Background: Direct oral anticoagulants (#DOACs ) offer advantages over warfarin; however, concerns exist regarding their association with acute interstitial lung diseases (ILDs). This study investigated the risk of acute-onset ILDs associated with DOAC use.Methods: We conducted a case-crossover study to assess the risk of hospitalization for acute-onset #ILDs following DOAC initiation using the JMDC database,… Continue reading Direct Oral Anticoagulant Consumption and the Risk of Acute Interstitial Lung Diseases: A Case-Crossover Study Using Japanese Administrative Data
Category: Pneumology
Long-Term Oxygen Therapy and Cognitive Function in Chronic Obstructive Pulmonary Disease: A Systematic Review
Objective: This study is aimed at evaluating the association between long-term #oxygen therapy (LTOT) and cognitive function in patients with chronic obstructive pulmonary disease (#COPD ).Methods: We conducted a systematic literature search across major databases for observational studies comparing cognitive outcomes between COPD patients receiving LTOT (≥ 15 h/day) and those not receiving it. Cognitive… Continue reading Long-Term Oxygen Therapy and Cognitive Function in Chronic Obstructive Pulmonary Disease: A Systematic Review
Type 2 Diabetes and the Lung – Cause and Consequence
Purpose of review: The purpose of this review is to synthesize literature investigating the relationship between type 2 #diabetes (T2D) and obstructive airway diseases and to identify implications for clinical care.Recent findings: Type 2 diabetes is a common and challenging comorbidity in patients with #asthma and chronic obstructive pulmonary disease (#COPD ). Basic, translational and… Continue reading Type 2 Diabetes and the Lung – Cause and Consequence
Cough as a clinical manifestation of giant cell arteritis
Objectives: #Cough is an underrecognized and atypical manifestation of giant cell #arteritis (GCA), which may lead to diagnostic delay. Literature on cough in GCA is limited and lacks comprehensive data on clinical relevance. The aim of this study was to assess the frequency of cough at diagnosis in GCA patients and to compare clinical characteristics… Continue reading Cough as a clinical manifestation of giant cell arteritis
Global perspective on pulmonary fibrosis: epidemiology, regional variations, gaps in care and future directions
Background: Pulmonary #fibrosis (PF) caused by interstitial lung diseases (ILDs) affects up to 0.1% of the global population. There is growing global interest in PF, evident from a nearly threefold increase in PF-related research publications over the last 15 years. Idiopathic PF, connective tissue disease-related ILD, sarcoidosis and hypersensitivity pneumonitis rank as the top four… Continue reading Global perspective on pulmonary fibrosis: epidemiology, regional variations, gaps in care and future directions
From hospital to home: Practical guidance when caring for patients with COPD and heart disease
Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from other chronic conditions, with cardiovascular disease being especially common. The presence of cardiovascular disease in patients with #COPD complicates overall disease management and is associated with worse morbidity and high mortality. Furthermore, patients who are hospitalised due to a COPD exacerbation are at an increased… Continue reading From hospital to home: Practical guidance when caring for patients with COPD and heart disease
Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition
Idiopathic pulmonary fibrosis ( #IPF ) is a progressive, fatal lung disease that develops in response to chronic epithelial injury. Unlike injury-induced homeostatic lung repair during which fibroblasts undergo apoptosis and clearance, the lungs of IPF patients continue to accumulate apoptosis-resistant, pro-fibrotic, extracellular matrix-producing fibroblasts. Here, we show that prevention of PDGFRα+ fibroblast apoptosis by… Continue reading Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition
The Role of Artificial Intelligence in Diagnosing Pulmonary Embolism: A Systematic Review and Meta-analysis
Introduction: Missed or delayed diagnosis of pulmonary embolism (#PE ) is associated with increased morbidity, mortality, and longer hospitalizations. This study aimed to evaluate the diagnostic accuracy of Artificial Intelligence (#AI ) models in detecting PE across imaging.Methods: We systematically searched PubMed/MEDLINE, Scopus, Embase and Web of Science from inception to 1 January 2025 without… Continue reading The Role of Artificial Intelligence in Diagnosing Pulmonary Embolism: A Systematic Review and Meta-analysis
Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
Asthma is a heterogeneous disease characterized by chronic airway inflammation and reversible airflow obstruction. Particularly in severe #asthma , airway #mucus plugs can contribute to substantial and persistent airflow obstruction, despite inhaled corticosteroid and bronchodilator treatment. Consequently, it is important that clinicians assess and treat mucus plugs. Increased mucus production and airway eosinophilia caused by… Continue reading Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
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