Association of postoperative #influenza vaccine on overall mortality in patients undergoing curative surgery for solid #tumors

Recent findings have found that the influenza vaccine induces changes in the immune system in favor of anti‐tumor cytotoxicity. The aim in this study was to investigate if an influenza vaccine given in the postoperative period decreased overall and cancer‐specific mortality in patients undergoing curative surgery for solid cancers. We conducted a registry‐based national observational study in Denmark in the period January 1, 2010 to … Continue reading Association of postoperative #influenza vaccine on overall mortality in patients undergoing curative surgery for solid #tumors

Association Between #Atopic Eczema and #Cancer in England and Denmark

Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases cancer risk and that immune stimulation increases cancer risk. Establishing baseline cancer risk in people with atopic eczema is important before exploring the association between new biologic drugs for atopic eczema and cancer risk.. ..In England, matched cohorts included 471 970 individuals with atopic eczema (median [IQR] age, 41.1 [24.9-60.7] … Continue reading Association Between #Atopic Eczema and #Cancer in England and Denmark

Association of the Implant Surface Texture Used in Reconstruction With #Breast Cancer Recurrence

The potential association between breast implant–related anaplastic large cell lymphoma (BIA-ALCL) and implant texture has raised concerns about the additional unexpected adverse effects of textured implants, including potentially adverse outcomes for other cancers. In addition to the risk of developing BIA-ALCL, breast cancer survivors may worry about whether the type of implant inserted is associated with recurrence of their original cancer—an issue for which little … Continue reading Association of the Implant Surface Texture Used in Reconstruction With #Breast Cancer Recurrence

#ASPIRIN AND THE RISK OF NON‐DIGESTIVE TRACT CANCERS: AN UPDATED META‐ANALYSIS TO 2019

Aspirin has been associated to a reduced risk of colorectal and other selected digestive tract cancers, but the evidence other neoplasms is still controversial. In order to provide an up‐to‐date quantification of the role of aspirin on lung, breast, endometrium, ovary, prostate, bladder, and kidney cancer, we conducted a systematic review and meta‐analysis of all observational studies published up to March 2019. We estimated pooled … Continue reading #ASPIRIN AND THE RISK OF NON‐DIGESTIVE TRACT CANCERS: AN UPDATED META‐ANALYSIS TO 2019

Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer

Several compounds found in coffee possess antioxidant, anti-inflammatory, and insulin-sensitizing effects, which may contribute to anticancer activity. Epidemiological studies have identified associations between increased coffee consumption and decreased recurrence and mortality of colorectal cancer. The association between coffee consumption and survival in patients with advanced or metastatic colorectal cancer is unknown.. ..Among the 1171 patients included in the analysis (694 men [59%]; median age, 59 … Continue reading Association of #Coffee Intake With Survival in Patients With Advanced or Metastatic #Colorectal Cancer

#Aspirin use and risk of #breast cancer in African American women

Use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been hypothesized to be associated with reduced risk of breast cancer; however, results of epidemiological studies have been mixed. Few studies have investigated these associations among African American women.. To assess the relation of aspirin use to risk of breast cancer in African American women, we conducted a prospective analysis within the Black Women’s Health … Continue reading #Aspirin use and risk of #breast cancer in African American women

Personal use of permanent hair #dyes and #cancer risk and mortality in US women: prospective cohort study

Ever users of permanent hair dyes had no significant increases in risk of solid cancers (n=20 805, excluding non-melanoma skin cancers; hazard ratio 0.98, 95% confidence interval 0.96 to 1.01) or hematopoietic cancers overall (n=1807; 1.00, 0.91 to 1.10) compared with non-users. Additionally, ever users did not have an increased risk of most specific cancers (cutaneous squamous cell carcinoma, bladder cancer, melanoma, estrogen receptor positive breast … Continue reading Personal use of permanent hair #dyes and #cancer risk and mortality in US women: prospective cohort study

Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults

The potential of physical activity (PA) to attenuate the effects of alcohol consumption on the risks of alcohol‐related cancer mortality is unknown. We used data from participants aged 30 years and over in 10 British population‐based surveys (Health Surveys for England 1994, 1997, 1998, 1999, 2003, 2004, 2006 and 2008 and the Scottish Health Surveys 1998 and 2003). Alcohol‐related cancer mortality included oral cavity, throat, larynx, … Continue reading Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults

Associations between consumption of dietary #fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort

..Our objectives were to assess the associations between the intake of DFs of different types [total (TDF), soluble (SF), insoluble (IF)] and from different sources (fruits, vegetables, whole grains, legumes, potatoes and tubers) and the risk of cardiovascular diseases (CVDs), cancer, type 2 diabetes (T2D), and mortality in the large-scale NutriNet-Santé prospective cohort (2009–2019).. ..T2D risk was inversely associated with TDFs [HR for quintile 5 … Continue reading Associations between consumption of dietary #fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort

#Alcohol, Alcoholic Beverages and Risk of #Esophageal Cancer by Histological Type: A Dose–Response Meta-Analysis of Observational Studies

We conducted a dose–response meta-analysis to explore the association between alcohol and particular alcoholic beverages with risk of esophageal cancer (EC) by histological type [esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)] and whether the association differs according to gender.. A total of 74 published articles involving 31,105 cases among 3,369,024 participants were included in this meta-analysis. The pooled RRs of the highest versus … Continue reading #Alcohol, Alcoholic Beverages and Risk of #Esophageal Cancer by Histological Type: A Dose–Response Meta-Analysis of Observational Studies

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

High rates of glycolysis in cancer cells are a well-established characteristic of many human tumors, providing rapidly proliferating cancer cells with metabolites that can be used as precursors for anabolic pathways. Maintenance of high glycolytic rates depends on the lactate dehydrogenase–catalyzed regeneration of NAD+ from GAPDH-generated NADH because an increased NADH:NAD+ ratio inhibits GAPDH. Here, using human breast cancer cell models, we identified a pathway … Continue reading p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

Fine Particulate Matter Air #Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients

Air pollution is a carcinogen and causes pulmonary and cardiac complications. We examined the association of fine particulate matter pollution (PM2.5) and mortality from cancer and all causes among pediatric, adolescent, and young adult (AYA) patients with cancer in Utah, a state with considerable variation in PM2.5.. ..Increases in PM2.5 per 5 μg/m3 were associated with cancer mortality in pediatric lymphomas and central nervous system … Continue reading Fine Particulate Matter Air #Pollution and Mortality among Pediatric, Adolescent, and Young Adult Cancer Patients