Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting. ObjectivesThe purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respiratory function in … Continue reading #Metoprolol in Critically Ill Patients With COVID-19
Category: Pneumology
Over 1 billion individuals worldwide experience some form of sleep apnoea, and this number is steadily rising. Obstructive sleep apnoea (OSA) can negatively influence one’s quality of life and potentially increase mortality risk. However, the association between OSA and mortality has not been reliably estimated. This meta-analysis estimates the risk of all-cause and cardiovascular mortality in … Continue reading Sudden death in individuals with obstructive sleep #apnoea: a systematic review and meta-analysis
Recent animal and human physiology studies indicate that noradrenergic and muscarinic processes are key mechanisms that mediate pharyngeal muscle control during sleep. The noradrenergic agent reboxetine combined with the anti-muscarinic hyoscine butylbromide has recently been shown to improve upper airway function during sleep in healthy individuals. However, whether these findings translate to the clinically relevant … Continue reading The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication levelcorrelates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restrictingearly SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples andexperiments with airway epithelial organoids. SARS-CoV-2 initially … Continue reading Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics
