Category: Infectivology

Endocrinology, Infectivology

EUGLYCEMIC DIABETIC #KETOACIDOSIS WITH #COVID-19 INFECTION IN PATIENTS WITH TYPE 2 DIABETES TAKING #SGLT2 INHIBITORS

Diabetes mellitus is associated with poor outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Diabetic ketoacidosis (DKA) has also been reported to occur with this virus. A cluster of cases of euglycemic DKA (euDKA) was identified in patients with type 2 diabetes mellitus using sodium-glucose cotransporter-2 inhibitors (SGLT2is) who developed SARS-CoV-2 infection.. ..Five cases of euDKA, presenting with glucose levels <300 mg/dL, were … Continue reading EUGLYCEMIC DIABETIC #KETOACIDOSIS WITH #COVID-19 INFECTION IN PATIENTS WITH TYPE 2 DIABETES TAKING #SGLT2 INHIBITORS

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Infectivology, Neurology, Psychiatry

6-month consequences of #COVID-19 in patients discharged from hospital: a cohort study

The long-term health consequences of COVID-19 remain largely unclear. The aim of this study was to describe the long-term health consequences of patients with COVID-19 who have been discharged from hospital and investigate the associated risk factors, in particular disease severity.. ..In total, 1733 of 2469 discharged patients with COVID-19 were enrolled after 736 were excluded. Patients had a median age of 57·0 (IQR 47·0–65·0) … Continue reading 6-month consequences of #COVID-19 in patients discharged from hospital: a cohort study

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Environment, Infectivology, Ophthalmology

Progression of #Myopia in School-Aged Children After #COVID-19 Home Confinement

Time spent in outdoor activities has decreased owing to home confinement for the coronavirus disease 2019 (COVID-19) pandemic. Concerns have been raised about whether home confinement may have worsened the burden of myopia owing to substantially decreased time spent outdoors and increased screen time at home.. .. Of the 123 535 children included in the study, 64 335 (52.1%) were boys. A total of 194 904 test results … Continue reading Progression of #Myopia in School-Aged Children After #COVID-19 Home Confinement

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Environment, Infectivology, Psychiatry

Evaluating the impact of a time orientation intervention on #well-being during the #COVID-19 lockdown: past, present or future?

Lockdown policies brought on by the COVID-19 pandemic pose a threat to well-being. This study examined the effectiveness of three positive psychology interventions, with different time-orientations, on well-being as well as predictors of well-being during lockdown. Participants (n= 216) completed measures of lockdown characteristics, attachment orientation, and emotion regulation, were then randomly allocated to one of four interventions; nostalgia (past), gratitude (present), best possible self … Continue reading Evaluating the impact of a time orientation intervention on #well-being during the #COVID-19 lockdown: past, present or future?

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Infectivology

Impact of Inappropriate #Antibiotic Therapy in Vancomycin-Resistant #Enterococcus Bacteremia

Vancomycin-resistant Enterococcus (VRE) bacteremia has significant morbidity and mortality. Empiric antibiotic regimens for treating patients with risk factors for multidrug-resistant organisms may not have medications directed at treating VRE.. ..The inpatient, 30-day, and 1-year mortality rates from VRE bacteremia were 23%, 31%, and 59%, respectively. Only 19% patients were discharged home. Inappropriate antibiotics were prescribed in 19% patients. Appropriate antibiotics were prescribed in 81% patients … Continue reading Impact of Inappropriate #Antibiotic Therapy in Vancomycin-Resistant #Enterococcus Bacteremia

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Infectivology

Early High-Titer #Plasma Therapy to Prevent Severe #Covid-19 in Older Adults

Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness. We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours … Continue reading Early High-Titer #Plasma Therapy to Prevent Severe #Covid-19 in Older Adults

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Diet, Infectivology

Low vitamin #D status is associated with #coronavirus disease 2019 outcomes: A systematic review and meta-analysis

Observational studies suggest that the risk and clinical prognosis of coronavirus disease 2019 (COVID-19) are related to low vitamin D status; however, the data are inconsistent.. ..A total of 10 articles with 361, 934 participants were selected for meta-analysis. Overall, the pooled OR in the fixed-effect model showed that vitamin D deficiency or insufficiency was associated with an increased risk of COVID-19 (OR = 1.43, 95% CI … Continue reading Low vitamin #D status is associated with #coronavirus disease 2019 outcomes: A systematic review and meta-analysis

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Infectivology

mRNA #Covid-19 #vaccines

The Advisory Committee on Immunization Practices (ACIP) has issued interim recommendations for the use of Pfizer-BioNTech and Moderna COVID-19 vaccines for the prevention of coronavirus disease 2019 (COVID-19) in the United States. Both vaccines are lipid nanoparticle-formulated, nucleoside-modified mRNA vaccines encoding the prefusion spike glycoprotein of SARS-CoV-2, the virus that causes COVID-19. These interim CDC clinical considerations are informed by data submitted to the Food … Continue reading mRNA #Covid-19 #vaccines

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Infectivology

#Baricitinib plus #Remdesivir for Hospitalized Adults with #Covid-19

Severe coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment with baricitinib, a Janus kinase inhibitor, plus remdesivir are not known. METHODS We conducted a double-blind, randomized, placebo-controlled trial evaluating baricitinib plus remdesivir in hospitalized adults with Covid-19. All the patients received remdesivir (≤10 days) and either baricitinib (≤14 days) or placebo (control). The primary outcome was the time to … Continue reading #Baricitinib plus #Remdesivir for Hospitalized Adults with #Covid-19

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Cardiology, Infectivology

Clinical Outcomes in Patients With Heart #Failure Hospitalized With #COVID-19

The purpose of this study was to evaluate in-hospital outcomes among patients with a history of heart failure (HF) hospitalized with coronavirus disease-2019 (COVID-19).. ..Among 1,212,153 patients with history of HF, 132,312 patients were hospitalized from April 1, 2020, to September 30, 2020. A total of 23,843 patients (18.0%) were hospitalized with acute HF, 8,383 patients (6.4%) were hospitalized with COVID-19, and 100,068 patients (75.6%) … Continue reading Clinical Outcomes in Patients With Heart #Failure Hospitalized With #COVID-19

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Infectivology

A Neutralizing Monoclonal #Antibody for Hospitalized Patients with Covid-19

LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Covid-19 METHODS In this platform trial of therapeutic agents, we randomly assigned hospitalized patients who had Covid-19 without end-organ failure … Continue reading A Neutralizing Monoclonal #Antibody for Hospitalized Patients with Covid-19

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Infectivology, Nephrology

Diagnosis-wide analysis of #COVID-19 complications: an exposure-crossover study

Many studies reporting coronavirus disease 2019 (COVID-19) complications have involved case series or small cohorts that could not establish a causal association with COVID-19 or provide risk estimates in different care settings. We sought to study all possible complications of COVID-19 to confirm previously reported complications and to identify potential complications not yet known.. ..Among 70 288 patients with COVID-19, 69 of 1724 analyzed ICD-10-CM … Continue reading Diagnosis-wide analysis of #COVID-19 complications: an exposure-crossover study

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