Selected Soybean Varieties Regulate Hepatic LDL-Cholesterol Homeostasis Depending on Their Glycinin:β-Conglycinin Ratio

Clinical studies indicate that the consumption of soybean protein might reduce cholesterol and LDL levels preventing the development of atherosclerotic cardiovascular diseases. However, soybean variety can influence soybean protein profile and therefore affect soybean protein health-promoting properties. This study investigated the composition and effects of nineteen soybean varieties digested under simulated gastrointestinal conditions on hepatic …

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Premature Cardiovascular Disease and Brain Health in Midlife: The CARDIA Study

Objectives: To understand the role of premature (defined as ≤ 60 years) CVD in brain health earlier in life, we examined the association of premature CVD with midlife cognition and white matter health.Methods: We studied a prospective cohort in the Coronary Artery Risk Development in Young Adults study, who were 18-30 years at baseline (1985-86) and followed …

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Proton Pump Inhibitor Use and Risks of Cardiovascular Disease and Mortality in Patients With Type 2 Diabetes 

Proton pump inhibitors (PPIs) are widely used drugs for gastric acid–related diseases and may affect the gut microbiome.ObjectiveWe aimed to evaluate the associations of PPI use with risks of cardiovascular disease (CVD) and all-cause mortality in patients with type 2 diabetes (T2D).MethodsWe analyzed the associations of PPI use with risks of coronary artery disease (CAD), …

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Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

BACKGROUND:Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.METHODS:From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General …

Continue reading Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

BACKGROUND:Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.METHODS:From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General …

Continue reading Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis