Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension

Previous studies on the effect of long working hours on blood pressure have shown inconsistent results. Mixed findings could be attributable to limitations related to blood pressure measurement and the lack of consideration of masked hypertension.. Ambulatory blood pressure was defined as the mean of the next readings recorded every 15 minutes during daytime working hours. Masked hypertension was defined as clinic blood pressure < … Continue reading Long #Working Hours and the Prevalence of Masked and Sustained #Hypertension

Associations of Processed #Meat, Unprocessed Red Meat, Poultry, or #Fish Intake With Incident #Cardiovascular Disease and All-Cause Mortality

Although the associations between processed meat intake and cardiovascular disease (CVD) and all-cause mortality have been established, the associations of unprocessed red meat, poultry, or fish consumption with CVD and all-cause mortality are still uncertain.. .. Intake of processed meat (adjusted HR, 1.03 [95% CI, 1.02-1.05]; adjusted ARD, 0.90% [95% CI, 0.43%-1.38%]) or unprocessed red meat (adjusted HR, 1.03 [95% CI, 1.01-1.05]; adjusted ARD, 0.76% … Continue reading Associations of Processed #Meat, Unprocessed Red Meat, Poultry, or #Fish Intake With Incident #Cardiovascular Disease and All-Cause Mortality

Updating insights into #rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses

individual patient level data (IPD) ..The odds ratios for myocardial infarction, heart failure, cardiovascular related death, and non-cardiovascular related death were 1.17 (0.92 to 1.51), 1.54 (1.14 to 2.09), 1.15 (0.55 to 2.41), and 1.18 (0.60 to 2.30), respectively. For analyses including trials for which IPD were not available, odds ratios for myocardial infarction and cardiovascular related death were attenuated (1.09, 0.88 to 1.35, and … Continue reading Updating insights into #rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses

Updating insights into #rosiglitazone and #cardiovascular risk through shared data: individual patient and summary level meta-analyses

..The odds ratios for myocardial infarction, heart failure, cardiovascular related death, and non-cardiovascular related death were 1.17 (0.92 to 1.51), 1.54 (1.14 to 2.09), 1.15 (0.55 to 2.41), and 1.18 (0.60 to 2.30), respectively. For analyses including trials for which IPD were not available, odds ratios for myocardial infarction and cardiovascular related death were attenuated (1.09, 0.88 to 1.35, and 1.12, 0.72 to 1.74, respectively). … Continue reading Updating insights into #rosiglitazone and #cardiovascular risk through shared data: individual patient and summary level meta-analyses

#Lifestyle Changes in Relation to Initiation of #Antihypertensive and #Lipid‐Lowering Medication: A Cohort Study

Lifestyle modification is a key component of cardiovascular disease prevention before and concurrently with pharmacologic interventions.. ..In participants who initiated medication use, body mass index increased more (difference in change 0.19; 95% CI, 0.16–0.22) and physical activity declined (−0.09 metabolic equivalent of task hour/day; 95% CI, −0.16 to −0.02) compared with noninitiators. The likelihood of becoming obese (odds ratio: 1.82; 95% CI, 1.63–2.03) and physically … Continue reading #Lifestyle Changes in Relation to Initiation of #Antihypertensive and #Lipid‐Lowering Medication: A Cohort Study

Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression

Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV). ..110 consecutive postmenopausal women (mean age 65.5) were included. Females with an earlier onset of MP (<45 … Continue reading Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression

#Pet Ownership and #Cardiovascular Health in the US general population

The 2013 American Heart Association Scientific Statement on pet ownership and cardiovascular risk suggested that dog ownership is probably associated with decreased cardiovascular risk. Several studies have been shown that pet ownership, particularly of dogs, is associated with increased physical activity levels, social support, and improved outcomes after a major cardiovascular event.. Pet owners were older, less likely to be women or widowed, and more … Continue reading #Pet Ownership and #Cardiovascular Health in the US general population

#Marijuana Use in Patients With #Cardiovascular Disease: JACC Review Topic of the Week

Marijuana use is increasing as more states are legalizing cannabis for both medicinal and recreational purposes. National survey data estimate that >2 million Americans with established cardiovascular diseases currently use or have used marijuana in its variety of forms, including inhalation and vaping. Cannabinoid receptors are distributed in multiple tissue beds and cells, including platelets, adipose tissue, and myocytes. Observational data suggest associations between marijuana … Continue reading #Marijuana Use in Patients With #Cardiovascular Disease: JACC Review Topic of the Week

High-#protein diets increase #cardiovascular risk by activating macrophage mTOR to suppress mitophagy

High-protein diets are commonly utilized for weight loss, yet they have been reported to raise cardiovascular risk. The mechanisms underlying this risk are unknown. Here, we show that dietary protein drives atherosclerosis and lesion complexity. Protein ingestion acutely elevates amino acid levels in blood and atherosclerotic plaques, stimulating macrophage mammalian target of rapamycin (mTOR) signalling. This is causal in plaque progression, because the effects of … Continue reading High-#protein diets increase #cardiovascular risk by activating macrophage mTOR to suppress mitophagy

Temporal Changes in Resting #Heart Rate, Left Ventricular Dysfunction, Heart #Failure and Cardiovascular Disease: CARDIA Study

..Higher alcohol consumption (β=0.03, p<0.001), lower physical activity (β=0.002,p=001), smoking (β=1.58, p<0.001), men (p<0.001), African-Americans (p<0.001), impaired left ventricular relaxation (e´,β=-0.13, p=0.002), and worse diastolic function (E/e´,β=0.1, p=0.01) were associated with longitudinal increases in resting heart rate. We observed 268 cardiovascular disease and 74 heart failure events over a median of 26 years. In Cox models, baseline and temporal changes in resting heart rate were … Continue reading Temporal Changes in Resting #Heart Rate, Left Ventricular Dysfunction, Heart #Failure and Cardiovascular Disease: CARDIA Study

Association of Isolated Diastolic #Hypertension as Defined by the 2017 ACC/AHA Blood Pressure Guideline With Incident Cardiovascular Outcomes

..the definition of hypertension was lowered from a blood pressure (BP) of greater than or equal to 140/90 to greater than or equal to 130/80 mm Hg. The new diastolic BP threshold of 80 mm Hg was recommended based on expert opinion and changes the definition of isolated diastolic hypertension (IDH). atherosclerotic cardiovascular disease (ASCVD) ..Compared with normotensive ARIC participants, IDH by the 2017 ACC/AHA … Continue reading Association of Isolated Diastolic #Hypertension as Defined by the 2017 ACC/AHA Blood Pressure Guideline With Incident Cardiovascular Outcomes