Background: Colorectal cancer (CRC) incidence is increasing among younger individuals in many countries. We examined CRC incidence and mortality by age group, site, and histology in Canada.Methods: Data from the Canadian Cancer Registry and the Canadian Vital Statistics Death Database were used to determine CRC incidence from 1992 to 2019 and mortality from 1974 to… Continue reading Colorectal cancer incidence and mortality by age group, colon location, and histology in Canada
Tag: cancer
Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report
Background: Hypoglycemia may result from multiple clinical conditions which are categorized based on clinical status. The first principal step in clinical diagnostic evaluation is measurement of plasma insulin, c-peptide, pro-insulin, and beta-hydroxybutyrate levels. One of the rare causes of hypoglycemia is a group of disorders known as non-islet cell tumor hypoglycemia (NICT), which results from… Continue reading Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report
Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Background: Ivermectin suppresses tumor growth in various cancers. However, the mechanism of action in cancer remains unclear. This study aimed to investigate the anticancer activity of ivermectin against gastric cancer cell lines and patient-derived organoids.Methods: Cell viability was measured in SNU719 and SNU620 gastric cancer cell lines. Protein expression levels of apoptosis-related markers were analyzed… Continue reading Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Full- vs Reduced-Dose Direct Oral Anticoagulants for Extended Treatment of Cancer-Associated Thrombosis: A Multicenter Retrospective Cohort Study
Extended anticoagulation is recommended in subjects with cancer-associated thrombosis (CAT). The API-CAT trial showed that reduced-dose apixaban is noninferior to full-dose for preventing recurrent venous thromboembolism (VTE), but the generalizability of these findings to real-world populations remains to be determined. We conducted a multicenter retrospective cohort study including patients with CAT receiving extended direct oral… Continue reading Full- vs Reduced-Dose Direct Oral Anticoagulants for Extended Treatment of Cancer-Associated Thrombosis: A Multicenter Retrospective Cohort Study
Spirituality, symptom burden and palliative care needs assessed by the Palliative Outcome Scale in those with cancer: a cross-sectional study
Background: Understanding symptom prevalence and #palliative care needs is essential to advancing palliative care research in South America. This study aimed to assess these outcomes using the Palliative Outcome Scale (POS) and explore their relationship with the self-rated importance of spirituality.Methods: A cross-sectional study was conducted among adult persons with cancer receiving palliative care at… Continue reading Spirituality, symptom burden and palliative care needs assessed by the Palliative Outcome Scale in those with cancer: a cross-sectional study
Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer
Importance: Patients with #breast cancer (BC) with comorbid #obesity or type 2 #diabetes (T2D) experience poorer survival. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are approved to treat these comorbidities; however, their associations with BC survival and recurrence remain unclear.Objective: To evaluate the association between GLP-1 RA use and 10-year all-cause mortality and recurrence-free survival (RFS)… Continue reading Survival and Recurrence With GLP-1 Receptor Agonists in Breast Cancer
Mechanical load inhibits cancer growth in mouse and human hearts
INTRODUCTIONThe #heart is rarely affected by #cancer ; both primary cardiac tumors and metastases are uncommon despite the high vascularization of the myocardium. The mechanisms underlying this resistance remain unclear.RATIONALEMechanical load has been proposed as a major mechanism halting cardiomyocyte proliferation early after birth, thus limiting the regenerative potential of the adult mammalian heart. We… Continue reading Mechanical load inhibits cancer growth in mouse and human hearts
Corticosteroid Use and Risk of Adverse Events in Metastatic Hormone-Sensitive Prostate Cancer
Background: Among the approved therapies for metastatic hormone-sensitive #prostate #cancer (mHSPC), abiraterone and docetaxel are administered concomitantly with #corticosteroids . This study evaluated the association between corticosteroid use and risk of adverse events among patients with mHSPC.Methods: We conducted an observational cohort study among patients ≥ 65 years of age who were enrolled in Medicare… Continue reading Corticosteroid Use and Risk of Adverse Events in Metastatic Hormone-Sensitive Prostate Cancer
#Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
The majority of breast cancers are driven by oestrogen receptor-α (ERα) activation, and endocrine therapy represents the mainstay treatment for these patients1. However, resistance is common and tumours often progress after years of endocrine suppression2. Periodic fasting enhances the efficacy of standard endocrine therapy and delays acquired drug resistance, although the underlying mechanisms remain unclear3.… Continue reading #Fasting boosts #breast cancer therapy efficacy via glucocorticoid activation
2 Medical News 