Association of Daily Step Count and Intensity With Incident Dementia in 78 430 Adults Living in the UK

Key Points
Question  Is there a dose-response association of daily step count and intensity with incidence of all-cause dementia among adults living in the UK?
Findings  This cohort study of adults assessed with wrist-worn accelerometers found that accruing more steps per day was associated with steady declines in dementia incidence risk, up to 9800 steps per day, beyond which the benefits upturned. The dose associated with 50% of maximal observed benefit was 3800 steps per day, and steps at higher intensity (cadence) were associated with lower incidence risk.
Meaning  The findings in this study suggest that accumulating more steps per day just under the popular threshold of 10 000 steps per day and performing steps at higher intensity may be associated with lower risk of dementia onset.