Persistent #Asthma is Associated with Increased Risk for Incident Atrial #Fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA)

Asthma and atrial fibrillation (AF) share an underlying inflammatory pathophysiology. We hypothesized that persistent asthmatics are at higher risk for developing AF and that this association would be attenuated by adjustment for baseline markers of systemic inflammation.

..Persistent asthma was defined as asthma requiring use of controller medications. Intermittent asthma was defined as asthma without use of controller medications..

..In risk-factor adjusted models, persistent asthmatics had a greater risk of incident AF (hazard ratio [HR] 1.49 [95% CI 1.03-2.14], p=0.03). Interleukin 6 (IL-6, HR 1.26 [95% CI 1.13-1.42]), tumor necrosis factor-α receptor 1 (TNF-α R1, HR 1.09 [95% CI 1.08-1.11]) and D-Dimer (HR 1.10 [95% CI 1.02-1.20]) predicted incident AF, but the relationship between asthma and incident AF was not attenuated by adjustment for any inflammation marker (IL-6, C-reactive protein, TNF-α R1, D-dimer, fibrinogen).

Conclusions – In a large multiethnic cohort with nearly 13 years follow-up, persistent asthma was associated with increased risk for incident AF. This association was not attenuated by adjustment for baseline inflammatory biomarkers