Purpose: To investigate whether glucagon-like peptide-1 receptor agonists are protective against retinal vascular occlusions. Methods: Using a large aggregated, de-identified electronic health records data platform in the United States, patients with type 2 diabetes ages ≥18 years prescribed glucagon-like peptide-1 receptor agonists or non-glucagon-like peptide-1 receptor agonists (controls) and having ophthalmology follow-up of at least… Continue reading The Impact of Glucagon-Like Peptide-1 Receptor Agonists on Risk of Retinal Vascular Occlusions
Category: Endocrinology
Psychosocial Factors Associated with Diabetes Distress Among Adults with Type 2 Diabetes Mellitus: The Roles of Perceived Social Support and Diabetes Management Self-Efficacy in an Indonesian Outpatient Sample
AbstractPurpose: Diabetes distress represents a diabetes-specific emotional burden associated with the challenges of long-term diabetes management. Psychosocial factors, including perceived social support and diabetes management self-efficacy, may influence how individuals experience and adapt to type 2 diabetes mellitus (T2DM). However, the relationships among these factors remain insufficiently characterized when diabetes distress is considered the primary… Continue reading Psychosocial Factors Associated with Diabetes Distress Among Adults with Type 2 Diabetes Mellitus: The Roles of Perceived Social Support and Diabetes Management Self-Efficacy in an Indonesian Outpatient Sample
Impact of preoperative osteoporosis on short- and long-term complications following ankle ORIF: A multi-institutional propensity-matched analysis
Background: Osteoporosis may impair fracture healing and fixation durability after ankle ORIF. This study evaluated postoperative complications of preoperative osteoporosis.Methods: Patients undergoing ankle ORIF from 2004 to 2022 with ≥ 2 years of follow-up were identified from a multi-institutional database. Those with and without preoperative osteoporosis, defined with ICD-10 code M80 & M81, were compared… Continue reading Impact of preoperative osteoporosis on short- and long-term complications following ankle ORIF: A multi-institutional propensity-matched analysis
Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
Lipoprotein(a) [Lp(a)] is a genetically determined, apolipoprotein B-containing lipoprotein that contributes to cardiovascular risk through atherogenic, proinflammatory, and potentially antifibrinolytic mechanisms. Genetic, epidemiological, and mechanistic evidence supports a causal role for elevated Lp(a) in atherosclerotic cardiovascular disease and calcific aortic valve disease. In contrast, associations with other cardiovascular phenotypes are less consistent. Since circulating concentrations… Continue reading Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
Preventing Weight Regain After Glucagon-Like Peptide‑1 Therapy Discontinuation: A Pilot Randomized Controlled Trial
Objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective treatments for obesity, but discontinuation is common due to cost, insurance coverage limitations, side effects, patient preference, and other factors. Weight regain often occurs rapidly after cessation, yet few evidence-based strategies exist to support weight maintenance during this transition. This pilot randomized trial examined whether a… Continue reading Preventing Weight Regain After Glucagon-Like Peptide‑1 Therapy Discontinuation: A Pilot Randomized Controlled Trial
Life-Threatening Hypertriglyceridemia in Diabetic Ketoacidosis Successfully Managed With Therapeutic Plasma Exchange: A Case Report and Review of Literature
Extremely severe hypertriglyceridemia associated with diabetic ketoacidosis (DKA), shock, cerebral edema, acute kidney injury (AKI), and pneumonia represents a rare but life-threatening clinical emergency, particularly when occurring as the initial presentation of previously undiagnosed diabetes mellitus (DM). In such critically ill patients, prompt management is challenging because clear evidence-based guidelines regarding the role and timing… Continue reading Life-Threatening Hypertriglyceridemia in Diabetic Ketoacidosis Successfully Managed With Therapeutic Plasma Exchange: A Case Report and Review of Literature
Effect of insulin sensitivity and secretion defects at mid-pregnancy on early postpartum glucose intolerance in women with gestational diabetes mellitus
Objective: This study aimed to evaluate how insulin sensitivity and secretion defects during mid-pregnancy influence the development of early postpartum glucose intolerance in women diagnosed with gestational diabetes mellitus (GDM).Methods: A total of 1,256 pregnant women diagnosed with GDM between October 2005 and March 2023 were enrolled. Participants were categorized into four groups: GDM-normal, GDM-secretion… Continue reading Effect of insulin sensitivity and secretion defects at mid-pregnancy on early postpartum glucose intolerance in women with gestational diabetes mellitus
Premature ovarian insufficiency in patients with thyroid-related poly-autoimmunity
Background: An anticipated menopause is a disquieting health problem; its association with autoimmune disorders has been reported. However, data about the presence of premature ovarian insufficiency (POI) and early menopause (EM) framed in thyroid-related poly-autoimmunity are rather scanty. In this view, we described the presence of a precocious menopause in a large cohort of women… Continue reading Premature ovarian insufficiency in patients with thyroid-related poly-autoimmunity
The Incretin Revolution: Integrating Incretin-Based Therapies into Clinical Care
Incretin-based therapies have changed the landscape of modern medical practice. Obesity-related disease processes including type 2 diabetes mellitus, cardiovascular disease, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, and obstructive sleep apnea improve in patients treated with these medications, and several now carry organ-specific regulatory indications. In this narrative review we summarize the mechanisms through… Continue reading The Incretin Revolution: Integrating Incretin-Based Therapies into Clinical Care
