Background: Indeterminate thyroid cytology remains a major diagnostic challenge. Thyroid nodules classified as Bethesda category (BC) III and IV carry an intermediate risk of malignancy, and their management often involves a choice between active surveillance and diagnostic surgery. This study aimed to assess the prevalence of benign, low-risk, and malignant lesions in surgically treated patients… Continue reading Prevalence and predictors of malignancy in Bethesda III and IV thyroid nodules undergoing surgery
Category: Endocrinology
Risk Assessment in MASLD and MetALD: Current Approaches and Future Directions
Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) exist on a continuous spectrum in which fibrosis stage remains the dominant predictor of liver‑related complications. Contemporary non‑invasive risk stratification uses simple serum scores (e.g., Fibrosis‑4 index [FIB‑4]) as a first step, followed by vibration‑controlled transient elastography (VCTE) or liver‑specific blood… Continue reading Risk Assessment in MASLD and MetALD: Current Approaches and Future Directions
Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Purpose: This study aimed to compare the associations and predictive performance of atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index for incident cardiometabolic multimorbidity (CMM).Methods: Data was analyzed from 2261 adults (mean age 63 years; 45.0% men) in the English Longitudinal Study of Ageing without a history of cardiometabolic disease at baseline (2008-2009).… Continue reading Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Background: Metabolic and bariatric surgery (MBS) is an effective treatment for severe obesity, yet postoperative weight loss outcomes vary considerably between patients. With the relevance of the gut microbiome for obesity, it is of interest to understand the potential role of the oral and gut microbiota for the outcome of MBS. This pilot, hypothesis-generating study… Continue reading Oral and gut microbiota features associated with weight-loss outcomes after metabolic and bariatric surgery: a pilot study
Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report
Background: Hypoglycemia may result from multiple clinical conditions which are categorized based on clinical status. The first principal step in clinical diagnostic evaluation is measurement of plasma insulin, c-peptide, pro-insulin, and beta-hydroxybutyrate levels. One of the rare causes of hypoglycemia is a group of disorders known as non-islet cell tumor hypoglycemia (NICT), which results from… Continue reading Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report
Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) represent a high-risk population with competing comorbidities, complex medication regimens, and overlapping inflammatory pathways. Although the role of sodium-glucose co-transporter-2 (SGLT2) inhibitors in managing type 2 diabetes is well-established, their impact on outcomes in diabetic patients with coexisting IBD remains unclear. This study aimed to investigate the… Continue reading Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
Association of stress hyperglycemia ratio with malnutrition, sarcopenia, and frailty in older adults: a cross-sectional study
Background: Stress hyperglycemia ratio (SHR), calculated using admission glucose and glycated hemoglobin (HbA1c), has emerged as a marker of acute metabolic stress and adverse outcomes. However, its relationship with major geriatric syndromes remains unclear. This study investigated the association between SHR and malnutrition, sarcopenia, and frailty in older adults attending a geriatric outpatient clinic.Methods: This… Continue reading Association of stress hyperglycemia ratio with malnutrition, sarcopenia, and frailty in older adults: a cross-sectional study
Association between HbA1c and red cell distribution width-standard deviation in newly diagnosed, treatment-naïve type 2 diabetes mellitus: a retrospective cross-sectional study
Background: Red cell distribution width-standard deviation (RDW-SD), a measure of erythrocyte volume heterogeneity, has attracted increasing interest as a hematologic marker linked to inflammation, oxidative stress, and metabolic dysfunction beyond anemia evaluation. However, evidence on the relationship between glycated hemoglobin (HbA1c) and RDW-SD in newly diagnosed, treatment-naïve type 2 diabetes mellitus (T2DM) remains limited. This… Continue reading Association between HbA1c and red cell distribution width-standard deviation in newly diagnosed, treatment-naïve type 2 diabetes mellitus: a retrospective cross-sectional study
The Impact of Hypoglycaemia on Quality of Life in Adults With Type 1 Diabetes Using Contemporary Diabetes Technologies: A US National Survey
Background: Use of contemporary diabetes technologies, including continuous glucose monitoring (CGM) and hybrid closed-loop insulin pumps (HCLs), has expanded rapidly among people with Type 1 diabetes. However, limited research has characterised the impact of hypoglycaemia on quality of life in this population.Methods: We analysed cross-sectional survey data from US adults aged ≥ 18 years who… Continue reading The Impact of Hypoglycaemia on Quality of Life in Adults With Type 1 Diabetes Using Contemporary Diabetes Technologies: A US National Survey
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