Exposure to microgravity (µG) during space flights produces a state of immunosuppression, leading to increased viral shedding, which could interfere with long term missions. However, the cellular mechanisms that underlie the immunosuppressive effects of µG are ill-defined. A deep understanding of human immune adaptations to µG is a necessary first step to design data-driven interventions … Continue reading Human #immune system adaptations to simulated #microgravity revealed by single-cell mass cytometry
Category: Infectivology
COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. ObjectiveTo elucidate the effect of calcifediol [25OHD3] treatment on COVID-19-related outcomes. DesignObservational cohort study from March to May, 2020. SettingPatients admitted to COVID-19 wards of … Continue reading #Calcifediol treatment and #COVID-19-related outcomes
Increased D-dimer levels have been shown to correlate with adverse outcomes in various clinical conditions. However, few studies with a large sample size have been performed thus far to evaluate the prognostic value of D-dimer in patients with infective endocarditis (IE). Methods613 patients with IE were included in the study and categorized into two groups … Continue reading Prognostic value of #D-dimer for adverse outcomes in patients with infective #endocarditis: an observational study
Nelfinavir (NFV) inhibits SARS-CoV-2 replication•Cepharanthine (CEP) inhibits SARS-CoV-2 attachment to target cells•Combination of NFV and CEP can synergistically augment antiviral activity•NFV and CEP are estimated to shorten the time to viral elimination at clinical doses SummaryAntiviral treatments targeting the coronavirus disease 2019 are urgently required. We screened a panel of already approved drugs in a … Continue reading Potential anti-COVID-19 agents, #cepharanthine and #nelfinavir, and their usage for combination treatment
