Risks associated with fatigue that accumulates during work shifts have historically been managed through working time arrangements that specify fixed maximum durations of work shifts and minimum durations of time off. By themselves, such arrangements are not sufficient to curb risks to performance, safety, and health caused by misalignment between work schedules and the biological … Continue reading Guiding principles for determining work #shift duration and addressing the effects of work shift duration on performance, safety, and health: guidance from the American Academy of #Sleep Medicine and the Sleep Research Society
Category: Environment
Humans refer to their mood state regularly in day-to-day as well as clinical interactions. Theoretical accounts suggest that when reporting on our mood we integrate over the history of our experiences; yet, the temporal structure of this integration remains unexamined. Here, we use a computational approach to quantitatively answer this question and show that early … Continue reading The temporal representation of #experience in subjective #mood
Many decisions under uncertainty entail the temporal accumulation of evidence that informs about the state of the environment. When environments are subject to hidden changes in their state, maximizing accuracy and reward requires non-linear accumulation of evidence. How this adaptive, non-linear computation is realized in the brain is unknown. We analyzed human behavior and cortical … Continue reading Adaptive circuit dynamics across human #cortex during evidence accumulation in changing #environments
Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty:We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection. Data … Continue reading #Ivermectin for Prevention and Treatment of #COVID-19 InfectionA Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines
