. ..PTSD was associated with a significant risk for all-cause dementia: pooled hazard ratio HR = 1.61 (95% CI 1.43–1.81, I2= 85.8%, P < 0.001; n = 1 693 678; 8 studies). Pooled HR was 1.61 (95% CI 1.46–1.78; I2= 80.9%, P … Continue reading Post-traumatic stress disorder as a risk factor for #dementia: systematic review and meta-analysis

Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

..Of the 7342 total sample, 4348 participants (60.3%) were women. At baseline, 4533 individuals (64.0%) were between ages 70 and 79 years, 2393 individuals (31.0%) were between 80 and 89 years, and 416 individuals (5.0%) were between 90 and 99 years; percentages were weighted. The percentage of deaths attributable to dementia was 13.6% (95% CI, 12.2%-15.0%) between 2000 and 2009. The mortality burden of dementia … Continue reading Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

Vital statistics are the primary source of data used to understand the mortality burden of dementia in the US, despite evidence that dementia is underreported on death certificates. Alternative estimates, drawing on population-based samples, are needed ..Of the 7342 total sample, 4348 participants (60.3%) were women. At baseline, 4533 individuals (64.0%) were between ages 70 and 79 years, 2393 individuals (31.0%) were between 80 and … Continue reading Estimates of the Association of #Dementia With US #Mortality Levels Using Linked Survey and Mortality Records

The temporal association between incident late‐life #depression and incident #dementia

There is an established association between depression and subsequent dementia. The present study examined temporal associations between incident late‐life depression and subsequent dementia, also considering age and sex.. ..Incident depression was associated with a higher risk of subsequent dementia (incidence rate ratios (IRR) adjusted for age and sex: IRR = 1.58, 95% CI = 1.51‐1.64). The strongest association was found for the shortest interval of … Continue reading The temporal association between incident late‐life #depression and incident #dementia

Dual #sensory impairment in older adults and risk of #dementia from the GEM Study

Hearing and vision loss are independently associated with dementia, but the impact of dual sensory impairment (DSI) on dementia risk is not well understood.. ..DSI was significantly associated with higher risk of all‐cause dementia (hazard ratio [HR] = 1.86; 95% confidence interval [CI] = 1.25‐2.76) and Alzheimer’s disease (HR = 2.12; 95% CI = 1.34‐3.36). Individually only visual impairment was independently associated with an increased … Continue reading Dual #sensory impairment in older adults and risk of #dementia from the GEM Study

Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease

To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in … Continue reading Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease

Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.. ..Overall incidence of dementia among patients with IBD was significantly elevated (5.5% vs 1.4% among controls). Patients with IBD were … Continue reading Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

Association of Blood Pressure Lowering With Incident #Dementia or Cognitive Impairment A Systematic Review and Meta-analysis

..The mean (SD) age of trial participants was 69 (5.4) years and 40 617 (42.2%) were women. The mean systolic baseline blood pressure was 154 (14.9) mm Hg and the mean diastolic blood pressure was 83.3 (9.9) mm Hg. The mean duration of follow-up was 49.2 months. Blood pressure lowering with antihypertensive agents compared with control was significantly associated with a reduced risk of dementia … Continue reading Association of Blood Pressure Lowering With Incident #Dementia or Cognitive Impairment A Systematic Review and Meta-analysis

Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study

After diagnosis of a health condition, information about survival and potential transition from community into institutional care can be helpful for patients and care providers. We sought to describe the association between a new diagnosis of dementia and risk of admission to a long-term care home and death at 5 years.. ..age ≥ 90 yr; odds ratio [OR] 9.5, 95% confidence interval [CI] 8.8–10.2 [reference: … Continue reading Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study

Association of Dual Decline in Memory and #Gait Speed With Risk for #Dementia Among Adults Older Than 60 Years

Dual decline in both memory and gait speed may characterize a group of older individuals at high risk for future dementia.. ..Participants were 60 years or older, had an initial gait speed of more than 0.6 m/s (ie, free of overt dismobility), with repeated measures of memory and gait speed before dementia diagnosis during a mean follow-up of 6.6 to 14.5 years. Within each study, … Continue reading Association of Dual Decline in Memory and #Gait Speed With Risk for #Dementia Among Adults Older Than 60 Years

Body #height in young adult men and risk of #dementia later in adult life

… A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were … Continue reading Body #height in young adult men and risk of #dementia later in adult life