Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease

Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI). Methods We compared the risk for recurrent CVD events among US adults with health insurance who were hospitalized for an MI between 2014 and 2017 and … Continue reading Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease

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Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix (ECM)–mimicking hydrogel using catalyst-free click chemistry covalent bonding between two elastin-like recombinamers (ELRs). The resulting customized hydrogel included functional domains for cell adhesion and protease cleavage sites, sensitive to cleavage by matrix metalloproteases overexpressed after myocardial infarction (MI). The … Continue reading Elastin-like recombinamers-based #hydrogel modulates post-ischemic remodeling in a non-transmural myocardial #infarction in sheep

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Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study

Data on the prognostic value of hypertensive response to exercise in cardiovascular disease are limited. The aim was to determine whether SBP reactions during exercise have any prognostic value in relation to the long-term risk of stroke and myocardial infarction (MI). Patients and methods: A representative cohort of men from Gothenburg, Sweden, born in 1913, who performed a maximum exercise test at age 54 years, … Continue reading Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study

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Physiologically increased total #bilirubin is associated with reduced risk of first #myocardial infarction: A meta-analysis and dose-response analysis

Bilirubin has potential predictive and prognostic value for myocardial infarction (MI), but the clinical evidence remains controversial. We performed this meta-analysis to systematically quantify the relationships between circulating bilirubin levels and the incidence of MI and post-MI adverse events. We searched the PubMed, Cochrane Library, Embase, and Web of Science databases for ad-hoc studies, published up to October 17, 2020, recording bilirubin before MI (predictive … Continue reading Physiologically increased total #bilirubin is associated with reduced risk of first #myocardial infarction: A meta-analysis and dose-response analysis

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Five‐Year Risk of Acute #Myocardial Infarction After Acute Ischemic #Stroke in Korea

The long‐term incidence of acute myocardial infarction (AMI) in patients with acute ischemic stroke (AIS) has not been well defined in large cohort studies of various race‐ethnic groups. A prospective cohort of patients with AIS who were registered in a multicenter nationwide stroke registry (CRCS‐K [Clinical Research Collaboration for Stroke in Korea] registry) was followed up for the occurrence of AMI through a linkage with … Continue reading Five‐Year Risk of Acute #Myocardial Infarction After Acute Ischemic #Stroke in Korea

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Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort

Findings of historical studies suggest that elevated LDL cholesterol is not associated with increased risk of myocardial infarction and atherosclerotic cardiovascular disease in patients older than 70 years. We aimed to test this hypothesis in a contemporary population of individuals aged 70–100 years.. ..Between Nov 25, 2003, and Feb 17, 2015, 91 131 individuals were enrolled in CGPS. During mean 7·7 (SD 3·2) years of follow-up … Continue reading Elevated #LDL cholesterol and increased risk of myocardial #infarction and #atherosclerotic cardiovascular disease in individuals aged 70–100 years: a contemporary primary prevention cohort

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Association of acute myocardial #infarction with #influenza: A nationwide observational study

Influenza may precipitate cardiovascular disease, but influenza typically peaks in winter, coinciding with other triggers of myocardial infarction (MI) such as low air temperature, high wind velocity, low atmospheric pressure, and short sunshine duration.. Weekly laboratory-confirmed influenza case reports were obtained from the Public Health Agency of Sweden from 2009 to 2016 and merged with the nationwide SWEDEHEART MI registry. Weekly incidence of MI was … Continue reading Association of acute myocardial #infarction with #influenza: A nationwide observational study

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Clinical Outcomes With #Beta-Blocker Use in Patients With Recent History of Myocardial #Infarction

It is uncertain whether beta-blockers (BBs) are beneficial in contemporary stable patients with prior myocardial infarction (MI). Therefore, we sought to examine the effectiveness of BB use in this population.. ..We included 33,811 patients with prior MI, of whom 21,440 (63.4%) were dispensed a BB. The median age was 78 years, and 56% were male. There was no difference in the 1-year hazard of death/hospitalization … Continue reading Clinical Outcomes With #Beta-Blocker Use in Patients With Recent History of Myocardial #Infarction

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Blood #Pressure at 6 Months after Acute Myocardial #Infarction and Outcomes at 2 Years: The Perils Associated With Excessively Low Blood Pressures

This study aimed to determine the association between achieved blood pressure at 6-month follow-up and cardiovascular outcomes at 2 years in patients treated with β-blockers and renin-angiotensin-aldosterone blockers after acute myocardial infarction (AMI).. ..Achieved blood pressures were categorized into 10-mm Hg increments. The primary outcome was all-cause death. The secondary outcome was a composite of all-cause death, MrI, and rHHF. Hazard ratios (HRs) were estimated … Continue reading Blood #Pressure at 6 Months after Acute Myocardial #Infarction and Outcomes at 2 Years: The Perils Associated With Excessively Low Blood Pressures

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A Comparison of Biomarker Rise in Type 1 and Type 2 Myocardial Infarction

..Type 1 myocardial infarction tended to be larger than type 2 myocardial infarction, with a significantly higher mean percentage rise for both cTnT and CK-MB as well as higher mean RULN (207 vs 86 for cTnT, P = 0.02; 9 vs 4 for CK-MB, P = 0.002). There was a trend toward a higher rise of cTnT than CK-MB in type 2 compared with type … Continue reading A Comparison of Biomarker Rise in Type 1 and Type 2 Myocardial Infarction

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Effect of Smartphone-Enabled #Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial #Infarction

..For patients randomized to regular care, 4 physical outpatient clinic visits were scheduled in the year following the initial event. In the intervention group, patients were given 4 smartphone-compatible devices (weight scale, BP monitor, rhythm monitor, and step counter). In addition, 2 in-person outpatient clinic visits were replaced by electronic visits ..In total, 200 patients (median age, 59.7 years [interquartile range, 52.9-65.6 years]; 156 men … Continue reading Effect of Smartphone-Enabled #Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial #Infarction

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