Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension

Previous studies on the effect of long working hours on blood pressure have shown inconsistent results. Mixed findings could be attributable to limitations related to blood pressure measurement and the lack of consideration of masked hypertension.. Ambulatory blood pressure was defined as the mean of the next readings recorded every 15 minutes during daytime working hours. Masked hypertension was defined as clinic blood pressure < … Continue reading Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension

Association of Isolated Diastolic #Hypertension as Defined by the 2017 ACC/AHA Blood Pressure Guideline With Incident Cardiovascular Outcomes

..the definition of hypertension was lowered from a blood pressure (BP) of greater than or equal to 140/90 to greater than or equal to 130/80 mm Hg. The new diastolic BP threshold of 80 mm Hg was recommended based on expert opinion and changes the definition of isolated diastolic hypertension (IDH). atherosclerotic cardiovascular disease (ASCVD) ..Compared with normotensive ARIC participants, IDH by the 2017 ACC/AHA … Continue reading Association of Isolated Diastolic #Hypertension as Defined by the 2017 ACC/AHA Blood Pressure Guideline With Incident Cardiovascular Outcomes

Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults

The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared with those with enalapril alone, but the lifetime stroke-free survival associated with the treatment is unknown.. ..Compared with enalapril alone, the enalapril plus folic acid treatment projected a mean lifetime stroke-free survival gain of 1.75 months, with an interquartile range … Continue reading Estimated #Stroke-Free Survival of #Folic Acid Therapy for Hypertensive Adults

Risk Factors for Heart #Failure in the Community: Differences by Age and Ejection #Fraction

..the comorbidities with the largest attributable risk of heart failure were arrhythmia (48.7%), hypertension (28.4%), and coronary artery disease (33.9%); together these explained 73.0% of heart failure. Similar associations were observed for patients with reduced and preserved ejection fraction, with the exception of hypertension. The risk of heart failure attributable to hypertension was 2-fold higher in patients with heart failure with preserved ejection fraction (38.7%) … Continue reading Risk Factors for Heart #Failure in the Community: Differences by Age and Ejection #Fraction

#Mindfulness-Based Blood #Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial

..Several determinants of hypertension were improved in participants not adhering to American Heart Association guidelines at baseline, including physical activity (p = 0.02), Dietary Approaches to Stop Hypertension-consistent diet (p<0.001), and alcohol consumption (p<0.001). Findings demonstrated mean 6.1 mmHg reduction in SBP (p = 0.008) at one year follow-up; effects were most pronounced in Stage 2 uncontrolled hypertensives (SBP≥140 mmHg), showing 15.1 mmHg reduction (p<0.001). … Continue reading #Mindfulness-Based Blood #Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial

Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort

Office-based Framingham Heart study–cardiovascular risk scores (FHS-CVS) were derived at ages 36, 53, and 69 years using systolic blood pressure, antihypertensive medication usage, smoking, diabetic status, and body mass index. Analysis models adjusted for age at imaging, sex, APOE genotype, socioeconomic position, and, where appropriate, total intracranial volume. ..At all points, these scores were associated with smaller whole-brain volumes (36 years: β coefficient per 1% … Continue reading Associations Between #vascular Risk Across Adulthood and #Brain Pathology in Late Life Evidence From a British Birth Cohort

#Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies

..We assessed the association of incident dementia and clinical Alzheimer’s disease with use of five AHM classes, within strata of baseline high (systolic blood pressure [SBP] ≥140 mm Hg or diastolic blood pressure [DBP] ≥90 mm Hg) and normal (SBP <140 mm Hg and DBP <90 mm Hg) blood pressure. ..There were 3728 incident cases of dementia and 1741 incident Alzheimer’s disease diagnoses. In the … Continue reading #Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies

Relationship between #obesity indices and #hypertension among middle-aged and elderly populations in Taiwan: A community-based, cross-sectional study

..The obesity indices included body mass index (BMI), body fat (BF) percentage and waist circumference (WC). Of the 396 people recruited, 200 had HTN. The age-adjusted Pearson’s coefficients of BMI, BF percentage and WC were 0.23 (p<0.001), 0.14 (p=0.01) and 0.26 (p<0.001), respectively. Multiple logistic regression of the HTN-related obesity indices showed that the ORs of BMI, BF percentage and WC were 1.15 (95% CI … Continue reading Relationship between #obesity indices and #hypertension among middle-aged and elderly populations in Taiwan: A community-based, cross-sectional study

Bilateral high-frequency hearing loss is associated with elevated blood #pressure and increased hypertension risk in occupational #noise exposed workers

..bilateral high-frequency hearing loss (BHFHL) Increasing years of occupational noise exposure and BHFHL were significantly associated with systolic and diastolic blood pressure increase (all P<0.001). The lineal trend was only significant in males, with adjusted ORs for hypertension gradually increasing with increasing years of occupational noise exposure (P<0.001). Furthermore, subjects having mild and high BHFHL had a higher hypertension risk of 34% and 281%, respectively … Continue reading Bilateral high-frequency hearing loss is associated with elevated blood #pressure and increased hypertension risk in occupational #noise exposed workers

Comprehensive comparative effectiveness and safety of first-line #antihypertensive drug classes: a systematic, multinational, large-scale analysis

..Most estimates revealed no effectiveness differences between classes; however, #thiazide or thiazide-like diuretics showed better primary effectiveness than angiotensin-converting enzyme inhibitors: acute myocardial infarction (HR 0·84, 95% CI 0·75–0·95), hospitalisation for heart failure (0·83, 0·74–0·95), and stroke (0·83, 0·74–0·95) risk while on initial treatment. Safety profiles also favoured thiazide or thiazide-like diuretics over angiotensin-converting enzyme inhibitors. The non-dihydropyridine calcium channel blockers were significantly inferior to … Continue reading Comprehensive comparative effectiveness and safety of first-line #antihypertensive drug classes: a systematic, multinational, large-scale analysis

Bedtime hypertension treatment improves #cardiovascular risk reduction: the Hygia Chronotherapy Trial

In this multicentre, controlled, prospective endpoint trial, 19 084 hypertensive patients (10 614 men/8470 women, 60.5 ± 13.7 years of age) were assigned (1:1) to ingest the entire daily dose of ≥1 hypertension medications at bedtime (n = 9552) or all of them upon awakening (n = 9532) ..Patients of the bedtime, compared with the upon-waking, treatment-time regimen showed significantly lower hazard ratio—adjusted for significant influential characteristics of age, sex, type 2 … Continue reading Bedtime hypertension treatment improves #cardiovascular risk reduction: the Hygia Chronotherapy Trial