Background: Acute myocardial infarction (#MI ) is associated with subsequent #cognitive decline. Whether the detection of prior MI using routine ECG and self-reported history can identify different trajectories of cognitive decline is uncertain. We sought to determine the association between prior MI and longitudinal cognitive assessments within a national, biracial cohort study.Methods: We included participants… Continue reading Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Category: Cardiology
A Novel, Interpretable Machine Learning Model Predicts Furosemide Dosing After Congenital Cardiac Surgery
Fluid overload is common after neonatal congenital #cardiac surgery (CCS) and is frequently managed with continuous furosemide infusions requiring iterative dose titration. An interpretable prediction model could support more consistent early postoperative dosing decisions. We hypothesized that a novel, interpretable machine learning approach could accurately predict furosemide dosing decisions in neonates following CCS. We identified… Continue reading A Novel, Interpretable Machine Learning Model Predicts Furosemide Dosing After Congenital Cardiac Surgery
Mechanical load inhibits cancer growth in mouse and human hearts
INTRODUCTIONThe #heart is rarely affected by #cancer ; both primary cardiac tumors and metastases are uncommon despite the high vascularization of the myocardium. The mechanisms underlying this resistance remain unclear.RATIONALEMechanical load has been proposed as a major mechanism halting cardiomyocyte proliferation early after birth, thus limiting the regenerative potential of the adult mammalian heart. We… Continue reading Mechanical load inhibits cancer growth in mouse and human hearts
Predictors and Outcomes of Pulmonary Embolism After Coronary Artery Bypass Grafting
Pulmonary embolism ( #PE ) can be a life-threatening complication following coronary artery bypass grafting (#CABG ). However, the impact of PE on short-term outcomes such as readmission and mortality remains poorly characterized. The Nationwide Readmission Database 2016 to 2021 was queried to identify patients with isolated CABG who were readmitted with PE within 30… Continue reading Predictors and Outcomes of Pulmonary Embolism After Coronary Artery Bypass Grafting
Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Aims: We evaluated the impact of scenario-based multifactorial control on the 3-year incidence of fatal/non-fatal cardiovascular disease (#CVD ) and associated healthcare costs in Asian patients with type 2 diabetes (#T2D ).Materials and methods: We applied the validated 'ABC' model to simulate the 3-year impact of attaining multiple treatment targets (HbA1c < 7%, blood pressure… Continue reading Impact of Simulated Risk Factor Management on Cardiovascular Disease and Costs in Type 2 Diabetes Using the ABC Model
Blood Pressure Control and Mortality Among US Veterans
Background: Intensive blood #pressure (#BP) control reduces mortality and cardiovascular disease in clinical trials. However, real-world BP measurements often differ from standardized protocols. We evaluated the impact of real-world systolic BP on mortality among US Veterans.Methods: We conducted a retrospective cohort study of Veterans with hypertension, defined by diagnostic codes, antihypertensive prescriptions, or ≥2 office… Continue reading Blood Pressure Control and Mortality Among US Veterans
Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
Background: #Sarcopenia, the age-related loss of skeletal muscle mass and function, has been linked to adverse health outcomes. Cross-sectional associations have been observed between skeletal and cardiac muscle mass and function in healthy, community-dwelling older adults during normative aging. Further longitudinal studies on the skeletal muscle-cardiac axis during aging are needed to inform the temporal… Continue reading Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
Ethanol Infusion of the Vein of Marshall-Based Strategies for Persistent Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Trials
Background and aims: Pulmonary vein isolation (PVI) alone achieves modest arrhythmia freedom in persistent atrial #fibrillation (PeAF). Ethanol infusion of the vein of #Marshall (EIVOM) overcomes heat-sink effects, facilitating mitral isthmus (MI) block, and may represent an effective adjunctive ablation strategy. We aimed to quantify the efficacy and safety of EIVOM through a meta-analysis of… Continue reading Ethanol Infusion of the Vein of Marshall-Based Strategies for Persistent Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Trials
Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
Purpose: Patients with acute coronary syndrome (#ACS ) on ticagrelor-based dual antiplatelet therapy (#DAPT ) have an increased risk of gastrointestinal (GI) bleeding. However, evidence supporting the protective role of proton pump inhibitors against DAPT-induced gastric mucosal injury remains limited.Materials and methods: This was a single-center, prospective, open-label, observational trial enrolling patients with ACS who… Continue reading Evaluation of Rabeprazole for Gastrointestinal Protection in Acute Coronary Syndrome Patients Treated with Aspirin and Ticagrelor: A Pilot Study
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