Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.. ..Overall incidence of dementia among patients with IBD was significantly elevated (5.5% vs 1.4% among controls). Patients with IBD were … Continue reading Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study

Association of Blood Pressure Lowering With Incident #Dementia or Cognitive Impairment A Systematic Review and Meta-analysis

..The mean (SD) age of trial participants was 69 (5.4) years and 40 617 (42.2%) were women. The mean systolic baseline blood pressure was 154 (14.9) mm Hg and the mean diastolic blood pressure was 83.3 (9.9) mm Hg. The mean duration of follow-up was 49.2 months. Blood pressure lowering with antihypertensive agents compared with control was significantly associated with a reduced risk of dementia … Continue reading Association of Blood Pressure Lowering With Incident #Dementia or Cognitive Impairment A Systematic Review and Meta-analysis

Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study

After diagnosis of a health condition, information about survival and potential transition from community into institutional care can be helpful for patients and care providers. We sought to describe the association between a new diagnosis of dementia and risk of admission to a long-term care home and death at 5 years.. ..age ≥ 90 yr; odds ratio [OR] 9.5, 95% confidence interval [CI] 8.8–10.2 [reference: … Continue reading Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study

Association of Dual Decline in Memory and #Gait Speed With Risk for #Dementia Among Adults Older Than 60 Years

Dual decline in both memory and gait speed may characterize a group of older individuals at high risk for future dementia.. ..Participants were 60 years or older, had an initial gait speed of more than 0.6 m/s (ie, free of overt dismobility), with repeated measures of memory and gait speed before dementia diagnosis during a mean follow-up of 6.6 to 14.5 years. Within each study, … Continue reading Association of Dual Decline in Memory and #Gait Speed With Risk for #Dementia Among Adults Older Than 60 Years

Body #height in young adult men and risk of #dementia later in adult life

… A total of 666,333 men, 70,608 brothers, and 7388 twin brothers born 1939–1959 and examined at the conscript board were followed in Danish nationwide registers (1969–2016). Cox regression models were applied to analyze the association between body height and dementia. Within-brothers and within-twin pair analyses were conducted to explore the role of shared familial factors including partly shared genetics. In total, 10,599 men were … Continue reading Body #height in young adult men and risk of #dementia later in adult life

Body #mass index, diet, physical inactivity, and the incidence of #dementia in 1 million UK women

..Fifteen years after the baseline survey, only 1% were lost to follow-up, and 89% remained alive with no detected dementia, of whom 18,695 had dementia detected later, at a mean age of 77 (SD 4) years. Dementia detection during years 15+ was associated with baseline obesity (BMI 30+ vs 20–24 kg/m2: RR 1.21, 95% confidence interval 1.16–1.26, p < 0.0001) but not clearly with low … Continue reading Body #mass index, diet, physical inactivity, and the incidence of #dementia in 1 million UK women

Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study

..We investigated the association between dementia diagnosis and recording of insomnia symptoms 5–10 years earlier in primary care. ..We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities. Results: The adjusted odds ratio for dementia in those with … Continue reading Are symptoms of #insomnia in primary care associated with subsequent onset of #dementia? A matched retrospective case-control study

#Illiteracy, #dementia risk, and cognitive trajectories among older adults with low education

..Analyses included 983 adults (≥65 years old, ≤4 years of schooling) who participated in a longitudinal community aging study. Literacy was self-reported (“Did you ever learn to read or write?”).. ..Illiterate participants were almost 3 times as likely to have dementia at baseline compared to literate participants. Among those who did not have dementia at baseline, illiterate participants were twice as likely to develop dementia. … Continue reading #Illiteracy, #dementia risk, and cognitive trajectories among older adults with low education

#Particulate matter and episodic #memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease

Evidence suggests exposure to particulate matter with aerodynamic diameter <2.5 μm (PM2.5) may increase the risk for Alzheimer’s disease and related dementias.. ..Long-term PM2.5 exposure was associated with increased Alzheimer’s disease pattern similarity scores, which accounted for 22.6% (95% CI: 1% to 68.9%) and 10.7% (95% CI: 1.0% to 30.3%) of the total adverse PM2.5 effects on Trials 1–3 and List B, respectively. The observed … Continue reading #Particulate matter and episodic #memory decline mediated by early neuroanatomic biomarkers of Alzheimer’s disease

#Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies

..We assessed the association of incident dementia and clinical Alzheimer’s disease with use of five AHM classes, within strata of baseline high (systolic blood pressure [SBP] ≥140 mm Hg or diastolic blood pressure [DBP] ≥90 mm Hg) and normal (SBP <140 mm Hg and DBP <90 mm Hg) blood pressure. ..There were 3728 incident cases of dementia and 1741 incident Alzheimer’s disease diagnoses. In the … Continue reading #Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies

Intact global #cognitive and #olfactory ability predicts lack of transition to #dementia

Odor identification deficits characterize Alzheimer’s disease and other dementias ..Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT) ..In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer’s disease (n = 101). Among participants with intact olfactory (B-SIT ≥ 11/12 correct) and cognitive (Blessed Orientation Memory Concentration Test ≤ 5/28 … Continue reading Intact global #cognitive and #olfactory ability predicts lack of transition to #dementia

Serum elaidic acid concentration and risk of #dementia. The Hisayama study

The associations between #trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) … Continue reading Serum elaidic acid concentration and risk of #dementia. The Hisayama study