Highlights•n-3 and n-6 PUFAs preferentially accumulate in lipid droplets of acidic cancer cells •Excess LC-PUFAs undergo peroxidation and induce ferroptosis in acidic cancer cells •DGAT inhibitors prevent the formation of lipid droplets and promote ferroptosis •DGATi enhance the tumor growth inhibitory effects of dietary n-3 LC-PUFAs in mice SummaryTumor acidosis promotes disease progression through a … Continue reading Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
Category: Oncology
Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ObjectivesThis study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia. MethodsA double-blind placebo-controlled randomized trial. The study included 120 incurable solid tumour patients with anorexia (appetite loss … Continue reading #Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
This study aimed to evaluate the association between thyroid dysfunction and breast cancer risk. We included 239,436 females of the UK Biobank cohort. Information on thyroid dysfunction, personal and family medical history, medications, reproductive factors, lifestyle, and socioeconomic characteristics was retrieved from baseline self-reported data and hospital inpatient databases. Breast cancer diagnoses were identified through … Continue reading #Thyroid dysfunction and #breast cancer risk among women in the UK Biobank cohort
Autonomous cortisol secretion in patients with adrenal incidentalomas is associated with increased mortality, but detailed information about the risk associated with specific levels of autonomous cortisol secretion is not available. Objective:To measure the association between mortality and levels of autonomous cortisol secretion in patients with adrenal incidentalomas. Design:Retrospective cohort study. (ClinicalTrials.gov: NCT03919734) Setting:Two hospitals in … Continue reading Association Between Mortality and Levels of Autonomous #Cortisol Secretion by Adrenal #Incidentalomas
