Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

The mainstay of control of the coronavirus disease 2019 (Covid-19) pandemic is vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a year, several vaccines have been developed and millions of doses delivered. Reporting of adverse events is a critical postmarketing activity. METHODS We report findings in 23 patients who presented with thrombosis and thrombocytopenia 6 to 24 days after receiving the first dose … Continue reading Pathologic Antibodies to #Platelet Factor 4 after ChAdOx1 #nCoV-19 #Vaccination

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Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

To the editors, The population with severe mental disorders (SMD) is a medically and socially vulnerable group for a worse outcome in COVID-19. This population has been identified as high-risk group for COVID-19 due to lower awareness of risk, higher prevalence of cognitive impairment and who have limitations to maintain adequate barriers against virus propagation such as living in long-term care facilities, and people with … Continue reading Lower risk of #SARS-CoV2 infection in individuals with severe #mental disorders on #antipsychotic treatment: A retrospective epidemiological study in a representative Spanish population

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Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis. Methods For this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled … Continue reading Vitamin #D supplementation to prevent acute respiratory #infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials

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Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis

Coronavirus disease 2019 (COVID-19) is associated with higher morbidity and mortality in patients on maintenance hemodialysis. Patients on dialysis tend to have a reduced immune response to infection or vaccination. We aimed to assess, for the first time to the best of our knowledge, the humoral response following vaccination with the BNT162b2 vaccine in patients on maintenance hemodialysis and the factors associated with it. Design, … Continue reading Humoral Response to the Pfizer BNT162b2 #Vaccine in Patients Undergoing Maintenance #Hemodialysis

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Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites

Probiotic milk-fermented microorganism mixtures (e.g., yogurt, kefir) are perceived as contributing to human health, and possibly capable of protecting against bacterial infections. Co-existence of probiotic microorganisms are likely maintained via complex biomolecular mechanisms, secreted metabolites mediating cell-cell communication, and other yet-unknown biochemical pathways. In particular, deciphering molecular mechanisms by which probiotic microorganisms inhibit proliferation of pathogenic bacteria would be highly important for understanding both the … Continue reading Cross-kingdom inhibition of bacterial virulence and communication by probiotic #yeast metabolites

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#COVID-19 Pandemic: A Wake-Up Call for Clean #Air

..Since its identification in Wuhan, China, coronavirus disease 2019 (COVID-19) has infected more than 104 million and killed over 2.2 million people worldwide (1). Recent studies of air pollution and COVID-19 cases and mortality in diverse international settings add convincingly to a large body of evidence showing that exposure to air pollution exacerbates viral respiratory infections and consequently widens health disparities. Meanwhile, the global lockdown … Continue reading #COVID-19 Pandemic: A Wake-Up Call for Clean #Air

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The #COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal #Antibodies for the Treatment of COVID-19

The COVID-19 Treatment Guidelines Panel (the Panel) recommends using one of the following combination anti-SARS-CoV-2 monoclonal antibodies to treat outpatients with mild to moderate COVID-19 who are at high risk of clinical progression, as defined by the Emergency Use Authorization (EUA) criteria (listed in alphabetical order): Bamlanivimab 700 mg plus etesevimab 1,400 mg (AIIa); or Casirivimab 1,200 mg plus imdevimab 1,200 mg (AIIa). Treatment should … Continue reading The #COVID-19 Treatment Guidelines Panel’s Statement on the Emergency Use Authorization of Anti-SARS-CoV-2 Monoclonal #Antibodies for the Treatment of COVID-19

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6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records

Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. Methods For this retrospective cohort study and time-to-event analysis, we used data … Continue reading 6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records

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Association of Vitamin #D Levels, Race/Ethnicity, and Clinical Characteristics With #COVID-19 Test Results

Deficient (ie, <20 ng/mL) or insufficient (ie, 20 to <30 ng/mL) 25-hydroxyvitamin D (also known as calcifediol) levels are more common in Black individuals than White individuals and are associated with increased coronavirus disease 2019 (COVID-19) risk. Whether COVID-19 risk is associated with differences in vitamin D levels of 30 ng/mL or greater is not known. Objective To examine whether COVID-19 test results are associated … Continue reading Association of Vitamin #D Levels, Race/Ethnicity, and Clinical Characteristics With #COVID-19 Test Results

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Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians

Antimicrobial overuse is a major health care issue that contributes to antibiotic resistance. Such overuse includes unnecessarily long durations of antibiotic therapy in patients with common bacterial infections, such as acute bronchitis with chronic obstructive pulmonary disease (COPD) exacerbation, community-acquired pneumonia (CAP), urinary tract infections (UTIs), and cellulitis. This article describes best practices for prescribing appropriate and short-duration antibiotic therapy for patients presenting with these … Continue reading Appropriate Use of Short-Course #Antibiotics in Common #Infections: Best Practice Advice From the American College of Physicians

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Online #Mindfulness May Target Psychological #Distress and Mental Health during #COVID-19

The COVID-19 pandemic has dramatically affected mental health, creating an urgent need for convenient and safe interventions to improve well-being. Online mindfulness interventions show promise for improving depression, anxiety, and general well-being. Objective To assess: 1) the impact of online mindfulness on psychological distress, 2) altruistic efforts, and 3) the quantity, quality, and availability of online mindfulness resources during the COVID-19 pandemic. Methods 233 participants … Continue reading Online #Mindfulness May Target Psychological #Distress and Mental Health during #COVID-19

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#Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With #Coronavirus Disease 2019

Coronavirus disease-2019 (COVID-19) is associated with hypercoagulability and increased thrombotic risk in critically ill patients. To our knowledge, no studies have evaluated whether aspirin use is associated with reduced risk of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality. METHODS: A retrospective, observational cohort study of adult patients admitted with COVID-19 to multiple hospitals in the United States between March 2020 and July … Continue reading #Aspirin Use Is Associated With Decreased Mechanical Ventilation, Intensive Care Unit Admission, and In-Hospital Mortality in Hospitalized Patients With #Coronavirus Disease 2019

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