Highlights: Ferroptosis (iron-dependent lipid peroxidation-driven cell death) is implicated in ischemic injury.NSTEMI patients showed significantly higher oxidative stress (↑LPO) and iron overload (↑iron, ↑ferritin) vs controls.Antioxidant defenses were reduced in NSTEMI (↓TAC, ↓TTG, ↓SOD, ↓GPx activity).This biomarker pattern supports ferroptosis activation contributing to myocardial injury in NSTEMI.Background: Ischemic heart disease is the leading cause of… Continue reading Is Ferroptosis and Oxidative Stress Involved in NSTEMI Patient’s?
Tag: AMI
Ultrashort vs Standard-Duration Dual Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing PCI: A Meta-Analysis
Background: The efficacy and safety of ultrashort (≤1-month) dual antiplatelet therapy (DAPT) followed by antiplatelet monotherapy remain uncertain in acute coronary syndrome (ACS) patients.Objectives: This study sought to compare ultrashort vs standard-duration DAPT in patients with ACS undergoing percutaneous coronary intervention (PCI).Methods: We conducted a systematic review and meta-analysis of randomized controlled trials until February… Continue reading Ultrashort vs Standard-Duration Dual Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing PCI: A Meta-Analysis
Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk
Background and objectives: Limited data on the comparative efficacy and safety of potent P2Y₁₂ inhibitors versus clopidogrel in patients with acute myocardial infarction (AMI) stratified by bleeding risk. This study evaluated the differential prognostic impact of potent P2Y₁₂ inhibitors in patients with AMI by bleeding risk.Methods: From the nationwide pooled registry of the Korea Acute… Continue reading Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk
Impact of β-blocker therapy after acute myocardial infarction in patients with preserved ejection fraction: a meta-analysis
Introduction: Despite earlier evidence, the benefit of long-term #β-blockers after myocardial infarction (MI) in patients with preserved or mildly reduced ejection fraction remains unclear in the modern reperfusion era.Methods: We conducted a PRISMA-guided systematic review and meta-analysis by searching the PubMed, Google Scholar, and Cochrane databases, pooling results using a random effects model with 95%… Continue reading Impact of β-blocker therapy after acute myocardial infarction in patients with preserved ejection fraction: a meta-analysis
Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Background: Acute myocardial infarction (#MI ) is associated with subsequent #cognitive decline. Whether the detection of prior MI using routine ECG and self-reported history can identify different trajectories of cognitive decline is uncertain. We sought to determine the association between prior MI and longitudinal cognitive assessments within a national, biracial cohort study.Methods: We included participants… Continue reading Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
Purpose: Patients with acute coronary syndrome (#ACS ) on ticagrelor-based dual antiplatelet therapy (#DAPT ) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors against DAPT-induced gastric mucosal injury remains limited.Materials and methods: This was a single-center, prospective, open-label, observational trial enrolling patients with ACS who… Continue reading Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
Electroacupuncture for slow flow/no-reflow in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a pilot randomized controlled trial
Background: Slow flow/no-reflow (SF-NR) complicates up to 44% of percutaneous #coronary interventions ( #PCI) for acute myocardial infarction (#AMI), worsening prognosis. Electroacupuncture (EA) may mitigate SF-NR, but clinical evidence is limited.Objective: This trial was designed to assess the feasibility and effectiveness of intraoperative EA in reducing SF-NR during PCI for AMI patients.Design setting and participants… Continue reading Electroacupuncture for slow flow/no-reflow in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a pilot randomized controlled trial
#Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Background and AimsRecent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equally to women and men remains unknown.MethodsUsing data from REBOOT (tREatment with Beta-blockers after myOcardial infarction withOut reduced ejection fracTion), the largest randomized trial evaluating the effect… Continue reading #Beta-blockers after myocardial #infarction: effects according to #sex in the REBOOT trial
Restrictive versus Liberal #Transfusion in Myocardial #Infarction — A Patient-Level Meta-Analysis
BackgroundClinical guidelines have concluded that there are insufficient data to provide recommendations for the hemoglobin threshold for the use of red cell transfusion in patients with acute myocardial infarction (MI) and anemia. After the recent publication of the Myocardial Infarction and Transfusion (MINT) trial, we performed an individual patient-level data meta-analysis to evaluate the effect… Continue reading Restrictive versus Liberal #Transfusion in Myocardial #Infarction — A Patient-Level Meta-Analysis
