#Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of death, this measurement is not routinely obtained in clinical practice.. We argue that BMI alone is not sufficient to properly assess or manage the cardiometabolic risk associated with increased adiposity.. ..We recommend that decreases in waist circumference are a critically important treatment target … Continue reading #Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

#Eating Jet Lag: A Marker of the Variability in Meal Timing and Its Association with #Body Mass Index

The timing of food intake has been associated with obesity and adverse metabolic outcomes, independently of the amount or content of food intake and activity level. However, the impact of the variability in the timing of food intake between weekends and weekdays on BMI (body mass index) remains unexplored. To address that, we propose to study a marker of the variability of meal timing on … Continue reading #Eating Jet Lag: A Marker of the Variability in Meal Timing and Its Association with #Body Mass Index

Abdominal #obesity and the risk of recurrent atherosclerotic cardiovascular disease after myocardial #infarction

..Univariate and multivariable-adjusted Cox regression models were used to calculate hazard ratios and 95% confidence intervals in quintiles of waist circumference as well as three categories of body mass index including normal weight, overweight and obesity. Results The majority of patients had abdominal obesity. During a median follow-up time of 3.8 years, 1232 men (7.3%) and 469 women (7.9%) experienced a recurrent atherosclerotic cardiovascular disease … Continue reading Abdominal #obesity and the risk of recurrent atherosclerotic cardiovascular disease after myocardial #infarction

#Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain

Excessive sucrose consumption elicits addiction-like craving that may underpin the obesity epidemic. Opioids and dopamine mediate the rewarding effects of drugs of abuse, and of natural rewards from stimuli such as palatable food.. ..After 12 days of sucrose access, BPND of both tracers had declined significantly in striatum, nucleus accumbens, thalamus, amygdala, cingulate cortex and prefrontal cortex, consistent with down-regulation of receptor densities. After a … Continue reading #Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain

Prevalence and clinical implications of #sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study

Emerging evidence on body composition suggests that sarcopenic obesity (obesity with depleted muscle mass) might be predictive of morbidity and mortality in non-malignant disease and also of toxicity to chemotherapy.. ..Available lumbar CT images of the obese patients were analysed for total skeletal muscle cross-sectional area; these values were also used to estimate total body fat-free mass (FFM).. ..Sarcopenic obesity was associated with poorer functional … Continue reading Prevalence and clinical implications of #sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study

Whole #milk compared with reduced-fat milk and childhood #overweight: a systematic review and meta-analysis

The majority of children in North America consume cow-milk daily. Children aged >2 y are recommended to consume reduced-fat (0.1–2%) cow-milk to lower the risk of obesity.. ..In 18 studies, higher cow-milk fat consumption was associated with lower child adiposity, and 10 studies did not identify an association. Meta-analysis included 14 of the 28 studies (n = 20,897) that measured the proportion of children who … Continue reading Whole #milk compared with reduced-fat milk and childhood #overweight: a systematic review and meta-analysis

Rising rural body-mass index is the main driver of the global #obesity epidemic in adults

Body-mass index (#BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities1,2. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity.. ..We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI … Continue reading Rising rural body-mass index is the main driver of the global #obesity epidemic in adults

The Effect of #Macronutrients on #Reproductive Hormones in Overweight and Obese Men: A Pilot Study

..Hypogonadal obese men find it difficult to lose weight. We investigated whether the modification of macronutrient intake can alter testosterone levels independently of the body mass index. Fasted overweight or obese fertile men were asked to consume meals of polyunsaturated fats (PUFA), monounsaturated fats (MUFA), refined carbohydrates (CHO, orange juice, OJ), whey and egg albumin and mixed meals of PUFA and CHO, PUFA and egg … Continue reading The Effect of #Macronutrients on #Reproductive Hormones in Overweight and Obese Men: A Pilot Study

Safety and efficacy of high-dose unfractionated #heparin versus high-dose enoxaparin for venous #thromboembolism prevention in morbidly obese hospitalized patients

..A single-center retrospective observational study was conducted in morbidly obese (body mass index ≥ 40 kg/m2) hospitalized patients who received either high-fixed dose enoxaparin (40 mg every 12 hours) or unfractionated heparin (7,500 units every 8 hours) for venous thromboembolism prophylaxis. ..In the 305 patients included (n=190 unfractionated heparin, n=115 enoxaparin), the incidence of major bleeding was significantly higher in the unfractionated heparin group (OR … Continue reading Safety and efficacy of high-dose unfractionated #heparin versus high-dose enoxaparin for venous #thromboembolism prevention in morbidly obese hospitalized patients

#Obesity Is the Most Common Risk Factor for Chronic #liver Disease

Obesity has been associated with liver fibrosis, yet guidelines do not emphasize it as an independent risk factor in which to have a high index of suspicion of advanced disease.. ..We prospectively recruited patients from a primary care practice with hazardous alcohol use and/or type 2 diabetes and/or obesity. Subjects were invited for a transient #elastography reading. A threshold of ≥8.0 kPa defined an elevated … Continue reading #Obesity Is the Most Common Risk Factor for Chronic #liver Disease