#Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis

The aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA. Methods People living with RA undertook identical assessments at baseline (T1, n = 104) and 6-month follow-up (T2, n = 54). Participants completed physical measures (e.g. height, weight, BMI) and routine clinical assessments to characterize RA disease activity (DAS-28). Participants also completed questionnaires to … Continue reading #Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis

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#Smile (or grimace) through the #pain? The effects of experimentally manipulated facial expressions on needle-injection responses.

Smiling has been previously shown to improve stress responses. We replicated and expanded this work by testing whether smiling helps with a potent real-world stressor: a vaccination-like needle injection. We also extended past research by examining grimacing, a facial expression known to naturally occur during stress and pain and one that shares some of the same facial action units as smiling. Participants (n = 231; … Continue reading #Smile (or grimace) through the #pain? The effects of experimentally manipulated facial expressions on needle-injection responses.

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Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

Acetaminophen (paracetamol) and ibuprofen are the most widely prescribed and available over-the-counter medications for management of fever and pain in children. Despite the common use of these medications, treatment recommendations for young children remain divergent.. ..Overall, 19 studies (11 randomized; 8 nonrandomized) of 241 138 participants from 7 countries and various health care settings (hospital-based and community-based) were included. Compared with acetaminophen, ibuprofen resulted in reduced … Continue reading Comparison of #Acetaminophen (Paracetamol) With #Ibuprofen for Treatment of Fever or Pain in Children Younger Than 2 Years

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Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia

..To investigate the effectiveness of therapies for reducing pain and improving quality of life (QOL) in people with fibromyalgia.. ..A total of 224 trials including 29 962 participants were included. High-quality evidence was found in favor of cognitive behavioral therapy (weighted mean difference [WMD], −0.9; 95% CI, −1.4 to −0.3) for pain in the short term and was found in favor of central nervous system depressants … Continue reading Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia

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A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

Acupuncture techniques have been in existence for centuries, with roots tied to Eastern Asian medicine. Ease of application, low cost, and minimal side effects make traditional acupuncture a perioperative modality that has been linked to decreased morbidity and mortality in patients undergoing surgical procedures and anesthesia (1). In the United States, in light of the opioid epidemic, there is a strong need to decrease perioperative … Continue reading A3091 – Traditional #Acupuncture And Battlefield Acupuncture Use In Mutimodal Perioperative #Anesthesia Care For Our Veteran Patients

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#SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

Global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues unabated. Binding of SARS-CoV-2’s Spike protein to host angiotensin converting enzyme 2 triggers viral entry, but other proteins may participate, including neuropilin-1 receptor (NRP-1). As both Spike protein and vascular endothelial growth factor-A (VEGF-A) – a pro-nociceptive and angiogenic factor, bind NRP-1, we tested if Spike could block VEGF-A/NRP-1 signaling. VEGF-A–triggered sensory neuronal firing … Continue reading #SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce #analgesia

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The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer … Continue reading The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

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Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis

Musculoskeletal pain is a common cause of pain in adolescence and can be an important predictor of future pain. The prevalence of hip or groin pain that could potentially affect different adolescent populations has not yet been systematically reviewed. This systematic review aimed to determine the prevalence of hip or groin pain in this population. Five electronic databases were searched until January 2019 for eligible … Continue reading Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis

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Let it be: #mindful acceptance down-regulates pain and negative emotion

Mindfulness training ameliorates clinical and self-report measures of depression and chronic pain, but its use as an emotion regulation strategy—in individuals who do not meditate—remains understudied. As such, whether it (i) down-regulates early affective brain processes or (ii) depends on cognitive control systems remains unclear. We exposed meditation-naïve participants to two kinds of stimuli: negative vs. neutral images and painful vs. warm temperatures. On alternating … Continue reading Let it be: #mindful acceptance down-regulates pain and negative emotion

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