APOE-ɛ4, late life cognitive activity, physical activity, and smoking, total flavonol intake was associated with slower decline in global cognition β estimate=0.004 (95% CI=0.001, 0.006), episodic memory β=0.004 (95% CI: 0.002, 0.006), semantic memory β=0.003 (95% CI: 0.001, 0.007), perceptual speed β=0.003 (95% CI: 0.001, 0.004), and working memory β=0.003 (95% CI: 0.001, 0.005) and marginally associated with visuospatial ability β=0.001 (95% CI: -0.001, 0.003). Analyses of individual flavonol constituents demonstrated that intakes of kaempferol and quercetin were associated with slower global cognitive decline [β=0.01 (95% CI: 0.006, 0.02) and β=0.004 (95% CI: 0.0005, 0.007)], respectively. Myricetin and isorhamnetin were not associated with global cognition.

Conclusion: Results suggest dietary intakes of total flavonols and several flavonol constituents may be associated with slower decline in global cognition and multiple cognitive abilities with older age

https://n.neurology.org/content/early/2022/11/22/WNL.0000000000201541.long