#Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis

Neuroticism is linked to mood disorders and Alzheimer’s disease, but fewer studies have tested the prospective association with Parkinson’s disease (PD). ObjectivesTo examine the association between neuroticism and risk of PD in a large cohort and a meta‐analysis of prospective cohort studies. MethodsParticipants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006–2010. Incident PD was ascertained using electronic health records or … Continue reading #Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis

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Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study

To determine treatment effects on the incidence of post-stroke epilepsy (PSE) using different doses of statin, a prospective hospital-based cohort study was designed to explore whether a double-dose statin treatment can better prevent the occurrence of PSE. Methods :A total of 1152 patients with newly diagnosed ischemic stroke admitted to our hospital from March to August 2017 were selected, 1033 of whom were followed-up. Patients … Continue reading Effects of double-dose #statin therapy for the prevention of post- #stroke #epilepsy: A prospective clinical study

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The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial

It is currently unknown whether exergaming is efficacious in people with major neurocognitive disorder (MNCD) residing in long-term care facilities. This pilot randomized controlled trial (RCT) explored the efficacy of a stepping exergame program on gait speed, balance, mobility, reaction time, cognitive and neuropsychiatric outcomes, quality of life, and daily life functioning in people with MNCD residing in long-term care facilities. Methods Participants were randomly … Continue reading The efficacy of #exergaming in people with major #neurocognitive disorder residing in long-term care facilities: a pilot randomized controlled trial

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Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage

To determine whether obstructive sleep apnea (OSA) is associated with intracerebral hemorrhage (ICH) risk, we assessed premorbid OSA exposure of patients with nontraumatic ICH and matched controls. Methods: Ethnic/Racial Variations of Intracerebral Hemorrhage is a multicenter, case-control study evaluating risk factors for ICH that recruited 3000 cases with ICH and 3000 controls. OSA status was ascertained using the Berlin Questionnaire as a surrogate for premorbid … Continue reading Obstructive Sleep #Apnea as a Risk Factor for Intracerebral #Hemorrhage

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#Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review

This review aimed to summarize the evidence on the risk of thromboembolism associated with carotid and aortic atherosclerosis in patients with AF, and the potential impact of their inclusion in current stroke risk stratification scores. Methods MEDLINE, Web of Science and EMBASE were systematically searched to identify all published studies providing relevant data through 28 February 2021. Results We identified 10 eligible studies. There was … Continue reading #Stroke risk associated with carotid and aortic #atherosclerosis in patients with atrial #fibrillation: A systematic review

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Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition

The purpose of this study was to clarify the association between self‐reported night sleep duration and cognitive functions such as word memory, story memory, attention, executive function, and processing speed of older adults with normal global cognitive function. Methods A total of 241 functionally independent older adults (mean age, 75.5 ± 6.4 years) participated in this study. No participants had a history of dementia diagnosis, … Continue reading Association between self‐reported night #sleep duration and #cognitive function among older adults with intact global cognition

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Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial

Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older medical patients. Methods This study was a randomized double-blind controlled … Continue reading Efficacy of #quetiapine for #delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial

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Association of Type 2 #Diabetes Mellitus and Glycemic Control With Intracranial Plaque Characteristics in Patients With Acute Ischemic #Stroke

Type 2 diabetes mellitus (T2DM) has shown to be associated with carotid plaque vulnerability. However, the impact of T2DM on intracranial artery atherosclerosis is not well‐understood. Purpose To evaluate the association of diabetes and glycemic control with intracranial atherosclerotic plaque characteristics identified by three‐dimensional contrast enhanced MR vessel wall imaging in patients after acute ischemic stroke. Study Type Prospective. Population Two hundred and eighty‐eight symptomatic … Continue reading Association of Type 2 #Diabetes Mellitus and Glycemic Control With Intracranial Plaque Characteristics in Patients With Acute Ischemic #Stroke

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Lamictal (#lamotrigine): Drug Safety Communication – Studies Show Increased Risk of #Heart Rhythm Problems in Patients with Heart Disease

Lamotrigine is used alone or with other medicines to treat seizures in patients 2 years and older. It may also be used as maintenance treatment in patients with the mental health condition bipolar disorder to help delay the occurrence of mood episodes such as depression, mania, or hypomania. RECOMMENDATIONS: Patients should not stop taking your medicine without first talking to your prescriber because stopping lamotrigine … Continue reading Lamictal (#lamotrigine): Drug Safety Communication – Studies Show Increased Risk of #Heart Rhythm Problems in Patients with Heart Disease

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Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies

Observational studies have linked cannabis use to an array of negative outcomes, including psychiatric symptoms, cognitive impairment, and educational and occupational underachievement. These associations are particularly strong when cannabis use occurs in adolescence. Nevertheless, causality remains unclear. The purpose of the present study was thus to examine associations between prospectively assessed adolescent cannabis use and young-adult outcomes (psychiatric, cognitive, and socioeconomic) in three longitudinal studies … Continue reading Associations between adolescent #cannabis use and young-adult functioning in three longitudinal twin studies

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#Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants

Worldwide, the prevalence of dementia is increasing and diet as a modifiable factor could play a role. Meat consumption has been cross-sectionally associated with dementia risk, but specific amounts and types related to risk of incident dementia remain poorly understood. Objective We aimed to investigate associations between meat consumption and risk of incident dementia in the UK Biobank cohort. Methods Meat consumption was estimated using … Continue reading #Meat consumption and risk of incident #dementia: cohort study of 493,888 UK Biobank participants

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Post-reversible cerebral vasoconstriction syndrome #headache

Chronic headache may persist after the remission of reversible cerebral vasoconstriction syndrome (RCVS) in some patients. We aimed to investigate the prevalence, characteristics, risk factors, and the impact of post-RCVS headache. Methods We prospectively recruited patients with RCVS and collected their baseline demographics, including psychological distress measured by Hospital Anxiety and Depression scale. We evaluated whether the patients developed post-RCVS headache 3 months after RCVS … Continue reading Post-reversible cerebral vasoconstriction syndrome #headache

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