#Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent

Benzophenone-3 is a putative endocrine disrupting chemical and common ingredient in sunscreens. The potential of endocrine disrupting chemicals to act as agonists or antagonists in critical hormonally regulated processes, such as mammary gland development and mammary tumorigenesis, demands evaluation of its potential in promoting breast cancer. This study identifies the effects of BP-3 on mammary tumorigenesis with high-fat diet during puberty versus adulthood in Trp53-null … Continue reading #Benzophenone-3 promotion of mammary tumorigenesis is diet-dependent

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#Coffee consumption and risk of #prostate cancer: a systematic review and meta-analysis

To conduct a systematic review with meta-analysis of cohort studies to evaluate the association of coffee consumption with the risk of prostate cancer.. ..Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative … Continue reading #Coffee consumption and risk of #prostate cancer: a systematic review and meta-analysis

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#Cancer Statistics, 2021

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by … Continue reading #Cancer Statistics, 2021

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Racial Disparities in Epigenetic Aging of the Right vs Left #Colon

There are well-documented racial differences in age-of-onset and laterality of colorectal cancer. Epigenetic age acceleration is postulated to be an underlying factor. However, comparative studies of side-specific colonic tissue epigenetic aging are lacking. Here, we performed DNA methylation analysis of matched right and left biopsies of normal colon from 128 individuals. Among African Americans (n = 88), the right colon showed accelerated epigenetic aging as compared to … Continue reading Racial Disparities in Epigenetic Aging of the Right vs Left #Colon

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Predicted #Heart Age Among #Cancer Survivors

What is already known about this topic? Cancer and cardiovascular disease (CVD) share long-term risk factors. Physician-patient communication using heart age has been effective in motivating patients to improve modifiable CVD risk factors. What is added by this report? The predicted heart age and excess heart age among cancer survivors were 57.2 and 8.5 years, respectively, for men and 54.8 and 6.5 years, respectively, for … Continue reading Predicted #Heart Age Among #Cancer Survivors

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Lower abdominal and pelvic radiation and #testicular germ cell tumor risk

Testicular germ cell tumor (TGCT) incidence has increased in recent decades along with the use and dose of diagnostic radiation. Here we examine the association between reported exposure to diagnostic radiation and TGCT risk.. ..There were 315 men with TGCT and 931 men without TGCT in our study. Compared to no exposures, risk of TGCT was significantly elevated among those reporting at least three exposures … Continue reading Lower abdominal and pelvic radiation and #testicular germ cell tumor risk

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Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to #cancer: French NutriNet-Santé study

High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human-like” mice. Human anti-Neu5Gc IgG and red meat are both independently proposed to increase cancer risk, yet how diet affects these antibodies is largely unknown.. ..We found that high-Neu5Gc diet, gender, and age affect the specificity, … Continue reading Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to #cancer: French NutriNet-Santé study

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Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract

Linked color imaging (LCI) is a new image-enhanced endoscopy technique that allows users to recognize slight differences in mucosal color To compare the performance of LCI with white light imaging (WLI) in detecting neoplastic lesions in the upper gastrointestinal tract.. ..752 patients were assigned to the WLI group and 750 to the LCI group. The percentage of patients with 1 or more neoplastic lesions diagnosed … Continue reading Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract

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Effect of time of day of recreational and household #physical activity on prostate and breast #cancer risk (MCC‐Spain study)

Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population‐based case‐control study (MCC‐Spain) if the time‐of‐day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in‐person interviews. Information on time‐of‐day of activity … Continue reading Effect of time of day of recreational and household #physical activity on prostate and breast #cancer risk (MCC‐Spain study)

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Association of postoperative #influenza vaccine on overall mortality in patients undergoing curative surgery for solid #tumors

Recent findings have found that the influenza vaccine induces changes in the immune system in favor of anti‐tumor cytotoxicity. The aim in this study was to investigate if an influenza vaccine given in the postoperative period decreased overall and cancer‐specific mortality in patients undergoing curative surgery for solid cancers. We conducted a registry‐based national observational study in Denmark in the period January 1, 2010 to … Continue reading Association of postoperative #influenza vaccine on overall mortality in patients undergoing curative surgery for solid #tumors

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Association Between #Atopic Eczema and #Cancer in England and Denmark

Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases cancer risk and that immune stimulation increases cancer risk. Establishing baseline cancer risk in people with atopic eczema is important before exploring the association between new biologic drugs for atopic eczema and cancer risk.. ..In England, matched cohorts included 471 970 individuals with atopic eczema (median [IQR] age, 41.1 [24.9-60.7] … Continue reading Association Between #Atopic Eczema and #Cancer in England and Denmark

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Association of the Implant Surface Texture Used in Reconstruction With #Breast Cancer Recurrence

The potential association between breast implant–related anaplastic large cell lymphoma (BIA-ALCL) and implant texture has raised concerns about the additional unexpected adverse effects of textured implants, including potentially adverse outcomes for other cancers. In addition to the risk of developing BIA-ALCL, breast cancer survivors may worry about whether the type of implant inserted is associated with recurrence of their original cancer—an issue for which little … Continue reading Association of the Implant Surface Texture Used in Reconstruction With #Breast Cancer Recurrence

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