#Depression and subsequent risk for incident rheumatoid #arthritis among women

We investigated the association of depression with subsequent risk of rheumatoid arthritis (RA) by serologic phenotype.. ..Among 195,358 women, we identified 858 incident RA cases (65% seropositive) over 3,087,556 person‐years (median 17.9 years/participant). Compared to women without depression, those with depression had multivariable HRs (95%CIs) of: 1.28(1.10‐1.48) for all RA; 1.12(0.93‐1.35) for seropositive RA; and 1.63(1.27‐2.09) for seronegative RA. When analyzing components of the composite … Continue reading #Depression and subsequent risk for incident rheumatoid #arthritis among women

Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis

To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.. ..2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion–synovitis volume on magnetic resonance imaging … Continue reading Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis

Warmth Prevents #Bone Loss Through the Gut #Microbiota

Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth … Continue reading Warmth Prevents #Bone Loss Through the Gut #Microbiota

Effectiveness of a high volume injection as treatment for chronic #Achilles #tendinopathy: randomised controlled trial

.. Primary outcome was pain and function assessed using the validated Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire at 24 weeks (analysed using a generalised estimation equations model). Secondary outcomes were patient satisfaction, return to sport, degree of ultrasonographic Doppler flow, visual analogue scale on 10 hop test, power and flexibility of the gastrocnemius and soleus muscles, pain detect questionnaire for neuropathic pain, and pain … Continue reading Effectiveness of a high volume injection as treatment for chronic #Achilles #tendinopathy: randomised controlled trial

The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer … Continue reading The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis

Atypical Femur #Fracture Risk versus Fragility Fracture Prevention with #Bisphosphonates

Bisphosphonates are effective in reducing hip and osteoporotic fractures. However, concerns about atypical femur fractures have contributed to substantially decreased bisphosphonate use, and the incidence of hip fractures may be increasing. Important uncertainties remain regarding the association between atypical femur fractures and bisphosphonates and other risk factors.. ..Among 196,129 women, 277 atypical femur fractures occurred. After multivariable adjustment, the risk of atypical fracture increased with … Continue reading Atypical Femur #Fracture Risk versus Fragility Fracture Prevention with #Bisphosphonates

Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis

Musculoskeletal pain is a common cause of pain in adolescence and can be an important predictor of future pain. The prevalence of hip or groin pain that could potentially affect different adolescent populations has not yet been systematically reviewed. This systematic review aimed to determine the prevalence of hip or groin pain in this population. Five electronic databases were searched until January 2019 for eligible … Continue reading Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis

New Therapy Reduces Chronic Low Back Pain in Large International Study

A new study hasfound that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain, one of the leading reasons why people seek medical care and the number one cause of disability worldwide. “This demonstration of efficacy is a major breakthrough in the global search to develop non-opioid treatments for chronic pain,” said John Markman, M.D., director of … Continue reading New Therapy Reduces Chronic Low Back Pain in Large International Study

#Obesity Progression between Young Adulthood and Midlife and Incident #Arthritis: A Retrospective Cohort Study of US Adults

..Among our sample of adults who were 40‐69 years old at their midlife weight measure (n=13,669), 3,603 developed an arthritis condition. Compared with adults who maintained a normal‐normal BMI, the normal‐overweight, normal‐obese, overweight‐obese, and obese‐obese groups had significantly elevated risk of incident arthritis conditions. The obese‐overweight group had lower risk of incident arthritis conditions compared with the obese‐obese group and comparable risk to the overweight‐overweight … Continue reading #Obesity Progression between Young Adulthood and Midlife and Incident #Arthritis: A Retrospective Cohort Study of US Adults

Comparison between clinical and ultrasound assessment of the ankle region in juvenile idiopathic #arthritis

To compare frequency of joint and tendon disease on ultrasound (US) and clinical examination (CE), and to investigate agreement between US and CE in ankles with clinically active juvenile idiopathic arthritis (JIA).. ..A total of 163 joints in 89 ankles had active synovitis on US. The tibiotalar joint (TTJ) was the most commonly affected joint on US and on CE. The intertarsal‐joint (ITJ) and the … Continue reading Comparison between clinical and ultrasound assessment of the ankle region in juvenile idiopathic #arthritis

Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies

..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis according to the symptomatic or radiological OA also found no … Continue reading Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies

Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee

..We enrolled 156 patients with a mean age of 56 years; 78 patients were assigned to each group. Baseline characteristics, including severity of pain and level of disability, were similar in the two groups. The mean (±SD) baseline WOMAC scores were 108.8±47.1 in the glucocorticoid injection group and 107.1±42.4 in the physical therapy group. At 1 year, the mean scores were 55.8±53.8 and 37.0±30.7, respectively … Continue reading Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee