Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

The effects of pharmacological blood pressure lowering at normal or high-normal blood pressure ranges in people with or without pre-existing cardiovascular disease remains uncertain. We analysed individual participant data from randomised trials to investigate the effects of blood pressure lowering treatment on the risk of major cardiovascular events by baseline levels of systolic blood pressure. MethodsWe did a meta-analysis of individual participant-level data from 48 … Continue reading Pharmacological blood #pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis

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Initial Findings From the North American #COVID-19 Myocardial #Infarction Registry

The coronavirus disease 2019 (COVID-19) pandemic has impacted many aspects of ST-segment elevation myocardial infarction (STEMI) care, including timely access to primary percutaneous coronary intervention (PPCI). ObjectivesThe goal of the NACMI (North American COVID-19 and STEMI) registry is to describe demographic characteristics, management strategies, and outcomes of COVID-19 patients with STEMI. MethodsA prospective, ongoing observational registry was created under the guidance of 3 cardiology societies. … Continue reading Initial Findings From the North American #COVID-19 Myocardial #Infarction Registry

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Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK

Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantified. MethodsThis population-based cohort study used routine UK primary care electronic health data linked to secondary care and death-registry records. We identified adults who were overweight or obese, … Continue reading Long-term body mass index changes in #overweight and #obese adults and the risk of heart failure, #cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK

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Exploring Posttraumatic #Stress Disorder as a #Cardiovascular Risk Factor in Women VeteransThe Heart of the Matter

The connection between emotional and physical health has long been recognized, with a great deal of research focusing on the risk of cardiovascular disease (CVD). The landmark INTERHEART study1 of nearly 30 000 people from 52 countries found that psychosocial factors, including depression and stressful life events, accounted for approximately one-third of the population-attributable risk of myocardial infarction. Subsequent studies have attempted to isolate the risk … Continue reading Exploring Posttraumatic #Stress Disorder as a #Cardiovascular Risk Factor in Women VeteransThe Heart of the Matter

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Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study

Highlights•We assessed the association between sugary drinks and mortality in Japan. •Sugary drink consumption was positively associated with all-cause mortality. •Sugary drinks increased risk of death from circulatory system diseases. AbstractBackgroundFew epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations. MethodsThis study included 70,486 participants in the Japan Public Health Center-based Prospective Study at the age of 45–74 … Continue reading Association of #sugary drink consumption with all-cause and cause-specific #mortality: the Japan Public Health Center-based Prospective Study

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Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study

The association between psychosocial stress and coronary heart disease (CHD) may be stronger in women than men and may differ across types of stressors. In this study, we assessed associations of psychosocial stressors, including job strain, stressful life events, and social strain with the incidence of CHD in women. Methods and Results We used longitudinal data from 80 825 WHI‐OS (Women’s Health Initiative Observational Study) … Continue reading Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study

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#Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review

This review aimed to summarize the evidence on the risk of thromboembolism associated with carotid and aortic atherosclerosis in patients with AF, and the potential impact of their inclusion in current stroke risk stratification scores. Methods MEDLINE, Web of Science and EMBASE were systematically searched to identify all published studies providing relevant data through 28 February 2021. Results We identified 10 eligible studies. There was … Continue reading #Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review

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#Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults

Mental stress has been shown to induce cardiovascular events, likely due to its negative impact on vascular function. Flavanols, plant-derived polyphenolic compounds, improve endothelial function and blood pressure (BP) in humans, however their effects during stress are not known. This study examined the effects of acute intake of cocoa flavanols on stress-induced changes on vascular function. In a randomised, controlled, double-blind, cross-over intervention study, 30 … Continue reading #Cocoa Flavanols Improve Vascular Responses to Acute Mental #Stress in Young Healthy Adults

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Lamictal (#lamotrigine): Drug Safety Communication – Studies Show Increased Risk of #Heart Rhythm Problems in Patients with Heart Disease

Lamotrigine is used alone or with other medicines to treat seizures in patients 2 years and older. It may also be used as maintenance treatment in patients with the mental health condition bipolar disorder to help delay the occurrence of mood episodes such as depression, mania, or hypomania. RECOMMENDATIONS: Patients should not stop taking your medicine without first talking to your prescriber because stopping lamotrigine … Continue reading Lamictal (#lamotrigine): Drug Safety Communication – Studies Show Increased Risk of #Heart Rhythm Problems in Patients with Heart Disease

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Effectiveness and Safety of Direct Oral #Anticoagulants Versus Warfarin in Patients With Valvular Atrial #Fibrillation

Direct oral anticoagulants (DOACs) are increasingly used in place of warfarin, but evidence about their effectiveness and safety in patients with valvular atrial fibrillation (AF) remains limited. Objective: To assess the effectiveness and safety of DOACs compared with warfarin in patients with valvular AF. Design: New-user retrospective propensity score–matched cohort study. Setting: U.S.-based commercial health care database from 1 January 2010 to 30 June 2019. … Continue reading Effectiveness and Safety of Direct Oral #Anticoagulants Versus Warfarin in Patients With Valvular Atrial #Fibrillation

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Association of spontaneous #abortion with all cause and cause specific premature #mortality: prospective cohort study

To investigate the association of spontaneous abortion with the risk of all cause and cause specific premature mortality (death before the age of 70). Design Prospective cohort study. Setting The Nurses’ Health Study II (1993-2017), United States. Participants 101 681 ever gravid female nurses participating in the Nurses’ Health Study II. Main outcomes measures Lifetime occurrence of spontaneous abortion in pregnancies lasting less than 6 months, … Continue reading Association of spontaneous #abortion with all cause and cause specific premature #mortality: prospective cohort study

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Effect of Marine #Omega-3 Fatty Acid and Vitamin #D Supplementation on Incident Atrial #Fibrillation

Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to have both benefits and risks with respect to incident AF, but large-scale, long-term randomized trial data are lacking. Objective To test the effects of … Continue reading Effect of Marine #Omega-3 Fatty Acid and Vitamin #D Supplementation on Incident Atrial #Fibrillation

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