Are there outcome differences between NAFLD and metabolic-associated fatty liver disease?

BackgroundGiven the association of NAFLD with metabolic risks, a name change to MAFLD is proposed. We compared the long-term outcomes of NAFLD and MAFLD. MethodsWe included patients with fatty liver disease (FLD) from NHANES III and NHANES 2017–2018 (FLD defined as moderate to severe hepatic steatosis by ultrasound for NHANES III and as having a …

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Heterogeneity in statin responses explained by variation in the human gut microbiome

Despite the undeniable cholesterol lowering benefits of statin therapy, considerable heterogeneity exists in individual responses to the same treatment. Human gut bacteria are known to metabolize statins in vitro, but there is limited information on how microbiome composition may contribute to statin on-target and/or adverse effects. Here, the authors identify a novel blood-based biomarker for …

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Poor sleep may undermine people’s attempts to keep weight off

New research being presented at this year’s European Congress on Obesity (ECO) in Maastricht, Netherlands (4-7 May), finds that not getting enough good quality sleep undermines people’s attempts to keep weight off after dieting, and suggests that around two hours of vigorous physical activity per week can help maintain better sleep. The study is by …

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Early detection of childhood overweight and related complications in a Danish population-based cohort aged 2–8 years

BackgroundOverweight in early childhood often tracks into adolescence and adulthood and early childhood is a critical period for developing sustained overweight. This study aims to investigate the early detection of childhood overweight (including obesity) and related cardiometabolic complications in a Danish population-based cohort of children aged 2.5–8 years in collaboration with primary care municipal dental …

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Association of Lithium Treatment With the Risk of Osteoporosis in Patients With Bipolar Disorder

Importance Osteoporosis, a systemic skeletal disorder associated with substantial morbidity and mortality, may be particularly common among individuals with bipolar disorder. Lithium, a first-line mood-stabilizing treatment for bipolar disorder, may have bone-protecting properties. Objective To evaluate if treatment with lithium is associated with a decrease in risk of osteoporosis among patients with bipolar disorder. Design, …

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