Association of Ambient and Household Air #Pollution With #Bone Mineral Content Among Adults in Peri-urban South India

..The annual mean (SD) PM2.5 exposure was 32.8 (2.5) μg/m3, and the annual mean (SD) BC exposure was 2.5 (0.2) μg/m3; 57.8% of participants used biomass cooking fuels. In fully adjusted models, PM2.5 was associated with lower BMC in the spine (mean difference, −0.57 g per 3 μg/m3 increase in PM2.5; 95% CI, −1.06 to −0.07 g per 3 μg/m3 increase in PM2.5) and hip (mean difference, −0.13 g per 3 μg/m3 increase in PM2.5; 95% CI, −0.3 to 0.03 g per 3 μg/m3 increase in PM2.5). After confounder adjustment, exposure to PM2.5 was also associated with lower bone mineral density in the spine (mean difference, −0.011 g/cm2 per 3 μg/m3 increase in PM2.5; 95% CI, −0.021 to 0 g/cm2 per 3 μg/m3 increase in PM2.5) and hip (mean difference, −0.004 g/cm2 per 3 μg/m3 increase in PM2.5; 95% CI, −0.008 to 0.001 g/cm2 per 3 μg/m3 increase in PM2.5).

Exposure to BC was associated with lower BMC in the spine (mean difference, −1.13 g per 1 μg/m3 increase in BC; 95% CI, −2.81 to 0.54 g per 1 μg/m3 increase in BC) and hip (mean difference, −0.35 g per 1 μg/m3 increase in BC; 95% CI, −0.96 to 0.25 g per 1 μg/m3 increase in BC), although the confidence intervals were wider. There was no association between biomass fuel use and spine BMC (mean difference, 0.12 g; 95% CI, −0.45 to 0.68 g).

Conclusions and Relevance In a cross-sectional analysis of a population-based cohort, ambient air pollution was associated with lower BMC in a young adult population in a peri-urban area of South India

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