#Obesity Progression between Young Adulthood and Midlife and Incident #Arthritis: A Retrospective Cohort Study of US Adults

..Among our sample of adults who were 40‐69 years old at their midlife weight measure (n=13,669), 3,603 developed an arthritis condition. Compared with adults who maintained a normal‐normal BMI, the normal‐overweight, normal‐obese, overweight‐obese, and obese‐obese groups had significantly elevated risk of incident arthritis conditions. The obese‐overweight group had lower risk of incident arthritis conditions compared with the obese‐obese group and comparable risk to the overweight‐overweight … Continue reading #Obesity Progression between Young Adulthood and Midlife and Incident #Arthritis: A Retrospective Cohort Study of US Adults

The associations of longitudinal changes in consumption of total and types of #dairy products and markers of metabolic risk and #adiposity: findings from the European Investigation into Cancer and Nutrition (EPIC)–Norfolk study, United Kingdom

..For adiposity, an increase in fermented dairy products [yogurt (total or low-fat) or low-fat cheese] consumption was associated with a lower increase in body weight and body mass index (BMI). For example, over 3.7 y, increasing yogurt consumption by 1 serving/d was associated with a smaller increase in body weight by 0.23 kg (95% CI: −0.46, −0.01 kg). An increase in full-fat milk, high-fat cheese, … Continue reading The associations of longitudinal changes in consumption of total and types of #dairy products and markers of metabolic risk and #adiposity: findings from the European Investigation into Cancer and Nutrition (EPIC)–Norfolk study, United Kingdom

Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation

Circadian (daily) regulation of metabolic pathways implies that food may be metabolized differentially over the daily cycle. To test that hypothesis, we monitored the metabolism of older subjects in a whole-room respiratory chamber over two separate 56-h sessions in a random crossover design. In one session, one of the 3 daily meals was presented as breakfast, whereas in the other session, a nutritionally equivalent meal … Continue reading Eating #breakfast and avoiding late-evening snacking sustains #lipid oxidation

A salt-induced kinase is required for the metabolic regulation of #sleep

Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep pressure, have low ATP levels despite … Continue reading A salt-induced kinase is required for the metabolic regulation of #sleep

Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study

..A small thigh circumference is associated with an increased risk of diabetes, cardiovascular diseases, and total mortality. The purpose of this study was to evaluate the association between thigh circumference and hypertension in the middle-aged and elderly population. ..Thigh circumference was negatively correlated with systolic blood pressure, diastolic blood pressure, fasting glucose, and total cholesterol. Compared with the lowest thigh circumference tertile group, the risk … Continue reading Large #thigh circumference is associated with lower blood #pressure in overweight and obese individuals: a community-based study

#Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study

Obesity (BMI ≥ 30 kg/m2) and unfavourable lifestyle were associated with higher risk for incident type 2 diabetes regardless of genetic predisposition (p > 0.05 for GRS–obesity and GRS–lifestyle interaction). The effect of obesity on type 2 diabetes risk (HR 5.81 [95% CI 5.16, 6.55]) was high, whereas the effects of high genetic risk (HR 2.00 [95% CI 1.76, 2.27]) and unfavourable lifestyle (HR 1.18 [95% CI 1.06, 1.30]) … Continue reading #Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study

Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women

..After 1 913 978 person-years of follow-up, 12 156 (36.6%) women were obese and 2014 (6.1%) had received a diagnosis of type 2 diabetes. Women born by cesarean delivery were more likely to be classified as obese and to have received a diagnosis of type 2 diabetes during follow-up. The multivariable-adjusted relative risk of obesity among women born by cesarean vs vaginal delivery was 1.11 (95% CI, 1.03-1.19). … Continue reading Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women

A Randomized, Controlled Trial of #Liraglutide for Adolescents with #Obesity

Liraglutide was superior to placebo with regard to the change from baseline in the BMI standard-deviation score at week 56 (estimated difference, −0.22; 95% confidence interval [CI], −0.37 to −0.08; P=0.002). A reduction in BMI of at least 5% was observed in 51 of 113 participants in the liraglutide group and in 20 of 105 participants in the placebo group (estimated percentage, 43.3% vs. 18.7%), … Continue reading A Randomized, Controlled Trial of #Liraglutide for Adolescents with #Obesity

#Colorectal Cancer Risk Following #Bariatric Surgery in a Nationwide Study of French Individuals With Obesity

..The mean (SD) follow-up was 6.2 (2.1) years for patients who underwent adjustable gastric banding, 5.5 (2.1) years for patients who underwent sleeve gastrectomy, and 5.7 (2.2) years for patients who underwent gastric bypass. In total, 13 052 incident colorectal cancers (1.2%) and 63 649 colorectal benign polyps were diagnosed. The rate of colorectal cancer was 0.6% in the bariatric surgery cohort and 1.3% in the cohort … Continue reading #Colorectal Cancer Risk Following #Bariatric Surgery in a Nationwide Study of French Individuals With Obesity

#Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of death, this measurement is not routinely obtained in clinical practice.. We argue that BMI alone is not sufficient to properly assess or manage the cardiometabolic risk associated with increased adiposity.. ..We recommend that decreases in waist circumference are a critically important treatment target … Continue reading #Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

#Eating Jet Lag: A Marker of the Variability in Meal Timing and Its Association with #Body Mass Index

The timing of food intake has been associated with obesity and adverse metabolic outcomes, independently of the amount or content of food intake and activity level. However, the impact of the variability in the timing of food intake between weekends and weekdays on BMI (body mass index) remains unexplored. To address that, we propose to study a marker of the variability of meal timing on … Continue reading #Eating Jet Lag: A Marker of the Variability in Meal Timing and Its Association with #Body Mass Index

Abdominal #obesity and the risk of recurrent atherosclerotic cardiovascular disease after myocardial #infarction

..Univariate and multivariable-adjusted Cox regression models were used to calculate hazard ratios and 95% confidence intervals in quintiles of waist circumference as well as three categories of body mass index including normal weight, overweight and obesity. Results The majority of patients had abdominal obesity. During a median follow-up time of 3.8 years, 1232 men (7.3%) and 469 women (7.9%) experienced a recurrent atherosclerotic cardiovascular disease … Continue reading Abdominal #obesity and the risk of recurrent atherosclerotic cardiovascular disease after myocardial #infarction