..The study reviewed coffee intake information and relevant data for 296,227 participants in the UK Biobank. The mean age of participants was 56.69 ± 7.98 and 51.6 percent of participants were female. Investigators used multivariate Cox proportional hazards regression analysis to test the association between coffee consumption and arrhythmia risk and plotted a Kaplan- Meier curve for cumulative incidence of arrhythmia by coffee intake.
The results demonstrated an association between regular coffee consumption and a significantly lower risk of arrhythmias. Over 5.25 ± 21 years, there were 13,138 incident arrhythmias diagnosed, including 4,748 patients with atrial fibrillation or atrial flutter, 798 supraventricular tachycardia, 386 ventricular tachycardia and 308 premature ventricular complex. Compared with no consumption, coffee consumption of 1-2, 3-4, or 5 or greater cups a day was associated with a significantly lower risk of arrhythmia (HR 0.90, p<0.0001; HR 0.86, p<0.0001; HR 0.85 p=0.0005; HR 0.88, P=0.05, respectively). Each additional daily cup of coffee was associated with three percent lower incidence of arrhythmia..