Fasting plasma #glucose level in the range of 90 to 99 mg/dL and the risk of the onset of type 2 #diabetes: Population-based Panasonic cohort study 2

As the association between fasting glucose concentration from 90 to 99 mg/dL and the onset of type 2 diabetes is still controversial, we aimed to assess it in 37,148 Japanese individuals with normal plasma glucose concentration.

Materials and Methods
This long-term retrospective cohort study included individuals with medical checkup at Panasonic Corporation from 2008 to 2018. In total, 1,028 participants developed type 2 diabetes.

Results
Cox regression analyses revealed that the risk for the onset of diabetes increased by 9.0% per 1 mg/dL increase in fasting plasma glucose concentration in subjects with concentration ranging from 90 to 99 mg/dL. Compared with individuals with fasting glucose concentration ≤89 mg/dL, the adjusted hazard ratios for developing diabetes were 1.53 (95% CI; 1.22–1.91), 1.76 (95% CI; 1.41–2.18), 1.89 (95% CI; 1.52–2.35), 3.17 (95% CI; 2.61–3.84), and 3.41 (95% CI; 2.79–4.15) at fasting plasma glucose concentration of 90–91, 92–93, 94–95, 96–97, and 98–99 mg/dL, respectively. In populations with obesity, the adjusted hazards ratios for developing diabetes were 1.56 (95% CI; 1.15–2.09), 1.82 (95% CI; 1.37–2.40), 2.05 (95% CI; 1.55–2.69), 3.53 (95% CI; 2.79–4.46), and 3.28 (95% CI; 2.53–4.22) at fasting plasma glucose concentration of 90–91, 92–93, 94–95, 96–97, and 98–99 mg/dL, respectively.

Conclusions
This study demonstrates that the risk of type 2 diabetes among the subjects having fasting plasma glucose concentration of 90-99 mg/dL, is progressively higher with the increasing level of fasting plasma glucose concentration in a Japanese people.

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