Metformin use and associated risk of total joint replacement in patients with type 2 diabetes: a population-based matched cohort study

Background: It is uncertain whether metformin use is associated with reduced risk of joint replacement in patients with type 2 diabetes mellitus. We aimed to establish whether metformin use was associated with a reduced risk of total knee replacement (TKR) or total hip replacement (THR) among these patients.Methods: We selected patients with type 2 diabetes mellitus that …

Continue reading Metformin use and associated risk of total joint replacement in patients with type 2 diabetes: a population-based matched cohort study

Simvastatin therapy in higher dosages deteriorates bone quality: Consistent evidence from population-wide patient data and interventional mouse studies

BackgroundCombining mouse experiments with big data analysis of the Austrian population, we investigated the association between high-dose statin treatment and bone quality.MethodsThe bone microarchitecture of the femur and vertebral body L4 was measured in male and ovariectomized female mice on a high-fat diet containing simvastatin (1.2 g/kg). A sex-specific matched big data analysis of Austrian health …

Continue reading Simvastatin therapy in higher dosages deteriorates bone quality: Consistent evidence from population-wide patient data and interventional mouse studies

Internal medicine physician embedded in an orthopedic service in a level 1 hospital: clinical impact

AbstractBackground: The aim of our study was to evaluate the impact of an internist physician specialized in diabetes, appointed as an in-house physician in the orthopedic wards, on improving clinical outcomes and in particular 30-day mortality. Methods: We analyzed a cohort of patients hospitalized more than 24 h in the orthopedic service. The analyses included a comparative …

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RORβ modulates a gene program that is protective against articular cartilage damage

Osteoarthritis (OA) is the most prevalent chronic joint disease which increases in frequency with age eventually impacting most people over the age of 65. OA is the leading cause of disability and impaired mobility, yet the pathogenesis of OA remains unclear. Treatments have focused mainly on pain relief and reducing joint swelling. Currently there are …

Continue reading RORβ modulates a gene program that is protective against articular cartilage damage

The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials

The effect of calcium supplementation on bone mineral accretion in people under 35 years old is inconclusive. To comprehensively summarize the evidence for the effect of calcium supplementation on bone mineral accretion in young populations (≤35 years).Methods:This is a systematic review and meta-analysis. The Pubmed, Embase, ProQuest, CENTRAL, WHO Global Index Medicus, Clinical Trials.gov, WHO …

Continue reading The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials