Multimorbidity in #asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA2LEN study

..Subjects with asthma, rhinitis and eczema were more likely to be sensitised to seasonal allergens (67 vs 32%, p<0.001), food allergens (54 vs. 18%, p<0.001) and to have a higher degree of sensitisation than subjects with only asthma (23 vs 10%, p<0.001). Subjects with allergic multimorbidity more often had allergic reactions to food (28 vs 10%, p=0.002), more respiratory symptoms and anxiety/depression (40% vs, 14%, p<0.001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers.

Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48 vs. 27%, p=0.016) and to have maternal heredity for allergy (53 vs. 33%, p=0.011) than subjects with only asthma.

Conclusion and clinical relevance
Asthmatics with allergic multimorbidity are more likely to be sensitised to seasonal aeroallergens, food allergens and they have a higher degree of sensitisation compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and/or depression.

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