Aims: We evaluated the impact of scenario-based multifactorial control on the 3-year incidence of fatal/non-fatal cardiovascular disease (#CVD ) and associated healthcare costs in Asian patients with type 2 diabetes (#T2D ).Materials and methods: We applied the validated 'ABC' model to simulate the 3-year impact of attaining multiple treatment targets (HbA1c < 7%, blood pressure… Continue reading Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Category: Endocrinology
Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Aims: Although pregabalin is a first-line therapy for painful #diabetic #polyneuropathy (PDPN), its optimal dose-response relationship remains unclear. We conducted a network meta-analysis to evaluate the efficacy and safety of fixed pregabalin dosages in PDPN patients.Materials and methods: We systematically searched major databases through October 2025 comparing various doses of pregabalin (75, 150, 300, and… Continue reading Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Evening snacks without increased nighttime caloric intake decrease fasting glucose in pregnant women with pregestational diabetes mellitus
ObjectiveTo investigate the association between chrononutrition and glycemic control parameters throughout the pregnancy in women with diabetes mellitus (DM).MethodsCross-sectional study with 117 pregnant women with pregestational DM. Food consumption was assessed using 24-h dietary recalls in the second and third trimesters of pregnancy. Chrononutrition parameters included number of eating episodes, eating pattern, mealtimes, and caloric… Continue reading Evening snacks without increased nighttime caloric intake decrease fasting glucose in pregnant women with pregestational diabetes mellitus
Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide
Aims: To describe #obesity treatments in real-world settings after discontinuation of #semaglutide or #tirzepatide and variability in weight change post-discontinuation.Materials and methods: This retrospective cohort study used electronic health records from 1 January 2021, to 30 June 2025, in a large health system in Ohio and Florida. Adults with overweight or obesity who initiated injectable… Continue reading Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide
Team-Based Pilot Program Incorporates Food Vouchers to Improve Health in Patients with Diabetes
An evaluation of a team-based pilot program with food vouchers.DesignSingle-arm prepost mixed-method study.SettingTwo safety-net primary care clinics in San Francisco.ParticipantsBlack/African American and/or Hispanic/Latinx patients with uncontrolled #diabetes (hemoglobin A1c >8%).Intervention(s)Six-month program including pharmacist and #nutritionist visits, transportation assistance, and smoking cessation resources, plus $160 per month of grocery and produce vouchers.Main Outcome Measure(s)#Glycemic control and… Continue reading Team-Based Pilot Program Incorporates Food Vouchers to Improve Health in Patients with Diabetes
Efficacy and Safety of Acupoint Catgut Embedding for Obesity Associated with Polycystic Ovary Syndrome: A Qualitative and Quantitative Analysis
AbstractAim: #Obesity is common in women with polycystic ovary syndrome (PCOS) and can exacerbate #PCOS symptoms. Although Acupoint catgut embedding (ACE) is frequently used to treat the clinical symptoms of simple obesity, it is unclear how it will affect obesity associated with PCOS. We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs)… Continue reading Efficacy and Safety of Acupoint Catgut Embedding for Obesity Associated with Polycystic Ovary Syndrome: A Qualitative and Quantitative Analysis
A Qualitative Study Exploring Diabetes Prevention Intervention Needs and Ideas Among Young Adults at High Risk for Diabetes
ObjectiveTo explore perspectives of #young adults with #prediabetes and high burden of social needs about their intervention needs and ideas for solutions to enable behavior change.DesignQualitative study with semistructured interviews.SettingOne safety-net hospital and 1 academic medical center in a US city.ParticipantsTwenty-four publicly-insured adults aged 18–26 years with prediabetes (63% female, 71% Latino/a/x, 29% Black, 61%… Continue reading A Qualitative Study Exploring Diabetes Prevention Intervention Needs and Ideas Among Young Adults at High Risk for Diabetes
Efficacy and safety of GLP-1 receptor agonists and SGLT2 inhibitors as adjuncts to insulin in type 1 diabetes: Systematic review and meta-analysis
AimsAdjunctive therapies to insulin for type 1 #diabetes mellitus (T1DM), including glucagon-like peptide-1 receptor agonists ( #GLP-1RAs ) and sodium–glucose cotransporter-2 inhibitors ( #SGLT2is ), may improve glycaemic control and reduce insulin requirements; however, safety concerns remain, particularly for diabetic ketoacidosis (DKA).Materials and MethodsPubMed, Ovid MEDLINE, Embase, Web of Science, Scopus and the Cochrane Library… Continue reading Efficacy and safety of GLP-1 receptor agonists and SGLT2 inhibitors as adjuncts to insulin in type 1 diabetes: Systematic review and meta-analysis
#Electroacupuncture ameliorates skeletal muscle #insulin resistance in #diabetic rats via PPAR-γ/NF-κB signaling pathway
Objectives: To observe the effect of electroacupuncture (EA) at "Sanyinjiao" (SP6) and "Zusanli" (ST36) on the expressions of peroxisome proliferator-activated γ receptor (PPAR-γ), nuclear factor-κB (NF-κB) and glucose transporter 4 (GLUT4) in skeletal muscle of Zucker Diabetic Fatty (ZDF) rats with type 2 diabetes mellitus (T2DM), so as to explore its possible mechanism in improving… Continue reading #Electroacupuncture ameliorates skeletal muscle #insulin resistance in #diabetic rats via PPAR-γ/NF-κB signaling pathway
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