A Randomized, Controlled Trial of #Liraglutide for Adolescents with #Obesity

Liraglutide was superior to placebo with regard to the change from baseline in the BMI standard-deviation score at week 56 (estimated difference, −0.22; 95% confidence interval [CI], −0.37 to −0.08; P=0.002). A reduction in BMI of at least 5% was observed in 51 of 113 participants in the liraglutide group and in 20 of 105 participants in the placebo group (estimated percentage, 43.3% vs. 18.7%), … Continue reading A Randomized, Controlled Trial of #Liraglutide for Adolescents with #Obesity

Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study

..362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the ORs associated with lying down ≥9 hours/day were 1.41 (95% CI … Continue reading Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study

Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity

..Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive ..We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but also environmental bacteria, showed tissue- and T2D-specific compartmentalisation. T2D signatures … Continue reading Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity

FDA Approves New Treatment for Adults with #Cushing’s Disease

The U.S. Food and Drug Administration today approved Isturisa (#osilodrostat) oral tablets for adults with Cushing’s disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease. Cushing’s disease is a rare disease in which the adrenal glands make too much of the cortisol hormone. Isturisa is the first FDA-approved drug to directly address this cortisol overproduction by … Continue reading FDA Approves New Treatment for Adults with #Cushing’s Disease

Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

There is a general consensus that overconsumption of sugar-sweetened beverages contributes to the prevalence of obesity and related comorbidities such as type 2 diabetes (T2D). Whether a similar relationship exists for no- or low-calorie “diet” drinks is a subject of intensive debate and controversy. Here, we demonstrate that consuming seven sucralose-sweetened beverages with, but not without, a carbohydrate over 10 days decreases insulin sensitivity in … Continue reading Short-Term Consumption of #Sucralose with, but Not without, #Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins

To assess whether initiation of insulin glargine (glargine), compared with initiation of neutral protamine Hagedorn (NPH) or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes.. Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06) or detemir (HR, 0.98; 95% CI 0.92–1.05). No increased risk … Continue reading Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins

Age at #period cessation and trajectories of #cardiovascular risk factors across mid and later life

To examine the association between age at period cessation and trajectories of anthropometry, blood pressure, lipids and glycated haemoglobin (HbA1c) from midlife to age 69 years.. ..We found no evidence that age at period cessation was associated with trajectories of log triglyceride, LDL-C and HDL-C from 53 to 69 years and trajectories of SBP or DBP from 36 to 69 years, regardless of whether period … Continue reading Age at #period cessation and trajectories of #cardiovascular risk factors across mid and later life

Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study

STUDY OBJECTIVES:Intensive care unit (ICU) nurses commonly work multiple consecutive 12-hr shifts that leave little time for sleep between work shifts. Working multiple consecutive shifts could compromise vigilance and patient care, especially with respect to managing high risk medications such as insulin infusions.. We identified patients who had hypoglycemia (glucose <=3.5mmol/l, 63 mg/dl) between December 2008 and December 2009 in 3 ICUs in Vancouver, British … Continue reading Consecutive Nursing #Shifts and the Risk of #Hypoglycemia in Critically Ill Patients Who Are Receiving Intravenous Insulin: A Multicentre Study

Body #mass index, #diabetes, and the risk of #Parkinson’s disease

..A total of 33,443 individuals were diagnosed with PD during the follow‐up period (7.3 years). An increased risk of PD incidence was observed in the underweight group versus the normal group (adjusted hazard ratio: 1.28; 95% confidence interval: 1.21–1.36), whereas a decreased risk of PD incidence was observed (adjusted hazard ratio: 0.88; 95% confidence interval: 0.88–0.93) in the obese group and (adjusted hazard ratio: 0.77; 95% … Continue reading Body #mass index, #diabetes, and the risk of #Parkinson’s disease

#Shift Workers at Risk for #Metabolic Syndrome

In this highly digitalized era, sleep disorders are becoming more common and are associated with an increased burden of chronic disease. Shift workers are at an increased risk for both sleep disorders and metabolic syndrome. In this article, the authors outline the connection between circadian discordance, hormonal imbalance, and the development of metabolic syndrome in shift workers. Based on a literature review of animal model … Continue reading #Shift Workers at Risk for #Metabolic Syndrome

#Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

Despite decades of unequivocal evidence that waist circumference provides both independent and additive information to BMI for predicting morbidity and risk of death, this measurement is not routinely obtained in clinical practice.. We argue that BMI alone is not sufficient to properly assess or manage the cardiometabolic risk associated with increased adiposity.. ..We recommend that decreases in waist circumference are a critically important treatment target … Continue reading #Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral #Obesity

Direct Oral #Anticoagulants in Atrial Fibrillation Patients with Concomitant #Hyperthyroidism

Patients with hyperthyroidism were excluded from randomized clinical trials of direct oral anticoagulants(DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).. After PSSW, DOAC had a comparable risk of ischemic stroke/systemic embolism (IS/SE) and a lower risk of major bleeding (hazard ratio (HR):0.65; [95% confidential interval (CI):0.44-0.96]; P=0.0295) than warfarin among patients with hyperthyroidism. There were comparable risks of IS/SE and major bleeding … Continue reading Direct Oral #Anticoagulants in Atrial Fibrillation Patients with Concomitant #Hyperthyroidism