Sex- and age-specific genetic analysis of chronic back #pain

Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity, and poorer response to treatment. Genetic factors acting in an age-specific manner have been implicated but never comprehensively explored. We performed sex- and age-stratified genome-wide association study and single nucleotide polymorphism-by-sex interaction analysis for cBP defined as “Back pain for 3+ months” in 202,077 males and 237,754 females … Continue reading Sex- and age-specific genetic analysis of chronic back #pain

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Utility of bedside leucocyte esterase testing to rule out septic #arthritis

Suspected septic arthritis is a common presentation to EDs. The underlying diagnosis is often non-infective pathology. Differentiating between aetiologies is difficult. A bedside test with high negative predictive value (NPV) may allow safe discharge of patients, reduce the time in the ED, hospital admission and associated costs. This study aims to evaluate the NPV of bedside leucocyte esterase (LE) in the assessment of these patients. … Continue reading Utility of bedside leucocyte esterase testing to rule out septic #arthritis

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The Value of Total #Knee Replacement in Patients With Knee #Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater A Cost-Effectiveness Analysis

Total knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of 40 kg/m2 or greater has raised concerns about the value of TKR in this population. Objective: To assess the value of TKR in recipients with a BMI of 40 kg/m2 or greater using a cost-effectiveness analysis. … Continue reading The Value of Total #Knee Replacement in Patients With Knee #Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater A Cost-Effectiveness Analysis

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Effect of #Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low #Back Pain A Randomized Clinical Trial

Osteopathic manipulative treatment (OMT) is frequently offered to people with nonspecific low back pain (LBP) but never compared with sham OMT for reducing LBP-specific activity limitations. Objective To compare the efficacy of standard OMT vs sham OMT for reducing LBP-specific activity limitations at 3 months in persons with nonspecific subacute or chronic LBP. Design, Setting, and Participants This prospective, parallel-group, single-blind, single-center, sham-controlled randomized clinical … Continue reading Effect of #Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low #Back Pain A Randomized Clinical Trial

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Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

To investigate if the combination of biologics with methotrexate (MTX) would have better performance than biological monotherapy in clinical efficiency and safety for the treatment of psoriasis and psoriatic arthritis (PsA). Methods. A systematic review of randomized controlled trials (RCTs) searched from the Pubmed, Cochrane Library, and Embase was conducted. Psoriasis Area and Severity Index (PASI) responses (including PASI50,75 and 90), and proportion of patients … Continue reading Are biologics combined with methotrexate better than biologics monotherapy in #psoriasis and psoriatic #arthritis: a meta‐analysis of randomized controlled trials

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#Height Loss in Old Age and #Fracture Risk Among Men in Late Life: A Prospective Cohort Study

To assess the association of height loss in old age with subsequent risk of hip and any clinical fracture in men late in life while accounting for the competing risk of mortality, we used data from 3,491 community‐dwelling men (mean age 79.2 years). Height loss between baseline and follow‐up (mean 7.0 years between examinations) was categorized as <1 cm (referent group), ≥1 to <2 cm, … Continue reading #Height Loss in Old Age and #Fracture Risk Among Men in Late Life: A Prospective Cohort Study

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Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain

Scalable delivery models of cognitive behavioral therapy for insomnia (CBT-I), an effective treatment, are needed for widespread implementation, particularly in rural and underserved populations lacking ready access to insomnia treatment. Objective To evaluate the effectiveness of telephone CBT-I vs education-only control (EOC) in older adults with moderate to severe osteoarthritis pain. Design, Setting, and Participants This is a randomized clinical trial of 327 participants 60 … Continue reading Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain

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Effect of High-Intensity Strength #Training on #Knee Pain and Knee Joint Compressive Forces Among Adults With Knee #Osteoarthritis

Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms. Objective To determine whether high-intensity strength training reduces knee pain and knee joint compressive forces more than low-intensity strength training and more than attention control in patients with knee osteoarthritis. Design, … Continue reading Effect of High-Intensity Strength #Training on #Knee Pain and Knee Joint Compressive Forces Among Adults With Knee #Osteoarthritis

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Finger Joint #Cartilage Evaluated by Semiquantitative #Ultrasound Score in Patients With #Rheumatoid Arthritis

Joint destruction in rheumatoid arthritis (RA) includes both bone and cartilage lesions. Since joint space narrowing (JSN) is not a direct evaluation of cartilage using radiography, we aimed to examine the validity of ultrasound (US) cartilage evaluation using a semiquantitative method in patients with RA. Methods We enrolled 103 patients with RA who were in remission or showing low disease activity and 42 healthy subjects. … Continue reading Finger Joint #Cartilage Evaluated by Semiquantitative #Ultrasound Score in Patients With #Rheumatoid Arthritis

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Association between current medication use and progression of radiographic #knee #osteoarthritis: data from the Osteoarthritis Initiative

Use of specific medications may accelerate the progression of radiographic knee osteoarthritis (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA. Methods We used longitudinal data from the Osteoarthritis Initiative (OAI); an observational study of risk factors for knee OA. At baseline, we selected participants with RKOA (KL grade ≥2) and excluded those with a history of knee-related … Continue reading Association between current medication use and progression of radiographic #knee #osteoarthritis: data from the Osteoarthritis Initiative

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Association of Potent and Very Potent Topical #Corticosteroids and the Risk of #Osteoporosis and Major Osteoporotic Fractures

Systemic and inhaled corticosteroids negatively affect bone remodeling and cause osteoporosis and bone fracture when given continuously or in high doses. However, risk of osteoporosis and major osteoporotic fracture (MOF) after application of topical corticosteroids (TCSs) is largely unexplored.. ..A total of 723 251 adults treated with the equivalent of at least 200 g of mometasone were included in the analysis (52.8% women; mean [SD] age, … Continue reading Association of Potent and Very Potent Topical #Corticosteroids and the Risk of #Osteoporosis and Major Osteoporotic Fractures

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Efficacy and safety of #antidepressants for the treatment of back pain and #osteoarthritis: systematic review and meta-analysis

.. 33 trials (5318 participants) were included. Moderate certainty evidence showed that serotonin-noradrenaline reuptake inhibitors (SNRIs) reduced back pain (mean difference −5.30, 95% confidence interval −7.31 to −3.30) at 3-13 weeks and low certainty evidence that SNRIs reduced osteoarthritis pain (−9.72, −12.75 to −6.69) at 3-13 weeks. Very low certainty evidence showed that SNRIs reduced sciatica at two weeks or less (−18.60, −31.87 to −5.33) … Continue reading Efficacy and safety of #antidepressants for the treatment of back pain and #osteoarthritis: systematic review and meta-analysis

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