Efficacy of low-dose oral minoxidil in the management of anticancer therapy-induced alopecia in patients with breast cancer: A retrospective cohort study

To the Editor: Alopecia is feared by most patients undergoing systemic anticancer therapy for breast cancer because of its negative impact on quality of life.1 Currently, evidence regarding management of persistent chemotherapy-induced alopecia ( pCIA) and endocrine therapy-induced alopecia (EIA) in patients with breast cancer is lacking.2-4 Although previous studies demonstrated successful use of lowdose …

Continue reading Efficacy of low-dose oral minoxidil in the management of anticancer therapy-induced alopecia in patients with breast cancer: A retrospective cohort study

Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids

SignificanceUnsaturated fatty acids are critical for maintaining membrane fluidity, cellular signaling, and lipid storage. Stearoyl-CoA desaturase (SCD) regulates the dynamics between saturated and unsaturated fatty acids. How SCD is involved in cancer cell fate decisions remains incompletely understood. Here, we leveraged transcriptomics, lipidomics, and single-cell stimulated Raman scattering microscopy to show that increased levels of …

Continue reading Ovarian cancer cell fate regulation by the dynamics between saturated and unsaturated fatty acids

Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma

Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using murine models of hepatocyte and biliary-specific lineage tracing, we show that Kras and Arid1a mutations drive the formation of CC and tumor precursors from the biliary compartment, …

Continue reading Arid1a mutation suppresses TGF-β signaling and induces cholangiocarcinoma

Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma

National guidelines on transplant selection have adopted successful downstaging to within Milan criteria (MC) as a viable option for the treatment of hepatocellular carcinoma (HCC) before liver transplant (LT). Recurrence of HCC after LT carries a poor prognosis, and treatment modalities remain challenging.Objective To establish the 10-year outcomes of patients with HCC after LT in …

Continue reading Ten-Year Outcomes of Liver Transplant and Downstaging for Hepatocellular Carcinoma

Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy

Background and AimsThe stroma in pancreatic ductal adenocarcinoma (PDAC) contributes to its immunosuppressive nature and therapeutic resistance. Herein we sought to modify signaling and enhance immunotherapy efficacy by targeting multiple stromal components through both intracellular and extracellular mechanisms.MethodsA murine liver metastasis syngeneic model of PDAC was treated with focal adhesion kinase inhibitor (FAKi), anti-PD-1 antibody …

Continue reading Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy