Editor’s summary
During sleep, there is an increase in the coordinated firing of neuronal ensembles that were previously active during behavior. These hippocampal sharp-wave ripples are necessary for sleep-dependent memory consolidation. However, how the hippocampus regulates such increases in ensemble reactivation and synchrony while keeping the overall homeostatic balance of the network is not known. Karaba et al. discovered a new type of network pattern, a barrage of activity, that originated in hippocampal area CA2 and involved pyramidal cells and a specific type of interneurons (see the Perspective by Mou and Ji). This barrage had differential effects on the efferent CA1 neurons and was dependent on experience. Optogenetic manipulations of this activity indicated its role in different tasks. Unlike sharp-wave ripples, which increase hippocampal output, this barrage decreased the output, thereby rebalancing the network. —Peter Stern
https://www.science.org/doi/10.1126/science.ado5708
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