Purpose: To determine the benefit of a behaviorally-designed incentive program and corticosteroid injections in reducing symptoms and promoting physical activity in patients with knee #osteoarthritis (KOA).Methods: This was a pragmatic, multi-site, factorially-designed, blinded, randomized clinical trial. Participants with a clinical diagnosis of KOA and an indication for joint injection (age 40-85 years; Kellgren-Lawrence X-ray grade… Continue reading Behavioral Incentives for Exercise and Intra-Articular Corticosteroids for Knee Osteoarthritis: Results from a Factorially Designed Pragmatic Randomized Clinical Trial
Category: Orthopedy
Electroacupuncture alleviates acute gouty arthritis by inhibiting NLRP3 inflammasome activation via modulation of the circadian-inflammation axis
Electroacupuncture (#EA ) has shown anti-inflammatory potential in #gouty #arthritis (GA). This study aimed to investigate its therapeutic effects and underlying mechanisms. Core acupoints (ST36 and SP6) were identified through data-mining. In MSU-induced GA rats, EA significantly alleviated joint swelling, improved gait, reduced serum TNF-α, IL-6 and IL-1β, and suppressed synovial inflammatory infiltration. Mechanistically, EA… Continue reading Electroacupuncture alleviates acute gouty arthritis by inhibiting NLRP3 inflammasome activation via modulation of the circadian-inflammation axis
Efficacy of electroacupuncture for pain relief in patients with osteonecrosis of the femoral head: protocol for a randomised, triple-blind, sham-controlled trial
Introduction #Osteonecrosis of the femoral head (ONFH) is a progressive and disabling condition, with pain being its predominant symptom. #Electroacupuncture (EA) has shown promise in the management of chronic pain; however, high-quality evidence on its efficacy and safety in ONFH is still lacking. The aim of this trial is to evaluate the efficacy and safety… Continue reading Efficacy of electroacupuncture for pain relief in patients with osteonecrosis of the femoral head: protocol for a randomised, triple-blind, sham-controlled trial
Pro-inflammatory dietary patterns are associated with increased pain and functional disability in sciatica: a hospital-based cross-sectional study
Background: #Sciatica is a common neuropathic pain condition associated with substantial functional disability. Emerging evidence suggests that #diet -induced inflammation may play a role in chronic pain development. However, the association between dietary inflammatory potential and clinical outcomes in sciatica remains unclear.Methods: In this cross-sectional study, we enrolled 598 patients diagnosed with sciatica from two… Continue reading Pro-inflammatory dietary patterns are associated with increased pain and functional disability in sciatica: a hospital-based cross-sectional study
Effects of Acupuncture on Time-Dependent Muscle Endurance in Men with Post-Anterior Cruciate Ligament Injury: A Randomized Controlled Crossover Trial
To investigate whether acupuncture enhances knee joint muscle endurance effectiveness and time-dependent effects after anterior cruciate ligament ( #ACL ) injuries.Methods:This randomized, single-blinded crossover trial included 20 males with ACL injuries. Participants were randomly divided into real acupuncture (RA) group and sham acupuncture (SA) group. RA was stimulated at ST32, ST34, ST36, SP10, and BL57;… Continue reading Effects of Acupuncture on Time-Dependent Muscle Endurance in Men with Post-Anterior Cruciate Ligament Injury: A Randomized Controlled Crossover Trial
Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
BackgroundAromatase inhibitor-induced arthralgia (AIA) is a frequent adverse effect of endocrine therapy in breast cancer survivors, often leading to treatment modification or discontinuation. Non-pharmacological interventions have been proposed to manage AIA, but evidence remains fragmented.ObjectiveTo synthesize recent randomized controlled trials (RCTs) evaluating the efficacy of non-pharmacological interventions for AIA.MethodsA systematic search of PubMed, Scopus, and… Continue reading Effectiveness of Non-Pharmacological Interventions for Hormone Therapy-Induced #Hand #Arthralgia in Breast Cancer Patients: A Systematic Review
Pain management in the perioperative orthogeriatric setting: Recommendations of the special interest group Orthogeriatrics of the German Geriatrics Society
Management of perioperative pain in older adults can be challenging. Multimorbidity, functional decline or diminished physiological reserves, the corresponding polypharmacy, age-related pharmacodynamic and pharmacokinetic changes need to be considered. #Pain assessment can be complicated by cognitive impairment and communication barriers. Older adults are at high risk of adverse consequences from surgery and undertreated pain as… Continue reading Pain management in the perioperative orthogeriatric setting: Recommendations of the special interest group Orthogeriatrics of the German Geriatrics Society
Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Background: #Cefazolin , a first-generation #cephalosporin , is the standard antibiotic for perioperative prophylaxis in patients undergoing hip or knee arthroplasty. Research has demonstrated significantly higher periprosthetic joint infection ( #PJI ) rates when non-cefazolin antibiotics are used for prophylaxis. Notably, cefazolin contains an R1 side chain that has not shown cross-reactivity with other cephalosporins.… Continue reading Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Purpose: Data on the reliability of point-of-care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) #D-dimer (DD), interleukin 6 (IL-6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL-6 and PCT in comparison… Continue reading Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
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