Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial

Nasal high flow (NHF) has demonstrated efficacy in relieving dyspnea in various patients with hypoxemic and hypercapnic respiratory failure. It may also reduce dyspnea in patients with acute severe asthma in the emergency department (ED). The aim of the study was to compare the efficacy of NHF with conventional oxygen therapy (COT) in improving dyspnea …

Continue reading Nasal High-flow €Oxygen Versus Conventional Oxygen Therapy for Acute Severe #Asthma Patients: A Pilot Randomized Controlled Trial

#Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery

...A total of 5522 (17%) children were born to mothers exposed to antibiotics during pregnancy. In adjusted analyses, children born to exposed mothers had higher odds of asthma (OR 1.14, 95% CI 1.05 to 1.24). There was no association with antibiotic exposure in the first trimester (OR 1.02, 95% CI 0.83 to 1.26), but higher …

Continue reading #Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery

Poor outcome of #SARS-CoV-2 infection in patients with severe #asthma on biologic therapy

It is unclear whether asthma and asthma medications increase or decrease the risk of severe COVID-19, and this is particularly true for patients with severe asthma receiving biologics. Objectives The aim of this study was to assess incidence and disease course of COVID-19 in patients with severe asthma on biologic therapy (omalizumab, mepolizumab, reslizumab, benralizumab, …

Continue reading Poor outcome of #SARS-CoV-2 infection in patients with severe #asthma on biologic therapy

Managing #Asthma in Adolescents and Adults 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program

Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has released the 2020 Asthma Guideline Update with updated evidence-based recommendations for treatment of patients with asthma.. ..From 20β€―572 identified references, 475 were included in the …

Continue reading Managing #Asthma in Adolescents and Adults 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program

Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study

..Subjects with asthma, rhinitis and eczema were more likely to be sensitised to seasonal allergens (67 vs 32%, p<0.001), food allergens (54 vs. 18%, p<0.001) and to have a higher degree of sensitisation than subjects with only asthma (23 vs 10%, p<0.001). Subjects with allergic multimorbidity more often had allergic reactions to food (28 vs …

Continue reading Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study