..Subjects with asthma, rhinitis and eczema were more likely to be sensitised to seasonal allergens (67 vs 32%, p<0.001), food allergens (54 vs. 18%, p<0.001) and to have a higher degree of sensitisation than subjects with only asthma (23 vs 10%, p<0.001). Subjects with allergic multimorbidity more often had allergic reactions to food (28 vs 10%, p=0.002), more respiratory symptoms and anxiety/depression (40% vs, 14%, p<0.001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers.
Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48 vs. 27%, p=0.016) and to have maternal heredity for allergy (53 vs. 33%, p=0.011) than subjects with only asthma.
Conclusion and clinical relevance
Asthmatics with allergic multimorbidity are more likely to be sensitised to seasonal aeroallergens, food allergens and they have a higher degree of sensitisation compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and/or depression.