Background: Meta analyses report beneficial effects of coffee intake on incident cardiovascular outcomes, however earlier studies are limited by smaller sample sizes. The aim was to evaluate associations between coffee intake and incident arrhythmia, CVD, and mortality, utilising the UK Biobank
Methods: The UK Biobank is a large prospective cohort with outcomes measured >10 years. Coffee intake, obtained from participant questionnaires, was divided into 0, <1, 1, 2-3, 4-5, >5 cups/day. Cox regression with hazard ratios (HR) was used to assess associations with incident arrhythmia, CVD, and mortality. CVD was defined as a composite of coronary heart disease (CHD), cardiac failure (CCF), and stroke

Results: The cohort consisted of 382535 individuals(age 57±13yrs, 52%female). Coffee intake of 2-3 cups/day showed the lowest risk for CVD (HR0.91, CI 0.88-0.94), CHD (HR0.90, CI 0.87-0.93), CCF (HR0.85, CI 0.81-0.90) and all cause mortality (HR0.86, CI 0.83-0.90). Stroke risk was lowest at <1 cup/day (HR0.85, CI 0.75-0.96). U shaped relationship exist between higher coffee intake and incident arrhythmia, with the lowest risk at 2-3 cups/day (HR0.92, CI 0.88-0.95). Cardiovascular mortality risk was lowest at 1 cup/day (HR0.83, CI 0.75-0.93) (all p<0·01)

Conclusion: Regular coffee intake, particularly at 2-3 cups/day, was associated with significant reductions in incident arrhythmia, CVD and cardiovascular/all cause mortality. Daily coffee intake should be considered part of a healthy diet

https://www.abstractsonline.com/pp8/#!/10461/presentation/8456