Objective: We aimed to assess the association of proton-pump inhibitor (PPI) use with muscle strength in older adults.Methods: All 1940-born residents of Turku, Finland were surveyed during 2016 and 2017 as part of the New Turku Older Adults Study. Associations between PPI use, regardless of dosing pattern, and physical function were analyzed using Welch's t-test,… Continue reading Association Between Proton-Pump Inhibitors and Muscle Strength in Older Adults: A Population-Based Analysis
Category: Neurology
Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Background: Patients with atrial fibrillation (AF) who are at increased risk of both thrombotic and haemorrhagic events represent a heterogeneous and broad clinical entity, characterized by the presence of several Janus-faced risk factors. We aimed to identify clinical phenotypes and assess the association of ABC pathway adherence with one-year outcomes in patients with AF at… Continue reading Phenotypic clustering and ABC pathway adherence in patients with atrial fibrillation at high risk of bleeding and stroke: Insights from three global registries
Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
Background: Older adults account for an increasing proportion of emergency department visits for mild traumatic brain injury (mTBI). Although age is incorporated as a high-risk criterion in major clinical decision rules, the operational impact of risk stratification on computed tomography (CT) utilization in very elderly patients remains uncertain.Methods: We conducted a retrospective cohort study including… Continue reading Limited clinical utility of risk stratification for CT decision-making in patients ≥ 75 years with mild traumatic brain injury
Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study
Background Intracerebral hemorrhage (ICH) is associated with high mortality and limited therapeutic options. The impact of statin therapy on outcomes following ICH remains controversial. Methods A retrospective cohort study was conducted using the TriNetX Global Collaborative Network. Adult patients (≥18 years) with nontraumatic ICH were identified and stratified based on statin use within three months… Continue reading Impact of Pre-injury Statin Use on Mortality and Short-Term Clinical Outcomes Following Intracerebral Hemorrhage: A Propensity-Matched Cohort Study
Ischemic Stroke as a Possible Initial Manifestation of Primary Sjögren’s Syndrome: A Case Report
Primary Sjögren's syndrome (pSS), a chronic autoimmune disorder primarily affecting the exocrine glands, typically presents with sicca symptoms. Neurological involvement in pSS is uncommon as an initial presentation. Ischemic stroke, in particular, is a rare manifestation, while seizures are more commonly secondary to underlying structural or inflammatory central nervous system involvement. Here, we report a… Continue reading Ischemic Stroke as a Possible Initial Manifestation of Primary Sjögren’s Syndrome: A Case Report
Validity and reliability of the Turkish version of the early symptom measurement of post-stroke depression short form (ESMPSD-SF)
The present methodological study was conducted to adapt the Early Symptom Measurement of Post-Stroke Depression developed by Li et al.1 into Turkish and to examine its validity and reliability. This study was conducted between September and December 2025 with a final sample of 120 patients diagnosed with stroke. Data were collected using a Personal Information… Continue reading Validity and reliability of the Turkish version of the early symptom measurement of post-stroke depression short form (ESMPSD-SF)
Chaos in the Equilibrium: A Rare Complication of Dialysis
Dialysis disequilibrium syndrome (DDS) is a rare but potentially life-threatening neurologic complication associated with hemodialysis (HD), particularly during initial treatments in patients with severe uremia. It is thought to result from rapid osmotic shifts between the plasma and the central nervous system during dialysis. We present the case of a 36-year-old woman with stage V… Continue reading Chaos in the Equilibrium: A Rare Complication of Dialysis
Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling
Growth/differentiation factor–15 (GDF15) is a secreted cytokine strongly associated with dementia risk. However, the extent to which GDF15 represents a biomarker and driver of dementia risk remains unclear. Across multiple cohorts, we demonstrated that plasma GDF15 is associated with greater dementia risk over 15- to 25-year follow-up periods when measured in midlife, with stronger associations… Continue reading Plasma GDF15 affects long-term dementia risk and alters neuroimmune signaling
Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea
Background: Prenatal exposure to particulate matter has been investigated as a potential environmental factor for autism spectrum disorder (ASD), but evidence remains heterogeneous, and nationwide data from non-Western populations are limited.Methods: We conducted a nationwide retrospective birth cohort study using the Big CHildren's ENvironmental health Study (Big-CHENS) database in South Korea, including 698,907 mother-father-child pairs… Continue reading Prenatal exposure to particulate matter and risk of autism spectrum disorder in children: a population-based cohort study in South Korea
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