Artificial sweeteners induce glucose intolerance by altering the gut microbiota

AbstractNon-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development …

Continue reading Artificial sweeteners induce glucose intolerance by altering the gut microbiota

Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles

Replacing nutritive sweetener with non-nutritive sweeteners (NNS) has the potential to improve glycaemic control. The objective of this study was to investigate the effects of consuming artificial NNS (that is, aspartame), natural NNS (that is, monk fruit and stevia), and sucrose-sweetened beverages on 24-h glucose profiles. Ten healthy males took part in this randomised, crossover …

Continue reading Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles

Midlife lipid and glucose levels are associated with Alzheimer’s disease

IntroductionIt is unknown whether vascular and metabolic diseases assessed in early adulthood are associated with Alzheimer's disease (AD) later in life. MethodsAssociation of AD with lipid fractions, glucose, blood pressure, body mass index (BMI), and smoking obtained prospectively from 4932 Framingham Heart Study (FHS) participants across nine quadrennial examinations was evaluated using Cox proportional hazard …

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Fasting plasma #glucose level in the range of 90 to 99 mg/dL and the risk of the onset of type 2 #diabetes: Population-based Panasonic cohort study 2

As the association between fasting glucose concentration from 90 to 99 mg/dL and the onset of type 2 diabetes is still controversial, we aimed to assess it in 37,148 Japanese individuals with normal plasma glucose concentration. Materials and MethodsThis long-term retrospective cohort study included individuals with medical checkup at Panasonic Corporation from 2008 to 2018. …

Continue reading Fasting plasma #glucose level in the range of 90 to 99 mg/dL and the risk of the onset of type 2 #diabetes: Population-based Panasonic cohort study 2

Acute and long-term disruption of #glycometabolic control after #SARS-CoV-2 infection

Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute respiratory syndrome coronavirus 2 infection may precipitate the onset of metabolic alterations by affecting glucose homeostasis. Here we describe abnormalities in glycometabolic control, insulin resistance and beta cell function in patients with …

Continue reading Acute and long-term disruption of #glycometabolic control after #SARS-CoV-2 infection