Fitness tracking reveals task-specific associations between memory, mental health, and physical activity

Physical activity can benefit both physical and mental well-being. Different forms of exercise (e.g., aerobic versus anaerobic; running versus walking, swimming, or yoga; high-intensity interval training versus endurance workouts; etc.) impact physical fitness in different ways. For example, running may substantially impact leg and heart strength but only moderately impact arm strength. We hypothesized that …

Continue reading Fitness tracking reveals task-specific associations between memory, mental health, and physical activity

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial

IntroductionDietary supplements are touted for cognitive protection, but supporting evidence is mixed. COSMOS-Mind tested whether daily administration of cocoa extract (containing 500 mg/day flavanols) versus placebo and a commercial multivitamin-mineral (MVM) versus placebo improved cognition in older women and men.MethodsCOSMOS-Mind, a large randomized two-by-two factorial 3-year trial, assessed cognition by telephone at baseline and annually. The …

Continue reading Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial

Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies

AbstractBackgroundEmerging evidence indicates that poor periodontal health adversely impacts cognition. This review examined the available longitudinal evidence concerning the effect of poor periodontal health on cognitive decline and dementia.MethodsComprehensive literature search was conducted on five electronic databases for relevant studies published until April 2022. Longitudinal studies having periodontal health as exposure and cognitive decline and/or …

Continue reading Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies

Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK

Key PointsQuestion  Is there a dose-response association of daily step count and intensity with incidence of all-cause dementia among adults living in the UK?Findings  This cohort study of adults assessed with wrist-worn accelerometers found that accruing more steps per day was associated with steady declines in dementia incidence risk, up to 9800 steps per day, beyond which …

Continue reading Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK

Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

BackgroundStatin therapy is effective for the prevention of atherosclerotic cardiovascular disease and is widely prescribed, but there are persisting concerns that statin therapy might frequently cause muscle pain or weakness. We aimed to address these through an individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin …

Continue reading Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials