Introduction: The #amyloid cascade hypothesis provided a compelling rationale for #Alzheimer's disease (AD) drug development, but many amyloid-β (Aβ)-targeted agents failed to show benefit. The present review article evaluated emerging Aβ-directed therapies, focusing on mechanisms, clinical efficacy, safety, and regulatory progress.Areas covered: The recent approvals of lecanemab and donanemab offered the first convincing evidence that… Continue reading Evaluating emerging amyloid-β centric drugs for the treatment of Alzheimer’s disease
Category: Neurology
Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients
Background: This study aimed to evaluate the prognostic significance of the C-reactive protein to albumin ratio (CAR) in predicting in-hospital #mortality among patients presenting with acute #stroke.Method: A total of 483 adult patients (≥ 18 years) consecutively hospitalized for stroke over a one-year period (July 2022 - July 2023) were analyzed retrospectively. Exclusion criteria include… Continue reading Prognostic value of C-reactive protein to albumin ratio for in-hospital mortality in acute stroke patients
Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis
Emerging evidence suggests a role for the gut bacteria in the pathogenesis of multiple sclerosis (#MS ); however, the role of other microorganisms and their diagnostic potential for MS remain poorly explored. Here, we analyzed large-scale metagenomic data derived from fecal samples (discovery cohort n = 1152; total n = 1306 across 3 geographically diverse… Continue reading Multikingdom microbiome-based machine learning enables multiple sclerosis diagnosis
Reversible alterations of brain acetate metabolism associated with alcohol consumption
#Alcohol consumption elevates circulating acetate. Prior studies showed that acute alcohol reduces brain glucose uptake and increases #brain acetate oxidation. Previously we showed that heavy drinkers have elevated capacity to oxidize brain acetate. Here we repeat the study, adding individuals with alcohol use disorder (AUD). Four groups were enrolled. The analysis data set included Light… Continue reading Reversible alterations of brain acetate metabolism associated with alcohol consumption
Pilot evaluation of a dance-based physical activity program for adults with Down syndrome
Introduction: Adults with #Down syndrome (DS) face barriers to traditional exercise modalities due in part to a lack of interest or enjoyment, desire for social connectedness during exercise, and difficulty completing traditional exercise movements because of physical limitations. Dance provides a potential alternative to conventional exercise and may address some of these barriers. The purpose… Continue reading Pilot evaluation of a dance-based physical activity program for adults with Down syndrome
Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Background: Acute myocardial infarction (#MI ) is associated with subsequent #cognitive decline. Whether the detection of prior MI using routine ECG and self-reported history can identify different trajectories of cognitive decline is uncertain. We sought to determine the association between prior MI and longitudinal cognitive assessments within a national, biracial cohort study.Methods: We included participants… Continue reading Prior Myocardial Infarction and Cognitive Decline: The REGARDS Cohort
Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
,BackgroundLower childhood #socioeconomic status (cSES) has been linked to a higher risk of #Alzheimer's disease and related #dementia (ADRD). Yet, the mechanisms underlying this association remain unclear.ObjectiveThis study examined whether poorer health behaviors in adulthood mediate the association between lower cSES and ADRD risk. We further explored whether the mediating effects of health behaviors vary… Continue reading Health behavior mechanisms linking childhood socioeconomic status to Alzheimer’s disease and related dementia risk: Exploring gender and racial/ethnic differences
Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Aims: Although pregabalin is a first-line therapy for painful #diabetic #polyneuropathy (PDPN), its optimal dose-response relationship remains unclear. We conducted a network meta-analysis to evaluate the efficacy and safety of fixed pregabalin dosages in PDPN patients.Materials and methods: We systematically searched major databases through October 2025 comparing various doses of pregabalin (75, 150, 300, and… Continue reading Optimising the Therapeutic Window: A Systematic Review and Network Meta-Analysis of Pregabalin Dosing Strategies for Painful Diabetic Neuropathy
Clinical effect of acupuncture on dysphagia following traumatic brain injury based on fiberoptic endoscopic evaluation of swallowing
Objectives: To investigate the clinical therapeutic effect on #dysphagia following traumatic #brain injury (TBI) treated with acupuncture using fiberoptic endoscopic evaluation of swallowing (FEES).Methods: A total of 68 patients with dysphagia following TBI were enrolled and randomly divided into a control group and an acupuncture group, with 34 patients in each group. In the control… Continue reading Clinical effect of acupuncture on dysphagia following traumatic brain injury based on fiberoptic endoscopic evaluation of swallowing
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