Potential Effects of #Coronaviruses on the #Cardiovascular System

Coronavirus disease 2019 can cause a viral pneumonia with additional extrapulmonary manifestations and complications. A large proportion of patients have underlying cardiovascular disease and/or cardiac risk factors. Factors associated with mortality include male sex, advanced age, and presence of comorbidities including hypertension, diabetes mellitus, cardiovascular diseases, and cerebrovascular diseases. Acute cardiac injury determined by elevated high-sensitivity troponin levels is commonly observed in severe cases and … Continue reading Potential Effects of #Coronaviruses on the #Cardiovascular System

EMA advises continued use of medicines for #hypertension, heart or #kidney disease during COVID-19 pandemic

EMA is aware of recent media reports and publications which question whether some medicines, for instance angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs, or sartan medicines), could worsen coronavirus disease (COVID-19). ACE inhibitors and ARBs are most commonly used for treating patients with high blood pressure, heart failure or kidney disease. It is important that patients do not interrupt their treatment with … Continue reading EMA advises continued use of medicines for #hypertension, heart or #kidney disease during COVID-19 pandemic

Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1

As the infection of 2019-nCoV #coronavirus is quickly developing into a global pneumonia epidemic, the careful analysis of its transmission and cellular mechanisms is sorely needed. In this Communication, we first analyzed two recent studies that concluded that snakes are the intermediate hosts of 2019-nCoV and that the 2019-nCoV spike protein insertions share a unique similarity to HIV-1. However, the reimplementation of the analyses, built … Continue reading Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1

AAO-HNS: #Anosmia, Hyposmia, and #Dysgeusia Symptoms of #Coronavirus Disease

Anecdotal evidence is rapidly accumulating from sites around the world that anosmia and dysgeusia are significant symptoms associated with the COVID-19 pandemic. Anosmia, in particular, has been seen in patients ultimately testing positive for the coronavirus with no other symptoms. We propose that these symptoms be added to the list of screening tools for possible COVID-19 infection. Anosmia, hyposmia, and dysgeusia in the absence of … Continue reading AAO-HNS: #Anosmia, Hyposmia, and #Dysgeusia Symptoms of #Coronavirus Disease

Factors Associated With #Mental Health Outcomes Among Health Care Workers Exposed to #Coronavirus Disease 2019

.. A total of 1257 of 1830 contacted individuals completed the survey, with a participation rate of 68.7%. A total of 813 (64.7%) were aged 26 to 40 years, and 964 (76.7%) were women. Of all participants, 764 (60.8%) were nurses, and 493 (39.2%) were physicians; 760 (60.5%) worked in hospitals in Wuhan, and 522 (41.5%) were frontline health care workers. A considerable proportion of … Continue reading Factors Associated With #Mental Health Outcomes Among Health Care Workers Exposed to #Coronavirus Disease 2019

The Effectiveness of Social #Distancing in Mitigating #COVID-19 Spread: a modelling analysis

..The application of all four social distancing interventions: school closure, workplace non-attendance, increased case isolation, and community contact reduction is highly effective in flattening the epidemic curve, reducing the maximum daily case numbers, and lengthening outbreak duration. These were also found to be effective even after 10 weeks delay from index case arrivals. The most effective single intervention was found to be increasing case isolation, … Continue reading The Effectiveness of Social #Distancing in Mitigating #COVID-19 Spread: a modelling analysis

A Person Can Carry And Transmit #COVID-19 Without Showing Symptoms, Scientists Confirm

Chinese researchers have confirmed a case of asymptomatic transmission of the new coronavirus: A 20-year-old woman from Wuhan passed it to five of her family members but never got physically sick herself.. ..A report from the Chinese Centre for Disease Control and Prevention analysed records of all of China’s reported cases of the virus from December 8 to February 11 and found that 1.2 percent … Continue reading A Person Can Carry And Transmit #COVID-19 Without Showing Symptoms, Scientists Confirm

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19

We report the kinetics of immune responses in relation to clinical and virological features of a patient with mild-to-moderate coronavirus disease 2019 (COVID-19) that required hospitalization. Increased antibody-secreting cells (ASCs), follicular helper T cells (TFH cells), activated CD4+ T cells and CD8+ T cells and immunoglobulin M (IgM) and IgG antibodies that bound the COVID-19-causing coronavirus SARS-CoV-2 were detected in blood before symptomatic recovery. These … Continue reading Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe #COVID-19

Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State

..A total of 21 cases were included (mean age, 70 years [range, 43-92 years]; 52% male). Comorbidities were identified in 18 cases (86%), with chronic kidney disease and congestive heart failure being the most common. Initial symptoms included shortness of breath (76%), fever (52%), and cough (48%) (Table 1). The mean onset of symptoms prior to presenting to the hospital was 3.5 days, and 17 … Continue reading Characteristics and Outcomes of 21 Critically Ill Patients With #COVID-19 in Washington State

A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19

..Treatment with lopinavir–ritonavir was not associated with a difference from standard care in the time to clinical improvement (hazard ratio for clinical improvement, 1.24; 95% confidence interval [CI], 0.90 to 1.72). Mortality at 28 days was similar in the lopinavir–ritonavir group and the standard-care group (19.2% vs. 25.0%; difference, −5.8 percentage points; 95% CI, −17.3 to 5.7). The percentages of patients with detectable viral RNA … Continue reading A Trial of #Lopinavir–#Ritonavir in Adults Hospitalized with Severe #Covid-19

Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1

..SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A). SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected … Continue reading Aerosol and Surface Stability of #SARS-CoV-2 as Compared with SARS-CoV-1