Recent animal and human physiology studies indicate that noradrenergic and muscarinic processes are key mechanisms that mediate pharyngeal muscle control during sleep. The noradrenergic agent reboxetine combined with the anti-muscarinic hyoscine butylbromide has recently been shown to improve upper airway function during sleep in healthy individuals. However, whether these findings translate to the clinically relevant … Continue reading The noradrenergic agent reboxetine plus antimuscarinic hyoscine butylbromide reduces sleep #apnoea severity: A double-blind, placebo-controlled, randomised crossover trial
Category: Pneumology
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication levelcorrelates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restrictingearly SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples andexperiments with airway epithelial organoids. SARS-CoV-2 initially … Continue reading Dynamic innate immune response determines susceptibility to #SARS-CoV-2 infection and early replication kinetics
Readmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac … Continue reading Readmission following both #cardiac and non-cardiac acute #dyspnoea is associated with a striking risk of death
Although depression is a common comorbidity of chronic obstructive pulmonary disease (COPD), the role of sex remains unexplored. We evaluated sex differences of risk factors of depressive symptoms in adults with COPD. MethodsThis was a population-based cross-sectional study using data from the 2014 and 2016 Korea National Health and Nutrition Examination Survey. Spirometry was used … Continue reading Sex differences in risk factors for #depressive symptoms in patients with #COPD: The 2014 and 2016 Korea National Health and Nutrition Examination Survey
