Coronavirus disease 2019 was for the first time reported in December 2019 in China, and has since spread throughout the world as a pandemic. In this point of view, we aim to discuss the occurrence of central nervous system symptomatology, and delirium, in patients suffering coronavirus disease 2019.
To date, most of the research done around this infectious disease caused by severe acute respiratory syndrome coronavirus 2 have focused on its general manifestations (fever, cough, fatigue, and/or shortness of breath) and the different aspects of its pathogenesis regarding the respiratory system. While less articles have focused on the neurocognitive alterations produced by severe acute respiratory syndrome coronavirus 2 infection, only a few have focused on delirium as severe acute respiratory syndrome coronavirus 2-infection-based central nervous system manifestation.
Nonetheless, emerging evidence shows that coronavirus disease 2019 could seriously affect the central nervous system. Since the current outbreak of coronavirus disease 2019 continues to constitute a public health emergency of international concern, here, we review the existing evidence on the mechanism of severe acute respiratory syndrome coronavirus 2 infection leading to central nervous system manifestations in general, delirium in particular, finally discussing the existing interaction between severe acute respiratory syndrome coronavirus 2 and Angiotensin-Converting Enzyme-2 receptors in the brain, a possible pathogenic process leading to the delirium symptomatology observed in some of the patients suffering the disease.