Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial

BackgroundDietary restriction of sodium has been suggested to prevent fluid overload and adverse outcomes for patients with heart failure. We designed the Study of Dietary Intervention under 100 mmol in Heart Failure (SODIUM-HF) to test whether or not a reduction in dietary sodium reduces the incidence of future clinical events. MethodsSODIUM-HF is an international, open-label, …

Continue reading Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial

Acute heart failure and iron deficiency: a prospective, multicentre, observational study

The prevalence and the natural course of iron deficiency (ID) in acute heart failure (AHF) are still unclear. We investigated the prevalence of ID in unselected patients admitted with AHF on admission, at discharge and up to 3 months thereafter. Methods and resultsIn this prospective, multicentre, observational study, 742 patients admitted with AHF were enrolled. …

Continue reading Acute heart failure and iron deficiency: a prospective, multicentre, observational study

Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial

Circulating high-sensitivity cardiac troponin T (hsTnT) predominantly reflects myocardial injury, and higher levels are associated with a higher risk of worsening heart failure (HF) and death in patients with HF with reduced ejection fraction (HFrEF). Less is known about the prognostic significance of changes in hsTnT over time, the effects of dapagliflozin on clinical outcomes …

Continue reading Serial Assessment of High-Sensitivity Cardiac #Troponin and the Effect of #Dapagliflozin in Patients with Heart #Failure with Reduced Ejection Fraction: An Analysis of the DAPA-HF Trial

Cardiac #radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

Cardiac radiotherapy (RT) may be effective in treating heart failure (HF) patients with refractory ventricular tachycardia (VT). The previously proposed mechanism of radiation-induced fibrosis does not explain the rapidity and magnitude with which VT reduction occurs clinically. Here, we demonstrate in hearts from RT patients that radiation does not achieve transmural fibrosis within the timeframe …

Continue reading Cardiac #radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis

Blood #pressure visit-to-visit variability and outcomes in patients with #heart failure with preserved ejection fraction

Previous studies report that blood pressure (BP) variability is associated with increased risk of adverse outcomes in patients diagnosed with cardiovascular disease. However, studies have not fully explored this association in patients with heart failure with preserved ejection fraction (HFpEF). This study sought to explore the association between visit-to-visit variability (VVV) of BP and clinical …

Continue reading Blood #pressure visit-to-visit variability and outcomes in patients with #heart failure with preserved ejection fraction