JAK inhibition reduces #SARS-CoV-2 #liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

Using AI we identified baricitinib as possessing anti-viral and anti-cytokine efficacy. We now show a 71% (95% CI 0.15-0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age 81 years). A further 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures of primary human liver cells, we demonstrate that interferon-alpha-2 (IFNα2) … Continue reading JAK inhibition reduces #SARS-CoV-2 #liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

Home #Oxygen Therapy for Adults with Chronic #Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Methods: The multidisciplinary panel created six research questions using a modified Delphi approach. A systematic review of the literature was completed, and the Grading of Recommendations Assessment, Development and Evaluation approach was used to formulate clinical recommendations. Recommendations: The panel … Continue reading Home #Oxygen Therapy for Adults with Chronic #Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of #COPD: the RESCUE trial

Exacerbations of COPD are one of the commonest causes of admission and readmission to hospital. The role of digital interventions to support self-management in improving outcomes is uncertain. We conducted an open, randomised controlled trial of a digital health platform application (app) in 41 COPD patients recruited following hospital admission with an acute exacerbation. Subjects were randomised to either receive usual care, including a written … Continue reading A randomised controlled feasibility trial of E-health application supported care vs usual care after exacerbation of #COPD: the RESCUE trial

Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort

To determine whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture and identify other factors associated with hip fracture. Patients and Methods: Observational nested case–control study was conducted in Aragon, Spain in 2010. We included COPD patients aged > 40 years, in the EpiChron cohort. Each COPD patient was matched for age, sex, and number of comorbidities with a control subject … Continue reading Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort

Nocturnal #Arrhythmias and Heart‐Rate Swings in Patients With Obstructive Sleep #Apnea Syndrome Treated With Beta Blockers

The higher cardiovascular variability and the increased prevalence of arrhythmias in patients with obstructive sleep apneas may contribute to their higher rate of fatal events during sleep. In this regard, the use of beta blockers (BB) is debated because they may induce bradyarrhythmias and alter the pattern of heart rate changes induced by apneas. Thus, the aim of our study is to quantify peri‐apneic heart‐rate … Continue reading Nocturnal #Arrhythmias and Heart‐Rate Swings in Patients With Obstructive Sleep #Apnea Syndrome Treated With Beta Blockers

Effect of #Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With #COVID-19 Pneumonia

The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile.. ..Patients in the experimental arm received intravenous tocilizumab within 8 hours from randomization (8 mg/kg up to a maximum of 800 mg), followed by a second dose after 12 hours. Patients in the control arm … Continue reading Effect of #Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With #COVID-19 Pneumonia

Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study

..Subjects with asthma, rhinitis and eczema were more likely to be sensitised to seasonal allergens (67 vs 32%, p<0.001), food allergens (54 vs. 18%, p<0.001) and to have a higher degree of sensitisation than subjects with only asthma (23 vs 10%, p<0.001). Subjects with allergic multimorbidity more often had allergic reactions to food (28 vs 10%, p=0.002), more respiratory symptoms and anxiety/depression (40% vs, 14%, … Continue reading Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study

Predictive Value of Initial #CT scan for Various Adverse Outcomes in Patients with #COVID-19 #Pneumonia

..This study investigates the predictive value of CT severity score (CSS) for length-of-stay (LOS) in hospital, initial disease severity, ICU admission, intubation, and mortality ..Total of 121 patients (60±16 years), including 54 women and 67 men, with positive RT-PCR tests were enrolled. We found a significant but weak correlation between CSS and qSOFA, as a measure of disease severity (r: 0.261, p= 0.003). No significant … Continue reading Predictive Value of Initial #CT scan for Various Adverse Outcomes in Patients with #COVID-19 #Pneumonia

American Society of Hematology 2020 guidelines for management of venous #thromboembolism: treatment of deep vein #thrombosis and pulmonary #embolism

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), occurs in ∼1 to 2 individuals per 1000 each year, corresponding to ∼300 000 to 600 000 events in the United States annually.. ..Strong recommendations include the use of thrombolytic therapy for patients with PE and hemodynamic compromise, use of an international normalized ratio (INR) range of 2.0 to 3.0 over a lower INR … Continue reading American Society of Hematology 2020 guidelines for management of venous #thromboembolism: treatment of deep vein #thrombosis and pulmonary #embolism

Effect of Face #Masks on Gas Exchange in Healthy Persons and Patients with #COPD

..In order to demonstrate the changes in end-tidal CO2 (ETCO2) and oxygen saturation (SpO2) before and after wearing a surgical mask, we used a convenience sample of 15 housestaff physicians without lung conditions (aged 31.1  1.9 years, 60% male) and 15 veterans with severe COPD (aged 71.6  8.7 years, FEV1 44.0  22.2%, 100% male). The patients needed to have a post-bronchodilator FEV1 … Continue reading Effect of Face #Masks on Gas Exchange in Healthy Persons and Patients with #COPD

Effect of convalescent #blood products for patients with severe acute #respiratory infections of #viral etiology: a systematic review and meta-analysis

To determine whether convalescent blood products (CBPs) could offer a survival advantage for patients with severe acute respiratory infections (SARI) of viral etiology.. ..According to observational studies, the cases received CPBs showed a decline of all-cause mortality compared with cases without using (OR 0.36, 95% CI 0.23 to 0.56, P < 0.00001). The all-cause mortality in the randomized controlled trials (RCTs) showed no difference between the interventional … Continue reading Effect of convalescent #blood products for patients with severe acute #respiratory infections of #viral etiology: a systematic review and meta-analysis

#Emergency Visits for #Thunderstorm-Related Respiratory Illnesses Among Older Adults

Thunderstorm-related atmospheric changes are expected to increase in severity with rising global temperatures. Although large-scale evidence is limited, vulnerable populations, such as older adults or those with common chronic respiratory diseases, like asthma or chronic obstructive pulmonary disease (COPD), are expected to be susceptible to negative health effects from these changes.The objective of this study was to determine whether increases in emergency department (ED) visits … Continue reading #Emergency Visits for #Thunderstorm-Related Respiratory Illnesses Among Older Adults