Introduction: Obesity is associated with an increased oxygen (O2) cost of breathing, which could contribute to dyspnea on exertion (DOE) and exercise intolerance. Many patients with heart failure with preserved ejection fraction (HFpEF) also have obesity, but whether an elevated O2 cost of breathing contributes to DOE and exercise intolerance in these patients is unclear.… Continue reading Oxygen cost of breathing and its association with dyspnea in older patients with heart failure with preserved ejection fraction and obesity
Category: Pneumology
Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report
Background: Hypoglycemia may result from multiple clinical conditions which are categorized based on clinical status. The first principal step in clinical diagnostic evaluation is measurement of plasma insulin, c-peptide, pro-insulin, and beta-hydroxybutyrate levels. One of the rare causes of hypoglycemia is a group of disorders known as non-islet cell tumor hypoglycemia (NICT), which results from… Continue reading Hypoglycemia unmasking a giant pulmonary solitary fibrous tumor: a case report
Direct Oral Anticoagulant Consumption and the Risk of Acute Interstitial Lung Diseases: A Case-Crossover Study Using Japanese Administrative Data
Background: Direct oral anticoagulants (#DOACs ) offer advantages over warfarin; however, concerns exist regarding their association with acute interstitial lung diseases (ILDs). This study investigated the risk of acute-onset ILDs associated with DOAC use.Methods: We conducted a case-crossover study to assess the risk of hospitalization for acute-onset #ILDs following DOAC initiation using the JMDC database,… Continue reading Direct Oral Anticoagulant Consumption and the Risk of Acute Interstitial Lung Diseases: A Case-Crossover Study Using Japanese Administrative Data
Long-Term Oxygen Therapy and Cognitive Function in Chronic Obstructive Pulmonary Disease: A Systematic Review
Objective: This study is aimed at evaluating the association between long-term #oxygen therapy (LTOT) and cognitive function in patients with chronic obstructive pulmonary disease (#COPD ).Methods: We conducted a systematic literature search across major databases for observational studies comparing cognitive outcomes between COPD patients receiving LTOT (≥ 15 h/day) and those not receiving it. Cognitive… Continue reading Long-Term Oxygen Therapy and Cognitive Function in Chronic Obstructive Pulmonary Disease: A Systematic Review
Type 2 Diabetes and the Lung – Cause and Consequence
Purpose of review: The purpose of this review is to synthesize literature investigating the relationship between type 2 #diabetes (T2D) and obstructive airway diseases and to identify implications for clinical care.Recent findings: Type 2 diabetes is a common and challenging comorbidity in patients with #asthma and chronic obstructive pulmonary disease (#COPD ). Basic, translational and… Continue reading Type 2 Diabetes and the Lung – Cause and Consequence
Cough as a clinical manifestation of giant cell arteritis
Objectives: #Cough is an underrecognized and atypical manifestation of giant cell #arteritis (GCA), which may lead to diagnostic delay. Literature on cough in GCA is limited and lacks comprehensive data on clinical relevance. The aim of this study was to assess the frequency of cough at diagnosis in GCA patients and to compare clinical characteristics… Continue reading Cough as a clinical manifestation of giant cell arteritis
Global perspective on pulmonary fibrosis: epidemiology, regional variations, gaps in care and future directions
Background: Pulmonary #fibrosis (PF) caused by interstitial lung diseases (ILDs) affects up to 0.1% of the global population. There is growing global interest in PF, evident from a nearly threefold increase in PF-related research publications over the last 15 years. Idiopathic PF, connective tissue disease-related ILD, sarcoidosis and hypersensitivity pneumonitis rank as the top four… Continue reading Global perspective on pulmonary fibrosis: epidemiology, regional variations, gaps in care and future directions
From hospital to home: Practical guidance when caring for patients with COPD and heart disease
Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from other chronic conditions, with cardiovascular disease being especially common. The presence of cardiovascular disease in patients with #COPD complicates overall disease management and is associated with worse morbidity and high mortality. Furthermore, patients who are hospitalised due to a COPD exacerbation are at an increased… Continue reading From hospital to home: Practical guidance when caring for patients with COPD and heart disease
Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition
Idiopathic pulmonary fibrosis ( #IPF ) is a progressive, fatal lung disease that develops in response to chronic epithelial injury. Unlike injury-induced homeostatic lung repair during which fibroblasts undergo apoptosis and clearance, the lungs of IPF patients continue to accumulate apoptosis-resistant, pro-fibrotic, extracellular matrix-producing fibroblasts. Here, we show that prevention of PDGFRα+ fibroblast apoptosis by… Continue reading Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition
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