Time Trends in Incidence of Reported Memory Concerns and Cognitive Decline: A Cohort Study in UK Primary Care

Purpose: To investigate time trends in incidence of recorded memory concerns (MC) and cognitive decline (CD) in a UK older population presenting to primary care with no prior diagnosis of dementia. To determine the risk of developing dementia in people with recorded memory concern and cognitive decline.Patients and methods: We included individuals aged 65– 99 …

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Amateur Boxing and DementiaCognitive Impairment Within the 35-Year Caerphilly Cohort Study

Objective:To examine the long-term effects of amateur boxing in a representative population sample of men. Design:The sample was examined every 5 years for 35 years. Cognition was assessed repeatedly from the third examination. Previous boxing experience and dementia were assessed at the fifth examination, and dementia assessed subsequently through medical records. Setting and Assessment of …

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Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration

•Adipocytes induce phenotypical changes in neurodegeneration through adipocyte NKAL.•Adipocyte specific NaKtide inhibited NKAL and improved systemic homeostasis.•NaKtide improved adipocyte phenotype and improved markers of neurodegeneration.•NaKtide improved genomic profile of hippocampus and adipose tissue in WD fed mice. SummaryRecent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the …

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Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates

•A processed-foods diet (PD) impaired learning and memory in aged male rats. •PD increased inflammatory genes in the hippocampus and amygdala of aged rats. •DHA supplementation prevented memory deficits in PD-fed aged rats. •DHA supplementation ameliorated increases in inflammatory gene expression. •PD consumption led to increased weight gain in young and aged rats. AbstractThe consumption …

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#Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline

Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and …

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