Circulating asymmetric #dimethylarginine and #cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort

The underlying mechanisms leading to dementia and Alzheimer’s disease (AD) are unclear. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, may be associated with cognitive decline, but population‐based evidence is lacking.. ..Change in cognitive performance was assessed in participants of the Aberdeen Birth Cohort of 1936 using longitudinal Raven’s progressive matrices (RPM) between 2000 and 2004. Multiple linear regression was used to estimate … Continue reading Circulating asymmetric #dimethylarginine and #cognitive decline: A 4‐year follow‐up study of the 1936 Aberdeen Birth Cohort

Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2

The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.. ..Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini‐Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status‐Modified (<30) and 0.48 for composite score (each … Continue reading Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2

#Cognitive Decline Over Time in Patients With Systolic #Heart Failure Insights From WARCEF

This study sought to characterize cognitive decline (CD) over time and its predictors in patients with systolic heart failure (HF) ..In logistic regression, CD was independently associated with higher baseline MMSE scores (odds ratio [OR]: 1.13; 95% confidence interval [CI]: 1.07 to 1.20]; p < 0.001), older age (OR: 1.37; 95% CI: 1.24 to 1.50; p < 0.001), nonwhite race/ethnicity (OR: 2.32; 95% CI: 1.72 … Continue reading #Cognitive Decline Over Time in Patients With Systolic #Heart Failure Insights From WARCEF

Playing analog #games is associated with reduced declines in #cognitive function: a 68 year longitudinal cohort study

..Our goal was to examine the association between playing games and change in cognitive function from age 11 to age 70, and from age 70 to 79.. Higher frequency of playing games was associated with higher cognitive function at age 70, controlling for age 11 cognitive function, and the majority of this association could not be explained by control variables. Playing more games was also … Continue reading Playing analog #games is associated with reduced declines in #cognitive function: a 68 year longitudinal cohort study

Dietary #salt promotes cognitive impairment through tau phosphorylation

Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral endothelial cells and cerebral hypoperfusion Here we report that dietary … Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation