INTRODUCTION
Our population-based study assessed whether clinically apparent Helicobacter pylori infection (CAHPI) is associated with the risk of Alzheimer’s disease (AD).
METHODS
We assembled a population-based cohort of all dementia-free subjects in the United Kingdom’s Clinical Practice Research Datalink (UK CPRD), aged ≥50 years (1988–2017). Using a nested case-control approach, we matched each newly developed case of AD with 40 controls. Conditional logistic regression estimated odds ratios (ORs) with 95% confidence intervals (CIs) of AD associated with CAHPI compared with no CAHPI during ≥2 years before the index date. We also used salmonellosis as a negative control exposure.
RESULTS
Among 4,262,092 dementia-free subjects, 40,455 developed AD after a mean 11 years of follow-up. CAHPI was associated with an increased risk of AD (OR, 1.11; 95% CI, 1.01–1.21) compared with no CAHPI. Salmonellosis was not associated with the risk of AD (OR, 1.03; 95% CI, 0.82–1.29).
DISCUSSION
CAHPI was associated with a moderately increased risk of AD.
Highlights
CAHPI was associated with an 11% increased risk of AD in subjects aged ≥50 years.
The increase in the risk of AD reached a peak of 24% a decade after CAHPI onset.
There was no major effect modification by age or sex.
Sensitivity analyses addressing several potential biases led to consistent results.
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.13561
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