Right ventricular (RV) size and function inform prognosis in many cardiovascular diseases, but assessment by two-dimensional transthoracic echocardiography is challenging. Here we show that a deep learning model, Dimensional Reconstruction of Imaging Data-Right Ventricle (DROID-RV), can estimate RV end-diastolic diameter and identify RV systolic dysfunction from transthoracic echocardiography videos. We trained DROID-RV in 17,141 ambulatory… Continue reading Deep learning-enabled assessment of right ventricular size and function is associated with cardiovascular outcomes
Category: Cardiology
Silicon-photonics optoacoustic sensor for fully wearable blood pressure monitoring
Cuffless blood pressure monitoring is essential for continuous cardiovascular assessment. Current wearable approaches rely on pulse-echo ultrasound patches that track pulsating arterial diameters. However, multi-element designs and precise alignment complicate their applicability as a fully wearable solution. We overcome these challenges by using a highly miniaturized silicon-photonics acoustic detector and optoacoustic excitation to generate ultrasound… Continue reading Silicon-photonics optoacoustic sensor for fully wearable blood pressure monitoring
Vitamin B12 and cardiovascular health: mechanisms, clinical evidence, and future directions
Cardiovascular disease (CVD) continues to be the primary cause of morbidity and death globally. New research shows that vitamin B₁₂ is very important for vascular health since it controls homocysteine metabolism, endothelial function, and one-carbon pathways. Deficiency not only causes hyperhomocysteinemia, oxidative stress, and vascular damage, but it also affects epigenetic pathways associated with atherosclerosis.… Continue reading Vitamin B12 and cardiovascular health: mechanisms, clinical evidence, and future directions
Caffeine and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Caffeine is one of the most commonly consumed drugs in the world. It is found in various naturally occurring substances and can be ingested in a synthetically derived pure form. The majority of human subject–based research is observational and has focused on beverages and foods that contain caffeine. The relationships between caffeine and cardiovascular risk… Continue reading Caffeine and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Stage 1 Registered Report: sex differences in anticoagulation and stroke outcomes among patients with atrial fibrillation: a registry-based cohort study
Women with atrial fibrillation have a higher risk of ischaemic stroke and worse functional outcomes than men but may be less likely to receive adequate anticoagulation. Preliminary single-centre findings in patients treated with endovascular thrombectomy for large vessel occlusion suggest that women may be under-anticoagulated prior to stroke onset. This Stage 1 Registered Report outlines… Continue reading Stage 1 Registered Report: sex differences in anticoagulation and stroke outcomes among patients with atrial fibrillation: a registry-based cohort study
In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians
Introduction: Older patients often present with complex coronary artery disease alongside multiple comorbidities. There is limited data on the outcomes of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) in octogenarians. We aim to investigate the in-hospital and 1-year outcomes following successful CTO-PCI in octogenarians.Methods: Consecutive patients who had successful CTO-PCI at a single… Continue reading In-Hospital and One-Year Outcomes After Percutaneous Coronary Intervention for Chronic Coronary Occlusion in Octogenarians
Retinal and coronary imaging in type 1 diabetes: links between retinopathy and subclinical cardiovascular disease
Cardiovascular disease (CVD) remains the leading cause of premature morbidity and mortality in individuals with type 1 diabetes mellitus (T1DM), despite advances in glycemic management and cardiovascular prevention. Conventional cardiovascular risk assessment may underestimate risk in T1DM, particularly among younger asymptomatic individuals, highlighting the need for markers of early vascular injury. Diabetic retinopathy (DR), a… Continue reading Retinal and coronary imaging in type 1 diabetes: links between retinopathy and subclinical cardiovascular disease
Metabolic Dysfunction-Associated Fatty Liver Disease-Cardiovascular-Kidney-Metabolic (MAFLD-CKM): A Modified Framework to Predict Long-Term Mortality
BACKGROUND Cardiovascular-kidney-metabolic (CKM) syndrome reframes cardio-renal-metabolic risk but omits hepatic dysfunction, particularly metabolic dysfunction-associated fatty liver disease (MAFLD). This study assesses whether integrating MAFLD into the CKM framework improves mortality risk discrimination compared with the original CKM framework. MATERIAL AND METHODS We used data of 10 335 adults aged 20 to 74 years from the… Continue reading Metabolic Dysfunction-Associated Fatty Liver Disease-Cardiovascular-Kidney-Metabolic (MAFLD-CKM): A Modified Framework to Predict Long-Term Mortality
Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
Lipoprotein(a) [Lp(a)] is a genetically determined, apolipoprotein B-containing lipoprotein that contributes to cardiovascular risk through atherogenic, proinflammatory, and potentially antifibrinolytic mechanisms. Genetic, epidemiological, and mechanistic evidence supports a causal role for elevated Lp(a) in atherosclerotic cardiovascular disease and calcific aortic valve disease. In contrast, associations with other cardiovascular phenotypes are less consistent. Since circulating concentrations… Continue reading Lipoprotein(a) Inhibition: Current Evidence, Therapeutic Landscape, and Future Directions
