INTRODUCTIONThe #heart is rarely affected by #cancer ; both primary cardiac tumors and metastases are uncommon despite the high vascularization of the myocardium. The mechanisms underlying this resistance remain unclear.RATIONALEMechanical load has been proposed as a major mechanism halting cardiomyocyte proliferation early after birth, thus limiting the regenerative potential of the adult mammalian heart. We… Continue reading Mechanical load inhibits cancer growth in mouse and human hearts
Category: Oncology
Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study
Background: Electrolyte abnormalities following #chemotherapy are common and clinically significant complications in cancer patients and are often associated with treatment delays and adverse outcomes. This study aims to develop and validate machine learning models to predict eight electrolyte abnormalities in cancer patients receiving chemotherapy.Methods: We retrospectively analyze medical records of cancer patients from two tertiary… Continue reading Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study
Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
BackgroundAromatase inhibitor-induced arthralgia (AIA) is a frequent adverse effect of endocrine therapy in breast cancer survivors, often leading to treatment modification or discontinuation. Non-pharmacological interventions have been proposed to manage AIA, but evidence remains fragmented.ObjectiveTo synthesize recent randomized controlled trials (RCTs) evaluating the efficacy of non-pharmacological interventions for AIA.MethodsA systematic search of PubMed, Scopus, and… Continue reading Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
Machine learning models classifiers enable a strong prediction of radioembolization-induced liver disease, and define a new bilirubin threshold for selection of patients
Purpose: Selective Internal Radiotherapy (SIRT) is an established treatment option for hepatocellular carcinoma (#HCC ). However, a major complication is radioembolization-induced liver disease (REILD).Methods: This retrospective study, analyzed patients treated with SIRT for HCC to identify clinical factors associated with REILD and to predict treatment response. Machine learning (#ML ) methods were applied to two… Continue reading Machine learning models classifiers enable a strong prediction of radioembolization-induced liver disease, and define a new bilirubin threshold for selection of patients
Corticosteroid Use and Risk of Adverse Events in Metastatic Hormone-Sensitive Prostate Cancer
Background: Among the approved therapies for metastatic hormone-sensitive #prostate #cancer (mHSPC), abiraterone and docetaxel are administered concomitantly with #corticosteroids . This study evaluated the association between corticosteroid use and risk of adverse events among patients with mHSPC.Methods: We conducted an observational cohort study among patients ≥ 65 years of age who were enrolled in Medicare… Continue reading Corticosteroid Use and Risk of Adverse Events in Metastatic Hormone-Sensitive Prostate Cancer
Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Background: Atezolizumab plus bevacizumab (atezo+bev) is a standard-of-care 1L treatment for unresectable hepatocellular carcinoma (uHCC). Understanding its adoption and use, clinical outcomes, and subsequent therapies are needed.Methods: This retrospective cohort study included 550 patients with u #HCC in the US who initiated 1L atezo+bev between June 2020 and April 2023. Medical records were abstracted to… Continue reading Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Effect of #statin use on prognostic outcomes in #hepatocellular carcinoma following #liver surgery: a systematic review and meta-analysis
Hepatocellular carcinoma (HCC) recurrence remains a significant clinical challenge, even among patients who undergo surgical treatment. Although statins exhibit anticancer properties through several biologically plausible mechanisms, robust clinical evidence supporting their role in preventing HCC recurrence is still limited. This meta-analysis aimed to evaluate the impact of statin use on the prognostic outcomes of patients… Continue reading Effect of #statin use on prognostic outcomes in #hepatocellular carcinoma following #liver surgery: a systematic review and meta-analysis
#Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocrine suppression2. Periodic fasting enhances the efficacy of standard endocrine therapy and delays acquired drug resistance, although the underlying mechanisms remain unclear3.… Continue reading #Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
#Cholangiocarcinoma 2026: status quo, unmet needs and priorities
Cholangiocarcinoma (CCA) is a cancer that originates within the bile ducts. Traditionally considered to be a rare neoplasm, increased awareness of CCA alongside advancements in diagnosis and the rising prevalence of certain risk factors have contributed to a global increase in incidence and mortality. CCAs are highly heterogeneous from the clinical, histomorphological and molecular perspectives… Continue reading #Cholangiocarcinoma 2026: status quo, unmet needs and priorities
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