Background: Understanding symptom prevalence and #palliative care needs is essential to advancing palliative care research in South America. This study aimed to assess these outcomes using the Palliative Outcome Scale (POS) and explore their relationship with the self-rated importance of spirituality.Methods: A cross-sectional study was conducted among adult persons with cancer receiving palliative care at… Continue reading Spirituality, symptom burden and palliative care needs assessed by the Palliative Outcome Scale in those with cancer: a cross-sectional study
Category: Oncology
Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer
Importance: Patients with #breast cancer (BC) with comorbid #obesity or type 2 #diabetes (T2D) experience poorer survival. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved to treat these comorbidities; however, their associations with BC survival and recurrence remain unclear.Objective: To evaluate the association between GLP-1 RA use and 10-year all-cause mortality and recurrence-free survival (RFS)… Continue reading Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer
Religious singing as an unusual sign of craniopharyngioma. Case report and literature review
#Craniopharyngiomas are rare and benign intracranial tumours arising in the sellar region. Typically, patients with craniopharyngioma present with headaches, visual disturbances and endocrine deficits due to compression of adjacent proximal structures. Primary psychiatric clinical presentation has been rarely reported. We present the case of a 59-year-old female with craniopharyngioma with suprasellar extension into the third… Continue reading Religious singing as an unusual sign of craniopharyngioma. Case report and literature review
Mechanical load inhibits cancer growth in mouse and human hearts
INTRODUCTIONThe #heart is rarely affected by #cancer ; both primary cardiac tumors and metastases are uncommon despite the high vascularization of the myocardium. The mechanisms underlying this resistance remain unclear.RATIONALEMechanical load has been proposed as a major mechanism halting cardiomyocyte proliferation early after birth, thus limiting the regenerative potential of the adult mammalian heart. We… Continue reading Mechanical load inhibits cancer growth in mouse and human hearts
Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study
Background: Electrolyte abnormalities following #chemotherapy are common and clinically significant complications in cancer patients and are often associated with treatment delays and adverse outcomes. This study aims to develop and validate machine learning models to predict eight electrolyte abnormalities in cancer patients receiving chemotherapy.Methods: We retrospectively analyze medical records of cancer patients from two tertiary… Continue reading Comprehensive validation of machine learning models predicting chemotherapy related electrolyte disorders in a multicenter study
Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
BackgroundAromatase inhibitor-induced arthralgia (AIA) is a frequent adverse effect of endocrine therapy in breast cancer survivors, often leading to treatment modification or discontinuation. Non-pharmacological interventions have been proposed to manage AIA, but evidence remains fragmented.ObjectiveTo synthesize recent randomized controlled trials (RCTs) evaluating the efficacy of non-pharmacological interventions for AIA.MethodsA systematic search of PubMed, Scopus, and… Continue reading Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
Machine learning models classifiers enable a strong prediction of radioembolization-induced liver disease, and define a new bilirubin threshold for selection of patients
Purpose: Selective Internal Radiotherapy (SIRT) is an established treatment option for hepatocellular carcinoma (#HCC ). However, a major complication is radioembolization-induced liver disease (REILD).Methods: This retrospective study, analyzed patients treated with SIRT for HCC to identify clinical factors associated with REILD and to predict treatment response. Machine learning (#ML ) methods were applied to two… Continue reading Machine learning models classifiers enable a strong prediction of radioembolization-induced liver disease, and define a new bilirubin threshold for selection of patients
Corticosteroid Use and Risk of Adverse Events in Metastatic Hormone-Sensitive Prostate Cancer
Background: Among the approved therapies for metastatic hormone-sensitive #prostate #cancer (mHSPC), abiraterone and docetaxel are administered concomitantly with #corticosteroids . This study evaluated the association between corticosteroid use and risk of adverse events among patients with mHSPC.Methods: We conducted an observational cohort study among patients ≥ 65 years of age who were enrolled in Medicare… Continue reading Corticosteroid Use and Risk of Adverse Events in Metastatic Hormone-Sensitive Prostate Cancer
Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Background: Atezolizumab plus bevacizumab (atezo+bev) is a standard-of-care 1L treatment for unresectable hepatocellular carcinoma (uHCC). Understanding its adoption and use, clinical outcomes, and subsequent therapies are needed.Methods: This retrospective cohort study included 550 patients with u #HCC in the US who initiated 1L atezo+bev between June 2020 and April 2023. Medical records were abstracted to… Continue reading Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
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