Background: The cardiovascular-kidney-metabolic (CKM) framework emphasizes the interplay of metabolic, renal, and cardiovascular abnormalities in cardiovascular disease risk. We aimed to develop a CKM syndrome age algorithm using routinely collected health checkup and claims data in Japan.Methods and results: We conducted a cohort study of 376,612 men and 478,853 women aged 20-79 years in the… Continue reading Cardiovascular-Kidney-Metabolic Syndrome Age Derived From Routine Health Checkup and Claims Data – Large-Scale Epidemiological Study
Category: Cardiology
Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Background: Patients with atrial fibrillation (AF) who are at increased risk of both thrombotic and haemorrhagic events represent a heterogeneous and broad clinical entity, characterized by the presence of several Janus-faced risk factors. We aimed to identify clinical phenotypes and assess the association of ABC pathway adherence with one-year outcomes in patients with AF at… Continue reading Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Purpose: This study aimed to compare the associations and predictive performance of atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index for incident cardiometabolic multimorbidity (CMM).Methods: Data was analyzed from 2261 adults (mean age 63 years; 45.0% men) in the English Longitudinal Study of Ageing without a history of cardiometabolic disease at baseline (2008-2009).… Continue reading Beyond conventional lipid markers: Atherogenic index of plasma and triglyceride-glucose index in relation to cardiometabolic multimorbidity in older adults
Left Atrial Reservoir Strain Improves Sudden Cardiac Death Risk Stratification in Hypertrophic Cardiomyopathy
Background: Current risk scores for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) have limited ability to identify high-risk subgroups. We aimed to investigate the prognostic value of left atrial reservoir strain (LARS) for SCD-related events and its utility for risk stratification.Methods: This retrospective cohort study included 1,761 patients with HCM from two referral centers.… Continue reading Left Atrial Reservoir Strain Improves Sudden Cardiac Death Risk Stratification in Hypertrophic Cardiomyopathy
Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk
Background and objectives: Limited data on the comparative efficacy and safety of potent P2Y₁₂ inhibitors versus clopidogrel in patients with acute myocardial infarction (AMI) stratified by bleeding risk. This study evaluated the differential prognostic impact of potent P2Y₁₂ inhibitors in patients with AMI by bleeding risk.Methods: From the nationwide pooled registry of the Korea Acute… Continue reading Differential Prognostic Impact of Potent P2Y₁₂ Inhibitors in Patients With Acute Myocardial Infarction by Bleeding Risk
Clinical Characteristics of Iron Deficiency in Patients with Chronic Heart Failure at a Major Referral Centre in Southern Nigeria
Background: Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF) and is associated with reduced functional capacity, diminished quality of life, and increased mortality. This study aimed to determine the prevalence of ID and its clinical characteristics.Methods: This descriptive cross-sectional study involved 136 patients with chronic HF at the University of… Continue reading Clinical Characteristics of Iron Deficiency in Patients with Chronic Heart Failure at a Major Referral Centre in Southern Nigeria
Fecal Incontinence as a Marker of Multisystem Cardiopulmonary-Kidney Disease and Mortality in US Adults: : A Nationally Representative Cohort Study
Objective: To determine whether fecal incontinence is associated with cardiovascular, pulmonary, and kidney disease, individually and in combination, and with all-cause mortality among community-dwelling US adults.Methods: Nationally representative cohort study using the National Health and Nutrition Examination Survey (NHANES) 2005-2010 with linkage to the National Death Index through December 31, 2019. The analytic cohort comprised… Continue reading Fecal Incontinence as a Marker of Multisystem Cardiopulmonary-Kidney Disease and Mortality in US Adults: : A Nationally Representative Cohort Study
Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications
Valvular cardiomyopathy has emerged as a key concept linking valvular heart disease (VHD) with myocardial remodeling and the development of heart failure (HF). This state-of-the-art review provides a comprehensive overview of pathophysiological mechanisms, multimodality imaging, and implication for valve interventions across the spectrum of VHD. We systematically address HF in the context of aortic valve… Continue reading Myocardial remodeling in valvular heart disease: pathophysiology, multimodality imaging and treatment implications
Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome
Homocysteine (HCY) has been implicated in cardiovascular disease through adverse effects on vascular endothelium, oxidative stress, and thrombogenic pathways. Saudi Arabia has a young population and an increasing burden of cardiovascular disease, yet regional data on HCY and B-vitamin profiles in premature acute coronary syndrome (ACS) remain limited. This single-center cross-sectional exploratory study evaluated serum… Continue reading Role of homocysteine, vitamins B12, B6, B1, and folate in Saudi patients with premature acute coronary syndrome
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