Introduction: Despite numerous studies confirming the beneficial effects of physical activity on cognitive function, there is a lack of randomised controlled trials involving long-term, continuous monitoring of physical activity that assess the effect of step-based intervention on cognition-related outcomes. Therefore, this study evaluated whether increasing daily step count improves cognitive performance and brain health markers… Continue reading Increasing daily step count in mild cognitive impairment: a 12-month randomised controlled trial
Tag: Cognitive Impairment
Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
IntroductionExergame-based training is emerging as the most effective exercise modality for improving cognition, yet its neural correlates remain largely unexplored. This study explored gray matter (GM) and white matter (WM) changes following the addition of ‘Brain-IT’ training to usual care in mild neurocognitive disorder (mNCD) and their associations with cognitive performance changes.MethodsWe included 41 participants… Continue reading Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
As viable pharmacotherapies and blood biomarkers emerge for dementia treatment and screening, there remains a great need for accurate, sensitive biomarkers of cognitive function. We have previously demonstrated that Fastball, a new Electroencephalography (EEG) method for the passive and objective measurement of recognition memory that requires no behavioural memory response or task comprehension, is sensitive… Continue reading A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
#Cognitive Decline After First-Time Transient #Ischemic Attack
Question When controlling for vascular and demographic factors, does transient ischemic attack confer an independent risk for cognitive decline?Findings In this longitudinal cohort study (Reasons for Geographic and Racial Differences in Stroke [REGARDS]), pre-event and postevent cognitive trajectories were compared in 356 individuals with TIA, 965 individuals with stroke, and 14 882 asymptomatic controls. A single,… Continue reading #Cognitive Decline After First-Time Transient #Ischemic Attack
Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
AbstractApolipoprotein E4 (APOE4) genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome plays a critical role in maintaining NO bioavailability during aging. The aim of this study was to assess interactions between the oral microbiome, NO biomarkers, and cognitive function in 60 participants with mild cognitive impairment (MCI)… Continue reading Oral #microbiome and nitric oxide biomarkers in older people with mild #cognitive impairment and APOE4 genotype
Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
Background and ObjectivesThe Systolic Blood Pressure Intervention Trial suggested that intensive lowering of systolic blood pressure (SBP) decreases the risk of developing dementia. However, an insufficient number of probable dementia cases stemming from the trial's early termination made results inconclusive. The goal of this study was to estimate the effect of intensive vs standard SBP… Continue reading Long-Term Effect of Intensive vs Standard Blood #Pressure Control on Mild Cognitive Impairment and Probable #Dementia in SPRINT
Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive… Continue reading Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Curve #Walking Reveals More #Gait Impairments in Older Adults with Mild #Cognitive Impairment than Straight Walking: A Kinect Camera-Based Study
Background:Mild cognitive impairment (MCI) can be an early sign of Alzheimer’s disease and other types of dementia detectable through gait analysis. Curve walking, which demands greater cognitive and motor skills, may be more sensitive in MCI detection than straight walking. However, few studies have compared gait performance in older adults with and without MCI in… Continue reading Curve #Walking Reveals More #Gait Impairments in Older Adults with Mild #Cognitive Impairment than Straight Walking: A Kinect Camera-Based Study
Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
BackgroundChronic liver diseases of all etiologies exist along a spectrum with varying degrees of hepatic fibrosis. Despite accumulating evidence implying associations between liver fibrosis and cognitive functioning, there is limited research exploring the underlying neurobiological factors and the possible mediating role of inflammation on the liver-brain axis.MethodsUsing data from the UK Biobank, we examined the cross-sectional association… Continue reading Elevated C-reactive protein mediates the liver-brain axis: a preliminary study
